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The map label for this gene is hemE

Identifier: 146298708

GI number: 146298708

Start: 1058440

End: 1059465

Strand: Direct

Name: hemE

Synonym: Fjoh_0946

Alternate gene names: 146298708

Gene position: 1058440-1059465 (Clockwise)

Preceding gene: 146298707

Following gene: 146298709

Centisome position: 17.36

GC content: 38.79

Gene sequence:

>1026_bases
ATGTTAAAAAACGACCTATTTTTAAAAGCATTAAAAGGAGAAACCGTTCAGCGTCCGCCAGTATGGATGATGCGTCAAGC
TGGAAGATATTTACCGGAATTCATCGAATTACGTGATAAATATGATTTCTTCACACGTTGTCAGACTCCAGAATTAGCTG
CTGAAATTACTGTACAGCCAATCCGCAGAATTGCTCCAGATGCCGCTATTTTGTTCTCAGACATTTTAGTTGTTCCGCAA
GCAATGGGAATCGAAGTTTTAATGAAAGAAAATATCGGTCCATTCATCCCAAATCCAATTCGTTCAATGGCTGATGTTCA
ACGAGTTTACGTTCCGGATATTCAGGAAAGTCTTGGTTATGTAATGGATGCAATCAAATTGACTAAAGAAATGCTGAACG
ACGAAGTTCCATTAATTGGTTTTGCTGGTTCGCCATGGACAATTTTCTGCTACGCTGTTGAAGGAAGAGGTTCTAAGAGT
TTTGATATGGCAAAAGGATTCTGCTTTTCAAATCCGGTTGCAGCACATACTTTATTGCAAAAAATCACTGATACTACAAT
TTTATACTTAAAAGAAAAAGTAAAAGCGGGAGTTGATGCCGTTCAGATTTTTGATTCTTGGGGAGGAATGCTTTCTCCTG
TTGATTATCAGGAATTCTCATGGAAATACATCAACCAAATCGTCGAAGCTTTGGCTGATTTAACTCCGGTTATTGTTTTC
GGAAAAGGATGCTGGTTTGCTCTTGGCGAAATGGGTAAAAGCCGTGCTTCTGCTCTTGGAGTAGACTGGACTTGTTCTGC
AAGAAATGCCCGTTACTTGTCTGGTGGAAACATTACACTACAAGGAAATTTTGATCCTTCAAGACTGCTTTCTCCAATTC
CAACAATCAAGAAAATGGTTCACGAAATGATCGATGAGTTTGGAAAAGATAAATATGTTGTAAATTTAGGACACGGAATT
TTACCAAATATTCCTGTAGATCACGCAAAAGCGTTTATCGACGCGGTTAAGGAATACGGACAATAG

Upstream 100 bases:

>100_bases
AATATAAATAGCAATAAGCTTTAGGCAGTAAGCCGTAAGCAAAAAATCATAGTTAAACAAGCTTAAAGCCTAAAGCTTAA
AGCCTAAAGCAAGGAAAAAA

Downstream 100 bases:

>100_bases
TCGTTGATAGTTTATGATTGATAGTTGTTGGATACGAATACTATCAACCATAAACCAACAACCATCAACTTAAAAATATG
CTAGCAAACCTAAACCTCAG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MLKNDLFLKALKGETVQRPPVWMMRQAGRYLPEFIELRDKYDFFTRCQTPELAAEITVQPIRRIAPDAAILFSDILVVPQ
AMGIEVLMKENIGPFIPNPIRSMADVQRVYVPDIQESLGYVMDAIKLTKEMLNDEVPLIGFAGSPWTIFCYAVEGRGSKS
FDMAKGFCFSNPVAAHTLLQKITDTTILYLKEKVKAGVDAVQIFDSWGGMLSPVDYQEFSWKYINQIVEALADLTPVIVF
GKGCWFALGEMGKSRASALGVDWTCSARNARYLSGGNITLQGNFDPSRLLSPIPTIKKMVHEMIDEFGKDKYVVNLGHGI
LPNIPVDHAKAFIDAVKEYGQ

Sequences:

