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The map label for this gene is mprA [H]

Identifier: 146283481

GI number: 146283481

Start: 3397127

End: 3398092

Strand: Direct

Name: mprA [H]

Synonym: PST_3154

Alternate gene names: 146283481

Gene position: 3397127-3398092 (Clockwise)

Preceding gene: 146283478

Following gene: 146283482

Centisome position: 74.38

GC content: 64.49

Gene sequence:

>966_bases
ATGCCCAACCCCCAGCTGAGCATCCTCGTCGTCGACGATGCCAAATTCTCCAGCGTCATGATCGGTCGCGCGCTGAGCAA
AGCCGGCTATCAGGACATACGCTTCGCCAGCAGCGCTGCCGATGCCCTCGCGCAGCACGCCCAGCGTCCCGCCCACGTTC
TGCTGGCGGACTGGCTGATGCCGGAAATGGACGGCCTGGAGCTCACCGGCCAGATTCGTCAGCGCGACGCCAGCAGCGGC
CACTACAGCTATATCATCCTGCTCACCGGTCGCGAGAGCGAAAATGCCCTCGGCGAGGCCTTCGACCACGGCGTCGACGA
CTTCATCAGCAAGTCGACAATGAACGAGCAGCTGCTGCCGCGCATCTACGCAGCCGACCGCCTGTGCGCCTCCCTGCAGC
GCCTGAAGCAGGAAAATCACCAACTGGCGGAAAACGTCGCCAGCCTTGAACAGCAGAGCCTGTTGGACCCGCTGACCGGA
TTGGGCAATGCCCGTTATCTGCACCAGCAGTTGGCCGCCAGCCTGCGCCAAGTGGAAAGCCGCGGCACGGCACTGTGCTA
CCTGCAGATCGGCCTGCCCGACGCCGGAGTGCTGAACGATCGTTACGGCGAAGCCGGTTATGCCGAGATACTGCGTGCCA
TCGCCGGGCGTTTGCAGCAGCTGGTCCGGCCGCTGGATGTGGTGTGCCGGATCGACGAGAAGCAGTTCGGGCTGCTGGCG
CTGATCGACGATCTTAAAGGCTGCTCGCCGAGCAGCTTCAAGCGCCTGCACGAAGGGCTCAACCTGCGGGCGCTGAAGAC
CAGCGAAGGCTTCGTCTCGATCAAGGCCGGCATCAGCCTGGTCAGCCTCGACGCCGAAGCGCTGCCGGTGACGCCCCAGG
CCATCATCGAACGTGCAGCAACCCTGCTGCCCAGCGCTTACAGCACCGGGCGTATCGTTCCGCTGCGCCTGAAGCAGCCG
GCCTGA

Upstream 100 bases:

>100_bases
GTCTTGACGGTTAAGAAAGCGCGGTCATTATAGCGATTCGACGTGTCAGCGCCCGCCCCCGGAGTGACAGGACGTCCCCC
TCCAATTGATTGAGCTCGCC

Downstream 100 bases:

>100_bases
GGCGATGACCTGGCACGTTCTCGGCGCAGGCGCGCTCGGCAGCCTCTGGGCCACCCGCCTGGCCAGAGCGGGGCTGCCGG
TACGTATCATCCTGCGTTCG

Product: two-component response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MPNPQLSILVVDDAKFSSVMIGRALSKAGYQDIRFASSAADALAQHAQRPAHVLLADWLMPEMDGLELTGQIRQRDASSG
HYSYIILLTGRESENALGEAFDHGVDDFISKSTMNEQLLPRIYAADRLCASLQRLKQENHQLAENVASLEQQSLLDPLTG
LGNARYLHQQLAASLRQVESRGTALCYLQIGLPDAGVLNDRYGEAGYAEILRAIAGRLQQLVRPLDVVCRIDEKQFGLLA
LIDDLKGCSPSSFKRLHEGLNLRALKTSEGFVSIKAGISLVSLDAEALPVTPQAIIERAATLLPSAYSTGRIVPLRLKQP
A

Sequences:

>Translated_321_residues
MPNPQLSILVVDDAKFSSVMIGRALSKAGYQDIRFASSAADALAQHAQRPAHVLLADWLMPEMDGLELTGQIRQRDASSG
HYSYIILLTGRESENALGEAFDHGVDDFISKSTMNEQLLPRIYAADRLCASLQRLKQENHQLAENVASLEQQSLLDPLTG
LGNARYLHQQLAASLRQVESRGTALCYLQIGLPDAGVLNDRYGEAGYAEILRAIAGRLQQLVRPLDVVCRIDEKQFGLLA
LIDDLKGCSPSSFKRLHEGLNLRALKTSEGFVSIKAGISLVSLDAEALPVTPQAIIERAATLLPSAYSTGRIVPLRLKQP
A
>Mature_320_residues
PNPQLSILVVDDAKFSSVMIGRALSKAGYQDIRFASSAADALAQHAQRPAHVLLADWLMPEMDGLELTGQIRQRDASSGH
YSYIILLTGRESENALGEAFDHGVDDFISKSTMNEQLLPRIYAADRLCASLQRLKQENHQLAENVASLEQQSLLDPLTGL
GNARYLHQQLAASLRQVESRGTALCYLQIGLPDAGVLNDRYGEAGYAEILRAIAGRLQQLVRPLDVVCRIDEKQFGLLAL
IDDLKGCSPSSFKRLHEGLNLRALKTSEGFVSIKAGISLVSLDAEALPVTPQAIIERAATLLPSAYSTGRIVPLRLKQPA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG3706

COG function: function code T; Response regulator containing a CheY-like receiver domain and a GGDEF domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 34994; Mature: 34862

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNPQLSILVVDDAKFSSVMIGRALSKAGYQDIRFASSAADALAQHAQRPAHVLLADWLM
CCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
PEMDGLELTGQIRQRDASSGHYSYIILLTGRESENALGEAFDHGVDDFISKSTMNEQLLP
CCCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHCCHHHHH
RIYAADRLCASLQRLKQENHQLAENVASLEQQSLLDPLTGLGNARYLHQQLAASLRQVES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
RGTALCYLQIGLPDAGVLNDRYGEAGYAEILRAIAGRLQQLVRPLDVVCRIDEKQFGLLA
CCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LIDDLKGCSPSSFKRLHEGLNLRALKTSEGFVSIKAGISLVSLDAEALPVTPQAIIERAA
HHHHHCCCCHHHHHHHHCCCCEEEEECCCCEEEEECCCEEEEECCCCCCCCHHHHHHHHH
TLLPSAYSTGRIVPLRLKQPA
HHCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
PNPQLSILVVDDAKFSSVMIGRALSKAGYQDIRFASSAADALAQHAQRPAHVLLADWLM
CCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
PEMDGLELTGQIRQRDASSGHYSYIILLTGRESENALGEAFDHGVDDFISKSTMNEQLLP
CCCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHCCHHHHH
RIYAADRLCASLQRLKQENHQLAENVASLEQQSLLDPLTGLGNARYLHQQLAASLRQVES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
RGTALCYLQIGLPDAGVLNDRYGEAGYAEILRAIAGRLQQLVRPLDVVCRIDEKQFGLLA
CCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LIDDLKGCSPSSFKRLHEGLNLRALKTSEGFVSIKAGISLVSLDAEALPVTPQAIIERAA
HHHHHCCCCHHHHHHHHCCCCEEEEECCCCEEEEECCCEEEEECCCCCCCCHHHHHHHHH
TLLPSAYSTGRIVPLRLKQPA
HHCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA