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The map label for this gene is folK [H]

Identifier: 146283615

GI number: 146283615

Start: 3567392

End: 3567943

Strand: Direct

Name: folK [H]

Synonym: PST_3295

Alternate gene names: 146283615

Gene position: 3567392-3567943 (Clockwise)

Preceding gene: 146283614

Following gene: 146283616

Centisome position: 78.11

GC content: 68.66

Gene sequence:

>552_bases
ATGCCGCCAACCCGGCCGACTGAGATGGAGCGCGTCTACATCGGCCTGGGCAGCAACCTGGCCGATCCCCAGCAGCAGCT
GCGTGGTGCCCTGCAGGCTCTGGCCGAGCTGCCAGGTAGCAGGCTGGCTGCAGTCTCCTCCCTCTATGCCAGCGACCCGC
TCGGGCCCGCCGACCAGCCACGCTACGTCAACGCGGTTGCGGCACTGGAGACCGACCTCGAGCCGCTGGCGCTGCTCGAT
GCCCTGCAGCGCATCGAACTGGCGCAGGGCCGCGAACGCAAGGCCGAACGCTGGGGCCCGCGCACCCTGGACCTGGATAT
CCTGCTGTTCGGCGAGCGACTGATCGACCAGCCGCGCCTCCAGGTTCCGCACTATCACATGCAGGCTCGGGCGTTCGTGC
TCTACCCGCTGGCCGAGATCGCTCCGCCGGAGCTGGTACTGCCCGATGGGCGACGGCTCGTCAACCTGCTCGCGGCCTGC
CCGTTCCGCGGGCTGGAGCGGCTCACCAATACGAGTGTCACCTGCGCGGTAACGAACGTAACGCGCAGGTAA

Upstream 100 bases:

>100_bases
AGCGAGCGGCGCAACATGATCCGCGGCCTCAGCGGCAAGGATGACGCCGGCGCGGCCAAGAAACGCCGCCGTGGCGGTCG
CCGTCGCCGCACGCCGGGCG

Downstream 100 bases:

>100_bases
CACTCGCGATTGACTTACTCTGCCGCCGCCGGGACTATAAGCGCCCTCTGCCACCTGCGGCCGTAGCACCCTTCCGGTGC
ACCGCCCGGCAATCCTGACC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MPPTRPTEMERVYIGLGSNLADPQQQLRGALQALAELPGSRLAAVSSLYASDPLGPADQPRYVNAVAALETDLEPLALLD
ALQRIELAQGRERKAERWGPRTLDLDILLFGERLIDQPRLQVPHYHMQARAFVLYPLAEIAPPELVLPDGRRLVNLLAAC
PFRGLERLTNTSVTCAVTNVTRR

Sequences:

>Translated_183_residues
MPPTRPTEMERVYIGLGSNLADPQQQLRGALQALAELPGSRLAAVSSLYASDPLGPADQPRYVNAVAALETDLEPLALLD
ALQRIELAQGRERKAERWGPRTLDLDILLFGERLIDQPRLQVPHYHMQARAFVLYPLAEIAPPELVLPDGRRLVNLLAAC
PFRGLERLTNTSVTCAVTNVTRR
>Mature_182_residues
PPTRPTEMERVYIGLGSNLADPQQQLRGALQALAELPGSRLAAVSSLYASDPLGPADQPRYVNAVAALETDLEPLALLDA
LQRIELAQGRERKAERWGPRTLDLDILLFGERLIDQPRLQVPHYHMQARAFVLYPLAEIAPPELVLPDGRRLVNLLAACP
FRGLERLTNTSVTCAVTNVTRR

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=159, Percent_Identity=57.2327044025157, Blast_Score=178, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324073, Length=144, Percent_Identity=36.1111111111111, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 20251; Mature: 20119

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPTRPTEMERVYIGLGSNLADPQQQLRGALQALAELPGSRLAAVSSLYASDPLGPADQP
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC
RYVNAVAALETDLEPLALLDALQRIELAQGRERKAERWGPRTLDLDILLFGERLIDQPRL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEHHEEECHHHHCCCCC
QVPHYHMQARAFVLYPLAEIAPPELVLPDGRRLVNLLAACPFRGLERLTNTSVTCAVTNV
CCCCHHHHHHHHEEEEHHHHCCCCEECCCCHHHHHHHHHCCHHHHHHHCCCCEEEEECCC
TRR
CCC
>Mature Secondary Structure 
PPTRPTEMERVYIGLGSNLADPQQQLRGALQALAELPGSRLAAVSSLYASDPLGPADQP
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC
RYVNAVAALETDLEPLALLDALQRIELAQGRERKAERWGPRTLDLDILLFGERLIDQPRL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEHHEEECHHHHCCCCC
QVPHYHMQARAFVLYPLAEIAPPELVLPDGRRLVNLLAACPFRGLERLTNTSVTCAVTNV
CCCCHHHHHHHHEEEEHHHHCCCCEECCCCHHHHHHHHHCCHHHHHHHCCCCEEEEECCC
TRR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]