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The map label for this gene is pth [H]

Identifier: 146283516

GI number: 146283516

Start: 3436285

End: 3436665

Strand: Direct

Name: pth [H]

Synonym: PST_3191

Alternate gene names: 146283516

Gene position: 3436285-3436665 (Clockwise)

Preceding gene: 146283515

Following gene: 146283517

Centisome position: 75.23

GC content: 63.78

Gene sequence:

>381_bases
ATGAACCGCAGCGGTCAAGCGGTGGCGGCATTGGCTGGCTTTTTCCGAATTCCCCCCGAGTCTATCCTGGTCGCCCATGA
TGAACTCGATATGCCCCCCGGCGTCGCCAAACTCAAGCAGGGTGGCGGTCATGGCGGGCACAACGGGCTGCGCGACATCA
TCGCCAAGCTTGGCAATCAGAACAGCTTTCACCGTCTGCGCCTGGGTATCGGCCATCCTGGCCACGCGAGCCTGGTCAGC
GGTTACGTGCTAGGGCGTGCGCCACAGGCCGAGCGCGAAAAGCTCGACGCCAGTATCGACTTCGCGCTGGACGTCGTGCC
AGAAATCCTGACCGGCGACTGGACCCGCGCCATGCAGCGCCTGCACAGCCAGAAGGCCTGA

Upstream 100 bases:

>100_bases
CGAAGGCGTCTCGCTCAGCAATGATCGCAAGTATTTCGGTCTGGTCGGCAAGTTCAGCCATCAGGGCGACGATATCCGCC
TACTCATCCCCACCACCTAC

Downstream 100 bases:

>100_bases
ACCTAACTCCGAGGCAAGATCACCATGGGATTCAACTGCGGCATCGTCGGTCTGCCCAACGTCGGCAAGTCCACCCTGTT
CAACGCCCTGACCAAATCCG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 126; Mature: 126

Protein sequence:

>126_residues
MNRSGQAVAALAGFFRIPPESILVAHDELDMPPGVAKLKQGGGHGGHNGLRDIIAKLGNQNSFHRLRLGIGHPGHASLVS
GYVLGRAPQAEREKLDASIDFALDVVPEILTGDWTRAMQRLHSQKA

Sequences:

>Translated_126_residues
MNRSGQAVAALAGFFRIPPESILVAHDELDMPPGVAKLKQGGGHGGHNGLRDIIAKLGNQNSFHRLRLGIGHPGHASLVS
GYVLGRAPQAEREKLDASIDFALDVVPEILTGDWTRAMQRLHSQKA
>Mature_126_residues
MNRSGQAVAALAGFFRIPPESILVAHDELDMPPGVAKLKQGGGHGGHNGLRDIIAKLGNQNSFHRLRLGIGHPGHASLVS
GYVLGRAPQAEREKLDASIDFALDVVPEILTGDWTRAMQRLHSQKA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=106, Percent_Identity=44.3396226415094, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787455, Length=126, Percent_Identity=61.1111111111111, Blast_Score=134, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 13503; Mature: 13503

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRSGQAVAALAGFFRIPPESILVAHDELDMPPGVAKLKQGGGHGGHNGLRDIIAKLGNQ
CCCCCHHHHHHHHHHCCCCHHEEEECCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCC
NSFHRLRLGIGHPGHASLVSGYVLGRAPQAEREKLDASIDFALDVVPEILTGDWTRAMQR
CCCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
LHSQKA
HHHCCC
>Mature Secondary Structure
MNRSGQAVAALAGFFRIPPESILVAHDELDMPPGVAKLKQGGGHGGHNGLRDIIAKLGNQ
CCCCCHHHHHHHHHHCCCCHHEEEECCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCC
NSFHRLRLGIGHPGHASLVSGYVLGRAPQAEREKLDASIDFALDVVPEILTGDWTRAMQR
CCCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
LHSQKA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA