Click here to switch to the map view.

The map label for this gene is envZ [H]

Identifier: 145301084

GI number: 145301084

Start: 4550135

End: 4551580

Strand: Direct

Name: envZ [H]

Synonym: ASA_4253

Alternate gene names: 145301084

Gene position: 4550135-4551580 (Clockwise)

Preceding gene: 145301083

Following gene: 145301085

Centisome position: 96.76

GC content: 61.34

Gene sequence:

>1446_bases
ATGAGGAGTGGCTGGTTCTGGCGGGCGCTGGTTCCCCGCTCCCTGCTGTCGCGGATGCTGCTGTTGCTGCTGCTCGCCAT
CCTGCTCTCCCAGACCATTCTCACCGGTATCTGGATGCAACAGATCCAGAAACGGGAGCTGGAAGGCATGCTCAGCACCA
CCCGCAATCTGGCACTGTCGGCCGCCTCCACCGTCAACTTCTTCAAATCCCTTCCGCTGCAGTACCGCCACATAGCGCTG
GATCAGCTGCGCAATATGGGGGGGAGCCGCTTCTTCGTGTCACTCAACGAGGAAGAGATCCACATCAGCGCCATCCCCGA
CAGCGAGCGCAAGACGCTGGTGCTCAAAGAGGTACAAGGGGTGCTGGTCCGCAAGCTCTCGGACGCCATGGCCATCAAGG
TGGATTTCTCCCGCCCCGAGGACCTGCACGTCTTCAACAACGACATCCTGCTGGCGGATCTGCCCTCCTCCTGGGCCCGC
TATACCCTGTCGCTGGAGCCGCTCAATCCGCCCGTGCTGGTGACCCAGATCGAGATAGAGCCGGGTGAATGGCTCTATCT
GGCGGCCCTGCTGCCCGCTCCCTACATGACCCTCGACGATACTGTGATGCCGAGCAACCAGGTGCGTTTCATCGCCCTGA
TGACTGTCTTCCTTTGTTTCTTCACCTTCCTGCTGGTGCGCTGGCAGACTCGCCCGCTGCGTCGGCTCGCCAAGGCGGCG
GTCAACCTGGGCAAGGATATAGACCAACCTTCGCTCAAAGAGGAAGGGGCGTCAGAAATCGTGGCGGCCACCCGCGCTTT
CAACATCATGCAGCACCGCATCCGCCGCTATATCGATGATAGAGAGCGGCTGTTCAGCTCCATCTCCCACGATCTCAAGA
CCCCCATCACCCGGCTGCGGCTGCGGGTCGAGCTGCTCGACGACGAGGTGCAGATCGGCAAGTTCAACAAGGATCTGGAC
GAGCTGGAGCTGATGGTCAAGGGGGCGCTGCAGACGGTGAAAGACACCGACATCCACGAGAACATAGAGCAGCTGGACAT
AGACGCCATGCTGGAGCAGATGGCCGAGTCCATGAACCTGCATGACGAACGGCTGACCATAGAGGGCCACTGCAAGCAGC
TCTACCGTGGCAAGCCGCTGGCGCTCAAGCGCTGCATCGGCAACCTGGTGGACAACGGCATCAAGTACGGCCAGAAGGTG
CGCATCATCATCATGGACGACGAGGAGATGCTGATCCTCTTCATCATGGATGAGGGCCCCGGCCTGCCGGACGATCAGTT
CGAGCGCATCTTCGAGCCCTACTACCGGCTCAGCACGGATCTGGCCGGCACCGGCCTTGGCTTGGGCATAGCCCGCAACA
TAGCCCACGCCCACGGCGGCGATCTGGTGCTGGAAAATCGCCCGCAGGGCGGCCTGCAGGCCACCCTCTCCCTACCAAGG
CAGTAA

Upstream 100 bases:

>100_bases
ACGCGGCAGTGGCTATATGCTGATTGCCGAAGTACACGAGATCCCGTGAAGGGTAAAAAGGTAGCAACGGCATGCTGAAC
GACAAAAGGCACGAGATCCC

Downstream 100 bases:

>100_bases
CCTTATGAAGTGGTTGTCTTTTTCTGTCATCACCCTGATCTCTTCGCCCGTTGCCGCCTCCCAGCGCGTCGGGGTGCTGC
ACGGGTGGCGTGCGGTCGGC

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MRSGWFWRALVPRSLLSRMLLLLLLAILLSQTILTGIWMQQIQKRELEGMLSTTRNLALSAASTVNFFKSLPLQYRHIAL
DQLRNMGGSRFFVSLNEEEIHISAIPDSERKTLVLKEVQGVLVRKLSDAMAIKVDFSRPEDLHVFNNDILLADLPSSWAR
YTLSLEPLNPPVLVTQIEIEPGEWLYLAALLPAPYMTLDDTVMPSNQVRFIALMTVFLCFFTFLLVRWQTRPLRRLAKAA
VNLGKDIDQPSLKEEGASEIVAATRAFNIMQHRIRRYIDDRERLFSSISHDLKTPITRLRLRVELLDDEVQIGKFNKDLD
ELELMVKGALQTVKDTDIHENIEQLDIDAMLEQMAESMNLHDERLTIEGHCKQLYRGKPLALKRCIGNLVDNGIKYGQKV
RIIIMDDEEMLILFIMDEGPGLPDDQFERIFEPYYRLSTDLAGTGLGLGIARNIAHAHGGDLVLENRPQGGLQATLSLPR
Q

Sequences:

>Translated_481_residues
MRSGWFWRALVPRSLLSRMLLLLLLAILLSQTILTGIWMQQIQKRELEGMLSTTRNLALSAASTVNFFKSLPLQYRHIAL
DQLRNMGGSRFFVSLNEEEIHISAIPDSERKTLVLKEVQGVLVRKLSDAMAIKVDFSRPEDLHVFNNDILLADLPSSWAR
YTLSLEPLNPPVLVTQIEIEPGEWLYLAALLPAPYMTLDDTVMPSNQVRFIALMTVFLCFFTFLLVRWQTRPLRRLAKAA
VNLGKDIDQPSLKEEGASEIVAATRAFNIMQHRIRRYIDDRERLFSSISHDLKTPITRLRLRVELLDDEVQIGKFNKDLD
ELELMVKGALQTVKDTDIHENIEQLDIDAMLEQMAESMNLHDERLTIEGHCKQLYRGKPLALKRCIGNLVDNGIKYGQKV
RIIIMDDEEMLILFIMDEGPGLPDDQFERIFEPYYRLSTDLAGTGLGLGIARNIAHAHGGDLVLENRPQGGLQATLSLPR
Q
>Mature_481_residues
MRSGWFWRALVPRSLLSRMLLLLLLAILLSQTILTGIWMQQIQKRELEGMLSTTRNLALSAASTVNFFKSLPLQYRHIAL
DQLRNMGGSRFFVSLNEEEIHISAIPDSERKTLVLKEVQGVLVRKLSDAMAIKVDFSRPEDLHVFNNDILLADLPSSWAR
YTLSLEPLNPPVLVTQIEIEPGEWLYLAALLPAPYMTLDDTVMPSNQVRFIALMTVFLCFFTFLLVRWQTRPLRRLAKAA
VNLGKDIDQPSLKEEGASEIVAATRAFNIMQHRIRRYIDDRERLFSSISHDLKTPITRLRLRVELLDDEVQIGKFNKDLD
ELELMVKGALQTVKDTDIHENIEQLDIDAMLEQMAESMNLHDERLTIEGHCKQLYRGKPLALKRCIGNLVDNGIKYGQKV
RIIIMDDEEMLILFIMDEGPGLPDDQFERIFEPYYRLSTDLAGTGLGLGIARNIAHAHGGDLVLENRPQGGLQATLSLPR
Q

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=269, Percent_Identity=33.0855018587361, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=31.25, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787894, Length=308, Percent_Identity=26.9480519480519, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790551, Length=287, Percent_Identity=27.1777003484321, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790861, Length=276, Percent_Identity=25.7246376811594, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=29.6137339055794, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=25.5395683453237, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1789403, Length=292, Percent_Identity=27.7397260273973, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786783, Length=338, Percent_Identity=21.0059171597633, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=224, Percent_Identity=25.4464285714286, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=23.7442922374429, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787374, Length=292, Percent_Identity=22.9452054794521, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI48994928, Length=242, Percent_Identity=24.3801652892562, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=303, Percent_Identity=24.0924092409241, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081816, Length=253, Percent_Identity=23.3201581027668, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54836; Mature: 54836

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSGWFWRALVPRSLLSRMLLLLLLAILLSQTILTGIWMQQIQKRELEGMLSTTRNLALS
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AASTVNFFKSLPLQYRHIALDQLRNMGGSRFFVSLNEEEIHISAIPDSERKTLVLKEVQG
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHH
VLVRKLSDAMAIKVDFSRPEDLHVFNNDILLADLPSSWARYTLSLEPLNPPVLVTQIEIE
HHHHHHCCCEEEEEECCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCCEEEEEEEEC
PGEWLYLAALLPAPYMTLDDTVMPSNQVRFIALMTVFLCFFTFLLVRWQTRPLRRLAKAA
CCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VNLGKDIDQPSLKEEGASEIVAATRAFNIMQHRIRRYIDDRERLFSSISHDLKTPITRLR
HHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
LRVELLDDEVQIGKFNKDLDELELMVKGALQTVKDTDIHENIEQLDIDAMLEQMAESMNL
HHHEECCCCCEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
HDERLTIEGHCKQLYRGKPLALKRCIGNLVDNGIKYGQKVRIIIMDDEEMLILFIMDEGP
CHHEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCC
GLPDDQFERIFEPYYRLSTDLAGTGLGLGIARNIAHAHGGDLVLENRPQGGLQATLSLPR
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCEECCCCCC
Q
C
>Mature Secondary Structure
MRSGWFWRALVPRSLLSRMLLLLLLAILLSQTILTGIWMQQIQKRELEGMLSTTRNLALS
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AASTVNFFKSLPLQYRHIALDQLRNMGGSRFFVSLNEEEIHISAIPDSERKTLVLKEVQG
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHH
VLVRKLSDAMAIKVDFSRPEDLHVFNNDILLADLPSSWARYTLSLEPLNPPVLVTQIEIE
HHHHHHCCCEEEEEECCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCCEEEEEEEEC
PGEWLYLAALLPAPYMTLDDTVMPSNQVRFIALMTVFLCFFTFLLVRWQTRPLRRLAKAA
CCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VNLGKDIDQPSLKEEGASEIVAATRAFNIMQHRIRRYIDDRERLFSSISHDLKTPITRLR
HHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
LRVELLDDEVQIGKFNKDLDELELMVKGALQTVKDTDIHENIEQLDIDAMLEQMAESMNL
HHHEECCCCCEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
HDERLTIEGHCKQLYRGKPLALKRCIGNLVDNGIKYGQKVRIIIMDDEEMLILFIMDEGP
CHHEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCC
GLPDDQFERIFEPYYRLSTDLAGTGLGLGIARNIAHAHGGDLVLENRPQGGLQATLSLPR
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCEECCCCCC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]