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The map label for this gene is livM [H]

Identifier: 146283319

GI number: 146283319

Start: 3216919

End: 3218175

Strand: Direct

Name: livM [H]

Synonym: PST_2984

Alternate gene names: 146283319

Gene position: 3216919-3218175 (Clockwise)

Preceding gene: 146283318

Following gene: 146283320

Centisome position: 70.43

GC content: 64.76

Gene sequence:

>1257_bases
ATGACCGGCAATCTGCGTATCGCTTTCTTCAGCGCCCTGCTGGTCATCGCCGTGGCGGTGCCGGTGTTCGGCCTGAAGCT
CACCACCGTCGGTATCCGCGTCGAGGTGCATGGCGCCGAAGCCGGCACCTTCTGGATCATCGCCGCCTGCGCGGTGGCCA
TGTTCGTCTGGCAACTGTTCCGCACGCATCTGGCCGCCGGCTGGGCCGCCAGCCCGAGCCTGCCGAGCGTGCCAGCCGGT
GCTGGCAACTTCCTCACCCTGCCCTCGACCCAACGCTGGATCATCCTGGCGCTGGTGCTGGTTGCGCTGGTCTGGCCGTT
CTACGGCTCGCGCGGTGCCGTGGACATCGCCACGCTGATCCTGATCTACGTGATGCTCGGCCTCGGCCTGAACATCGTGG
TCGGGCTGGCCGGCCTGCTGGACCTGGGTTACGTCGGCTTCTACGCCGTGGGCGCCTACACCTACGCGTTGCTGTCGCAC
TACTACGGGGTCGGCTTCTGGACCGCGCTGCCAATCGCCGGAGCGATGGCCGCACTGTTCGGCTTCCTGCTCGGTTTCCC
GGTACTGCGTCTACGCGGTGACTACCTGGCCATCGTGACGCTGGGGTTCGGCGAGATCATCCGCATCCTGCTGCGCAACA
TGACCAGCATCACCGGCGGCCCCAACGGCATCAGCGGCATCGACAAGCCAACCTTCTTCGGCCTGTCGTTCGACCGCCGC
GCCGCCGAAGGCATGCAGACCTTCCATGAGTACTTCGGCATCGCCTACAACTCGGTGAACAAGGTGATCTTCCTCTACCT
GATCGCCCTGCTGCTGGTACTGCTGACCCTGTTCGTGATCAACCGGCTGCTGCGCATGCCGATCGGCCGCGCCTGGGAAG
CCCTGCGCGAAGACGAGATCGCCTGCCGCGCACTCGGCATGAACCCCACGGTGATCAAGCTTTCCGCGTTCACCCTCGGC
GCCACCTTCGCCGGGTTCGCCGGCAGCTTCTTCGCTGCACGCCAGGGGCTGGTCTCGCCGGAGTCATTCACCTTTATCGA
GTCGGCGATCATTCTCGCCATCGTCGTGCTGGGTGGCATGGGCTCGCAGCTCGGCGTGATTCTCGCAGCCATCGTGATGA
TCCTGCTGCCCGAGCTGATGCGCGAGTTCAGCGAATACCGCATGTTGATGTTCGGCGCCCTGATGGTGCTGATGATGATC
TGGCGTCCGCAAGGCCTGCTGCCGATGCAACGCCCGCACCTGGAGCTGAAGCAATGA

Upstream 100 bases:

>100_bases
TCGGCGATCAGTACAAGGACGTCGTGGCCTTCAGCCTGCTCGTGCTCGTGCTGCTGTTCCGCCCCACCGGCATCCTTGGC
CGCCCGGAGGTGGAAAAGGT

Downstream 100 bases:

>100_bases
GCCGCCCGATCCTGGAAGTACGCGGCCTGACCATGCGCTTCGGCGGCCTGCTGGCCGTCAACGAGGTGGCGCTGACCGTA
CACGACAAGCAGGTGGTTTC

Product: leucine/isoleucine/valine transporter permease subunit

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTGNLRIAFFSALLVIAVAVPVFGLKLTTVGIRVEVHGAEAGTFWIIAACAVAMFVWQLFRTHLAAGWAASPSLPSVPAG
AGNFLTLPSTQRWIILALVLVALVWPFYGSRGAVDIATLILIYVMLGLGLNIVVGLAGLLDLGYVGFYAVGAYTYALLSH
YYGVGFWTALPIAGAMAALFGFLLGFPVLRLRGDYLAIVTLGFGEIIRILLRNMTSITGGPNGISGIDKPTFFGLSFDRR
AAEGMQTFHEYFGIAYNSVNKVIFLYLIALLLVLLTLFVINRLLRMPIGRAWEALREDEIACRALGMNPTVIKLSAFTLG
ATFAGFAGSFFAARQGLVSPESFTFIESAIILAIVVLGGMGSQLGVILAAIVMILLPELMREFSEYRMLMFGALMVLMMI
WRPQGLLPMQRPHLELKQ

Sequences:

>Translated_418_residues
MTGNLRIAFFSALLVIAVAVPVFGLKLTTVGIRVEVHGAEAGTFWIIAACAVAMFVWQLFRTHLAAGWAASPSLPSVPAG
AGNFLTLPSTQRWIILALVLVALVWPFYGSRGAVDIATLILIYVMLGLGLNIVVGLAGLLDLGYVGFYAVGAYTYALLSH
YYGVGFWTALPIAGAMAALFGFLLGFPVLRLRGDYLAIVTLGFGEIIRILLRNMTSITGGPNGISGIDKPTFFGLSFDRR
AAEGMQTFHEYFGIAYNSVNKVIFLYLIALLLVLLTLFVINRLLRMPIGRAWEALREDEIACRALGMNPTVIKLSAFTLG
ATFAGFAGSFFAARQGLVSPESFTFIESAIILAIVVLGGMGSQLGVILAAIVMILLPELMREFSEYRMLMFGALMVLMMI
WRPQGLLPMQRPHLELKQ
>Mature_417_residues
TGNLRIAFFSALLVIAVAVPVFGLKLTTVGIRVEVHGAEAGTFWIIAACAVAMFVWQLFRTHLAAGWAASPSLPSVPAGA
GNFLTLPSTQRWIILALVLVALVWPFYGSRGAVDIATLILIYVMLGLGLNIVVGLAGLLDLGYVGFYAVGAYTYALLSHY
YGVGFWTALPIAGAMAALFGFLLGFPVLRLRGDYLAIVTLGFGEIIRILLRNMTSITGGPNGISGIDKPTFFGLSFDRRA
AEGMQTFHEYFGIAYNSVNKVIFLYLIALLLVLLTLFVINRLLRMPIGRAWEALREDEIACRALGMNPTVIKLSAFTLGA
TFAGFAGSFFAARQGLVSPESFTFIESAIILAIVVLGGMGSQLGVILAAIVMILLPELMREFSEYRMLMFGALMVLMMIW
RPQGLLPMQRPHLELKQ

Specific function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=419, Percent_Identity=62.7684964200477, Blast_Score=451, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 45346; Mature: 45215

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGNLRIAFFSALLVIAVAVPVFGLKLTTVGIRVEVHGAEAGTFWIIAACAVAMFVWQLF
CCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
RTHLAAGWAASPSLPSVPAGAGNFLTLPSTQRWIILALVLVALVWPFYGSRGAVDIATLI
HHHHHCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LIYVMLGLGLNIVVGLAGLLDLGYVGFYAVGAYTYALLSHYYGVGFWTALPIAGAMAALF
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFLLGFPVLRLRGDYLAIVTLGFGEIIRILLRNMTSITGGPNGISGIDKPTFFGLSFDRR
HHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHH
AAEGMQTFHEYFGIAYNSVNKVIFLYLIALLLVLLTLFVINRLLRMPIGRAWEALREDEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ACRALGMNPTVIKLSAFTLGATFAGFAGSFFAARQGLVSPESFTFIESAIILAIVVLGGM
HHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
GSQLGVILAAIVMILLPELMREFSEYRMLMFGALMVLMMIWRPQGLLPMQRPHLELKQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGNLRIAFFSALLVIAVAVPVFGLKLTTVGIRVEVHGAEAGTFWIIAACAVAMFVWQLF
CCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
RTHLAAGWAASPSLPSVPAGAGNFLTLPSTQRWIILALVLVALVWPFYGSRGAVDIATLI
HHHHHCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LIYVMLGLGLNIVVGLAGLLDLGYVGFYAVGAYTYALLSHYYGVGFWTALPIAGAMAALF
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFLLGFPVLRLRGDYLAIVTLGFGEIIRILLRNMTSITGGPNGISGIDKPTFFGLSFDRR
HHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHH
AAEGMQTFHEYFGIAYNSVNKVIFLYLIALLLVLLTLFVINRLLRMPIGRAWEALREDEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ACRALGMNPTVIKLSAFTLGATFAGFAGSFFAARQGLVSPESFTFIESAIILAIVVLGGM
HHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
GSQLGVILAAIVMILLPELMREFSEYRMLMFGALMVLMMIWRPQGLLPMQRPHLELKQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2120183; 10984043 [H]