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The map label for this gene is add

Identifier: 146283925

GI number: 146283925

Start: 3894106

End: 3895056

Strand: Direct

Name: add

Synonym: PST_3608

Alternate gene names: 146283925

Gene position: 3894106-3895056 (Clockwise)

Preceding gene: 146283924

Following gene: 146283926

Centisome position: 85.26

GC content: 63.3

Gene sequence:

>951_bases
ATGCACGACTGGCTCAACAACCTGCCCAAGGCCGAACTCCACCTGCACCTGGAGGGCTCGCTGGAGCCGGAACTGATGTT
CCGTCTGGCCGAGCGCAACAAGATCGCCCTGCCCTGGAATGACGTCGAAGCACTGCGCAGCGCCTACAACTTCGGCAACC
TGCAGGAGTTCCTCGATCTCTACTACGCTGGCGCCGACGTGCTGCGTACCGAGCAGGACTTCTATGACCTGACCTGGGCC
TACCTGCAGAAGTGCGAAGAGCAGAACGTGGTGCACACCGAGCCCTTCTTCGATCCGCAGACCCACACCGACCGCGGCGT
ACCGTTCGAGGCCGCGCTCAACGGCATCAGCGCCGCGCTGGCCGATGGCCGCGAGCTGCTGGGCATCAGCAGCGGGCTGA
TCCTCAGTTTCCTGCGCCACCTGCCGGAAGAGGAAGCCTTCAAGACCCTGGAACAGGCATTGCCCTATCGCAACGCCTTC
TTCGCCGTCGGCCTGGACAGCTCCGAAGTCGGCCATCCGCCGAGCAAGTTCCAGCGCGTGTTCGACAAGGCGCGTGGCGA
AGGCTTGCTGACCGTTGCCCATGCCGGCGAGGAAGGTCCGCCCGAGTACATCTGGCAGGCACTCGACCTGCTCAAGGTCA
GCCGGATCGACCATGGTGTACGTGCCGCGGAAGATCCGAAGCTGATCGCCCGGCTGATCGAGGAGCAGATTCCACTGACG
GTCTGCCCGCTGTCCAACACCAAGCTCAAGGTGTTTGCCGACATGCGTCAGCACAACATCCTCGACCTGCTGGAGCAGGG
CGTGAAGGTCACGGTGAATTCGGACGATCCGGCCTATTTTGGCGGCTATGTCACGGAGAATTTCGTCGCGCTGCACGAAA
GCCTGGGCATGACCGAAGCCCAGGCCCGCCGCCTGGCGCAGAACAGCCTGGACGCCCGCCTGGCATACTGA

Upstream 100 bases:

>100_bases
TCATTCGGGAGTGCTAGACGGGACAAACTGGTCGGCTGGCATATCAGTTGCTCCAACCCACCGATAGAATGCCCGCACAC
CCGAAAGACGAGAATTCGCG

Downstream 100 bases:

>100_bases
GCCATTCGTCGGCGCAAGGCCGACCTGCGACACCATGGCTCGCCGCACGGGCCATGGCTGCGCCTAGACTGTGCGGCGTT
CGACACGTGAGGAGATCGCC

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MHDWLNNLPKAELHLHLEGSLEPELMFRLAERNKIALPWNDVEALRSAYNFGNLQEFLDLYYAGADVLRTEQDFYDLTWA
YLQKCEEQNVVHTEPFFDPQTHTDRGVPFEAALNGISAALADGRELLGISSGLILSFLRHLPEEEAFKTLEQALPYRNAF
FAVGLDSSEVGHPPSKFQRVFDKARGEGLLTVAHAGEEGPPEYIWQALDLLKVSRIDHGVRAAEDPKLIARLIEEQIPLT
VCPLSNTKLKVFADMRQHNILDLLEQGVKVTVNSDDPAYFGGYVTENFVALHESLGMTEAQARRLAQNSLDARLAY

Sequences:

