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The map label for this gene is hexR [H]

Identifier: 146283815

GI number: 146283815

Start: 3788454

End: 3789251

Strand: Direct

Name: hexR [H]

Synonym: PST_3498

Alternate gene names: 146283815

Gene position: 3788454-3789251 (Clockwise)

Preceding gene: 146283808

Following gene: 146283820

Centisome position: 82.95

GC content: 67.17

Gene sequence:

>798_bases
GTGGCCGAAGTCATCCTGCGCAACCCTCAGCAGGCCACCCGCTTCAGCATCGCCGCCCTGGCGCAGACCGCACAGGTCAG
CGAGCCGACGGTGAATCGCTTCTGCCGCTCGTTCGGCGTTAGCGGCTACCCGGAACTGAAAATGCAGCTGGCGCAGAGCC
TGGCCAGCGGCGCCGCCTATGTCAGCCAGGCGGTAGAGCCCGACGACGGCCCGGCGGAATACACACGCAAGATCTTCGGC
TCGGCCATCGCCTCGCTGGACAGCGCCTGCCAGAGCCTCGACCCGCAACTGGTCAGCCGCGCCGTGGACCTGATGATCCA
GGCCCGCCAGATCCACTTTTTCGGCCTCGGCGCCTCGGCCTCGGTGGCACTGGATGCGCAGCACAAGTTCTTCCGCTTCA
ACCTGGCGGTGACCGCCCATTCGGACGTGCTGATGCAGCGCATGCTGGCGTCCGTAGCGCACACGGGCGAGCTGTTCGTG
ATCATTTCCTACACCGGGCGTACCCGCGAGCTGGTGGAAGTGGCGCGCATCGCGCGCCAGAACGGCGCCTCGGTACTCGG
CCTGACCGCCGCCGGCTCGCCGCTGGCCCAGGCCAGCACGCTGAGCCTGAACATTCCACTGCCCGAGGACACCGACATCT
ACATGCCGATGACCTCGCGCATCATCCAGCTGACGGTGCTCGACGTGCTCGCCACCGGCATGACCCTGCGCCGCGGCGTG
GATTTCCAGCCGCACCTGCGCAAGGTGAAGGAAAGCCTCAACGCCAGCCGTTATCCGGCGGACGAGGAGCCGAGCTGA

Upstream 100 bases:

>100_bases
ACCTCTGACCCGCCGCATCAGGATCGTCATGGACCGCGTACACAATCTGCTCGAGCAGATCCAGCGTCGCATCGAAGACC
TCAACAAGGCCGAGCGCAAG

Downstream 100 bases:

>100_bases
CGCCGCCAGCCCGACCGCTCGGGCATCGACAATCCCGAGCCATGATGCGGAGCTCGCAGCCCCGGAAGGAACCACGCACC
GCTCCATGATGTTGCTCCAA

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MAEVILRNPQQATRFSIAALAQTAQVSEPTVNRFCRSFGVSGYPELKMQLAQSLASGAAYVSQAVEPDDGPAEYTRKIFG
SAIASLDSACQSLDPQLVSRAVDLMIQARQIHFFGLGASASVALDAQHKFFRFNLAVTAHSDVLMQRMLASVAHTGELFV
IISYTGRTRELVEVARIARQNGASVLGLTAAGSPLAQASTLSLNIPLPEDTDIYMPMTSRIIQLTVLDVLATGMTLRRGV
DFQPHLRKVKESLNASRYPADEEPS

Sequences:

>Translated_265_residues
MAEVILRNPQQATRFSIAALAQTAQVSEPTVNRFCRSFGVSGYPELKMQLAQSLASGAAYVSQAVEPDDGPAEYTRKIFG
SAIASLDSACQSLDPQLVSRAVDLMIQARQIHFFGLGASASVALDAQHKFFRFNLAVTAHSDVLMQRMLASVAHTGELFV
IISYTGRTRELVEVARIARQNGASVLGLTAAGSPLAQASTLSLNIPLPEDTDIYMPMTSRIIQLTVLDVLATGMTLRRGV
DFQPHLRKVKESLNASRYPADEEPS
>Mature_264_residues
AEVILRNPQQATRFSIAALAQTAQVSEPTVNRFCRSFGVSGYPELKMQLAQSLASGAAYVSQAVEPDDGPAEYTRKIFGS
AIASLDSACQSLDPQLVSRAVDLMIQARQIHFFGLGASASVALDAQHKFFRFNLAVTAHSDVLMQRMLASVAHTGELFVI
ISYTGRTRELVEVARIARQNGASVLGLTAAGSPLAQASTLSLNIPLPEDTDIYMPMTSRIIQLTVLDVLATGMTLRRGVD
FQPHLRKVKESLNASRYPADEEPS

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=258, Percent_Identity=55.8139534883721, Blast_Score=300, Evalue=8e-83,
Organism=Escherichia coli, GI87082369, Length=229, Percent_Identity=25.3275109170306, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788767, Length=223, Percent_Identity=25.5605381165919, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082130, Length=196, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 28668; Mature: 28537

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVILRNPQQATRFSIAALAQTAQVSEPTVNRFCRSFGVSGYPELKMQLAQSLASGAAY
CCCCEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VSQAVEPDDGPAEYTRKIFGSAIASLDSACQSLDPQLVSRAVDLMIQARQIHFFGLGASA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEECCCCC
SVALDAQHKFFRFNLAVTAHSDVLMQRMLASVAHTGELFVIISYTGRTRELVEVARIARQ
EEEEECCCEEEEEEEEEECHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHH
NGASVLGLTAAGSPLAQASTLSLNIPLPEDTDIYMPMTSRIIQLTVLDVLATGMTLRRGV
CCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHCHHHHCCC
DFQPHLRKVKESLNASRYPADEEPS
CCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AEVILRNPQQATRFSIAALAQTAQVSEPTVNRFCRSFGVSGYPELKMQLAQSLASGAAY
CCCEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VSQAVEPDDGPAEYTRKIFGSAIASLDSACQSLDPQLVSRAVDLMIQARQIHFFGLGASA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEECCCCC
SVALDAQHKFFRFNLAVTAHSDVLMQRMLASVAHTGELFVIISYTGRTRELVEVARIARQ
EEEEECCCEEEEEEEEEECHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHH
NGASVLGLTAAGSPLAQASTLSLNIPLPEDTDIYMPMTSRIIQLTVLDVLATGMTLRRGV
CCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHCHHHHCCC
DFQPHLRKVKESLNASRYPADEEPS
CCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]