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The map label for this gene is 146298981

Identifier: 146298981

GI number: 146298981

Start: 1394254

End: 1394793

Strand: Direct

Name: 146298981

Synonym: Fjoh_1221

Alternate gene names: NA

Gene position: 1394254-1394793 (Clockwise)

Preceding gene: 146298980

Following gene: 146298982

Centisome position: 22.87

GC content: 36.85

Gene sequence:

>540_bases
ATGGCTATAGCAAAACCATTCAATCTAACAAAATGGATTGAAGATAACCGACAATTACTAAAACCACCAGTTGGAAATAA
AAATCTATATGTTGATTCAGGCGATTATATTGTAATGATTGTTGCCGGACCAAACGCACGAAAAGATTATCATTATAATG
AAACCGAAGAACTTTTCTATCAGTTAGAAGGCAGTATTAAAGTGGTAATTCAGGAAGATGGCGAACGTAAGGAAATGGAA
TTAAATGCAGGAGATATGTATTTACATCCTGCAAAAGTACCGCACTCGCCTGTTCGTTCCGAAGGTTCAATAGGATTGGT
CATTGAGCGCAAACGTGCAGGACTTGGATATACCGACGGGCTTCTTTGGCATTGCGATAACTGCAATCATAAATTGTACG
AAGTGTATTTTGAGTTACATAATATTGAAAAAGACTTTCTTCCTCATTTCGAACATTTCTATAATTCAGAAGAATTAAGA
ACCTGCGATAAATGCGGCACCGTAATGGAAACAGACCCTAGATTTACGGCTAAGAAATAA

Upstream 100 bases:

>100_bases
AAGTCACAGTTTTTGATCAAAGGTTGCATCTGAATGCTGTGACCGCAACTGTATACTGAATACTTTTCACTACCTTAGCT
TTTCATAAATTCTGAAAAAA

Downstream 100 bases:

>100_bases
TTTATTTATCTCGAATATGAATCGAATAGTAACCCGACAGGTTTAAAACCTGTCGGGTTTATTTTTATGTTAAAGAAAAT
CACGTGTATCATTTTTGATA

Product: 3-hydroxyanthranilate 3,4-dioxygenase

Products: NA

Alternate protein names: 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MAIAKPFNLTKWIEDNRQLLKPPVGNKNLYVDSGDYIVMIVAGPNARKDYHYNETEELFYQLEGSIKVVIQEDGERKEME
LNAGDMYLHPAKVPHSPVRSEGSIGLVIERKRAGLGYTDGLLWHCDNCNHKLYEVYFELHNIEKDFLPHFEHFYNSEELR
TCDKCGTVMETDPRFTAKK

Sequences:

>Translated_179_residues
MAIAKPFNLTKWIEDNRQLLKPPVGNKNLYVDSGDYIVMIVAGPNARKDYHYNETEELFYQLEGSIKVVIQEDGERKEME
LNAGDMYLHPAKVPHSPVRSEGSIGLVIERKRAGLGYTDGLLWHCDNCNHKLYEVYFELHNIEKDFLPHFEHFYNSEELR
TCDKCGTVMETDPRFTAKK
>Mature_178_residues
AIAKPFNLTKWIEDNRQLLKPPVGNKNLYVDSGDYIVMIVAGPNARKDYHYNETEELFYQLEGSIKVVIQEDGERKEMEL
NAGDMYLHPAKVPHSPVRSEGSIGLVIERKRAGLGYTDGLLWHCDNCNHKLYEVYFELHNIEKDFLPHFEHFYNSEELRT
CDKCGTVMETDPRFTAKK

Specific function: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-HAO family [H]

Homologues:

Organism=Homo sapiens, GI188497625, Length=169, Percent_Identity=34.9112426035503, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562218, Length=161, Percent_Identity=36.6459627329193, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6322485, Length=178, Percent_Identity=40.4494382022472, Blast_Score=128, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010329
- InterPro:   IPR011051
- InterPro:   IPR014710 [H]

Pfam domain/function: PF06052 3-HAO [H]

EC number: =1.13.11.6 [H]

Molecular weight: Translated: 20769; Mature: 20638

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIAKPFNLTKWIEDNRQLLKPPVGNKNLYVDSGDYIVMIVAGPNARKDYHYNETEELFY
CCCCCCCCCHHHHHCCHHCCCCCCCCCEEEEECCCEEEEEEECCCCCCCCCCCHHHHHHE
QLEGSIKVVIQEDGERKEMELNAGDMYLHPAKVPHSPVRSEGSIGLVIERKRAGLGYTDG
EECCCEEEEEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
LLWHCDNCNHKLYEVYFELHNIEKDFLPHFEHFYNSEELRTCDKCGTVMETDPRFTAKK
EEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCEEECCCCCCCCC
>Mature Secondary Structure 
AIAKPFNLTKWIEDNRQLLKPPVGNKNLYVDSGDYIVMIVAGPNARKDYHYNETEELFY
CCCCCCCCHHHHHCCHHCCCCCCCCCEEEEECCCEEEEEEECCCCCCCCCCCHHHHHHE
QLEGSIKVVIQEDGERKEMELNAGDMYLHPAKVPHSPVRSEGSIGLVIERKRAGLGYTDG
EECCCEEEEEECCCCCEEEEECCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
LLWHCDNCNHKLYEVYFELHNIEKDFLPHFEHFYNSEELRTCDKCGTVMETDPRFTAKK
EEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]