Click here to switch to the map view.

The map label for this gene is pgi

Identifier: 146283619

GI number: 146283619

Start: 3570544

End: 3572208

Strand: Direct

Name: pgi

Synonym: PST_3299

Alternate gene names: 146283619

Gene position: 3570544-3572208 (Clockwise)

Preceding gene: 146283618

Following gene: 146283620

Centisome position: 78.17

GC content: 64.02

Gene sequence:

>1665_bases
ATGAGCTATTACCAGCATCCGCTCGATGTCACCGGCCTGCCGTCCTGGAAGGCCCTGGAAGAACACCGCCTGGCCATGCA
GCACTTCAGCATGCGCGAGGCCTTCAAGGCCGATCCGACGCGCTTCGATGACCTGTCGGTTTCCTGCAGCGGCCTGTTCC
TCGACTATTCGAAGAACCTCATCACCCCGGAGACCCGCACCCTGCTGGTCAATCTGGCCCGCGAGGCCGGCGTCGAGCAG
GCCGCCCGCGCCATGTTCGAGGGCGAACGGATCAATGCATCGGAGAATCGCCCGGTGCTGCACACGGCCCTGCGCCGTCC
CATGGGCGACTCGGTGATGGTCGACGGCAAGAACATCATGCGCGACGTGCACACCGCCCTGGCGCAGATGACCGACATCG
TCACCCGCATCCACAACAACCTGTGGCGCGGCTTCAGCGACAAGACCATCACCGACGTCGTGAACATCGGCATCGGTGGC
TCGTTCCTCGGCCCACAGCTGGTCTCCGAGGCGCTGCTGCCGTTCACCCAGCACGGCGTGCGGACGCACTACCTGGCCAA
CATCGACGGCAGCGAATTCCGCGAGGTGACCGCCAAGCTGAATGTCGAGACCACGCTGTTCATCATCTCCAGCAAGACCT
TCGGCACCCTCGAGACGCTGAAGAACGCCCAGGCGGCCCGCAACTGGTACCTGGGCAAGGGCGGCACCGAGGAAAAGCTC
TACCGCCACTTCATCGCCGTGACCAGCAACAAGCAGGCGGCCGTCGACTTCGGCATTCGCGAGAAGAACATCTTCCCCAT
GTGGGACTGGGTCGGCGGGCGCTACTCGCTGTGGTCGGCGATCGGCCTGCCCATCGCCCTGGCCATCGGCATGTCCAACT
TCAAGGACCTGCTCTCCGGCGCCTACAGCATGGACCAGCATTTCCTCAGCGAGCCGTTCGAAAGCAACATGCCGGTGCTG
CTGGCGATGCTCGGCATCTGGTACCACAACTTCTGGGGCGCGCAGAGCTACGCCTTCCTGCCCTATGACCACTACCTGCG
CAACTTCGTCAAACACCTGCAGCAGATGGACATGGAATCCAACGGCAAGAGCGTGCGCCAGGATGGCACGCCAGTGTCCT
GCAGCACCGGGCCGGTGATCTGGGGCGGTGTCGGTGCCAACGGCCAGCACGCCTACCACCAGCTGTTGCACCAGGGCACG
CCGCTGATTCCAGCCGACTTCATCGTGCCGGTTGTCAGTCACAATCCGGTAGCCGATCACCACGAATGGCTCTATGCCAA
CTGCCTGTCGCAGAGCCAGGCGCTGATGCTCGGCAAGACCCGCGAGGAAGCCGAAGCCGAACTGCGTGCCAAGGGCCTGA
GCGAGGCCGAAGTCCAGCGCCTGGCGCCGCACAAGGTGATTCCGGGCAACCGACCGAGCAACACCCTGGTGATGGAAACC
ATCAGCCCCGGCCGTCTCGGCGCGCTCATCGCGCTGTACGAGCACAAGGTCTTCGTCCAGGGCGTGATCTGGGGCATCAA
CTCCTTCGACCAGTGGGGTGTCGAGCTGGGCAAGGAGCTGGGCAAGGCCGTCTACAACCAGATGACCCGCTTCGATGCGG
CGCCGGCGGAAGACGCCTCGACTCAGGGCCTGATCGACTTCTTCCGCGGCCGTCATCGCGGTTGA

Upstream 100 bases:

>100_bases
CGGTCATACACATCACTGAATCCCGAGGCAATCATGGCGCGCTCGTTGCGCGAATTCCCGGGGTTCAGCGGCCTGTCAAA
GCAAAGGAAGCCGCATCACC

Downstream 100 bases:

>100_bases
ACGCACCTGCTGACCGGACGCTGCTGCAGCGTCCGGTCCCCTTCCGTCGCATGCTCCCTGCCCTGCCCGCGGCCCTCGGC
GCCTGATCGGGTAACATCGC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSYYQHPLDVTGLPSWKALEEHRLAMQHFSMREAFKADPTRFDDLSVSCSGLFLDYSKNLITPETRTLLVNLAREAGVEQ
AARAMFEGERINASENRPVLHTALRRPMGDSVMVDGKNIMRDVHTALAQMTDIVTRIHNNLWRGFSDKTITDVVNIGIGG
SFLGPQLVSEALLPFTQHGVRTHYLANIDGSEFREVTAKLNVETTLFIISSKTFGTLETLKNAQAARNWYLGKGGTEEKL
YRHFIAVTSNKQAAVDFGIREKNIFPMWDWVGGRYSLWSAIGLPIALAIGMSNFKDLLSGAYSMDQHFLSEPFESNMPVL
LAMLGIWYHNFWGAQSYAFLPYDHYLRNFVKHLQQMDMESNGKSVRQDGTPVSCSTGPVIWGGVGANGQHAYHQLLHQGT
PLIPADFIVPVVSHNPVADHHEWLYANCLSQSQALMLGKTREEAEAELRAKGLSEAEVQRLAPHKVIPGNRPSNTLVMET
ISPGRLGALIALYEHKVFVQGVIWGINSFDQWGVELGKELGKAVYNQMTRFDAAPAEDASTQGLIDFFRGRHRG

Sequences:

>Translated_554_residues
MSYYQHPLDVTGLPSWKALEEHRLAMQHFSMREAFKADPTRFDDLSVSCSGLFLDYSKNLITPETRTLLVNLAREAGVEQ
AARAMFEGERINASENRPVLHTALRRPMGDSVMVDGKNIMRDVHTALAQMTDIVTRIHNNLWRGFSDKTITDVVNIGIGG
SFLGPQLVSEALLPFTQHGVRTHYLANIDGSEFREVTAKLNVETTLFIISSKTFGTLETLKNAQAARNWYLGKGGTEEKL
YRHFIAVTSNKQAAVDFGIREKNIFPMWDWVGGRYSLWSAIGLPIALAIGMSNFKDLLSGAYSMDQHFLSEPFESNMPVL
LAMLGIWYHNFWGAQSYAFLPYDHYLRNFVKHLQQMDMESNGKSVRQDGTPVSCSTGPVIWGGVGANGQHAYHQLLHQGT
PLIPADFIVPVVSHNPVADHHEWLYANCLSQSQALMLGKTREEAEAELRAKGLSEAEVQRLAPHKVIPGNRPSNTLVMET
ISPGRLGALIALYEHKVFVQGVIWGINSFDQWGVELGKELGKAVYNQMTRFDAAPAEDASTQGLIDFFRGRHRG
>Mature_553_residues
SYYQHPLDVTGLPSWKALEEHRLAMQHFSMREAFKADPTRFDDLSVSCSGLFLDYSKNLITPETRTLLVNLAREAGVEQA
ARAMFEGERINASENRPVLHTALRRPMGDSVMVDGKNIMRDVHTALAQMTDIVTRIHNNLWRGFSDKTITDVVNIGIGGS
FLGPQLVSEALLPFTQHGVRTHYLANIDGSEFREVTAKLNVETTLFIISSKTFGTLETLKNAQAARNWYLGKGGTEEKLY
RHFIAVTSNKQAAVDFGIREKNIFPMWDWVGGRYSLWSAIGLPIALAIGMSNFKDLLSGAYSMDQHFLSEPFESNMPVLL
AMLGIWYHNFWGAQSYAFLPYDHYLRNFVKHLQQMDMESNGKSVRQDGTPVSCSTGPVIWGGVGANGQHAYHQLLHQGTP
LIPADFIVPVVSHNPVADHHEWLYANCLSQSQALMLGKTREEAEAELRAKGLSEAEVQRLAPHKVIPGNRPSNTLVMETI
SPGRLGALIALYEHKVFVQGVIWGINSFDQWGVELGKELGKAVYNQMTRFDAAPAEDASTQGLIDFFRGRHRG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=547, Percent_Identity=49.1773308957952, Blast_Score=565, Evalue=1e-161,
Organism=Homo sapiens, GI296080693, Length=547, Percent_Identity=46.0694698354662, Blast_Score=514, Evalue=1e-145,
Organism=Escherichia coli, GI1790457, Length=544, Percent_Identity=48.3455882352941, Blast_Score=562, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71996708, Length=525, Percent_Identity=52, Blast_Score=571, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI71996703, Length=525, Percent_Identity=52, Blast_Score=570, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=44.4444444444444, Blast_Score=483, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24651916, Length=531, Percent_Identity=51.9774011299435, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24651914, Length=531, Percent_Identity=51.9774011299435, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI17737445, Length=531, Percent_Identity=51.9774011299435, Blast_Score=570, Evalue=1e-163,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_PSEU5 (A4VPM9)

Other databases:

- EMBL:   CP000304
- RefSeq:   YP_001173772.1
- ProteinModelPortal:   A4VPM9
- SMR:   A4VPM9
- STRING:   A4VPM9
- GeneID:   5096260
- GenomeReviews:   CP000304_GR
- KEGG:   psa:PST_3299
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   RTSITSA
- PhylomeDB:   A4VPM9
- ProtClustDB:   PRK00179
- BioCyc:   PSTU379731:PST_3299-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 61889; Mature: 61758

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 359-359 ACT_SITE 390-390 ACT_SITE 518-518

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYYQHPLDVTGLPSWKALEEHRLAMQHFSMREAFKADPTRFDDLSVSCSGLFLDYSKNL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECEEEEECCCCC
ITPETRTLLVNLAREAGVEQAARAMFEGERINASENRPVLHTALRRPMGDSVMVDGKNIM
CCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCEEECCHHHH
RDVHTALAQMTDIVTRIHNNLWRGFSDKTITDVVNIGIGGSFLGPQLVSEALLPFTQHGV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
RTHYLANIDGSEFREVTAKLNVETTLFIISSKTFGTLETLKNAQAARNWYLGKGGTEEKL
CEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHH
YRHFIAVTSNKQAAVDFGIREKNIFPMWDWVGGRYSLWSAIGLPIALAIGMSNFKDLLSG
HHHHHHEECCCCEEEECCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSMDQHFLSEPFESNMPVLLAMLGIWYHNFWGAQSYAFLPYDHYLRNFVKHLQQMDMES
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHCCCCC
NGKSVRQDGTPVSCSTGPVIWGGVGANGQHAYHQLLHQGTPLIPADFIVPVVSHNPVADH
CCCHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCH
HEWLYANCLSQSQALMLGKTREEAEAELRAKGLSEAEVQRLAPHKVIPGNRPSNTLVMET
HHHHHHHHHCCCHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCEEEEEE
ISPGRLGALIALYEHKVFVQGVIWGINSFDQWGVELGKELGKAVYNQMTRFDAAPAEDAS
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TQGLIDFFRGRHRG
HHHHHHHHHCCCCC
>Mature Secondary Structure 
SYYQHPLDVTGLPSWKALEEHRLAMQHFSMREAFKADPTRFDDLSVSCSGLFLDYSKNL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECEEEEECCCCC
ITPETRTLLVNLAREAGVEQAARAMFEGERINASENRPVLHTALRRPMGDSVMVDGKNIM
CCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCEEECCHHHH
RDVHTALAQMTDIVTRIHNNLWRGFSDKTITDVVNIGIGGSFLGPQLVSEALLPFTQHGV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
RTHYLANIDGSEFREVTAKLNVETTLFIISSKTFGTLETLKNAQAARNWYLGKGGTEEKL
CEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHH
YRHFIAVTSNKQAAVDFGIREKNIFPMWDWVGGRYSLWSAIGLPIALAIGMSNFKDLLSG
HHHHHHEECCCCEEEECCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSMDQHFLSEPFESNMPVLLAMLGIWYHNFWGAQSYAFLPYDHYLRNFVKHLQQMDMES
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHCCCCC
NGKSVRQDGTPVSCSTGPVIWGGVGANGQHAYHQLLHQGTPLIPADFIVPVVSHNPVADH
CCCHHHCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCH
HEWLYANCLSQSQALMLGKTREEAEAELRAKGLSEAEVQRLAPHKVIPGNRPSNTLVMET
HHHHHHHHHCCCHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCEEEEEE
ISPGRLGALIALYEHKVFVQGVIWGINSFDQWGVELGKELGKAVYNQMTRFDAAPAEDAS
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TQGLIDFFRGRHRG
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA