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The map label for this gene is proC [H]

Identifier: 146284279

GI number: 146284279

Start: 4303700

End: 4304485

Strand: Direct

Name: proC [H]

Synonym: PST_3967

Alternate gene names: 146284279

Gene position: 4303700-4304485 (Clockwise)

Preceding gene: 146284278

Following gene: 146284280

Centisome position: 94.23

GC content: 68.19

Gene sequence:

>786_bases
ATGGCCGCCAGCCTGATCGGCGGGCTGCGTGCCCAGGGCATCGCCGCTGATGCCATCCGCGCCAGCGACCCGGGTGCCGA
ACAGCGCGCGAAAATCAGCGCCGAACACGGCATCCAGACCTTCGCCCAGAATGCCGAAGCACTGGCTGACGCCGATGTGG
TGGTGCTGTCGGTTAAGCCGCAGGTGATGCAGGCCGTCTGCCGCGACCTGGCCGCCCACCTCGAACAAGGGCCGCTGATC
GTGTCCATCGCCGCCGGCATCAGCTGCGACAGCCTGCAGCGCTGGCTCGGCCCGCGGCCGCAGGCGATCGTGCGCTGCAT
GCCCAACACACCGGCGCTGCTGCGCCAGGGCGTCAGCGGCTTGTTTGCCAACGCCCAGGTCAGTGCCGAGCAGAAGGCCC
AGGCCGAACAGCTGCTGTCAGCCGTCGGCATGGCGCTGTGGCTCGACGAGGAGCACCTGATCGATGCGGTGACTGCCGTT
TCCGGCAGTGGCCCGGCCTATTTCTTCCTACTCATCGAGGCGATGACCGCTGCCGGCCAGCAGCTCGGCCTGCCTCGCGA
AACCGCCGCCCAGCTGACCCTGCAGACCGCGCTGGGAGCAGCCCGCATGGCCTGTGAGAGCGATGTCGAGGCGGCCGAAC
TGCGACGCCGCGTCACCTCGCCGAACGGAACCACCGAAGCGGCGATCAAAGCCTTCCAGGCTGGCGGCTTCGAGCAGCTG
GTGCAGCAGGCATTGAACGCCGCTGCACAACGCTCGGCCGAACTGGCCGAACAACTGGGCCAATAA

Upstream 100 bases:

>100_bases
CGCATCGGCACTGCTCTCTTCGGCGCCCGTGACTACGGCCGCCCTCAATAAAGGAATCGCTATGACCTCTCCCCGCATCG
CCTTCATCGGCGCCGGCAAC

Downstream 100 bases:

>100_bases
GGAGCATTCATGTCCCAACTCTCGCAAGCCCTGATCCTCGTCATCCAGACCCTGGGCAGCCTTTACCTGCTGATCGTGCT
GCTGCGCTTCATCCTCCAGC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MAASLIGGLRAQGIAADAIRASDPGAEQRAKISAEHGIQTFAQNAEALADADVVVLSVKPQVMQAVCRDLAAHLEQGPLI
VSIAAGISCDSLQRWLGPRPQAIVRCMPNTPALLRQGVSGLFANAQVSAEQKAQAEQLLSAVGMALWLDEEHLIDAVTAV
SGSGPAYFFLLIEAMTAAGQQLGLPRETAAQLTLQTALGAARMACESDVEAAELRRRVTSPNGTTEAAIKAFQAGGFEQL
VQQALNAAAQRSAELAEQLGQ

Sequences:

>Translated_261_residues
MAASLIGGLRAQGIAADAIRASDPGAEQRAKISAEHGIQTFAQNAEALADADVVVLSVKPQVMQAVCRDLAAHLEQGPLI
VSIAAGISCDSLQRWLGPRPQAIVRCMPNTPALLRQGVSGLFANAQVSAEQKAQAEQLLSAVGMALWLDEEHLIDAVTAV
SGSGPAYFFLLIEAMTAAGQQLGLPRETAAQLTLQTALGAARMACESDVEAAELRRRVTSPNGTTEAAIKAFQAGGFEQL
VQQALNAAAQRSAELAEQLGQ
>Mature_260_residues
AASLIGGLRAQGIAADAIRASDPGAEQRAKISAEHGIQTFAQNAEALADADVVVLSVKPQVMQAVCRDLAAHLEQGPLIV
SIAAGISCDSLQRWLGPRPQAIVRCMPNTPALLRQGVSGLFANAQVSAEQKAQAEQLLSAVGMALWLDEEHLIDAVTAVS
GSGPAYFFLLIEAMTAAGQQLGLPRETAAQLTLQTALGAARMACESDVEAAELRRRVTSPNGTTEAAIKAFQAGGFEQLV
QQALNAAAQRSAELAEQLGQ

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=261, Percent_Identity=37.1647509578544, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI24797097, Length=261, Percent_Identity=37.1647509578544, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI21361454, Length=261, Percent_Identity=36.0153256704981, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI198041662, Length=259, Percent_Identity=30.5019305019305, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786585, Length=259, Percent_Identity=34.7490347490347, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17569021, Length=258, Percent_Identity=38.7596899224806, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17540664, Length=277, Percent_Identity=28.158844765343, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320861, Length=222, Percent_Identity=31.5315315315315, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21358587, Length=258, Percent_Identity=35.2713178294574, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24648116, Length=269, Percent_Identity=31.9702602230483, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=35.672514619883, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27174; Mature: 27043

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASLIGGLRAQGIAADAIRASDPGAEQRAKISAEHGIQTFAQNAEALADADVVVLSVKP
CCCHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCH
QVMQAVCRDLAAHLEQGPLIVSIAAGISCDSLQRWLGPRPQAIVRCMPNTPALLRQGVSG
HHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCHHHHHEECCCCHHHHHHHHHH
LFANAQVSAEQKAQAEQLLSAVGMALWLDEEHLIDAVTAVSGSGPAYFFLLIEAMTAAGQ
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QLGLPRETAAQLTLQTALGAARMACESDVEAAELRRRVTSPNGTTEAAIKAFQAGGFEQL
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHH
VQQALNAAAQRSAELAEQLGQ
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AASLIGGLRAQGIAADAIRASDPGAEQRAKISAEHGIQTFAQNAEALADADVVVLSVKP
CCHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCH
QVMQAVCRDLAAHLEQGPLIVSIAAGISCDSLQRWLGPRPQAIVRCMPNTPALLRQGVSG
HHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCHHHHHEECCCCHHHHHHHHHH
LFANAQVSAEQKAQAEQLLSAVGMALWLDEEHLIDAVTAVSGSGPAYFFLLIEAMTAAGQ
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QLGLPRETAAQLTLQTALGAARMACESDVEAAELRRRVTSPNGTTEAAIKAFQAGGFEQL
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHH
VQQALNAAAQRSAELAEQLGQ
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]