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The map label for this gene is cpxA [H]

Identifier: 145300466

GI number: 145300466

Start: 3886069

End: 3887358

Strand: Direct

Name: cpxA [H]

Synonym: ASA_3593

Alternate gene names: 145300466

Gene position: 3886069-3887358 (Clockwise)

Preceding gene: 145300465

Following gene: 145300471

Centisome position: 82.64

GC content: 62.09

Gene sequence:

>1290_bases
ATGATCCTCAAGGGCCACCTGTTCTGGAAGATACTGTTCGGCTTCTGGTTCACCATCATAATGATGAGCCAGCTGCTATG
GGTCGCTTTCAGTCTCTACAGCCATGAAGGACCGCCAGAGGAGAGAATGGCGCGGCAGCTGGCCGGGCGGCAACTGAACT
CGGCGGCGACCCTGCTGCAAGAAAAGGGGCCCGCCACCCTGAACACCCTGACGACCAACTGGCCCGCCGAGGAACGCCCG
CTTCTGCATATCCAGCAGAGTGAAGCCGCCCAATCCCCTTTCCCTCATCTGCTTACCCGCACTGTCAAAGGAGCCGATGG
CCAGCGTTACTGGCTTGGTTACGACACGTCCGGCCTGCAGCAACAACTGGCACCGCCGCCGCGACGCAACGACTGGCTCA
ACATGCCGCCCCCCATGTGGTGGATAGGCGGCCTCGGCGGTCTCTTCTTCAGCGCCCTGCTCGCCTGGCATCTGACCCGT
CCTATGAACCAGTTTCGGCAGGGATTCGAGCGTCTCGCCCAGGGTGATCTGGGCGTGTGTCTCTATCCTCTGATGCGACG
ACGCCACGACGAGATCCGCGAGGCGGCCCGTGACTTCGATGCCATGGCCGAGCGGTTGCAACTGCTGGTCGAGAGCCGTG
AACAGCTGCTGCACGACGTCTCCCACGAGCTGCGCTCTCCCCTCGCACGCCTGCAACTGGCTATCGGTCTGGCCCAACAG
GATCCGGCCAGGATCGAGGGATCCCTGGCGCGGATCCAGCTCGAAACCCATCGCATGGACAAGATGATCGGCGAACTGCT
CACCCTCACCCGCGCCAGCCACGGCGAACGGGACTGTGAGGAGTATTACGATCTGCAAGCCCTGGTTGAGGCTGTGGTGA
GCGATGCCCGCTACGAGGCGCAGCATATGGGTGTCGAGATAAGACAACTGGTGGATGAGGCGGTGGACCACACCATCTGT
GGTCAGGCTGAGCTTATCCGCCGCGCGCTCGACAATGTGGTGCGCAATGCCCTACGCTTCTCTCACCCTGGCCAATCCAT
CACCCTGACCCTGCACAGGCAAGGGGGAGAGTTCGCCATCGAGGTGGTGGATCAAGGCATGGGGGTGGACGAAACCAAGC
TCTCCAGCATGTTCGATCCCTTCGTGCGGATCGGGTCCCCTTCTGCAGGCAAGGGCTATGGGCTGGGACTCGCCATCACT
CGTAAAGCCATTCAGGCCCAGGGCGGCCGGGTCGAGGCCAGAAATGGCGATAACGGCGGTTTGATAGTCACCCTCTCCCT
GCCGGGCTAG

Upstream 100 bases:

>100_bases
GCGTCGACGTGCACATCTGCAATATCCACCAGAAGCTGCAGGCGCTGGCGGGTGAGGTCATCGGCATAGAGACGGTGCGC
AGCATAGGATACCGGCTGAC

Downstream 100 bases:

>100_bases
CCCTTTATTCCAGCTCAGCCATCTGGTCGCGTCGTTCGAGAGCGCTGAGGCGGGCACTCATCCCCGCAACCTTTGCAGCT
GGCCGATGGCTGCGCCCGTG

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MILKGHLFWKILFGFWFTIIMMSQLLWVAFSLYSHEGPPEERMARQLAGRQLNSAATLLQEKGPATLNTLTTNWPAEERP
LLHIQQSEAAQSPFPHLLTRTVKGADGQRYWLGYDTSGLQQQLAPPPRRNDWLNMPPPMWWIGGLGGLFFSALLAWHLTR
PMNQFRQGFERLAQGDLGVCLYPLMRRRHDEIREAARDFDAMAERLQLLVESREQLLHDVSHELRSPLARLQLAIGLAQQ
DPARIEGSLARIQLETHRMDKMIGELLTLTRASHGERDCEEYYDLQALVEAVVSDARYEAQHMGVEIRQLVDEAVDHTIC
GQAELIRRALDNVVRNALRFSHPGQSITLTLHRQGGEFAIEVVDQGMGVDETKLSSMFDPFVRIGSPSAGKGYGLGLAIT
RKAIQAQGGRVEARNGDNGGLIVTLSLPG

Sequences:

>Translated_429_residues
MILKGHLFWKILFGFWFTIIMMSQLLWVAFSLYSHEGPPEERMARQLAGRQLNSAATLLQEKGPATLNTLTTNWPAEERP
LLHIQQSEAAQSPFPHLLTRTVKGADGQRYWLGYDTSGLQQQLAPPPRRNDWLNMPPPMWWIGGLGGLFFSALLAWHLTR
PMNQFRQGFERLAQGDLGVCLYPLMRRRHDEIREAARDFDAMAERLQLLVESREQLLHDVSHELRSPLARLQLAIGLAQQ
DPARIEGSLARIQLETHRMDKMIGELLTLTRASHGERDCEEYYDLQALVEAVVSDARYEAQHMGVEIRQLVDEAVDHTIC
GQAELIRRALDNVVRNALRFSHPGQSITLTLHRQGGEFAIEVVDQGMGVDETKLSSMFDPFVRIGSPSAGKGYGLGLAIT
RKAIQAQGGRVEARNGDNGGLIVTLSLPG
>Mature_429_residues
MILKGHLFWKILFGFWFTIIMMSQLLWVAFSLYSHEGPPEERMARQLAGRQLNSAATLLQEKGPATLNTLTTNWPAEERP
LLHIQQSEAAQSPFPHLLTRTVKGADGQRYWLGYDTSGLQQQLAPPPRRNDWLNMPPPMWWIGGLGGLFFSALLAWHLTR
PMNQFRQGFERLAQGDLGVCLYPLMRRRHDEIREAARDFDAMAERLQLLVESREQLLHDVSHELRSPLARLQLAIGLAQQ
DPARIEGSLARIQLETHRMDKMIGELLTLTRASHGERDCEEYYDLQALVEAVVSDARYEAQHMGVEIRQLVDEAVDHTIC
GQAELIRRALDNVVRNALRFSHPGQSITLTLHRQGGEFAIEVVDQGMGVDETKLSSMFDPFVRIGSPSAGKGYGLGLAIT
RKAIQAQGGRVEARNGDNGGLIVTLSLPG

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=32.1033210332103, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=27.8985507246377, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787894, Length=234, Percent_Identity=30.3418803418803, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1786783, Length=290, Percent_Identity=28.2758620689655, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1789808, Length=310, Percent_Identity=27.4193548387097, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786600, Length=255, Percent_Identity=26.2745098039216, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=274, Percent_Identity=29.5620437956204, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=330, Percent_Identity=25.1515151515152, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790861, Length=250, Percent_Identity=26.4, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789403, Length=243, Percent_Identity=27.5720164609054, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082128, Length=254, Percent_Identity=26.7716535433071, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=28.936170212766, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=25.9433962264151, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=223, Percent_Identity=28.6995515695067, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789149, Length=239, Percent_Identity=24.6861924686192, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=23.0125523012552, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=251, Percent_Identity=20.7171314741036, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48193; Mature: 48193

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKGHLFWKILFGFWFTIIMMSQLLWVAFSLYSHEGPPEERMARQLAGRQLNSAATLLQ
CEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHH
EKGPATLNTLTTNWPAEERPLLHIQQSEAAQSPFPHLLTRTVKGADGQRYWLGYDTSGLQ
HCCCCEEHEEECCCCCCCCCEEEEEHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCHHHH
QQLAPPPRRNDWLNMPPPMWWIGGLGGLFFSALLAWHLTRPMNQFRQGFERLAQGDLGVC
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LYPLMRRRHDEIREAARDFDAMAERLQLLVESREQLLHDVSHELRSPLARLQLAIGLAQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DPARIEGSLARIQLETHRMDKMIGELLTLTRASHGERDCEEYYDLQALVEAVVSDARYEA
CCHHHCCCHHHEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QHMGVEIRQLVDEAVDHTICGQAELIRRALDNVVRNALRFSHPGQSITLTLHRQGGEFAI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEE
EVVDQGMGVDETKLSSMFDPFVRIGSPSAGKGYGLGLAITRKAIQAQGGRVEARNGDNGG
HHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCC
LIVTLSLPG
EEEEEECCC
>Mature Secondary Structure
MILKGHLFWKILFGFWFTIIMMSQLLWVAFSLYSHEGPPEERMARQLAGRQLNSAATLLQ
CEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHH
EKGPATLNTLTTNWPAEERPLLHIQQSEAAQSPFPHLLTRTVKGADGQRYWLGYDTSGLQ
HCCCCEEHEEECCCCCCCCCEEEEEHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCHHHH
QQLAPPPRRNDWLNMPPPMWWIGGLGGLFFSALLAWHLTRPMNQFRQGFERLAQGDLGVC
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LYPLMRRRHDEIREAARDFDAMAERLQLLVESREQLLHDVSHELRSPLARLQLAIGLAQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DPARIEGSLARIQLETHRMDKMIGELLTLTRASHGERDCEEYYDLQALVEAVVSDARYEA
CCHHHCCCHHHEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QHMGVEIRQLVDEAVDHTICGQAELIRRALDNVVRNALRFSHPGQSITLTLHRQGGEFAI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEE
EVVDQGMGVDETKLSSMFDPFVRIGSPSAGKGYGLGLAITRKAIQAQGGRVEARNGDNGG
HHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCC
LIVTLSLPG
EEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]