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The map label for this gene is ndh [H]

Identifier: 146283952

GI number: 146283952

Start: 3925938

End: 3927233

Strand: Direct

Name: ndh [H]

Synonym: PST_3635

Alternate gene names: 146283952

Gene position: 3925938-3927233 (Clockwise)

Preceding gene: 146283951

Following gene: 146283953

Centisome position: 85.96

GC content: 63.5

Gene sequence:

>1296_bases
ATGTCACATCGAATCGTAATCGTCGGCGGCGGCGCTGGCGGCCTGGAGCTTGCTACCCGCCTGGGTAGAACCCTGGGCAA
GCGCGGCAAAGCCCGGGTCACCCTGGTCGACGCGAATCTCACCCACATCTGGAAGCCGCTGCTGCATGAAGTGGCAGCCG
GCTCGCTGAACTCGTCAGCCGACGAGCTCAACTATGTGGCGCAAGCCAAGTGGAATCACTTCGAGTTCCAGATGGGCCGC
ATGGCCGGCCTGGACCGTGCGAACAAGTGCATCCGCCTGGAAGCCACACGCGACGAGTTCGGCGTGGAGCTCGTGCCCTC
GCGTGCGTTGAACTACGACACTCTGGTGATAGCGGTCGGCAGCACGACCAACGACTTCGGAACCCCCGGGGCCGCCGAGC
ACTGCATTTTCCTGGATACCCGCGAGCAGGCCGAACGCTTCCATCGCCAGCTGCTGAGCCGTTACATGAAGGCACATGCC
GGTGAAACCGGGCCGAGCGGCATCAGCATGGCCATCGTCGGCGCTGGCGCCACCGGTGTCGAACTGGCCGCCGAACTGCT
GCATGCAGCCAAGGAACTGGCCGCCTATGGCCTCGATGGAATCAAGCCGGAAGATGTGAAGATCACGCTCATCGAGGCCG
GCCCGAAGGTTCTGCCGGCACTGCCCGAGCGCATCAGCCAACCGGTACACCAGACACTGCTCGACTTGGGTGTGAAGGTG
CTGACCGGCGCAGCGGTCAGCGAAGTCACCGCCGACGGCCTGCACACCAAGCAGGGTGAATTCGTGCCGGCCAGCCTCAA
AGTCTGGGCGGCCGGCATCAAGGCACCCGCCTTCCTGCATGAAATCGATGGGCTGGAGACCAACCGGATCAATCAACTGG
TCGTCCACCCCACCCTGCAGAGCACCCGCGACGAGAACATATTCGCCTTCGGCGACTGCGCCGCCTGCCCGCAGCCGGAC
AGCGACCGGAACGTGCCGCCTCGCGCCCAGGCAGCCCACCAGCAGGCGTCAATGCTGGCCCGGTCGATCCGCAACCGACT
GGAAGGCAAACCCCTGCCGACCTACCGCTACAAGGATTACGGCTCGCTGATATCGCTCTCGACCTTCTCGGCCGTGGGCA
ATCTGATGGGCAATTTGACGGGCAACGTCATGCTCGAGGGCTGGCTGGCGAGGATGTTCTATATCTCGCTGTACCGCATG
CACCAGATTGCACTGTACGGCATGCCGCGCACGCTGCTGATGATGCTGGGCGACAAGCTCAGCCGTAGTACCGAACCACG
CCTGAAACTCCATTGA

Upstream 100 bases:

>100_bases
TCGGCCTCGGGCTTCTGAGCCGCCTCCTGAGTCGCCTGGTGCTTTGAGCTTCGCTCGCCCCGTCGCGCCGCCGTTTCTCT
TGCAGCTATGAGTCATTCCC

Downstream 100 bases:

>100_bases
CGCATTGATGGCGCACCCGAGCGGTGCGCCATCTGGCAAGCACTAAACGGCAGGCAATAAAAAAGCTGGATGCCCGTATG
GACATCCAGCTTTTCATGCT

Product: NADH dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSHRIVIVGGGAGGLELATRLGRTLGKRGKARVTLVDANLTHIWKPLLHEVAAGSLNSSADELNYVAQAKWNHFEFQMGR
MAGLDRANKCIRLEATRDEFGVELVPSRALNYDTLVIAVGSTTNDFGTPGAAEHCIFLDTREQAERFHRQLLSRYMKAHA
GETGPSGISMAIVGAGATGVELAAELLHAAKELAAYGLDGIKPEDVKITLIEAGPKVLPALPERISQPVHQTLLDLGVKV
LTGAAVSEVTADGLHTKQGEFVPASLKVWAAGIKAPAFLHEIDGLETNRINQLVVHPTLQSTRDENIFAFGDCAACPQPD
SDRNVPPRAQAAHQQASMLARSIRNRLEGKPLPTYRYKDYGSLISLSTFSAVGNLMGNLTGNVMLEGWLARMFYISLYRM
HQIALYGMPRTLLMMLGDKLSRSTEPRLKLH

Sequences:

>Translated_431_residues
MSHRIVIVGGGAGGLELATRLGRTLGKRGKARVTLVDANLTHIWKPLLHEVAAGSLNSSADELNYVAQAKWNHFEFQMGR
MAGLDRANKCIRLEATRDEFGVELVPSRALNYDTLVIAVGSTTNDFGTPGAAEHCIFLDTREQAERFHRQLLSRYMKAHA
GETGPSGISMAIVGAGATGVELAAELLHAAKELAAYGLDGIKPEDVKITLIEAGPKVLPALPERISQPVHQTLLDLGVKV
LTGAAVSEVTADGLHTKQGEFVPASLKVWAAGIKAPAFLHEIDGLETNRINQLVVHPTLQSTRDENIFAFGDCAACPQPD
SDRNVPPRAQAAHQQASMLARSIRNRLEGKPLPTYRYKDYGSLISLSTFSAVGNLMGNLTGNVMLEGWLARMFYISLYRM
HQIALYGMPRTLLMMLGDKLSRSTEPRLKLH
>Mature_430_residues
SHRIVIVGGGAGGLELATRLGRTLGKRGKARVTLVDANLTHIWKPLLHEVAAGSLNSSADELNYVAQAKWNHFEFQMGRM
AGLDRANKCIRLEATRDEFGVELVPSRALNYDTLVIAVGSTTNDFGTPGAAEHCIFLDTREQAERFHRQLLSRYMKAHAG
ETGPSGISMAIVGAGATGVELAAELLHAAKELAAYGLDGIKPEDVKITLIEAGPKVLPALPERISQPVHQTLLDLGVKVL
TGAAVSEVTADGLHTKQGEFVPASLKVWAAGIKAPAFLHEIDGLETNRINQLVVHPTLQSTRDENIFAFGDCAACPQPDS
DRNVPPRAQAAHQQASMLARSIRNRLEGKPLPTYRYKDYGSLISLSTFSAVGNLMGNLTGNVMLEGWLARMFYISLYRMH
QIALYGMPRTLLMMLGDKLSRSTEPRLKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=429, Percent_Identity=57.5757575757576, Blast_Score=485, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6323794, Length=359, Percent_Identity=27.2980501392758, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323515, Length=444, Percent_Identity=24.5495495495495, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320118, Length=438, Percent_Identity=24.6575342465753, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 46841; Mature: 46709

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHRIVIVGGGAGGLELATRLGRTLGKRGKARVTLVDANLTHIWKPLLHEVAAGSLNSSA
CCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCH
DELNYVAQAKWNHFEFQMGRMAGLDRANKCIRLEATRDEFGVELVPSRALNYDTLVIAVG
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCEEECCCCCCCCCEEEEEEC
STTNDFGTPGAAEHCIFLDTREQAERFHRQLLSRYMKAHAGETGPSGISMAIVGAGATGV
CCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHH
ELAAELLHAAKELAAYGLDGIKPEDVKITLIEAGPKVLPALPERISQPVHQTLLDLGVKV
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
LTGAAVSEVTADGLHTKQGEFVPASLKVWAAGIKAPAFLHEIDGLETNRINQLVVHPTLQ
HHCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEEECCHH
STRDENIFAFGDCAACPQPDSDRNVPPRAQAAHQQASMLARSIRNRLEGKPLPTYRYKDY
CCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GSLISLSTFSAVGNLMGNLTGNVMLEGWLARMFYISLYRMHQIALYGMPRTLLMMLGDKL
CCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
SRSTEPRLKLH
CCCCCCCEECC
>Mature Secondary Structure 
SHRIVIVGGGAGGLELATRLGRTLGKRGKARVTLVDANLTHIWKPLLHEVAAGSLNSSA
CCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCH
DELNYVAQAKWNHFEFQMGRMAGLDRANKCIRLEATRDEFGVELVPSRALNYDTLVIAVG
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCEEECCCCCCCCCEEEEEEC
STTNDFGTPGAAEHCIFLDTREQAERFHRQLLSRYMKAHAGETGPSGISMAIVGAGATGV
CCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHH
ELAAELLHAAKELAAYGLDGIKPEDVKITLIEAGPKVLPALPERISQPVHQTLLDLGVKV
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
LTGAAVSEVTADGLHTKQGEFVPASLKVWAAGIKAPAFLHEIDGLETNRINQLVVHPTLQ
HHCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCEEEEECCHH
STRDENIFAFGDCAACPQPDSDRNVPPRAQAAHQQASMLARSIRNRLEGKPLPTYRYKDY
CCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GSLISLSTFSAVGNLMGNLTGNVMLEGWLARMFYISLYRMHQIALYGMPRTLLMMLGDKL
CCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
SRSTEPRLKLH
CCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]