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The map label for this gene is glxR [H]

Identifier: 146283443

GI number: 146283443

Start: 3354779

End: 3355669

Strand: Direct

Name: glxR [H]

Synonym: PST_3116

Alternate gene names: 146283443

Gene position: 3354779-3355669 (Clockwise)

Preceding gene: 146283442

Following gene: 146283444

Centisome position: 73.45

GC content: 65.21

Gene sequence:

>891_bases
ATGGCTAAAATCGGATTCATCGGCACCGGCATCATGGGCAAGCCCATGGCAATCAACCTGCAGAAGGCCGGCCACCAGAT
TTTCCTGTCCCAGCACCACGACCAGGCGCCGGCCGAACTGACCGAAGCCGGCGCCATCGGCCTGGCCAATCCGCAGGAAG
TCGCCCAGGAAGCCGAGTTCATCATCGTCATGGTGCCGGACACCCCGCAGGTCGAAGACGTGCTGTTCCGTGCCGATGGC
GTGGCCGCTGGCGTCGGCGCCGGCAAGGTGGTGATCGACATGAGTTCGATCTCCCCCACTGCCACCAAGCAGTTCGCCGA
GAAGATCAAGGCCACCGGCGCTGAATACCTCGACGCCCCGGTATCCGGTGGTGAAGTCGGCGCCAAGGCGGCCACCCTGT
CGATCATGGTCGGCGGTAGCGAAGCGGCCTTCGAACGCGCGCTGCCACTGTTCCAGGCGATGGGCAAGAACATCACCCGC
GTCGGCGAGAACGGCGATGGCCAGACGGCCAAGGTGGCCAACCAGATCATCGTCGCACTGAACATCCAGGCGGTCGCCGA
GGCACTGCTGTTCGCCGCACGCAACGGTGCCGACCCGGCCAAGGTGCGCGAGGCGCTGATGGGCGGTTTCGCCGGCTCGA
AGATTCTCGAGGTACACGGCGAGCGCATGATCAAGGGCACCTTCGACCCGGGCTTCCGCATCAGCCTGCACCAGAAGGAC
CTCAACCTCGCCCTGGCCGGTGCCCGCGAGCTGGGCCTGAACCTGCCCAACACCGCCAATGCCCAGCAGGTGTTCAGCAC
CTGCGCGGCAATCGGCGGCAGCGGCTGGGACCATTCGGCGCTGATCAAGGGCCTGGAGCACATGGCCAACTTCTCGATCC
GCAAGGAGTAA

Upstream 100 bases:

>100_bases
CTGGCTGAAAAGCCACAACGCCATCTGATCAACAGCGCGCCGCCCAGGCAGCAACGCGGGCCGCACAGCGGCCTGCACCA
CAGAATCGAGGAGAACACTC

Downstream 100 bases:

>100_bases
AGCCTTCGAGCACGCTGCAATGGGCCAGCGACCCCACCTTCAGGGACAGACAGACCGGGTGGTGGGTCATCGCAACGCCC
GCGCAGCGCCGCTCAAAGGG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MAKIGFIGTGIMGKPMAINLQKAGHQIFLSQHHDQAPAELTEAGAIGLANPQEVAQEAEFIIVMVPDTPQVEDVLFRADG
VAAGVGAGKVVIDMSSISPTATKQFAEKIKATGAEYLDAPVSGGEVGAKAATLSIMVGGSEAAFERALPLFQAMGKNITR
VGENGDGQTAKVANQIIVALNIQAVAEALLFAARNGADPAKVREALMGGFAGSKILEVHGERMIKGTFDPGFRISLHQKD
LNLALAGARELGLNLPNTANAQQVFSTCAAIGGSGWDHSALIKGLEHMANFSIRKE

Sequences:

>Translated_296_residues
MAKIGFIGTGIMGKPMAINLQKAGHQIFLSQHHDQAPAELTEAGAIGLANPQEVAQEAEFIIVMVPDTPQVEDVLFRADG
VAAGVGAGKVVIDMSSISPTATKQFAEKIKATGAEYLDAPVSGGEVGAKAATLSIMVGGSEAAFERALPLFQAMGKNITR
VGENGDGQTAKVANQIIVALNIQAVAEALLFAARNGADPAKVREALMGGFAGSKILEVHGERMIKGTFDPGFRISLHQKD
LNLALAGARELGLNLPNTANAQQVFSTCAAIGGSGWDHSALIKGLEHMANFSIRKE
>Mature_295_residues
AKIGFIGTGIMGKPMAINLQKAGHQIFLSQHHDQAPAELTEAGAIGLANPQEVAQEAEFIIVMVPDTPQVEDVLFRADGV
AAGVGAGKVVIDMSSISPTATKQFAEKIKATGAEYLDAPVSGGEVGAKAATLSIMVGGSEAAFERALPLFQAMGKNITRV
GENGDGQTAKVANQIIVALNIQAVAEALLFAARNGADPAKVREALMGGFAGSKILEVHGERMIKGTFDPGFRISLHQKDL
NLALAGARELGLNLPNTANAQQVFSTCAAIGGSGWDHSALIKGLEHMANFSIRKE

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=305, Percent_Identity=32.1311475409836, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=28.4210526315789, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=62.8865979381443, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI145693186, Length=293, Percent_Identity=42.320819112628, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI1790315, Length=286, Percent_Identity=36.013986013986, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789092, Length=282, Percent_Identity=31.9148936170213, Blast_Score=118, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17557316, Length=286, Percent_Identity=31.1188811188811, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24655230, Length=297, Percent_Identity=35.016835016835, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI19922568, Length=297, Percent_Identity=35.016835016835, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28574115, Length=280, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30793; Mature: 30662

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIGFIGTGIMGKPMAINLQKAGHQIFLSQHHDQAPAELTEAGAIGLANPQEVAQEAEF
CCEECEEECCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHCCCCCCCCHHHHHCCCCE
IIVMVPDTPQVEDVLFRADGVAAGVGAGKVVIDMSSISPTATKQFAEKIKATGAEYLDAP
EEEECCCCCCHHHHHHHCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHCCC
VSGGEVGAKAATLSIMVGGSEAAFERALPLFQAMGKNITRVGENGDGQTAKVANQIIVAL
CCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHEEEEE
NIQAVAEALLFAARNGADPAKVREALMGGFAGSKILEVHGERMIKGTFDPGFRISLHQKD
EHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHEEECCCEEEECCCCCCEEEEEECCC
LNLALAGARELGLNLPNTANAQQVFSTCAAIGGSGWDHSALIKGLEHMANFSIRKE
CCEEEECHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AKIGFIGTGIMGKPMAINLQKAGHQIFLSQHHDQAPAELTEAGAIGLANPQEVAQEAEF
CEECEEECCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHCCCCCCCCHHHHHCCCCE
IIVMVPDTPQVEDVLFRADGVAAGVGAGKVVIDMSSISPTATKQFAEKIKATGAEYLDAP
EEEECCCCCCHHHHHHHCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHCCC
VSGGEVGAKAATLSIMVGGSEAAFERALPLFQAMGKNITRVGENGDGQTAKVANQIIVAL
CCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHEEEEE
NIQAVAEALLFAARNGADPAKVREALMGGFAGSKILEVHGERMIKGTFDPGFRISLHQKD
EHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHEEECCCEEEECCCCCCEEEEEECCC
LNLALAGARELGLNLPNTANAQQVFSTCAAIGGSGWDHSALIKGLEHMANFSIRKE
CCEEEECHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]