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The map label for this gene is ilvY [H]

Identifier: 145301072

GI number: 145301072

Start: 4528897

End: 4529790

Strand: Direct

Name: ilvY [H]

Synonym: ASA_4237

Alternate gene names: 145301072

Gene position: 4528897-4529790 (Clockwise)

Preceding gene: 145301070

Following gene: 145301074

Centisome position: 96.31

GC content: 64.09

Gene sequence:

>894_bases
ATGGATCTTCGCAATCTCGAGCTGTTTCTCCACCTCGCCGACTCCCTTCACTTTGGCAAGAGTGCCGATGCCATGGCGGT
CAGCCCCTCCACCCTGAGCCGCGCCATTCAGCGACTGGAGCAGGAGACCGGCTGCGTGCTGTTCGAGCGGGACAACCGCA
GCGTGCGGCTCACCTCGGCGGGTGAGAAACTGCGGGAGTTTGGCGGCAGCCTGTTGCAGGAGTGGCGCCAGCTCAAGCAG
GAGCTCAAACGCAGCGACGAACCGCTGCAAGGACGGCTGCGGGTGTTCTGCTCGGTCACCGCCAGCTACTTTCTGCTGCC
CGAGGTGCTGGAGCGCTTTCGTCGCCGCTATCCCCAACTGGAGATCAAGCTGGAGACCGGCGACCCGGCGCTGGCGGTGG
ACAAGATCCTGGCTGACGAGGCCGATCTCGCCATCGCCGCGCGGCCGGATGCGCTCTCCGCCAAGCTGGAATTTGCCAGC
CTGCAGCAGGTGCCACTGGTATTCATTGCCCCCCGTACCGCACCGCAACAGAGCCAGTGGTTCTTGCAGGGTGAGCCGGA
CTGGGAGCGACTGCCGCTGATACTCTCCGAACAGGGTCTGGCACGAAAGCGCTGTGACCAGTGGTTTCGCAACAAGGGAA
TTGCCCCCAACATCTATGCCGAGGTTGCAGGCAACGAGGGCATAGTCGCCATGGTGGCGCTCGGTTTTGGCGTCGGGCTG
GTGCCTGCCGCCGTGATCGATCACAGCCCCATGGGGGAGAAGGTGCGCATCGTCGAGCCCAGACCGGCGCTCAAGCCATT
CGACGTCGGTATCGCAGTGCTCAAGAAGCGGCTGGAAGAGCCTCTTATCCGCGCCTTCTGGGATACGGCGCGCGGCCAGG
GTTCACTGCGCTGA

Upstream 100 bases:

>100_bases
TATTCGAAACAGTATGTTGCAGGAATTGAAAGATGATTCTTCGCAATCTCAAGCTGTTTCTCCCCCACGCCAGCAAACGC
GCCGCCGCAGGAATAGAAAG

Downstream 100 bases:

>100_bases
CGGGGTGGCCGTGACCGGCGCATAGATTAGCGAGGGGTCAGCCATCATGATGCGGCTCCTGGCGGGCAGATCCGGATTAT
GCAGCTCAAGCATGACCCGC

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MDLRNLELFLHLADSLHFGKSADAMAVSPSTLSRAIQRLEQETGCVLFERDNRSVRLTSAGEKLREFGGSLLQEWRQLKQ
ELKRSDEPLQGRLRVFCSVTASYFLLPEVLERFRRRYPQLEIKLETGDPALAVDKILADEADLAIAARPDALSAKLEFAS
LQQVPLVFIAPRTAPQQSQWFLQGEPDWERLPLILSEQGLARKRCDQWFRNKGIAPNIYAEVAGNEGIVAMVALGFGVGL
VPAAVIDHSPMGEKVRIVEPRPALKPFDVGIAVLKKRLEEPLIRAFWDTARGQGSLR

Sequences:

>Translated_297_residues
MDLRNLELFLHLADSLHFGKSADAMAVSPSTLSRAIQRLEQETGCVLFERDNRSVRLTSAGEKLREFGGSLLQEWRQLKQ
ELKRSDEPLQGRLRVFCSVTASYFLLPEVLERFRRRYPQLEIKLETGDPALAVDKILADEADLAIAARPDALSAKLEFAS
LQQVPLVFIAPRTAPQQSQWFLQGEPDWERLPLILSEQGLARKRCDQWFRNKGIAPNIYAEVAGNEGIVAMVALGFGVGL
VPAAVIDHSPMGEKVRIVEPRPALKPFDVGIAVLKKRLEEPLIRAFWDTARGQGSLR
>Mature_297_residues
MDLRNLELFLHLADSLHFGKSADAMAVSPSTLSRAIQRLEQETGCVLFERDNRSVRLTSAGEKLREFGGSLLQEWRQLKQ
ELKRSDEPLQGRLRVFCSVTASYFLLPEVLERFRRRYPQLEIKLETGDPALAVDKILADEADLAIAARPDALSAKLEFAS
LQQVPLVFIAPRTAPQQSQWFLQGEPDWERLPLILSEQGLARKRCDQWFRNKGIAPNIYAEVAGNEGIVAMVALGFGVGL
VPAAVIDHSPMGEKVRIVEPRPALKPFDVGIAVLKKRLEEPLIRAFWDTARGQGSLR

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=291, Percent_Identity=49.8281786941581, Blast_Score=267, Evalue=5e-73,
Organism=Escherichia coli, GI157672245, Length=245, Percent_Identity=29.3877551020408, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788748, Length=300, Percent_Identity=26.3333333333333, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787879, Length=253, Percent_Identity=26.8774703557312, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787806, Length=256, Percent_Identity=25.390625, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790399, Length=246, Percent_Identity=26.8292682926829, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI145693105, Length=266, Percent_Identity=22.5563909774436, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI87082132, Length=246, Percent_Identity=28.4552845528455, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1788887, Length=306, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1787530, Length=250, Percent_Identity=23.2, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788296, Length=234, Percent_Identity=27.7777777777778, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI2367136, Length=261, Percent_Identity=26.8199233716475, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788481, Length=269, Percent_Identity=27.5092936802974, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081978, Length=182, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=24.1379310344828, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789639, Length=176, Percent_Identity=27.8409090909091, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789204, Length=293, Percent_Identity=24.9146757679181, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788297, Length=244, Percent_Identity=22.5409836065574, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081904, Length=215, Percent_Identity=25.1162790697674, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786401, Length=143, Percent_Identity=27.972027972028, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790262, Length=254, Percent_Identity=24.8031496062992, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI48994962, Length=85, Percent_Identity=34.1176470588235, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33292; Mature: 33292

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRNLELFLHLADSLHFGKSADAMAVSPSTLSRAIQRLEQETGCVLFERDNRSVRLTSA
CCCCHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHCCEEEEEECCCEEEEEHH
GEKLREFGGSLLQEWRQLKQELKRSDEPLQGRLRVFCSVTASYFLLPEVLERFRRRYPQL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
EIKLETGDPALAVDKILADEADLAIAARPDALSAKLEFASLQQVPLVFIAPRTAPQQSQW
EEEEECCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCE
FLQGEPDWERLPLILSEQGLARKRCDQWFRNKGIAPNIYAEVAGNEGIVAMVALGFGVGL
EECCCCCHHHCCEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEHHHHHHHHHH
VPAAVIDHSPMGEKVRIVEPRPALKPFDVGIAVLKKRLEEPLIRAFWDTARGQGSLR
HHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDLRNLELFLHLADSLHFGKSADAMAVSPSTLSRAIQRLEQETGCVLFERDNRSVRLTSA
CCCCHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHCCEEEEEECCCEEEEEHH
GEKLREFGGSLLQEWRQLKQELKRSDEPLQGRLRVFCSVTASYFLLPEVLERFRRRYPQL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
EIKLETGDPALAVDKILADEADLAIAARPDALSAKLEFASLQQVPLVFIAPRTAPQQSQW
EEEEECCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCE
FLQGEPDWERLPLILSEQGLARKRCDQWFRNKGIAPNIYAEVAGNEGIVAMVALGFGVGL
EECCCCCHHHCCEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEHHHHHHHHHH
VPAAVIDHSPMGEKVRIVEPRPALKPFDVGIAVLKKRLEEPLIRAFWDTARGQGSLR
HHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]