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The map label for this gene is cpxR [H]

Identifier: 145301037

GI number: 145301037

Start: 4496293

End: 4496988

Strand: Direct

Name: cpxR [H]

Synonym: ASA_4200

Alternate gene names: 145301037

Gene position: 4496293-4496988 (Clockwise)

Preceding gene: 145301032

Following gene: 145301038

Centisome position: 95.62

GC content: 62.5

Gene sequence:

>696_bases
ATGCACAAAATACTCCTGGTCGACGACGATCTCGAGCTGACTCAGCTGCTCACCGAAATTCTGACCCTGGAAGGCTTCCA
GGTGACTGTCGCCGAGGATGGCGAAGAGGGGTTGCTGCGGCTGGCCGAGCAGGACTTCAACCTGGTGCTGCTTGACGTGA
TGATGCCCAGGCTCAACGGCTTCGCCATGCTGGCAAAGCTGCGTGAGACCCACGACACCCCGGTGCTGATGCTGACTGCG
CGGGGCGACAGCCAGGACAGGGTCAACGGGCTGGAGGCGGGCGCCGATGATTACCTTGCCAAACCCTTTGATGACAGAGA
GTTGCTGGCCCGGATCCGCGCCATACTGCGCCGGACCCAGAGTGCGCAACCCCAGCGTGGCGGTACTTCCGAAGAGATCC
GCTTCATGGATCTGGTTCTGCAGCCGGGCTTGCAGCAAGCCAGCAGCGGCGAACAACTGCTGGAGCTCACCGCCACCGAG
TTCGGGCTGCTGGAGTGTCTGCTGCGCAATCCCGGCCAGATCGTCAGCAAGAGCCAGCTCTCGGAGCTGGTGCTCGGCAA
GAAACTGGAACCCTTCGATCGCGCCATCGACATGCACCTGAGCAACCTGCGCAAGAAGCTGCCGGAGCGCACCGATGGCC
AGCCCCGCTTCAAGACGGTGCGCGGACGCGGCTATCTGTGGCTGGAACAAGCATGA

Upstream 100 bases:

>100_bases
TGTTGATGGCTCAAAACCGGCTTTCCTCTTGCGGTTAAAAATCTATTATACCCTGACCCCTGCGTCACTTTGGCGCGAAA
AATCAGCGGAATGACCCTAG

Downstream 100 bases:

>100_bases
ACACGGCCCGCACCTTCAATGGCCTCTCCACCCAGATCTTCCTCTGGTTCTGGTTCATGCTGCTGGTCGTGGTCGCCGCT
GTCGTGATACTGCCGACCCT

Product: two-component system response regulator CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MHKILLVDDDLELTQLLTEILTLEGFQVTVAEDGEEGLLRLAEQDFNLVLLDVMMPRLNGFAMLAKLRETHDTPVLMLTA
RGDSQDRVNGLEAGADDYLAKPFDDRELLARIRAILRRTQSAQPQRGGTSEEIRFMDLVLQPGLQQASSGEQLLELTATE
FGLLECLLRNPGQIVSKSQLSELVLGKKLEPFDRAIDMHLSNLRKKLPERTDGQPRFKTVRGRGYLWLEQA

Sequences:

>Translated_231_residues
MHKILLVDDDLELTQLLTEILTLEGFQVTVAEDGEEGLLRLAEQDFNLVLLDVMMPRLNGFAMLAKLRETHDTPVLMLTA
RGDSQDRVNGLEAGADDYLAKPFDDRELLARIRAILRRTQSAQPQRGGTSEEIRFMDLVLQPGLQQASSGEQLLELTATE
FGLLECLLRNPGQIVSKSQLSELVLGKKLEPFDRAIDMHLSNLRKKLPERTDGQPRFKTVRGRGYLWLEQA
>Mature_231_residues
MHKILLVDDDLELTQLLTEILTLEGFQVTVAEDGEEGLLRLAEQDFNLVLLDVMMPRLNGFAMLAKLRETHDTPVLMLTA
RGDSQDRVNGLEAGADDYLAKPFDDRELLARIRAILRRTQSAQPQRGGTSEEIRFMDLVLQPGLQQASSGEQLLELTATE
FGLLECLLRNPGQIVSKSQLSELVLGKKLEPFDRAIDMHLSNLRKKLPERTDGQPRFKTVRGRGYLWLEQA

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=60.5263157894737, Blast_Score=247, Evalue=6e-67,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=38.7931034482759, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=39.2070484581498, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=36.4444444444444, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=38.1165919282511, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=35.8407079646018, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=34.5132743362832, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=33.0396475770925, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=36.1607142857143, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1790552, Length=228, Percent_Identity=39.0350877192982, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=33.1877729257642, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=33.4801762114537, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI1787229, Length=208, Percent_Identity=31.7307692307692, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=30.8016877637131, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=35.4545454545455, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=119, Percent_Identity=37.8151260504202, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1790299, Length=124, Percent_Identity=35.4838709677419, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788905, Length=124, Percent_Identity=36.2903225806452, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=101, Percent_Identity=35.6435643564356, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26050; Mature: 26050

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKILLVDDDLELTQLLTEILTLEGFQVTVAEDGEEGLLRLAEQDFNLVLLDVMMPRLNG
CCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEEHHHHHHHHCH
FAMLAKLRETHDTPVLMLTARGDSQDRVNGLEAGADDYLAKPFDDRELLARIRAILRRTQ
HHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHH
SAQPQRGGTSEEIRFMDLVLQPGLQQASSGEQLLELTATEFGLLECLLRNPGQIVSKSQL
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SELVLGKKLEPFDRAIDMHLSNLRKKLPERTDGQPRFKTVRGRGYLWLEQA
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEECC
>Mature Secondary Structure
MHKILLVDDDLELTQLLTEILTLEGFQVTVAEDGEEGLLRLAEQDFNLVLLDVMMPRLNG
CCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEEHHHHHHHHCH
FAMLAKLRETHDTPVLMLTARGDSQDRVNGLEAGADDYLAKPFDDRELLARIRAILRRTQ
HHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHH
SAQPQRGGTSEEIRFMDLVLQPGLQQASSGEQLLELTATEFGLLECLLRNPGQIVSKSQL
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SELVLGKKLEPFDRAIDMHLSNLRKKLPERTDGQPRFKTVRGRGYLWLEQA
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]