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The map label for this gene is yedX [H]

Identifier: 146283439

GI number: 146283439

Start: 3350392

End: 3350802

Strand: Direct

Name: yedX [H]

Synonym: PST_3112

Alternate gene names: 146283439

Gene position: 3350392-3350802 (Clockwise)

Preceding gene: 146283438

Following gene: 146283441

Centisome position: 73.35

GC content: 61.07

Gene sequence:

>411_bases
ATGAAATCACTACGTTCAATTGCCGCCGGCTTGATGCTCAGTGGCCTGTCCGGTCTCACCCTCGCAGCTGGCAACCCGCT
CAGCGTGCACGTGCTGAACCTGGAAAACGGTCTGCCCTCGCCGGATGTGCGCGTCACCCTGGAACAACGTCAGGGTGACG
CCTGGAAATCACTCAACAGCGGCGAGACCAACGCGCAGGGTCGGATCACGGCGCTCTACCCGGAAGGCAAGACGCTGGAA
AAAGGCACCTATCGCGTCACCTTCAAGACCGGCGACTGGTTCGCCACGCAGAAGGCCAGCACCTTTTTCCTCGAAGTTCC
GGTGATCTTCGAAGCCGATGGCAGCGTCGAGCACTACCACATCCCGCTGCTGCTGAGCCCCTACGGCTTCTCCACCTACC
GCGGCAACTGA

Upstream 100 bases:

>100_bases
GGCGTGGCCGGTGCCGGCGGTGCCAAGAACGACGAGGCCTGCGCCGTGGCCGCCATCGAGAAACTGCTGCCCTCCTCCCA
CTGAAGAAAAGGAAAACACC

Downstream 100 bases:

>100_bases
GCCGCTCAGCGCACTTCCCAGTAGCCCGGTGCGTTGTAGATGTCCTTCAGGTAGTCGATGAAGAAACGCACCTTGGCCGG
CAGGTAGCGCTGCTGCGGGT

Product: transthyretin family protein

Products: NA

Alternate protein names: HIU hydrolase; HIUHase; Transthyretin-like protein; TLP [H]

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MKSLRSIAAGLMLSGLSGLTLAAGNPLSVHVLNLENGLPSPDVRVTLEQRQGDAWKSLNSGETNAQGRITALYPEGKTLE
KGTYRVTFKTGDWFATQKASTFFLEVPVIFEADGSVEHYHIPLLLSPYGFSTYRGN

Sequences:

>Translated_136_residues
MKSLRSIAAGLMLSGLSGLTLAAGNPLSVHVLNLENGLPSPDVRVTLEQRQGDAWKSLNSGETNAQGRITALYPEGKTLE
KGTYRVTFKTGDWFATQKASTFFLEVPVIFEADGSVEHYHIPLLLSPYGFSTYRGN
>Mature_136_residues
MKSLRSIAAGLMLSGLSGLTLAAGNPLSVHVLNLENGLPSPDVRVTLEQRQGDAWKSLNSGETNAQGRITALYPEGKTLE
KGTYRVTFKTGDWFATQKASTFFLEVPVIFEADGSVEHYHIPLLLSPYGFSTYRGN

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=115, Percent_Identity=53.0434782608696, Blast_Score=129, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI115532920, Length=131, Percent_Identity=34.3511450381679, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115532922, Length=110, Percent_Identity=36.3636363636364, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115534555, Length=110, Percent_Identity=33.6363636363636, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652571, Length=110, Percent_Identity=35.4545454545455, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 14789; Mature: 14789

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLRSIAAGLMLSGLSGLTLAAGNPLSVHVLNLENGLPSPDVRVTLEQRQGDAWKSLNS
CCHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEECCCCCCCCEEEEEECCCCCCHHCCCC
GETNAQGRITALYPEGKTLEKGTYRVTFKTGDWFATQKASTFFLEVPVIFEADGSVEHYH
CCCCCCCCEEEECCCCCEECCCEEEEEEECCCEEEECCCCEEEEEEEEEEECCCCEEEEE
IPLLLSPYGFSTYRGN
EEEEECCCCCEEECCC
>Mature Secondary Structure
MKSLRSIAAGLMLSGLSGLTLAAGNPLSVHVLNLENGLPSPDVRVTLEQRQGDAWKSLNS
CCHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEECCCCCCCCEEEEEECCCCCCHHCCCC
GETNAQGRITALYPEGKTLEKGTYRVTFKTGDWFATQKASTFFLEVPVIFEADGSVEHYH
CCCCCCCCEEEECCCCCEECCCEEEEEEECCCEEEECCCCEEEEEEEEEEECCCCEEEEE
IPLLLSPYGFSTYRGN
EEEEECCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]