>Translated_316_residues
MHDWLNNLPKAELHLHLEGSLEPELMFRLAERNKIALPWNDVEALRSAYNFGNLQEFLDLYYAGADVLRTEQDFYDLTWA
YLQKCEEQNVVHTEPFFDPQTHTDRGVPFEAALNGISAALADGRELLGISSGLILSFLRHLPEEEAFKTLEQALPYRNAF
FAVGLDSSEVGHPPSKFQRVFDKARGEGLLTVAHAGEEGPPEYIWQALDLLKVSRIDHGVRAAEDPKLIARLIEEQIPLT
VCPLSNTKLKVFADMRQHNILDLLEQGVKVTVNSDDPAYFGGYVTENFVALHESLGMTEAQARRLAQNSLDARLAY
>Mature_316_residues
MHDWLNNLPKAELHLHLEGSLEPELMFRLAERNKIALPWNDVEALRSAYNFGNLQEFLDLYYAGADVLRTEQDFYDLTWA
YLQKCEEQNVVHTEPFFDPQTHTDRGVPFEAALNGISAALADGRELLGISSGLILSFLRHLPEEEAFKTLEQALPYRNAF
FAVGLDSSEVGHPPSKFQRVFDKARGEGLLTVAHAGEEGPPEYIWQALDLLKVSRIDHGVRAAEDPKLIARLIEEQIPLT
VCPLSNTKLKVFADMRQHNILDLLEQGVKVTVNSDDPAYFGGYVTENFVALHESLGMTEAQARRLAQNSLDARLAY

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=322, Percent_Identity=25.776397515528, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI29029552, Length=104, Percent_Identity=31.7307692307692, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI29029550, Length=129, Percent_Identity=31.7829457364341, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787910, Length=311, Percent_Identity=27.9742765273312, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32565969, Length=319, Percent_Identity=24.4514106583072, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538512, Length=315, Percent_Identity=24.4444444444444, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324188, Length=324, Percent_Identity=44.1358024691358, Blast_Score=266, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24645260, Length=314, Percent_Identity=24.8407643312102, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_PSEU5 (A4VQI5)

Other databases:

- EMBL:   CP000304
- RefSeq:   YP_001174078.1
- ProteinModelPortal:   A4VQI5
- SMR:   A4VQI5
- STRING:   A4VQI5
- GeneID:   5096569
- GenomeReviews:   CP000304_GR
- KEGG:   psa:PST_3608
- eggNOG:   COG1816
- HOGENOM:   HBG630382
- OMA:   YFGGYLN
- PhylomeDB:   A4VQI5
- ProtClustDB:   PRK09358
- BioCyc:   PSTU379731:PST_3608-MONOMER
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 35602; Mature: 35602

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 197-197 BINDING 16-16 BINDING 18-18 BINDING 276-276

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDWLNNLPKAELHLHLEGSLEPELMFRLAERNKIALPWNDVEALRSAYNFGNLQEFLDL
CCCHHHCCCCEEEEEEECCCCCHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCHHHHHHH
YYAGADVLRTEQDFYDLTWAYLQKCEEQNVVHTEPFFDPQTHTDRGVPFEAALNGISAAL
HHHCHHHHHCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
ADGRELLGISSGLILSFLRHLPEEEAFKTLEQALPYRNAFFAVGLDSSEVGHPPSKFQRV
HCCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHH
FDKARGEGLLTVAHAGEEGPPEYIWQALDLLKVSRIDHGVRAAEDPKLIARLIEEQIPLT
HHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEE
VCPLSNTKLKVFADMRQHNILDLLEQGVKVTVNSDDPAYFGGYVTENFVALHESLGMTEA
EECCCCCCCCEEHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHH
QARRLAQNSLDARLAY
HHHHHHHHCCHHCCCC
>Mature Secondary Structure
MHDWLNNLPKAELHLHLEGSLEPELMFRLAERNKIALPWNDVEALRSAYNFGNLQEFLDL
CCCHHHCCCCEEEEEEECCCCCHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCHHHHHHH
YYAGADVLRTEQDFYDLTWAYLQKCEEQNVVHTEPFFDPQTHTDRGVPFEAALNGISAAL
HHHCHHHHHCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
ADGRELLGISSGLILSFLRHLPEEEAFKTLEQALPYRNAFFAVGLDSSEVGHPPSKFQRV
HCCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHH
FDKARGEGLLTVAHAGEEGPPEYIWQALDLLKVSRIDHGVRAAEDPKLIARLIEEQIPLT
HHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEE
VCPLSNTKLKVFADMRQHNILDLLEQGVKVTVNSDDPAYFGGYVTENFVALHESLGMTEA
EECCCCCCCCEEHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHH
QARRLAQNSLDARLAY
HHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA