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The map label for this gene is hcr [H]

Identifier: 146283682

GI number: 146283682

Start: 3644169

End: 3646361

Strand: Direct

Name: hcr [H]

Synonym: PST_3365

Alternate gene names: 146283682

Gene position: 3644169-3646361 (Clockwise)

Preceding gene: 146283681

Following gene: 146283683

Centisome position: 79.79

GC content: 68.54

Gene sequence:

>2193_bases
GTGCTGACGGAAGGCTTCGTGGGGTGGAAGCGAGTCGCCGCCCTGGCCACGCTGGCGATGCTGCTGGCTCATGGAGCGGC
CGGCGCTCAGTCGGCTGCTGATCCACACGCAGCCCATCCGCCAGACAAGACCGGCGGCACGACGGCTGCGCAGCCGGACG
CTGCCGGCACGTCATCGGCCCGGGACAGCGGCTCGATGGCTGGTATGCCGATGGGCACCACGCCGCCGGCTGGCGCGCCG
ATGGGCGATGACGATCACGCCGCGCATCATCCGGACAAGGCCGGAAGCATGGCGGTACCGCAGCCGGCGCCAGCCGATGG
CATGCCGGCGCAAAGCAGCAGCTCGATGAACGGCATGCCGATGAGCGCCACACCGCCGGCTGACGCATCGGCGGGCGATG
ACGATCACGCCGCGCATCACCCGGACGCGACTGCCAGCATGCCGGCTTCGAGTGGTGCATCGATGGCCGGTTCCATGGGC
GGCATGATGGCCGGTTCCATGGGCGGCATGATGGACGACATGATGCGCGGCTGCCGCGGAGACGAGTGCGGTCGGGATCG
GCGCCTCAACAAGCTGCTGTATCCGCAGCTGATGGCGCTGCCGGATCTACCGCCGGAGCGGCGCGCGAGCGTTGAGCAGC
TCGCCCACCACCGGATGCACGAAGGGATCCAGCTATTGGCGTCCCTGTCGTCGGAGGCGTCGCACGCGGTCCAGCGCAAC
GACTACGGCGGCCTGCAGGAAGCATCCGACCGCATGCGCGTGGCCTGGGGCGAATTCGACAGCGGCTTGTCGGCCTACCG
CGCACTGGCCGAAGGACAGGCGCCGCGGGGGATCGCGCTGGCGTGGTTCCGGCGCGAGATGAACCTGACCGATCCCCTGA
CCACGGCCCCGGCGCACGGCGTCTTCGGCCTGTCGGGCTTCCACTACTTCACGATGGCGTTGCTGCTGGCCTTTGCGCTG
CTGGCCGCCTGGATGTACGTGGCGCGAACCCGACGCACGAATGCGGTCCTCGCCACGTTGCGCACCGGGGCACCGGTGCC
TCCGGCCCCCGCCGCTGCGCCTCGTTCCGGTGTGGCGCCGGCCCCCGCGGCGTCCGTGTCTCCGGGCGTGCCGGCCGAGG
GCGAGCCGCAGGCACGCGCACCCGTGTCCACCATGGGCGGCTGGGTGGGCAAGCTGCGGGTCGCACGCGTCTTCCAGGAG
ACGCCCAAGGTCAAGACGTTTCGGCTGGCGCCAGTGGAGGGCGTGGGTGCGCTGCCGTTCGAGTTCGAGCCCGGCCAGTT
CCTCACGCTTTCGGTGCATTCAGGCGGGAACCAGGTCAAGCGCTCGTATTCGATCGCTTCATCGCCATGCTGCCACGGCT
GGTGCGACCTGACGGTCAAGCACGAAAGCGGCGGCATCGTCTCGGGTTACCTGCACGAGCAGGTGAAGGAAGGCGATCTC
CTCGATGCGTCCGGCCCCTACGGCCGCTTCACCTTCCGCGGCGTCGAGTCCGACAGTGTCGTGTTCCTGGGCGGCGGCGT
CGGCATCACGCCGCTGATGAGTTCCATCCGCTACCTGACCGACCAGAGCTGGAACGGCCGGATCGACCTGGTCTACGCCT
GCAAGGACCTGGAAAGCGTGATCTTCCGCGACGAGCTGAACCAACTCGCCCGCCGGCATCCGAACCTGCATGTGTCCATC
GTGCTGAGCGACGAGTCATCGGCGGCATGGACCGGCCCGCGTGGGTTCATCACCGCCGAACTGCTGGGGCAGATTCCGCA
GATCCGTTCGCGCCGCATCCACTTGTGCGGTCCGTCGGTGATGATGGACGCGGTCCGCAACGAACTGGGCAAGCTGGGCA
TCGACCTGGCGTCGGTTCATTCCGAGCTGTTCCTGAGCCCCTCCAGGACAGTGCCTCCCGGCCTGGAGGTGTCGGCGGGC
GACACGGCGACGGCCGTCACCTGCAGCTTCGAGCGGTCCGGAAAAAAGGCGCCGCTGGCGGCCGGCCAGACCGTTCTCGA
GGCCGCCGAAGAGGTCGGCGTTCCGATCGAATATGCCTGCCGGCAGGGTTACTGCGGCCTCTGCAAGATCAAGCTGCTGT
CGGGCGAGGTCACCATGGACGTGGACGACGGTCTGACGCCACTCGATCGTTCCTCGGGCGTGATCCTGGCCTGCCAGGCG
AAAGCGTCGGCCGATATCTCGGTGGATGCGTAG

Upstream 100 bases:

>100_bases
AGATGCAGAAGGTCGACGCCACCATGCAGAAGATGGATTCGAGCATGGGCGGGGGCATGGCCAAGAAGAAGATGGGCCAT
ATGTAGTGGAGGCCGCCGCG

Downstream 100 bases:

>100_bases
ATGCGCAACCAGGATCGCATCATCGCGACGATCATCTTCTCGATGCTGGTGGTCCTGTGGCTGGGTTTCCTGGTGCACCG
CTCTTCCTTCTTCGCCGGAA

Product: oxidoreductase, FAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 730; Mature: 730

Protein sequence:

>730_residues
MLTEGFVGWKRVAALATLAMLLAHGAAGAQSAADPHAAHPPDKTGGTTAAQPDAAGTSSARDSGSMAGMPMGTTPPAGAP
MGDDDHAAHHPDKAGSMAVPQPAPADGMPAQSSSSMNGMPMSATPPADASAGDDDHAAHHPDATASMPASSGASMAGSMG
GMMAGSMGGMMDDMMRGCRGDECGRDRRLNKLLYPQLMALPDLPPERRASVEQLAHHRMHEGIQLLASLSSEASHAVQRN
DYGGLQEASDRMRVAWGEFDSGLSAYRALAEGQAPRGIALAWFRREMNLTDPLTTAPAHGVFGLSGFHYFTMALLLAFAL
LAAWMYVARTRRTNAVLATLRTGAPVPPAPAAAPRSGVAPAPAASVSPGVPAEGEPQARAPVSTMGGWVGKLRVARVFQE
TPKVKTFRLAPVEGVGALPFEFEPGQFLTLSVHSGGNQVKRSYSIASSPCCHGWCDLTVKHESGGIVSGYLHEQVKEGDL
LDASGPYGRFTFRGVESDSVVFLGGGVGITPLMSSIRYLTDQSWNGRIDLVYACKDLESVIFRDELNQLARRHPNLHVSI
VLSDESSAAWTGPRGFITAELLGQIPQIRSRRIHLCGPSVMMDAVRNELGKLGIDLASVHSELFLSPSRTVPPGLEVSAG
DTATAVTCSFERSGKKAPLAAGQTVLEAAEEVGVPIEYACRQGYCGLCKIKLLSGEVTMDVDDGLTPLDRSSGVILACQA
KASADISVDA

Sequences:

>Translated_730_residues
MLTEGFVGWKRVAALATLAMLLAHGAAGAQSAADPHAAHPPDKTGGTTAAQPDAAGTSSARDSGSMAGMPMGTTPPAGAP
MGDDDHAAHHPDKAGSMAVPQPAPADGMPAQSSSSMNGMPMSATPPADASAGDDDHAAHHPDATASMPASSGASMAGSMG
GMMAGSMGGMMDDMMRGCRGDECGRDRRLNKLLYPQLMALPDLPPERRASVEQLAHHRMHEGIQLLASLSSEASHAVQRN
DYGGLQEASDRMRVAWGEFDSGLSAYRALAEGQAPRGIALAWFRREMNLTDPLTTAPAHGVFGLSGFHYFTMALLLAFAL
LAAWMYVARTRRTNAVLATLRTGAPVPPAPAAAPRSGVAPAPAASVSPGVPAEGEPQARAPVSTMGGWVGKLRVARVFQE
TPKVKTFRLAPVEGVGALPFEFEPGQFLTLSVHSGGNQVKRSYSIASSPCCHGWCDLTVKHESGGIVSGYLHEQVKEGDL
LDASGPYGRFTFRGVESDSVVFLGGGVGITPLMSSIRYLTDQSWNGRIDLVYACKDLESVIFRDELNQLARRHPNLHVSI
VLSDESSAAWTGPRGFITAELLGQIPQIRSRRIHLCGPSVMMDAVRNELGKLGIDLASVHSELFLSPSRTVPPGLEVSAG
DTATAVTCSFERSGKKAPLAAGQTVLEAAEEVGVPIEYACRQGYCGLCKIKLLSGEVTMDVDDGLTPLDRSSGVILACQA
KASADISVDA
>Mature_730_residues
MLTEGFVGWKRVAALATLAMLLAHGAAGAQSAADPHAAHPPDKTGGTTAAQPDAAGTSSARDSGSMAGMPMGTTPPAGAP
MGDDDHAAHHPDKAGSMAVPQPAPADGMPAQSSSSMNGMPMSATPPADASAGDDDHAAHHPDATASMPASSGASMAGSMG
GMMAGSMGGMMDDMMRGCRGDECGRDRRLNKLLYPQLMALPDLPPERRASVEQLAHHRMHEGIQLLASLSSEASHAVQRN
DYGGLQEASDRMRVAWGEFDSGLSAYRALAEGQAPRGIALAWFRREMNLTDPLTTAPAHGVFGLSGFHYFTMALLLAFAL
LAAWMYVARTRRTNAVLATLRTGAPVPPAPAAAPRSGVAPAPAASVSPGVPAEGEPQARAPVSTMGGWVGKLRVARVFQE
TPKVKTFRLAPVEGVGALPFEFEPGQFLTLSVHSGGNQVKRSYSIASSPCCHGWCDLTVKHESGGIVSGYLHEQVKEGDL
LDASGPYGRFTFRGVESDSVVFLGGGVGITPLMSSIRYLTDQSWNGRIDLVYACKDLESVIFRDELNQLARRHPNLHVSI
VLSDESSAAWTGPRGFITAELLGQIPQIRSRRIHLCGPSVMMDAVRNELGKLGIDLASVHSELFLSPSRTVPPGLEVSAG
DTATAVTCSFERSGKKAPLAAGQTVLEAAEEVGVPIEYACRQGYCGLCKIKLLSGEVTMDVDDGLTPLDRSSGVILACQA
KASADISVDA

Specific function: NADH oxidoreductase acting in concert with HCP [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI47778923, Length=218, Percent_Identity=28.8990825688073, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI49574502, Length=218, Percent_Identity=27.0642201834862, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI284448553, Length=206, Percent_Identity=27.6699029126214, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI6552328, Length=206, Percent_Identity=27.6699029126214, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI193794826, Length=206, Percent_Identity=27.6699029126214, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI4503327, Length=206, Percent_Identity=27.6699029126214, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1787098, Length=337, Percent_Identity=31.1572700296736, Blast_Score=147, Evalue=3e-36,
Organism=Escherichia coli, GI1787658, Length=350, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1788104, Length=312, Percent_Identity=32.3717948717949, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788903, Length=254, Percent_Identity=29.1338582677165, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17563926, Length=247, Percent_Identity=28.7449392712551, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17563928, Length=223, Percent_Identity=28.6995515695067, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323510, Length=200, Percent_Identity=28.5, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323552, Length=192, Percent_Identity=25.5208333333333, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322699, Length=178, Percent_Identity=25.8426966292135, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24662938, Length=219, Percent_Identity=27.3972602739726, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281366101, Length=219, Percent_Identity=27.3972602739726, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24662934, Length=219, Percent_Identity=27.3972602739726, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR000951
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 76357; Mature: 76357

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTEGFVGWKRVAALATLAMLLAHGAAGAQSAADPHAAHPPDKTGGTTAAQPDAAGTSSA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RDSGSMAGMPMGTTPPAGAPMGDDDHAAHHPDKAGSMAVPQPAPADGMPAQSSSSMNGMP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MSATPPADASAGDDDHAAHHPDATASMPASSGASMAGSMGGMMAGSMGGMMDDMMRGCRG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHCHHHHHHHHCCCC
DECGRDRRLNKLLYPQLMALPDLPPERRASVEQLAHHRMHEGIQLLASLSSEASHAVQRN
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DYGGLQEASDRMRVAWGEFDSGLSAYRALAEGQAPRGIALAWFRREMNLTDPLTTAPAHG
CCCCHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCCCCCCCCCCC
VFGLSGFHYFTMALLLAFALLAAWMYVARTRRTNAVLATLRTGAPVPPAPAAAPRSGVAP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCCCCCCCCCCCC
APAASVSPGVPAEGEPQARAPVSTMGGWVGKLRVARVFQETPKVKTFRLAPVEGVGALPF
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCE
EFEPGQFLTLSVHSGGNQVKRSYSIASSPCCHGWCDLTVKHESGGIVSGYLHEQVKEGDL
EECCCCEEEEEEECCCHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEHHHHHHHHCCCE
LDASGPYGRFTFRGVESDSVVFLGGGVGITPLMSSIRYLTDQSWNGRIDLVYACKDLESV
ECCCCCCCCEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHH
IFRDELNQLARRHPNLHVSIVLSDESSAAWTGPRGFITAELLGQIPQIRSRRIHLCGPSV
HHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHCCHHHHCCEEEEECHHH
MMDAVRNELGKLGIDLASVHSELFLSPSRTVPPGLEVSAGDTATAVTCSFERSGKKAPLA
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCEEEEEEHHCCCCCCCCH
AGQTVLEAAEEVGVPIEYACRQGYCGLCKIKLLSGEVTMDVDDGLTPLDRSSGVILACQA
HHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCEEEEEEC
KASADISVDA
CCCCCCEECC
>Mature Secondary Structure
MLTEGFVGWKRVAALATLAMLLAHGAAGAQSAADPHAAHPPDKTGGTTAAQPDAAGTSSA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RDSGSMAGMPMGTTPPAGAPMGDDDHAAHHPDKAGSMAVPQPAPADGMPAQSSSSMNGMP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MSATPPADASAGDDDHAAHHPDATASMPASSGASMAGSMGGMMAGSMGGMMDDMMRGCRG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHCHHHHHHHHCCCC
DECGRDRRLNKLLYPQLMALPDLPPERRASVEQLAHHRMHEGIQLLASLSSEASHAVQRN
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DYGGLQEASDRMRVAWGEFDSGLSAYRALAEGQAPRGIALAWFRREMNLTDPLTTAPAHG
CCCCHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCCCCCCCCCCC
VFGLSGFHYFTMALLLAFALLAAWMYVARTRRTNAVLATLRTGAPVPPAPAAAPRSGVAP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCCCCCCCCCCCC
APAASVSPGVPAEGEPQARAPVSTMGGWVGKLRVARVFQETPKVKTFRLAPVEGVGALPF
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCE
EFEPGQFLTLSVHSGGNQVKRSYSIASSPCCHGWCDLTVKHESGGIVSGYLHEQVKEGDL
EECCCCEEEEEEECCCHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEHHHHHHHHCCCE
LDASGPYGRFTFRGVESDSVVFLGGGVGITPLMSSIRYLTDQSWNGRIDLVYACKDLESV
ECCCCCCCCEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHH
IFRDELNQLARRHPNLHVSIVLSDESSAAWTGPRGFITAELLGQIPQIRSRRIHLCGPSV
HHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHCCHHHHCCEEEEECHHH
MMDAVRNELGKLGIDLASVHSELFLSPSRTVPPGLEVSAGDTATAVTCSFERSGKKAPLA
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCEEEEEEHHCCCCCCCCH
AGQTVLEAAEEVGVPIEYACRQGYCGLCKIKLLSGEVTMDVDDGLTPLDRSSGVILACQA
HHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCEEEEEEC
KASADISVDA
CCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10651802 [H]