>Translated_341_residues
MLKNDLFLKALKGETVQRPPVWMMRQAGRYLPEFIELRDKYDFFTRCQTPELAAEITVQPIRRIAPDAAILFSDILVVPQ
AMGIEVLMKENIGPFIPNPIRSMADVQRVYVPDIQESLGYVMDAIKLTKEMLNDEVPLIGFAGSPWTIFCYAVEGRGSKS
FDMAKGFCFSNPVAAHTLLQKITDTTILYLKEKVKAGVDAVQIFDSWGGMLSPVDYQEFSWKYINQIVEALADLTPVIVF
GKGCWFALGEMGKSRASALGVDWTCSARNARYLSGGNITLQGNFDPSRLLSPIPTIKKMVHEMIDEFGKDKYVVNLGHGI
LPNIPVDHAKAFIDAVKEYGQ
>Mature_341_residues
MLKNDLFLKALKGETVQRPPVWMMRQAGRYLPEFIELRDKYDFFTRCQTPELAAEITVQPIRRIAPDAAILFSDILVVPQ
AMGIEVLMKENIGPFIPNPIRSMADVQRVYVPDIQESLGYVMDAIKLTKEMLNDEVPLIGFAGSPWTIFCYAVEGRGSKS
FDMAKGFCFSNPVAAHTLLQKITDTTILYLKEKVKAGVDAVQIFDSWGGMLSPVDYQEFSWKYINQIVEALADLTPVIVF
GKGCWFALGEMGKSRASALGVDWTCSARNARYLSGGNITLQGNFDPSRLLSPIPTIKKMVHEMIDEFGKDKYVVNLGHGI
LPNIPVDHAKAFIDAVKEYGQ

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=349, Percent_Identity=45.5587392550143, Blast_Score=316, Evalue=2e-86,
Organism=Escherichia coli, GI2367337, Length=347, Percent_Identity=45.2449567723343, Blast_Score=306, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=45.042492917847, Blast_Score=306, Evalue=2e-84,
Organism=Drosophila melanogaster, GI19921920, Length=346, Percent_Identity=42.7745664739884, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI221330099, Length=346, Percent_Identity=42.7745664739884, Blast_Score=298, Evalue=3e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_FLAJ1 (A5FLE7)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001193299.1
- ProteinModelPortal:   A5FLE7
- SMR:   A5FLE7
- STRING:   A5FLE7
- GeneID:   5091360
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_0946
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   CLSK851825
- BioCyc:   FJOH376686:FJOH_0946-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38126; Mature: 38126

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 44-44 BINDING 74-74 BINDING 151-151 BINDING 206-206 BINDING 318-318

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNDLFLKALKGETVQRPPVWMMRQAGRYLPEFIELRDKYDFFTRCQTPELAAEITVQP
CCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IRRIAPDAAILFSDILVVPQAMGIEVLMKENIGPFIPNPIRSMADVQRVYVPDIQESLGY
HHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHH
VMDAIKLTKEMLNDEVPLIGFAGSPWTIFCYAVEGRGSKSFDMAKGFCFSNPVAAHTLLQ
HHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCCHHHHCCCCCCCCHHHHHHHH
KITDTTILYLKEKVKAGVDAVQIFDSWGGMLSPVDYQEFSWKYINQIVEALADLTPVIVF
HHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
GKGCWFALGEMGKSRASALGVDWTCSARNARYLSGGNITLQGNFDPSRLLSPIPTIKKMV
CCCHHHHHHHHCHHHHHHCCCCEEECCCCCEEEECCEEEEECCCCHHHHHCCCHHHHHHH
HEMIDEFGKDKYVVNLGHGILPNIPVDHAKAFIDAVKEYGQ
HHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKNDLFLKALKGETVQRPPVWMMRQAGRYLPEFIELRDKYDFFTRCQTPELAAEITVQP
CCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IRRIAPDAAILFSDILVVPQAMGIEVLMKENIGPFIPNPIRSMADVQRVYVPDIQESLGY
HHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHH
VMDAIKLTKEMLNDEVPLIGFAGSPWTIFCYAVEGRGSKSFDMAKGFCFSNPVAAHTLLQ
HHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCCHHHHCCCCCCCCHHHHHHHH
KITDTTILYLKEKVKAGVDAVQIFDSWGGMLSPVDYQEFSWKYINQIVEALADLTPVIVF
HHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
GKGCWFALGEMGKSRASALGVDWTCSARNARYLSGGNITLQGNFDPSRLLSPIPTIKKMV
CCCHHHHHHHHCHHHHHHCCCCEEECCCCCEEEECCEEEEECCCCHHHHHCCCHHHHHHH
HEMIDEFGKDKYVVNLGHGILPNIPVDHAKAFIDAVKEYGQ
HHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA