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The map label for this gene is menA [H]

Identifier: 145300607

GI number: 145300607

Start: 4031820

End: 4032725

Strand: Direct

Name: menA [H]

Synonym: ASA_3739

Alternate gene names: 145300607

Gene position: 4031820-4032725 (Clockwise)

Preceding gene: 145300598

Following gene: 145300608

Centisome position: 85.74

GC content: 62.8

Gene sequence:

>906_bases
ATGACAAATACCTTCTCTATCTGGTTGCTGGCGGCGCGTTTGCGAACCTTGCCGCTCGCGTGCTCCTCCATTTTGCTGGG
CTCGGGGCTGGCGGCCAGTCGTGGGGCCTTCGATGGCACCATAATGACACTCTCCCTGCTGACCGCCATACTGCTGCAGA
TCCTCTCCAATCTGGCCAACGATTACGGGGATGCGGTATCCGGTGCGGACAATGGCGAGCGGATTGGCCCCCAGCGTGCC
GTGGTCTCGGGTCTCATCACCCAAAAGCAGATGTGCGTGGCCATGGGGCTGACCGCCCTGGCTGCCGTGGTTAGCGGCCT
CTCTCTGCTGGGTTGCGCCTTTGGCGATCAGTGGCTGCAGATCCTCACTTTCGTGGTGCTGGGTGGCGCAGCCATAGTCG
CGGCCATCACCTACACGGTGGGCAAGACCCCTTACGGCTATCGCGGGTTCGGGGATATCTCGGTGTTCCTCTTCTTCGGT
CTGCTGGGGGTACTCGGCTCCTACTATCTGTTTACCAAGACACTGGCGTGGGATCTGCTGCTGCCGGCCACTGCCTGCGG
CCTGCTGGCGACCGCCGTGCTCAACATCAACAATGTGCGGGATATAGAGACGGATGCGGTCAGCGGCAAGATCACCCTGG
CGGTGCGGCTGGGTCGCAACCGTGCCATCGCCTACCACTGGCTGTTGCTGGGGGCGGCGCTGGTCAGCACCATCGCCTTC
CTGCTGACCCAGCCCGCCAGTTTCTGGCCCTGGATCTTCCTGCCTGCCATGAAGCCCCTCACCGATGCTGCGCGCACCCT
GCGTGAAAGCTACGATGGCGAGGTGCTGACCGGTGCCCTCAAGAAGACCGCCATCAGCGCCTTCCTGTTCAGCCTGCTGC
TCTCCATCGGGTTGGCGCTCTCCTGA

Upstream 100 bases:

>100_bases
AAATCGCCCGGGGAGCTTACCTCCCGAGGCGCCAAGTATACCGAAATCCAGTTCGATAACCCTTAACACGATCAATATCT
GATTGTTTGGCCATCACAAT

Downstream 100 bases:

>100_bases
TGGGATGCTTGCTTGTTTTTTTTATGTGAAAAGGGCTCCCGATGCGGGAGCCCTTTTTGTGTGCTGACGCGACTCGTTGG
CACGTCACCAGTCAGACAGG

Product: 1,4-dihydroxy-2-naphthoateoctaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTNTFSIWLLAARLRTLPLACSSILLGSGLAASRGAFDGTIMTLSLLTAILLQILSNLANDYGDAVSGADNGERIGPQRA
VVSGLITQKQMCVAMGLTALAAVVSGLSLLGCAFGDQWLQILTFVVLGGAAIVAAITYTVGKTPYGYRGFGDISVFLFFG
LLGVLGSYYLFTKTLAWDLLLPATACGLLATAVLNINNVRDIETDAVSGKITLAVRLGRNRAIAYHWLLLGAALVSTIAF
LLTQPASFWPWIFLPAMKPLTDAARTLRESYDGEVLTGALKKTAISAFLFSLLLSIGLALS

Sequences:

>Translated_301_residues
MTNTFSIWLLAARLRTLPLACSSILLGSGLAASRGAFDGTIMTLSLLTAILLQILSNLANDYGDAVSGADNGERIGPQRA
VVSGLITQKQMCVAMGLTALAAVVSGLSLLGCAFGDQWLQILTFVVLGGAAIVAAITYTVGKTPYGYRGFGDISVFLFFG
LLGVLGSYYLFTKTLAWDLLLPATACGLLATAVLNINNVRDIETDAVSGKITLAVRLGRNRAIAYHWLLLGAALVSTIAF
LLTQPASFWPWIFLPAMKPLTDAARTLRESYDGEVLTGALKKTAISAFLFSLLLSIGLALS
>Mature_300_residues
TNTFSIWLLAARLRTLPLACSSILLGSGLAASRGAFDGTIMTLSLLTAILLQILSNLANDYGDAVSGADNGERIGPQRAV
VSGLITQKQMCVAMGLTALAAVVSGLSLLGCAFGDQWLQILTFVVLGGAAIVAAITYTVGKTPYGYRGFGDISVFLFFGL
LGVLGSYYLFTKTLAWDLLLPATACGLLATAVLNINNVRDIETDAVSGKITLAVRLGRNRAIAYHWLLLGAALVSTIAFL
LTQPASFWPWIFLPAMKPLTDAARTLRESYDGEVLTGALKKTAISAFLFSLLLSIGLALS

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Escherichia coli, GI1790365, Length=294, Percent_Identity=50, Blast_Score=251, Evalue=3e-68,
Organism=Drosophila melanogaster, GI17737429, Length=289, Percent_Identity=26.643598615917, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 31759; Mature: 31628

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTFSIWLLAARLRTLPLACSSILLGSGLAASRGAFDGTIMTLSLLTAILLQILSNLAN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DYGDAVSGADNGERIGPQRAVVSGLITQKQMCVAMGLTALAAVVSGLSLLGCAFGDQWLQ
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILTFVVLGGAAIVAAITYTVGKTPYGYRGFGDISVFLFFGLLGVLGSYYLFTKTLAWDLL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPATACGLLATAVLNINNVRDIETDAVSGKITLAVRLGRNRAIAYHWLLLGAALVSTIAF
HHHHHHHHHHHHHHHCCCCCCCCHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
LLTQPASFWPWIFLPAMKPLTDAARTLRESYDGEVLTGALKKTAISAFLFSLLLSIGLAL
HHHCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
S
C
>Mature Secondary Structure 
TNTFSIWLLAARLRTLPLACSSILLGSGLAASRGAFDGTIMTLSLLTAILLQILSNLAN
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DYGDAVSGADNGERIGPQRAVVSGLITQKQMCVAMGLTALAAVVSGLSLLGCAFGDQWLQ
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILTFVVLGGAAIVAAITYTVGKTPYGYRGFGDISVFLFFGLLGVLGSYYLFTKTLAWDLL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPATACGLLATAVLNINNVRDIETDAVSGKITLAVRLGRNRAIAYHWLLLGAALVSTIAF
HHHHHHHHHHHHHHHCCCCCCCCHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
LLTQPASFWPWIFLPAMKPLTDAARTLRESYDGEVLTGALKKTAISAFLFSLLLSIGLAL
HHHCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]