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The map label for this gene is gmk [H]

Identifier: 146298505

GI number: 146298505

Start: 819451

End: 820023

Strand: Direct

Name: gmk [H]

Synonym: Fjoh_0742

Alternate gene names: 146298505

Gene position: 819451-820023 (Clockwise)

Preceding gene: 146298504

Following gene: 146298506

Centisome position: 13.44

GC content: 36.3

Gene sequence:

>573_bases
ATGAACAAAGGAAAACTAATTGTTTTTTCGGCACCTTCAGGATCAGGAAAAACAACTATCGTAAAACATTTATTAGGTCA
GGAAGATTTAAATCTTGAATTTTCGATTTCGGCTGCATCGCGTGCACCGCGTGGTGAAGAAGTACACGGAAAGGATTATT
ATTTTATTTCGCTGGAAGAATTCAAAAAACACATTAAAGCAGAGGATTTCCTGGAATGGGAAGAAGTTTACCGAGATAAC
TTTTACGGTACTTTAAAATCGGAGATTGAAAGAATCTGGGCTTTAGGAAAAAATGTCATTTTTGACATTGACGTGGTTGG
CGGTCTTCGTATTAAACATAAATTTCCCGAAGAAACTCTAGCTGTTTTCGTTAAACCTCCAAGTGTTGACGAATTAAAAC
GCCGATTAAAACAACGTTCTACAGAAAGTGAAGACAAAATCAATATGCGTATTGCAAAAGCTTCTGTAGAATTGGCAACT
GCTCCACAATTTGACGCTATTATCAAAAACTATGATTTATCAGTTGCCCTTGAAGAAGCACATCAACTGGTAAAGGATTT
TGTATCTAAGTAG

Upstream 100 bases:

>100_bases
GATTAAAGAACAAGTATTGAATGTGCTTTAAAGCTTAAAGCATAAATACCACACAAATATCAAGCTTAGAGCATATTGCT
TAAAGCCTAAAGCATACACA

Downstream 100 bases:

>100_bases
TTATTTAGTCATTAGTTGTTAGTCCTTAGTCTGAAACACATCAAGCTAAAAATTTTACATGAGCGGTATTAAATCTTACA
AAGAGTTATTCATTTGGCAA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MNKGKLIVFSAPSGSGKTTIVKHLLGQEDLNLEFSISAASRAPRGEEVHGKDYYFISLEEFKKHIKAEDFLEWEEVYRDN
FYGTLKSEIERIWALGKNVIFDIDVVGGLRIKHKFPEETLAVFVKPPSVDELKRRLKQRSTESEDKINMRIAKASVELAT
APQFDAIIKNYDLSVALEEAHQLVKDFVSK

Sequences:

>Translated_190_residues
MNKGKLIVFSAPSGSGKTTIVKHLLGQEDLNLEFSISAASRAPRGEEVHGKDYYFISLEEFKKHIKAEDFLEWEEVYRDN
FYGTLKSEIERIWALGKNVIFDIDVVGGLRIKHKFPEETLAVFVKPPSVDELKRRLKQRSTESEDKINMRIAKASVELAT
APQFDAIIKNYDLSVALEEAHQLVKDFVSK
>Mature_190_residues
MNKGKLIVFSAPSGSGKTTIVKHLLGQEDLNLEFSISAASRAPRGEEVHGKDYYFISLEEFKKHIKAEDFLEWEEVYRDN
FYGTLKSEIERIWALGKNVIFDIDVVGGLRIKHKFPEETLAVFVKPPSVDELKRRLKQRSTESEDKINMRIAKASVELAT
APQFDAIIKNYDLSVALEEAHQLVKDFVSK

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=193, Percent_Identity=34.1968911917098, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI4504221, Length=193, Percent_Identity=34.1968911917098, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI226874831, Length=193, Percent_Identity=34.1968911917098, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI262118263, Length=142, Percent_Identity=31.6901408450704, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI4505237, Length=142, Percent_Identity=31.6901408450704, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI262118255, Length=142, Percent_Identity=31.6901408450704, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI262118259, Length=142, Percent_Identity=31.6901408450704, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI38570142, Length=185, Percent_Identity=25.4054054054054, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1790080, Length=186, Percent_Identity=38.7096774193548, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI193203132, Length=188, Percent_Identity=36.1702127659575, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=188, Percent_Identity=36.1702127659575, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320662, Length=185, Percent_Identity=41.0810810810811, Blast_Score=140, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21356141, Length=181, Percent_Identity=39.2265193370166, Blast_Score=120, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21658; Mature: 21658

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKGKLIVFSAPSGSGKTTIVKHLLGQEDLNLEFSISAASRAPRGEEVHGKDYYFISLEE
CCCCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEHHH
FKKHIKAEDFLEWEEVYRDNFYGTLKSEIERIWALGKNVIFDIDVVGGLRIKHKFPEETL
HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEECCEEEECCCCCCCE
AVFVKPPSVDELKRRLKQRSTESEDKINMRIAKASVELATAPQFDAIIKNYDLSVALEEA
EEEECCCCHHHHHHHHHHCCCCCCCHHEEEEEEEEEEEECCCCHHHHHHCCCCEEHHHHH
HQLVKDFVSK
HHHHHHHHCC
>Mature Secondary Structure
MNKGKLIVFSAPSGSGKTTIVKHLLGQEDLNLEFSISAASRAPRGEEVHGKDYYFISLEE
CCCCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEHHH
FKKHIKAEDFLEWEEVYRDNFYGTLKSEIERIWALGKNVIFDIDVVGGLRIKHKFPEETL
HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEECCEEEECCCCCCCE
AVFVKPPSVDELKRRLKQRSTESEDKINMRIAKASVELATAPQFDAIIKNYDLSVALEEA
EEEECCCCHHHHHHHHHHCCCCCCCHHEEEEEEEEEEEECCCCHHHHHHCCCCEEHHHHH
HQLVKDFVSK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]