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The map label for this gene is cpxA [H]

Identifier: 145301038

GI number: 145301038

Start: 4496985

End: 4498340

Strand: Direct

Name: cpxA [H]

Synonym: ASA_4201

Alternate gene names: 145301038

Gene position: 4496985-4498340 (Clockwise)

Preceding gene: 145301037

Following gene: 145301039

Centisome position: 95.63

GC content: 60.99

Gene sequence:

>1356_bases
ATGAACACGGCCCGCACCTTCAATGGCCTCTCCACCCAGATCTTCCTCTGGTTCTGGTTCATGCTGCTGGTCGTGGTCGC
CGCTGTCGTGATACTGCCGACCCTGGATCCCCGCAACATAATTCCGTTACCCGCCCACGAGATGGTGCGGATGAACAACA
ACCTGAAAGCCCTGCAGCGGGGTGCCGACCCCAATCAGGATTTCGATCTGGCCAAGGCCATAGAGGCGGCGGGTCTGTTG
CCGGTGGACAATATCTACCTGCGCGACGAGAAGGGCCAGATGCAATCCAGCACGCGGCTCAGCAAGTTCGTCGTCCGCTT
CATGGTCGACTCGGACAACCCTGCCAAGCCCATGCTGGGCAGCGAGCACCAGAGGGCCATCGCCGGTCCCTTCGAGATGG
AGCACCACGGTCAGACCTATCACGTCTACTTCGGCCTCAATGTCGAAAACTCCTATCTGTTCCTGTTTATCCAGATCCTG
GATCACCCGATCCAGATCCTGGGGATCGCCATGCTGGTCAGTACACCACTCTGCCTGTTGCTGGCCTGGCGACTGACCCG
TCCCATACTGCAGTTGCAGCGATCAGTCTCCCAGTTGGCGGAGGGCAACCTGGAAGTACAGATCCCCAATCTGGGGCGAC
GTGACGAGATCGGCCAGCTGGCGGATCACGTCAGCCACATGGTCGACACGCTCAAGAGCATGATCCAGAAGCAGAAACAG
CTGCTGTCCGACATATCCCACGAGCTGCGCAGCCCCCTCACCCGTATCCAGCTGGCGCAGGCGCTGATCCGCCGCAAGCA
GGGCGACAGCAACGAGCTGGCACGGATAGAGTCGGAGATTGGGCGGCTGGACAAGCTGATAGGCGACCTGCTCGACCTGT
CACGGGTACAGCAGCATGTGGAGGCACCAGTGGTGATGCCGTTGGCCGAACTGCTGGAGCCCATGCTGGACGACGCCATG
TTCGAAGCCAACCAGAGCGGCAAGCAACTCCGGCTGCCGCCACTGCCGACCGAGTCGATCAGGATGTGGCCCGAGCTGCT
GGCACGGGCGCTGGAAAATCCCCTGCGCAACGCACTCAAGTACGCTCACAAGTTCATCAAACTGGATTGGTATCGGGAAG
GAAGAGAGTGGGTCATCACCATCCGTGATGACGGCCCGGGTGTGCCGGTGGCGCAACAGGAGCAGCTGTTCCTGCCCTTC
TTTCGGGTGGATGATGCCCGCAACGCCAAGACCGGCGGCACCGGGCTGGGGCTGGCCATCGCCTCGGAGGCAATCCAGCG
CCATGGCGGCACCATTCGCGCCAGTTGCAATCAACCAACCGGGCTGACTATCACCATACGTCTGCCTATTGGCTGA

Upstream 100 bases:

>100_bases
TGCACCTGAGCAACCTGCGCAAGAAGCTGCCGGAGCGCACCGATGGCCAGCCCCGCTTCAAGACGGTGCGCGGACGCGGC
TATCTGTGGCTGGAACAAGC

Downstream 100 bases:

>100_bases
GCCATCTCTTTTCATCCAGGCGGGCGCTGGGTATGCTGGCGCCCTTTTCCGCCCCATCTCGGCCCGCATCAGGATCCCGC
CATGCTCGATATCGTGCTCT

Product: two-component system sensor histidine kinase CpxA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MNTARTFNGLSTQIFLWFWFMLLVVVAAVVILPTLDPRNIIPLPAHEMVRMNNNLKALQRGADPNQDFDLAKAIEAAGLL
PVDNIYLRDEKGQMQSSTRLSKFVVRFMVDSDNPAKPMLGSEHQRAIAGPFEMEHHGQTYHVYFGLNVENSYLFLFIQIL
DHPIQILGIAMLVSTPLCLLLAWRLTRPILQLQRSVSQLAEGNLEVQIPNLGRRDEIGQLADHVSHMVDTLKSMIQKQKQ
LLSDISHELRSPLTRIQLAQALIRRKQGDSNELARIESEIGRLDKLIGDLLDLSRVQQHVEAPVVMPLAELLEPMLDDAM
FEANQSGKQLRLPPLPTESIRMWPELLARALENPLRNALKYAHKFIKLDWYREGREWVITIRDDGPGVPVAQQEQLFLPF
FRVDDARNAKTGGTGLGLAIASEAIQRHGGTIRASCNQPTGLTITIRLPIG

Sequences:

>Translated_451_residues
MNTARTFNGLSTQIFLWFWFMLLVVVAAVVILPTLDPRNIIPLPAHEMVRMNNNLKALQRGADPNQDFDLAKAIEAAGLL
PVDNIYLRDEKGQMQSSTRLSKFVVRFMVDSDNPAKPMLGSEHQRAIAGPFEMEHHGQTYHVYFGLNVENSYLFLFIQIL
DHPIQILGIAMLVSTPLCLLLAWRLTRPILQLQRSVSQLAEGNLEVQIPNLGRRDEIGQLADHVSHMVDTLKSMIQKQKQ
LLSDISHELRSPLTRIQLAQALIRRKQGDSNELARIESEIGRLDKLIGDLLDLSRVQQHVEAPVVMPLAELLEPMLDDAM
FEANQSGKQLRLPPLPTESIRMWPELLARALENPLRNALKYAHKFIKLDWYREGREWVITIRDDGPGVPVAQQEQLFLPF
FRVDDARNAKTGGTGLGLAIASEAIQRHGGTIRASCNQPTGLTITIRLPIG
>Mature_451_residues
MNTARTFNGLSTQIFLWFWFMLLVVVAAVVILPTLDPRNIIPLPAHEMVRMNNNLKALQRGADPNQDFDLAKAIEAAGLL
PVDNIYLRDEKGQMQSSTRLSKFVVRFMVDSDNPAKPMLGSEHQRAIAGPFEMEHHGQTYHVYFGLNVENSYLFLFIQIL
DHPIQILGIAMLVSTPLCLLLAWRLTRPILQLQRSVSQLAEGNLEVQIPNLGRRDEIGQLADHVSHMVDTLKSMIQKQKQ
LLSDISHELRSPLTRIQLAQALIRRKQGDSNELARIESEIGRLDKLIGDLLDLSRVQQHVEAPVVMPLAELLEPMLDDAM
FEANQSGKQLRLPPLPTESIRMWPELLARALENPLRNALKYAHKFIKLDWYREGREWVITIRDDGPGVPVAQQEQLFLPF
FRVDDARNAKTGGTGLGLAIASEAIQRHGGTIRASCNQPTGLTITIRLPIG

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=458, Percent_Identity=37.3362445414847, Blast_Score=218, Evalue=9e-58,
Organism=Escherichia coli, GI1787894, Length=309, Percent_Identity=28.8025889967638, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789808, Length=266, Percent_Identity=29.6992481203008, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=29.7491039426523, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786783, Length=318, Percent_Identity=24.8427672955975, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787374, Length=273, Percent_Identity=27.1062271062271, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=30.2752293577982, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788549, Length=238, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=31.7391304347826, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87081816, Length=329, Percent_Identity=24.3161094224924, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=27.4305555555556, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=26.9709543568465, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789149, Length=329, Percent_Identity=25.2279635258359, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786600, Length=244, Percent_Identity=24.1803278688525, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082128, Length=291, Percent_Identity=25.7731958762887, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790861, Length=294, Percent_Identity=27.2108843537415, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=26.1603375527426, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789403, Length=239, Percent_Identity=26.7782426778243, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50812; Mature: 50812

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTARTFNGLSTQIFLWFWFMLLVVVAAVVILPTLDPRNIIPLPAHEMVRMNNNLKALQR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHHC
GADPNQDFDLAKAIEAAGLLPVDNIYLRDEKGQMQSSTRLSKFVVRFMVDSDNPAKPMLG
CCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
SEHQRAIAGPFEMEHHGQTYHVYFGLNVENSYLFLFIQILDHPIQILGIAMLVSTPLCLL
CCCCHHHCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LAWRLTRPILQLQRSVSQLAEGNLEVQIPNLGRRDEIGQLADHVSHMVDTLKSMIQKQKQ
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLSDISHELRSPLTRIQLAQALIRRKQGDSNELARIESEIGRLDKLIGDLLDLSRVQQHV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAPVVMPLAELLEPMLDDAMFEANQSGKQLRLPPLPTESIRMWPELLARALENPLRNALK
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YAHKFIKLDWYREGREWVITIRDDGPGVPVAQQEQLFLPFFRVDDARNAKTGGTGLGLAI
HHHHHHHHHEEECCCEEEEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHH
ASEAIQRHGGTIRASCNQPTGLTITIRLPIG
HHHHHHHCCCEEEECCCCCCCEEEEEEECCC
>Mature Secondary Structure
MNTARTFNGLSTQIFLWFWFMLLVVVAAVVILPTLDPRNIIPLPAHEMVRMNNNLKALQR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHHC
GADPNQDFDLAKAIEAAGLLPVDNIYLRDEKGQMQSSTRLSKFVVRFMVDSDNPAKPMLG
CCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
SEHQRAIAGPFEMEHHGQTYHVYFGLNVENSYLFLFIQILDHPIQILGIAMLVSTPLCLL
CCCCHHHCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
LAWRLTRPILQLQRSVSQLAEGNLEVQIPNLGRRDEIGQLADHVSHMVDTLKSMIQKQKQ
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLSDISHELRSPLTRIQLAQALIRRKQGDSNELARIESEIGRLDKLIGDLLDLSRVQQHV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAPVVMPLAELLEPMLDDAMFEANQSGKQLRLPPLPTESIRMWPELLARALENPLRNALK
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YAHKFIKLDWYREGREWVITIRDDGPGVPVAQQEQLFLPFFRVDDARNAKTGGTGLGLAI
HHHHHHHHHEEECCCEEEEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHHH
ASEAIQRHGGTIRASCNQPTGLTITIRLPIG
HHHHHHHCCCEEEECCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]