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The map label for this gene is cyoE-1

Identifier: 146284482

GI number: 146284482

Start: 4524676

End: 4525575

Strand: Direct

Name: cyoE-1

Synonym: PST_4171

Alternate gene names: 146284482

Gene position: 4524676-4525575 (Clockwise)

Preceding gene: 146284481

Following gene: 146284483

Centisome position: 99.06

GC content: 66.11

Gene sequence:

>900_bases
ATGGCGACTCTACTCAGCGAACGCGGCGCTCAGGCCAGCTGGCGCGACTACCTGGAGCTGACCAAGCCGAAGGTGGTGCT
GCTGATGCTCATCACCTCGCTGGTGGGCATGTTCCTCGCCACCCGCGCCGGTGTGCCCTGGACGGTGCTGCTGTTCGGCA
ACCTCGGCATCGCCCTGTGCGCCGGCGGCGCGGCGGCGGTGAACCATGTGGTGGACCGGCAGATCGATTCGGTGATGGCC
CGCACCCACAAGCGGCCACTGGCAGAAGGCCGGGTCTCGCCGGCGGCGGCACTGACCTTCGCCTTCGTCCTCGGCGTCAG
CGGGCTGGCCCTGCTGCTGACCTTCACCAACGCCCTCGCCGCCTGGCTGACGCTGGCCTCGCTGATCGGTTACGCGGTGA
TCTATACCGGCTTTCTCAAGCGCGCCACACCGCAGAACATCGTCATCGGCGGCCTGGCCGGCGCCGCGCCGCCCCTGCTC
GGCTGGGTCGCGGTAACCGGCCAGGTCACCGCCGAGCCGCTGCTGCTGGTGCTGATCATCTTCGCCTGGACGCCGCCACA
CTTCTGGGCCCTGGCGATCCACCGCAAGGACGAGTACGCCAAGGTCAACGTGCCGATGCTGCCGGTGACCCATGGCGTGC
ACTACACCAAGGTGCACATCCTGCTCTACACCGCCATGCTGCTGGCGGTCAGCTTCATGCCCTTCGCCATTCACATGAGC
GGCCCGCTGTACCTGGCCGCCGCGGTGCTGCTGGGCGCGCGCTTCCTCTACTGGACCATCGCGCTATACCGCGACAGCCG
GCCACATGCGGCAATCAAGACGTTCAAATTCAGCATCTGGTACCTGTTCGCGCTGTTCATCGCGCTGCTGGTTGATCATT
ATCTGCTACTCGATTTCTAG

Upstream 100 bases:

>100_bases
GCCAGCCTGCACATGCCACCCGGCAAACCGAGCCTGCATCGATTTCGAACACGACTGGGCAGCTCGATCTGCCCCGCGCA
TGACCACAAGGAGAACCCCC

Downstream 100 bases:

>100_bases
TGGTCTGTGCGGTGAGCGGGTTGAGGCAAGTTCGGATGAACATGGCTCCGAGACAAGGCGCTGCGACGAGTCATAGCGAG
CTATGGCAAGGAGCAGCAAC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MATLLSERGAQASWRDYLELTKPKVVLLMLITSLVGMFLATRAGVPWTVLLFGNLGIALCAGGAAAVNHVVDRQIDSVMA
RTHKRPLAEGRVSPAAALTFAFVLGVSGLALLLTFTNALAAWLTLASLIGYAVIYTGFLKRATPQNIVIGGLAGAAPPLL
GWVAVTGQVTAEPLLLVLIIFAWTPPHFWALAIHRKDEYAKVNVPMLPVTHGVHYTKVHILLYTAMLLAVSFMPFAIHMS
GPLYLAAAVLLGARFLYWTIALYRDSRPHAAIKTFKFSIWYLFALFIALLVDHYLLLDF

Sequences:

>Translated_299_residues
MATLLSERGAQASWRDYLELTKPKVVLLMLITSLVGMFLATRAGVPWTVLLFGNLGIALCAGGAAAVNHVVDRQIDSVMA
RTHKRPLAEGRVSPAAALTFAFVLGVSGLALLLTFTNALAAWLTLASLIGYAVIYTGFLKRATPQNIVIGGLAGAAPPLL
GWVAVTGQVTAEPLLLVLIIFAWTPPHFWALAIHRKDEYAKVNVPMLPVTHGVHYTKVHILLYTAMLLAVSFMPFAIHMS
GPLYLAAAVLLGARFLYWTIALYRDSRPHAAIKTFKFSIWYLFALFIALLVDHYLLLDF
>Mature_298_residues
ATLLSERGAQASWRDYLELTKPKVVLLMLITSLVGMFLATRAGVPWTVLLFGNLGIALCAGGAAAVNHVVDRQIDSVMAR
THKRPLAEGRVSPAAALTFAFVLGVSGLALLLTFTNALAAWLTLASLIGYAVIYTGFLKRATPQNIVIGGLAGAAPPLLG
WVAVTGQVTAEPLLLVLIIFAWTPPHFWALAIHRKDEYAKVNVPMLPVTHGVHYTKVHILLYTAMLLAVSFMPFAIHMSG
PLYLAAAVLLGARFLYWTIALYRDSRPHAAIKTFKFSIWYLFALFIALLVDHYLLLDF

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=193, Percent_Identity=35.2331606217617, Blast_Score=111, Evalue=9e-25,
Organism=Escherichia coli, GI1786631, Length=281, Percent_Identity=33.8078291814947, Blast_Score=161, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71998235, Length=196, Percent_Identity=34.6938775510204, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6325085, Length=274, Percent_Identity=28.4671532846715, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI19921064, Length=278, Percent_Identity=30.2158273381295, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYOE_PSEU5 (A4VS42)

Other databases:

- EMBL:   CP000304
- RefSeq:   YP_001174635.1
- STRING:   A4VS42
- GeneID:   5097130
- GenomeReviews:   CP000304_GR
- KEGG:   psa:PST_4171
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   MALTEEW
- PhylomeDB:   A4VS42
- ProtClustDB:   PRK04375
- BioCyc:   PSTU379731:PST_4171-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32608; Mature: 32477

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x20502e98)-; HASH(0x20e5b948)-; HASH(0x20e4647c)-; HASH(0x20a513a8)-; HASH(0x20896d60)-; HASH(0x20e5406c)-; HASH(0x20f3e5a4)-; HASH(0x20e5b630)-; HASH(0x20e1834c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLLSERGAQASWRDYLELTKPKVVLLMLITSLVGMFLATRAGVPWTVLLFGNLGIALC
CCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHH
AGGAAAVNHVVDRQIDSVMARTHKRPLAEGRVSPAAALTFAFVLGVSGLALLLTFTNALA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWLTLASLIGYAVIYTGFLKRATPQNIVIGGLAGAAPPLLGWVAVTGQVTAEPLLLVLII
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHH
FAWTPPHFWALAIHRKDEYAKVNVPMLPVTHGVHYTKVHILLYTAMLLAVSFMPFAIHMS
HHCCCCHHEEEEEEECCCCEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEECC
GPLYLAAAVLLGARFLYWTIALYRDSRPHAAIKTFKFSIWYLFALFIALLVDHYLLLDF
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
ATLLSERGAQASWRDYLELTKPKVVLLMLITSLVGMFLATRAGVPWTVLLFGNLGIALC
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHH
AGGAAAVNHVVDRQIDSVMARTHKRPLAEGRVSPAAALTFAFVLGVSGLALLLTFTNALA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWLTLASLIGYAVIYTGFLKRATPQNIVIGGLAGAAPPLLGWVAVTGQVTAEPLLLVLII
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHH
FAWTPPHFWALAIHRKDEYAKVNVPMLPVTHGVHYTKVHILLYTAMLLAVSFMPFAIHMS
HHCCCCHHEEEEEEECCCCEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEECC
GPLYLAAAVLLGARFLYWTIALYRDSRPHAAIKTFKFSIWYLFALFIALLVDHYLLLDF
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA