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The map label for this gene is 146283202

Identifier: 146283202

GI number: 146283202

Start: 3083075

End: 3084457

Strand: Direct

Name: 146283202

Synonym: PST_2867

Alternate gene names: NA

Gene position: 3083075-3084457 (Clockwise)

Preceding gene: 146283200

Following gene: 146283203

Centisome position: 67.5

GC content: 65.8

Gene sequence:

>1383_bases
ATGGACGAAAACAGCAGCGTACTGATCGACTGCGGGCAATTTCAGGGCGACGACGAAGCGGGGCACGAAGATGAGCTGGC
GCTGGATTTCTCCGTCGAGGGTGTCAAGGCGCTGATCGTGACGCACGTGCACATCGACCATGTCGGGCGTATCCCGAACC
TGCTGGCAGCGGGCTTCGACGGGCCGATCCTGTGCAGCGAACCGTCCGCCCGGCTGCTGCCGATCGTACTGGAGGATGCC
TTCCGGCTCTCCATCAGCCGTGACCAGGACCAACTGGAGCGCTACCTCAAGGTCGTCGAGCAACGCATCATCGCCCTGCC
CTACGATCACTGGTTCACCCTCAACGAAACCGACGGCCGCGCGTGCAAGGTACGCCTGCAGCCGGCGGGGCATGTGCTGG
GTTCGGCCTACGTCGAGCTGGAGCTCAGCGAGGGCTCCGACGTCCAGCGCGTGGTATTCAGCGGCGACCTGGGCGCGCCA
CATTCACCGCTGCTGCCGGACCTGGTACCGCCCGAGCGCGCCGATCTGCTGATTCTCGAAAGCACCTATGGCGACCGCCG
CCACGAGGATCGCGCGCACCGCCGCGAGCGGTTGCAGGCTGCCATCGAGCGGGCTCTGGCCGACCAGGGCACGGTGCTCA
TTCCCTCGTTCAGTATCGGCCGAACGCAGGAGCTGCTGTTCGAGCTGGAGGAAATCCTCCACGAGAAGCGCGAAGCGGCC
GAAGCCAGCGGCACGCCTGTCGAAGCGCCAGAACAGGCCAGGGATGGCGACCCCGATATCGACTGGCCGCAGCTTCCCAT
CATCCTCGACTCGCCGCTCGCCAGCCGCTTCACTGCCACGTACAAGGAGTTGCAAGGCTACTGGGACGAAGACGCCCGTC
ATCGCCTGGAGGAAGGCCGCAAGCCGCTGTCGTTCAAGCAGCTCATCACCGTCGACAGCCATGACGAACACATGCGCATC
GTCGAACACCTCGCACAGACCGCACGCCCGGCCATCGTCATCGCCGGCAACGGCATGTGCTCGGGCGGACGCATCGTCAA
TTACCTCAAGGCCATGCTGGGGGACCCGCGACACAACGTGGTGTTCGTCGGCTACCAGGGCAAGGGCACGCCGGGACGGG
ACATACAGACCTACGGGCCGGACGGCGGCTTCGTCGATCTGGACGCAGAGCGCATCGACATCCGCGCCGGCATCGACAGC
GTCGGTGGCTATTCCGCCCACGCCGACCAAGCGGACCTGGTGGGCTTCGTCACTCGCATGCAGCAATGGCCGAGCGAGGT
CCGCCTGATCCACGGCGAGGACCAGGCCAAGCAGCGCCTGGCCGAGGTGCTCCGCGAGCGCTACGAGAAGGCCAGCCGGC
AAGGCCGGGTGGTTATCCCATGA

Upstream 100 bases:

>100_bases
GAGCCCTATCGGTCCACGTTAAGGACACCCGATGAAGCATCCAAAACTCATCCACCACGGCGCTCGCGAAGGCGTGACCG
GCTCGTGTCATCAATTGTGG

Downstream 100 bases:

>100_bases
GGCCCGTGAGCCCCATCCTCATGGCTGATCCCGATGCGTGACAGCTGGCCACCGGGCAGCATGCCTGCGCGAAGCCAGCT
ACAGTGCAAGTTCACGTCAA

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MDENSSVLIDCGQFQGDDEAGHEDELALDFSVEGVKALIVTHVHIDHVGRIPNLLAAGFDGPILCSEPSARLLPIVLEDA
FRLSISRDQDQLERYLKVVEQRIIALPYDHWFTLNETDGRACKVRLQPAGHVLGSAYVELELSEGSDVQRVVFSGDLGAP
HSPLLPDLVPPERADLLILESTYGDRRHEDRAHRRERLQAAIERALADQGTVLIPSFSIGRTQELLFELEEILHEKREAA
EASGTPVEAPEQARDGDPDIDWPQLPIILDSPLASRFTATYKELQGYWDEDARHRLEEGRKPLSFKQLITVDSHDEHMRI
VEHLAQTARPAIVIAGNGMCSGGRIVNYLKAMLGDPRHNVVFVGYQGKGTPGRDIQTYGPDGGFVDLDAERIDIRAGIDS
VGGYSAHADQADLVGFVTRMQQWPSEVRLIHGEDQAKQRLAEVLRERYEKASRQGRVVIP

Sequences:

>Translated_460_residues
MDENSSVLIDCGQFQGDDEAGHEDELALDFSVEGVKALIVTHVHIDHVGRIPNLLAAGFDGPILCSEPSARLLPIVLEDA
FRLSISRDQDQLERYLKVVEQRIIALPYDHWFTLNETDGRACKVRLQPAGHVLGSAYVELELSEGSDVQRVVFSGDLGAP
HSPLLPDLVPPERADLLILESTYGDRRHEDRAHRRERLQAAIERALADQGTVLIPSFSIGRTQELLFELEEILHEKREAA
EASGTPVEAPEQARDGDPDIDWPQLPIILDSPLASRFTATYKELQGYWDEDARHRLEEGRKPLSFKQLITVDSHDEHMRI
VEHLAQTARPAIVIAGNGMCSGGRIVNYLKAMLGDPRHNVVFVGYQGKGTPGRDIQTYGPDGGFVDLDAERIDIRAGIDS
VGGYSAHADQADLVGFVTRMQQWPSEVRLIHGEDQAKQRLAEVLRERYEKASRQGRVVIP
>Mature_460_residues
MDENSSVLIDCGQFQGDDEAGHEDELALDFSVEGVKALIVTHVHIDHVGRIPNLLAAGFDGPILCSEPSARLLPIVLEDA
FRLSISRDQDQLERYLKVVEQRIIALPYDHWFTLNETDGRACKVRLQPAGHVLGSAYVELELSEGSDVQRVVFSGDLGAP
HSPLLPDLVPPERADLLILESTYGDRRHEDRAHRRERLQAAIERALADQGTVLIPSFSIGRTQELLFELEEILHEKREAA
EASGTPVEAPEQARDGDPDIDWPQLPIILDSPLASRFTATYKELQGYWDEDARHRLEEGRKPLSFKQLITVDSHDEHMRI
VEHLAQTARPAIVIAGNGMCSGGRIVNYLKAMLGDPRHNVVFVGYQGKGTPGRDIQTYGPDGGFVDLDAERIDIRAGIDS
VGGYSAHADQADLVGFVTRMQQWPSEVRLIHGEDQAKQRLAEVLRERYEKASRQGRVVIP

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=418, Percent_Identity=24.6411483253589, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI33300633, Length=475, Percent_Identity=24, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32566029, Length=449, Percent_Identity=25.3897550111359, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323307, Length=473, Percent_Identity=24.5243128964059, Blast_Score=116, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24648013, Length=450, Percent_Identity=24.8888888888889, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21358523, Length=464, Percent_Identity=24.1379310344828, Blast_Score=115, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 51204; Mature: 51204

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDENSSVLIDCGQFQGDDEAGHEDELALDFSVEGVKALIVTHVHIDHVGRIPNLLAAGFD
CCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEEEHHHHCCCHHHHHCCCC
GPILCSEPSARLLPIVLEDAFRLSISRDQDQLERYLKVVEQRIIALPYDHWFTLNETDGR
CCEEECCCCCCEEHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
ACKVRLQPAGHVLGSAYVELELSEGSDVQRVVFSGDLGAPHSPLLPDLVPPERADLLILE
EEEEEECCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEE
STYGDRRHEDRAHRRERLQAAIERALADQGTVLIPSFSIGRTQELLFELEEILHEKREAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
EASGTPVEAPEQARDGDPDIDWPQLPIILDSPLASRFTATYKELQGYWDEDARHRLEEGR
HCCCCCCCCCHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHCC
KPLSFKQLITVDSHDEHMRIVEHLAQTARPAIVIAGNGMCSGGRIVNYLKAMLGDPRHNV
CCCCHHHEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCE
VFVGYQGKGTPGRDIQTYGPDGGFVDLDAERIDIRAGIDSVGGYSAHADQADLVGFVTRM
EEEEEECCCCCCCCCEEECCCCCEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
QQWPSEVRLIHGEDQAKQRLAEVLRERYEKASRQGRVVIP
HHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEECC
>Mature Secondary Structure
MDENSSVLIDCGQFQGDDEAGHEDELALDFSVEGVKALIVTHVHIDHVGRIPNLLAAGFD
CCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEEEHHHHCCCHHHHHCCCC
GPILCSEPSARLLPIVLEDAFRLSISRDQDQLERYLKVVEQRIIALPYDHWFTLNETDGR
CCEEECCCCCCEEHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
ACKVRLQPAGHVLGSAYVELELSEGSDVQRVVFSGDLGAPHSPLLPDLVPPERADLLILE
EEEEEECCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEE
STYGDRRHEDRAHRRERLQAAIERALADQGTVLIPSFSIGRTQELLFELEEILHEKREAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
EASGTPVEAPEQARDGDPDIDWPQLPIILDSPLASRFTATYKELQGYWDEDARHRLEEGR
HCCCCCCCCCHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHCC
KPLSFKQLITVDSHDEHMRIVEHLAQTARPAIVIAGNGMCSGGRIVNYLKAMLGDPRHNV
CCCCHHHEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCE
VFVGYQGKGTPGRDIQTYGPDGGFVDLDAERIDIRAGIDSVGGYSAHADQADLVGFVTRM
EEEEEECCCCCCCCCEEECCCCCEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
QQWPSEVRLIHGEDQAKQRLAEVLRERYEKASRQGRVVIP
HHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA