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The map label for this gene is coIII [H]

Identifier: 146284477

GI number: 146284477

Start: 4521082

End: 4521978

Strand: Direct

Name: coIII [H]

Synonym: PST_4166

Alternate gene names: 146284477

Gene position: 4521082-4521978 (Clockwise)

Preceding gene: 146284476

Following gene: 146284479

Centisome position: 98.99

GC content: 63.21

Gene sequence:

>897_bases
ATGAGCCAACAGACCACCCACGAGCAGTACTACGTTCCTGATCAGAGCAAATGGCCGATCATCGCCACCATCGCCCTGCT
GGTCACCTTCTATGGCCTGGGCAGCTGGTTCAACGACCTCAAGGCCGCCCGTGATTCGTCCAACGGGCCGCTGATCTTCT
TCGTCGGCGCGCTGCTGATCGCCTACATGATGTTCGGCTGGTTCGGCGCTGTGGTGAAGGAAAGCCGCGCGGGGCTGTAC
AGCGCACAGATGGATCGCTCGTTCCGCTGGGGCATGAGCTGGTTCATCTTCTCGGAGGTGATGTTCTTCCTCGCCTTCTT
CGGCGCGCTCTTCTACATCCGCTACTGGACCGGCCCCTGGCTCGCCGGCGAGGGCGACAAGGGCATCAGCAACATGCTCT
GGCCCGGCTTCGAGTACAGCTGGCCGCTGCTGAACAACCCCGACCCGAAGCTCTACCCGGCGCCGGAGGGCACCATCAGC
GCCTGGGGCCTGCCGCTGATCAACACCATCCTGCTGGTCAGCTCCAGCTTCACCCTGACCTGGGCGCACCATGCGCTGCG
CAAGAACAACCGCCAGCACCTGAAGATCGGCCTGGGCCTGACCGTGCTGCTCGGCGTGGCATTCCTGATCCTGCAGATCG
AGGAGTATGTGCACGCCTACACCGAACTCGGGCTGACGCTGGGCTCGGGCATCTATGGCGCGACCTTCTTCATGCTCACC
GGCTTTCACGGCGCCCACGTGACCATGGGCGCGATCATCCTCACGGTGATGCTGGTGCGCATCCTGCGCGGGCACTTCAG
CCCGGAGCAGCACTTCGGTTTCGAGGCGGCGGCCTGGTACTGGCACTTCGTCGACGTGGTGTGGATCGCGCTGTTCGTGT
TCGTCTACGTGATCTAG

Upstream 100 bases:

>100_bases
TGCATCACCTGACCCTCGCCTACACGCTGTTCGACATCACGTCCCGCCAGCCGCCGGTGGCCGTCAACGCCGCATCGGCC
CCGGCCAAGGAGAGTCTGCA

Downstream 100 bases:

>100_bases
GGAGCTCTCAGAAACCGAAGGCGGGGCGTAGCTGCCCCGTATAGAAACCCCAGCCGATCAGCGCGACGGTCAGCGCGCTG
AGGGTGACGCGGATGAACAG

Product: cytochrome c oxidase, subunit III

Products: NA

Alternate protein names: Cytochrome aa3 subunit 3; Cytochrome c oxidase polypeptide III; Oxidase aa(3) subunit 3 [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSQQTTHEQYYVPDQSKWPIIATIALLVTFYGLGSWFNDLKAARDSSNGPLIFFVGALLIAYMMFGWFGAVVKESRAGLY
SAQMDRSFRWGMSWFIFSEVMFFLAFFGALFYIRYWTGPWLAGEGDKGISNMLWPGFEYSWPLLNNPDPKLYPAPEGTIS
AWGLPLINTILLVSSSFTLTWAHHALRKNNRQHLKIGLGLTVLLGVAFLILQIEEYVHAYTELGLTLGSGIYGATFFMLT
GFHGAHVTMGAIILTVMLVRILRGHFSPEQHFGFEAAAWYWHFVDVVWIALFVFVYVI

Sequences:

>Translated_298_residues
MSQQTTHEQYYVPDQSKWPIIATIALLVTFYGLGSWFNDLKAARDSSNGPLIFFVGALLIAYMMFGWFGAVVKESRAGLY
SAQMDRSFRWGMSWFIFSEVMFFLAFFGALFYIRYWTGPWLAGEGDKGISNMLWPGFEYSWPLLNNPDPKLYPAPEGTIS
AWGLPLINTILLVSSSFTLTWAHHALRKNNRQHLKIGLGLTVLLGVAFLILQIEEYVHAYTELGLTLGSGIYGATFFMLT
GFHGAHVTMGAIILTVMLVRILRGHFSPEQHFGFEAAAWYWHFVDVVWIALFVFVYVI
>Mature_297_residues
SQQTTHEQYYVPDQSKWPIIATIALLVTFYGLGSWFNDLKAARDSSNGPLIFFVGALLIAYMMFGWFGAVVKESRAGLYS
AQMDRSFRWGMSWFIFSEVMFFLAFFGALFYIRYWTGPWLAGEGDKGISNMLWPGFEYSWPLLNNPDPKLYPAPEGTISA
WGLPLINTILLVSSSFTLTWAHHALRKNNRQHLKIGLGLTVLLGVAFLILQIEEYVHAYTELGLTLGSGIYGATFFMLTG
FHGAHVTMGAIILTVMLVRILRGHFSPEQHFGFEAAAWYWHFVDVVWIALFVFVYVI

Specific function: Cytochrome O Terminal Oxidase Complex Is The Component Of The Aerobic Respiratory Chain Of E.Coli That Predominates When Cells Are Grown At High Aeration. [C]

COG id: COG1845

COG function: function code C; Heme/copper-type cytochrome/quinol oxidase, subunit 3

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 3 family [H]

Homologues:

Organism=Homo sapiens, GI251831113, Length=297, Percent_Identity=36.026936026936, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1786633, Length=133, Percent_Identity=36.0902255639098, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6226542, Length=231, Percent_Identity=30.3030303030303, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000298
- InterPro:   IPR013833 [H]

Pfam domain/function: PF00510 COX3 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 33832; Mature: 33701

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50253 COX3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQTTHEQYYVPDQSKWPIIATIALLVTFYGLGSWFNDLKAARDSSNGPLIFFVGALLI
CCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AYMMFGWFGAVVKESRAGLYSAQMDRSFRWGMSWFIFSEVMFFLAFFGALFYIRYWTGPW
HHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LAGEGDKGISNMLWPGFEYSWPLLNNPDPKLYPAPEGTISAWGLPLINTILLVSSSFTLT
ECCCCCCCHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCCHHH
WAHHALRKNNRQHLKIGLGLTVLLGVAFLILQIEEYVHAYTELGLTLGSGIYGATFFMLT
HHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GFHGAHVTMGAIILTVMLVRILRGHFSPEQHFGFEAAAWYWHFVDVVWIALFVFVYVI
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SQQTTHEQYYVPDQSKWPIIATIALLVTFYGLGSWFNDLKAARDSSNGPLIFFVGALLI
CCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AYMMFGWFGAVVKESRAGLYSAQMDRSFRWGMSWFIFSEVMFFLAFFGALFYIRYWTGPW
HHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LAGEGDKGISNMLWPGFEYSWPLLNNPDPKLYPAPEGTISAWGLPLINTILLVSSSFTLT
ECCCCCCCHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCCHHH
WAHHALRKNNRQHLKIGLGLTVLLGVAFLILQIEEYVHAYTELGLTLGSGIYGATFFMLT
HHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GFHGAHVTMGAIILTVMLVRILRGHFSPEQHFGFEAAAWYWHFVDVVWIALFVFVYVI
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3019767; 2832167; 7651515 [H]