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The map label for this gene is zraR [H]

Identifier: 146283613

GI number: 146283613

Start: 3563877

End: 3565292

Strand: Direct

Name: zraR [H]

Synonym: PST_3293

Alternate gene names: 146283613

Gene position: 3563877-3565292 (Clockwise)

Preceding gene: 146283612

Following gene: 146283614

Centisome position: 78.03

GC content: 64.83

Gene sequence:

>1416_bases
ATGTCACACATACTGATCGTCGAAGACGAAACCATCATCCGCTCAGCCCTGCGGCGCCTCCTCGAACGCAACCAGTACGA
GGTCAGCGAAGCCGGCTCGGTGCAGGAAGCACAGGAGCGCTACAGCATCCCGGGTTTCGACCTCATCGTCAGCGACCTGC
GACTGCCCGGCGCACCCGGCACCGAACTGATCAAACTGGCCGAAGGCACACCGGTGCTGATCATGACCAGCTACGCCAGC
CTGCGCTCGGCGGTGGACTCCATGAAGATGGGCGCGGTGGACTACATCGCCAAGCCCTTCGATCACGACGAAATGCTGCA
GACCGTGGCGCGCATCCTTCAGGATCATCAGCAGAGCGCCGCAGCCCTCGCTCAGCCGAGCCGTGGCAATGGCAGCGCCC
CAAGCGACGCGGCACAGGGCGACATCGGCATCATCGGCCACTGCGCACCGATGCAGGACCTGTTCAGCAAGATCCGCAAG
GTCGCCCCCACCGATTCCAACGTGCTGATCCAGGGCGAGTCGGGCACCGGCAAGGAACTGGTGGCGCGGGCACTGCACAA
TCTCTCGCGACGGGCCAAGGCGCCGATGATCTCGGTGAACTGCGCGGCCATTCCGGAAACCTTGATCGAATCCGAGCTGT
TCGGCCACGAGAAGGGGGCCTTCACCGGGGCCAGCGCCGGTCGCGCCGGCCTGGTCGAGGCAGCCGATGGCGGCACCCTG
TTCCTCGACGAAATCGGCGAACTGCCACTGGAAGCCCAGGCGCGCCTGCTGCGCGTACTGCAGGAAGGTGAGATCCGCCG
CGTCGGCTCGGTGCAGTCGCAGAAGGTCGATGTGCGTCTGATCGCCGCCACCCACCGCGACCTGAAAACCCTTGCCAAGA
CCGGCCAGTTCCGCGAAGACCTTTATTACCGCCTGCACGTGATCGCGCTCAAGCTGCCGCCGCTGCGCGAGCGCGGCAAC
GACGTGCTCGAAATCGCCAAGGCGTTCCTGGCGCGCCAGGGCGAACGCATGAGCAGCGACGAGATGCGCTTCTCGCGCGA
CGCCGAACAGGCGATTCGTCACTACTCCTGGCCCGGCAACGTGCGCGAACTGGAAAACGCCATCGAGCGCGCGGCGATCC
TCAGCGAGAGCCCGGAGATCGACGCCGAGCTGCTGGGCATCGATATCGAACTCGACGAGCTGGACGATGAATTCGAAGAA
GATTCACTCGGCGGCATCCGCGGTATCGCTGGTGGCAACGAGCCGACCGAGGATCTCTCGCTGGAGGACTACTTCCAGCA
TTTCGTGCTCGAGCATCAGGACCACATGACCGAGACCGAACTGGCGCGCAAGCTCGGCATCAGCCGCAAATGCCTGTGGG
AACGCCGCCAGCGCCTGGGCATTCCGCGGCGCAAGTCCAGTAGCGCCGCCGGGTAA

Upstream 100 bases:

>100_bases
CTGCCGCGGCATGTCGAAGCGTCACACGCCGTAAGTTGAAGAGGCGACTGCCGTACCGGCCCGGCGCCGGTTCTGCCTCC
AGACCGTCGAGAGAGTACTG

Downstream 100 bases:

>100_bases
TTTGTTACCGCCGGCGCATCGTTCGTAACAAAAACCGGGAGCATCGGTAACGACGCCCCGGTTTTTTCTTGCCTTCCGCC
AAGCCTGGAAATCACAACTC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSHILIVEDETIIRSALRRLLERNQYEVSEAGSVQEAQERYSIPGFDLIVSDLRLPGAPGTELIKLAEGTPVLIMTSYAS
LRSAVDSMKMGAVDYIAKPFDHDEMLQTVARILQDHQQSAAALAQPSRGNGSAPSDAAQGDIGIIGHCAPMQDLFSKIRK
VAPTDSNVLIQGESGTGKELVARALHNLSRRAKAPMISVNCAAIPETLIESELFGHEKGAFTGASAGRAGLVEAADGGTL
FLDEIGELPLEAQARLLRVLQEGEIRRVGSVQSQKVDVRLIAATHRDLKTLAKTGQFREDLYYRLHVIALKLPPLRERGN
DVLEIAKAFLARQGERMSSDEMRFSRDAEQAIRHYSWPGNVRELENAIERAAILSESPEIDAELLGIDIELDELDDEFEE
DSLGGIRGIAGGNEPTEDLSLEDYFQHFVLEHQDHMTETELARKLGISRKCLWERRQRLGIPRRKSSSAAG

Sequences:

>Translated_471_residues
MSHILIVEDETIIRSALRRLLERNQYEVSEAGSVQEAQERYSIPGFDLIVSDLRLPGAPGTELIKLAEGTPVLIMTSYAS
LRSAVDSMKMGAVDYIAKPFDHDEMLQTVARILQDHQQSAAALAQPSRGNGSAPSDAAQGDIGIIGHCAPMQDLFSKIRK
VAPTDSNVLIQGESGTGKELVARALHNLSRRAKAPMISVNCAAIPETLIESELFGHEKGAFTGASAGRAGLVEAADGGTL
FLDEIGELPLEAQARLLRVLQEGEIRRVGSVQSQKVDVRLIAATHRDLKTLAKTGQFREDLYYRLHVIALKLPPLRERGN
DVLEIAKAFLARQGERMSSDEMRFSRDAEQAIRHYSWPGNVRELENAIERAAILSESPEIDAELLGIDIELDELDDEFEE
DSLGGIRGIAGGNEPTEDLSLEDYFQHFVLEHQDHMTETELARKLGISRKCLWERRQRLGIPRRKSSSAAG
>Mature_470_residues
SHILIVEDETIIRSALRRLLERNQYEVSEAGSVQEAQERYSIPGFDLIVSDLRLPGAPGTELIKLAEGTPVLIMTSYASL
RSAVDSMKMGAVDYIAKPFDHDEMLQTVARILQDHQQSAAALAQPSRGNGSAPSDAAQGDIGIIGHCAPMQDLFSKIRKV
APTDSNVLIQGESGTGKELVARALHNLSRRAKAPMISVNCAAIPETLIESELFGHEKGAFTGASAGRAGLVEAADGGTLF
LDEIGELPLEAQARLLRVLQEGEIRRVGSVQSQKVDVRLIAATHRDLKTLAKTGQFREDLYYRLHVIALKLPPLRERGND
VLEIAKAFLARQGERMSSDEMRFSRDAEQAIRHYSWPGNVRELENAIERAAILSESPEIDAELLGIDIELDELDDEFEED
SLGGIRGIAGGNEPTEDLSLEDYFQHFVLEHQDHMTETELARKLGISRKCLWERRQRLGIPRRKSSSAAG

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=477, Percent_Identity=41.9287211740042, Blast_Score=324, Evalue=6e-90,
Organism=Escherichia coli, GI1788550, Length=467, Percent_Identity=42.1841541755889, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1790299, Length=381, Percent_Identity=44.0944881889764, Blast_Score=304, Evalue=6e-84,
Organism=Escherichia coli, GI1788905, Length=424, Percent_Identity=39.622641509434, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI87082117, Length=340, Percent_Identity=45.2941176470588, Blast_Score=258, Evalue=8e-70,
Organism=Escherichia coli, GI1789087, Length=324, Percent_Identity=44.4444444444444, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI87082152, Length=234, Percent_Identity=54.2735042735043, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1789233, Length=244, Percent_Identity=49.5901639344262, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1786524, Length=326, Percent_Identity=42.3312883435583, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI87081872, Length=231, Percent_Identity=45.4545454545455, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1787583, Length=328, Percent_Identity=36.5853658536585, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1789828, Length=300, Percent_Identity=33.6666666666667, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87081858, Length=306, Percent_Identity=31.0457516339869, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1786599, Length=117, Percent_Identity=32.4786324786325, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51857; Mature: 51726

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHILIVEDETIIRSALRRLLERNQYEVSEAGSVQEAQERYSIPGFDLIVSDLRLPGAPG
CCCEEEECCHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCCCC
TELIKLAEGTPVLIMTSYASLRSAVDSMKMGAVDYIAKPFDHDEMLQTVARILQDHQQSA
HHHEEECCCCCEEEEECHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AALAQPSRGNGSAPSDAAQGDIGIIGHCAPMQDLFSKIRKVAPTDSNVLIQGESGTGKEL
HHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
VARALHNLSRRAKAPMISVNCAAIPETLIESELFGHEKGAFTGASAGRAGLVEAADGGTL
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEE
FLDEIGELPLEAQARLLRVLQEGEIRRVGSVQSQKVDVRLIAATHRDLKTLAKTGQFRED
EHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEEEHHHHHHHHHHHCCCHHHH
LYYRLHVIALKLPPLRERGNDVLEIAKAFLARQGERMSSDEMRFSRDAEQAIRHYSWPGN
HHHHHHEEEEECCCHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCC
VRELENAIERAAILSESPEIDAELLGIDIELDELDDEFEEDSLGGIRGIAGGNEPTEDLS
HHHHHHHHHHHHHHCCCCCCCCEEEEEEEEHHHHCCHHHHCCCCCEECCCCCCCCCCCCC
LEDYFQHFVLEHQDHMTETELARKLGISRKCLWERRQRLGIPRRKSSSAAG
HHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SHILIVEDETIIRSALRRLLERNQYEVSEAGSVQEAQERYSIPGFDLIVSDLRLPGAPG
CCEEEECCHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCCCC
TELIKLAEGTPVLIMTSYASLRSAVDSMKMGAVDYIAKPFDHDEMLQTVARILQDHQQSA
HHHEEECCCCCEEEEECHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AALAQPSRGNGSAPSDAAQGDIGIIGHCAPMQDLFSKIRKVAPTDSNVLIQGESGTGKEL
HHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
VARALHNLSRRAKAPMISVNCAAIPETLIESELFGHEKGAFTGASAGRAGLVEAADGGTL
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEE
FLDEIGELPLEAQARLLRVLQEGEIRRVGSVQSQKVDVRLIAATHRDLKTLAKTGQFRED
EHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEEEHHHHHHHHHHHCCCHHHH
LYYRLHVIALKLPPLRERGNDVLEIAKAFLARQGERMSSDEMRFSRDAEQAIRHYSWPGN
HHHHHHEEEEECCCHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCC
VRELENAIERAAILSESPEIDAELLGIDIELDELDDEFEEDSLGGIRGIAGGNEPTEDLS
HHHHHHHHHHHHHHCCCCCCCCEEEEEEEEHHHHCCHHHHCCCCCEECCCCCCCCCCCCC
LEDYFQHFVLEHQDHMTETELARKLGISRKCLWERRQRLGIPRRKSSSAAG
HHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]