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The map label for this gene is dut [H]

Identifier: 145301066

GI number: 145301066

Start: 4522538

End: 4522996

Strand: Direct

Name: dut [H]

Synonym: ASA_4231

Alternate gene names: 145301066

Gene position: 4522538-4522996 (Clockwise)

Preceding gene: 145301065

Following gene: 145301067

Centisome position: 96.18

GC content: 59.26

Gene sequence:

>459_bases
ATGACAACACAAATTGAGCTGAAAATTCTGGATGCCCGCATCGGCACCGAGTACCCGCTGCCCGCCTACGCCACTCCGGG
CTCTGCCGGTATGGACCTGCGTGCGCTGCTGGATGCGCCCATCACTCTGGCACCAGGCGACACCATTCTGGTACCGACCG
GTCTGGCCATCCACATTCAGGATCCCGGCTTGTGCGCCACCATCTTGCCCCGCTCCGGCCTCGGCCATAAGCACGGCATT
GTGCTGGGCAACCTGGTGGGCCTCATCGATTCCGATTACCAGGGCCAGCTGATGGTTTCGGTCTGGAATCGTGGCAACGA
CAGTTTCACCATGCAACCCGGTGAACGCATCGCCCAACTGGTGATAATGCCGGTGGTGCAGGCCAGCTTCCAACTGGTCG
ATGAGTTCAATCAGAGTGAACGGGGTGAAGGCGGTTTTGGTTCTTCTGGTCGCCAATAA

Upstream 100 bases:

>100_bases
CACACCAGCACTCGCTGAGCAACGATCAATTCATGACTGCCCGGACTGTACCGAGTATCCCGGGTGTCCACACAAGAACC
CATTGAAAAACGAACGATTC

Downstream 100 bases:

>100_bases
CAGACCACACAGGCCCCCGGGCCTGTGCCTAATAACAGAATCAAGCCATTGTTTTTTTAGGGGAATCCATGGCAAGCAGT
AATCAGAAACAGAGTCGGCG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MTTQIELKILDARIGTEYPLPAYATPGSAGMDLRALLDAPITLAPGDTILVPTGLAIHIQDPGLCATILPRSGLGHKHGI
VLGNLVGLIDSDYQGQLMVSVWNRGNDSFTMQPGERIAQLVIMPVVQASFQLVDEFNQSERGEGGFGSSGRQ

Sequences:

>Translated_152_residues
MTTQIELKILDARIGTEYPLPAYATPGSAGMDLRALLDAPITLAPGDTILVPTGLAIHIQDPGLCATILPRSGLGHKHGI
VLGNLVGLIDSDYQGQLMVSVWNRGNDSFTMQPGERIAQLVIMPVVQASFQLVDEFNQSERGEGGFGSSGRQ
>Mature_151_residues
TTQIELKILDARIGTEYPLPAYATPGSAGMDLRALLDAPITLAPGDTILVPTGLAIHIQDPGLCATILPRSGLGHKHGIV
LGNLVGLIDSDYQGQLMVSVWNRGNDSFTMQPGERIAQLVIMPVVQASFQLVDEFNQSERGEGGFGSSGRQ

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI4503423, Length=146, Percent_Identity=33.5616438356164, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI70906444, Length=141, Percent_Identity=34.7517730496454, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI70906441, Length=146, Percent_Identity=33.5616438356164, Blast_Score=83, Evalue=8e-17,
Organism=Escherichia coli, GI1790071, Length=149, Percent_Identity=74.496644295302, Blast_Score=238, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71988561, Length=132, Percent_Identity=37.1212121212121, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319729, Length=132, Percent_Identity=35.6060606060606, Blast_Score=75, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583610, Length=136, Percent_Identity=36.7647058823529, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921126, Length=136, Percent_Identity=36.7647058823529, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16169; Mature: 16038

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQIELKILDARIGTEYPLPAYATPGSAGMDLRALLDAPITLAPGDTILVPTGLAIHIQ
CCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCEEECCCCEEEECCCEEEEEE
DPGLCATILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSVWNRGNDSFTMQPGERIAQL
CCCCEEEECCCCCCCCCCCEEEHHEEHHCCCCCCCEEEEEEECCCCCCEEECCHHHHHHH
VIMPVVQASFQLVDEFNQSERGEGGFGSSGRQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTQIELKILDARIGTEYPLPAYATPGSAGMDLRALLDAPITLAPGDTILVPTGLAIHIQ
CCEEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCEEECCCCEEEECCCEEEEEE
DPGLCATILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSVWNRGNDSFTMQPGERIAQL
CCCCEEEECCCCCCCCCCCEEEHHEEHHCCCCCCCEEEEEEECCCCCCEEECCHHHHHHH
VIMPVVQASFQLVDEFNQSERGEGGFGSSGRQ
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA