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The map label for this gene is pgi [H]

Identifier: 145301070

GI number: 145301070

Start: 4525421

End: 4527070

Strand: Direct

Name: pgi [H]

Synonym: ASA_4235

Alternate gene names: 145301070

Gene position: 4525421-4527070 (Clockwise)

Preceding gene: 145301068

Following gene: 145301072

Centisome position: 96.24

GC content: 58.3

Gene sequence:

>1650_bases
ATGAAAAATATCAATCCAACCCAGACCCAGGCCTGGCAGGCGCTGGAAGCCCATTTTGCAGCTAACAAAGAGACTCGACT
CAAGGATCTGTTCGCGCAGGACCCGAAGCGCTTCGACAAGTTCTCCCTCACCTTTGGCGGCGACATTCTGGTCGACTACT
CCAAGAACCTGATCACCGAGGAAACCCTCAAGTTGCTGGTTGATCTGGCCAAAGAGACCGATCTTCGCAGCGCGATCGAT
GCCATGTTCAATGGCGAGAAGATCAACATGACCGAAGGGCGCTCCGTACTGCACGTGGCCCTGCGCAACCGCTCCGACCG
CCCCATCGAGTGCGACGGCAAGGATGTGATGCCGGAAGTGAACGCCGTGCTGGCCAAGATGAAGGGCTTCTGCGAGAAGA
TCATCTCAGGCGAGTGGAAAGGCTACACCGGCAAGGCGATCCAGCACGTGGTCAACATCGGTATCGGTGGCTCTGATCTG
GGCCCTGTGATGATCACAGAGGCACTGCGCCCCTACAAAAACCACCTGCAGATGCACTTCGTCTCCAACGTCGATGGCAC
CCACATCGCCGAGACTCTCAAAGAGATTGATGCGGAAACCACCCTGTTCCTGGTGGCCTCCAAGACCTTCACCACTCAGG
AGACCATGACCAACGCCCTGACCGCCCGCGACTGGTTCATCAAGATCGCCGGTGACAAGGCCCACGTGGCCAAGCACTTC
GCTGCCCTCTCCACTAACGGCAAGGCCGTGGCCGAGTTCGGCATCGACACCGACAACATGTTCGAGTTCTGGGACTGGGT
TGGCGGCCGTTACTCATCCTGGTCTGCCATCGGCATGCCTATCGCCCTGTCCGTCGGTTTCGACAACTTCGAAGCCCTGC
TGCAAGGCGCCTTCGAAATGGACATGCACTTTGCCACTGCCTCCTATGAGCAGAACGTGCCTGTGCTGCTGGCGCTGATT
GGCCTGTGGTACAACAACTTCCATGGTGCCGAGTCCGAAGCCATTCTGCCGTACGATCAGTACATGCACCGCTTCCCTGC
CTACTTCCAGCAGGGCAACATGGAATCCAACGGCAAGTACGTGGATCGCAACGGCAATCCGGTTGACCACCAGACTGGCC
CCATCATCTGGGGTGAGCCGGGCACCAACGGCCAGCACGCCTTCTACCAGCTGATCCACCAGGGTACCAAGCTGATCCCC
TGTGACTTCCTAGCACCGGCCATCAGCCACAACCCGATCGGTGACCACCACCCGAAACTGCTGGCCAACTTCTTCGCCCA
AACCGAGGCACTGGCCTTCGGCAAGAGCAAAGAACAGGTCGAAGCCGAGTTCCTTGCTGCCGGCAAAACCCTGGAGCAGG
TCGAGGATCTGGTGCCGTTCAAGGTGTTCGAAGGCAACCGCCCGACCAACAGCATACTGTTCAAGAGCCTGACCCCGAAA
ACCCTGGGTGCCTTGATCGCCATGTACGAGCACAAGATCTTCGTACAGGGCGCAATCTGGAACATCTTCTCCTTCGACCA
GTGGGGCGTGGAGCTGGGCAAACAGCTGGCCAACAAGATACTGCCGGAACTCAACACCGCCGAGGCTGTCACCAGCCACG
ACTGCTCCACCAACGGTCTGATCAACACCTGGAAAGCGTGGAAAGCCTGA

Upstream 100 bases:

>100_bases
TGGGCTCGGTATAATGGGCCCGGTATAGTGCTCGAATAATAAGGTTTGGCGGGAGCCTTGCCTGCAAGGTTCAAACACAA
CTTGGAAGATCGGTAATCCT

Downstream 100 bases:

>100_bases
TTTATCCGGCCTTTCTGAATGCAAAAGCCCCGCTCGATGAGCGGGGCTTTTTTATAGCTGTCGGGCCGGATTTTCTGGCT
GGCCGGTCGGGTGTCCAGTC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKNINPTQTQAWQALEAHFAANKETRLKDLFAQDPKRFDKFSLTFGGDILVDYSKNLITEETLKLLVDLAKETDLRSAID
AMFNGEKINMTEGRSVLHVALRNRSDRPIECDGKDVMPEVNAVLAKMKGFCEKIISGEWKGYTGKAIQHVVNIGIGGSDL
GPVMITEALRPYKNHLQMHFVSNVDGTHIAETLKEIDAETTLFLVASKTFTTQETMTNALTARDWFIKIAGDKAHVAKHF
AALSTNGKAVAEFGIDTDNMFEFWDWVGGRYSSWSAIGMPIALSVGFDNFEALLQGAFEMDMHFATASYEQNVPVLLALI
GLWYNNFHGAESEAILPYDQYMHRFPAYFQQGNMESNGKYVDRNGNPVDHQTGPIIWGEPGTNGQHAFYQLIHQGTKLIP
CDFLAPAISHNPIGDHHPKLLANFFAQTEALAFGKSKEQVEAEFLAAGKTLEQVEDLVPFKVFEGNRPTNSILFKSLTPK
TLGALIAMYEHKIFVQGAIWNIFSFDQWGVELGKQLANKILPELNTAEAVTSHDCSTNGLINTWKAWKA

Sequences:

>Translated_549_residues
MKNINPTQTQAWQALEAHFAANKETRLKDLFAQDPKRFDKFSLTFGGDILVDYSKNLITEETLKLLVDLAKETDLRSAID
AMFNGEKINMTEGRSVLHVALRNRSDRPIECDGKDVMPEVNAVLAKMKGFCEKIISGEWKGYTGKAIQHVVNIGIGGSDL
GPVMITEALRPYKNHLQMHFVSNVDGTHIAETLKEIDAETTLFLVASKTFTTQETMTNALTARDWFIKIAGDKAHVAKHF
AALSTNGKAVAEFGIDTDNMFEFWDWVGGRYSSWSAIGMPIALSVGFDNFEALLQGAFEMDMHFATASYEQNVPVLLALI
GLWYNNFHGAESEAILPYDQYMHRFPAYFQQGNMESNGKYVDRNGNPVDHQTGPIIWGEPGTNGQHAFYQLIHQGTKLIP
CDFLAPAISHNPIGDHHPKLLANFFAQTEALAFGKSKEQVEAEFLAAGKTLEQVEDLVPFKVFEGNRPTNSILFKSLTPK
TLGALIAMYEHKIFVQGAIWNIFSFDQWGVELGKQLANKILPELNTAEAVTSHDCSTNGLINTWKAWKA
>Mature_549_residues
MKNINPTQTQAWQALEAHFAANKETRLKDLFAQDPKRFDKFSLTFGGDILVDYSKNLITEETLKLLVDLAKETDLRSAID
AMFNGEKINMTEGRSVLHVALRNRSDRPIECDGKDVMPEVNAVLAKMKGFCEKIISGEWKGYTGKAIQHVVNIGIGGSDL
GPVMITEALRPYKNHLQMHFVSNVDGTHIAETLKEIDAETTLFLVASKTFTTQETMTNALTARDWFIKIAGDKAHVAKHF
AALSTNGKAVAEFGIDTDNMFEFWDWVGGRYSSWSAIGMPIALSVGFDNFEALLQGAFEMDMHFATASYEQNVPVLLALI
GLWYNNFHGAESEAILPYDQYMHRFPAYFQQGNMESNGKYVDRNGNPVDHQTGPIIWGEPGTNGQHAFYQLIHQGTKLIP
CDFLAPAISHNPIGDHHPKLLANFFAQTEALAFGKSKEQVEAEFLAAGKTLEQVEDLVPFKVFEGNRPTNSILFKSLTPK
TLGALIAMYEHKIFVQGAIWNIFSFDQWGVELGKQLANKILPELNTAEAVTSHDCSTNGLINTWKAWKA

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=543, Percent_Identity=65.7458563535912, Blast_Score=735, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=543, Percent_Identity=62.0626151012891, Blast_Score=676, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=76.3205828779599, Blast_Score=880, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=546, Percent_Identity=63.1868131868132, Blast_Score=714, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=541, Percent_Identity=63.5859519408503, Blast_Score=713, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=58.8342440801457, Blast_Score=646, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=549, Percent_Identity=61.9307832422586, Blast_Score=699, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=549, Percent_Identity=61.9307832422586, Blast_Score=699, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=549, Percent_Identity=61.9307832422586, Blast_Score=699, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 61202; Mature: 61202

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNINPTQTQAWQALEAHFAANKETRLKDLFAQDPKRFDKFSLTFGGDILVDYSKNLITE
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHCCEEEEECCEEEEECCCCHHHH
ETLKLLVDLAKETDLRSAIDAMFNGEKINMTEGRSVLHVALRNRSDRPIECDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEHHHHHCCCCCCCCCCCCCCCHHH
NAVLAKMKGFCEKIISGEWKGYTGKAIQHVVNIGIGGSDLGPVMITEALRPYKNHLQMHF
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCEEEEE
VSNVDGTHIAETLKEIDAETTLFLVASKTFTTQETMTNALTARDWFIKIAGDKAHVAKHF
ECCCCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCEEEEEEECCHHHHHHHH
AALSTNGKAVAEFGIDTDNMFEFWDWVGGRYSSWSAIGMPIALSVGFDNFEALLQGAFEM
HHHCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHH
DMHFATASYEQNVPVLLALIGLWYNNFHGAESEAILPYDQYMHRFPAYFQQGNMESNGKY
HHHHEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGNPVDHQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFLAPAISHNPIGDHHPKL
ECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHH
LANFFAQTEALAFGKSKEQVEAEFLAAGKTLEQVEDLVPFKVFEGNRPTNSILFKSLTPK
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHCCCEEEECCCCCCHHHEEECCCHH
TLGALIAMYEHKIFVQGAIWNIFSFDQWGVELGKQLANKILPELNTAEAVTSHDCSTNGL
HHHHHHHHHHCEEEEEEHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCC
INTWKAWKA
CCCHHHCCC
>Mature Secondary Structure
MKNINPTQTQAWQALEAHFAANKETRLKDLFAQDPKRFDKFSLTFGGDILVDYSKNLITE
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHCCEEEEECCEEEEECCCCHHHH
ETLKLLVDLAKETDLRSAIDAMFNGEKINMTEGRSVLHVALRNRSDRPIECDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEHHHHHCCCCCCCCCCCCCCCHHH
NAVLAKMKGFCEKIISGEWKGYTGKAIQHVVNIGIGGSDLGPVMITEALRPYKNHLQMHF
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCEEEEE
VSNVDGTHIAETLKEIDAETTLFLVASKTFTTQETMTNALTARDWFIKIAGDKAHVAKHF
ECCCCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCEEEEEEECCHHHHHHHH
AALSTNGKAVAEFGIDTDNMFEFWDWVGGRYSSWSAIGMPIALSVGFDNFEALLQGAFEM
HHHCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHH
DMHFATASYEQNVPVLLALIGLWYNNFHGAESEAILPYDQYMHRFPAYFQQGNMESNGKY
HHHHEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGNPVDHQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFLAPAISHNPIGDHHPKL
ECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHH
LANFFAQTEALAFGKSKEQVEAEFLAAGKTLEQVEDLVPFKVFEGNRPTNSILFKSLTPK
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHCCCEEEECCCCCCHHHEEECCCHH
TLGALIAMYEHKIFVQGAIWNIFSFDQWGVELGKQLANKILPELNTAEAVTSHDCSTNGL
HHHHHHHHHHCEEEEEEHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCC
INTWKAWKA
CCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA