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The map label for this gene is gcvR [H]

Identifier: 145300279

GI number: 145300279

Start: 3677373

End: 3677924

Strand: Direct

Name: gcvR [H]

Synonym: ASA_3397

Alternate gene names: 145300279

Gene position: 3677373-3677924 (Clockwise)

Preceding gene: 145300275

Following gene: 145300280

Centisome position: 78.2

GC content: 56.16

Gene sequence:

>552_bases
ATGGACGAGAGAAGATTTATGACTCACTACCTGGTCGTAACGGCCATAGGCACGGACAGGCCTGGCATCGTCAATGAAGT
TACTCGCCACGTCAGTGGGTGTGGCTGCAACATTGTCGATAGCCGTCTTGGTATCTTCGGTAATGAATTCACCTTCATCA
TGCTGCTGTCCGGTGACTGGAACAGCCTGATGCAACTCGAGATAAGCCTGCCCCTGCGCAGCCAGGAGTGGGAGCTCATC
ACCATGATGAAGCGCACCGAGCGTCACCATTCGCTGCAATACGACATCAGCGCCAACGCCGAGATCCTGATCCGGGATCA
GCCTGGCATCGTAAGTCAGTGCACCCAGTTCTTCAGCGACCACGGCTGGGACATCCAGGCCATGCAGACCATGACGCTGG
AGCAACAGCCCTACAACCTGCTCAAGGCAAGCTTCCAGCTCAATCTGGCCAAGCAGGGAGAAGCCGCCGGTTCGGATACG
GCCTTCGCCGGATTCTGTCGTGAACTCGGCGCCGAATCGTTCGAATTCATCGTCAACAACAAACACGCCTGA

Upstream 100 bases:

>100_bases
AGGCAGGGCTCGCCGCAACAACATTCTCAACAAGGTTGTCATGTCAGAGTGCAGAGAGTGGCCAGAGCGCTCCCACTGTA
CTCACATTCACAACCAGCTA

Downstream 100 bases:

>100_bases
CGACCAACACCAAGGAGAATCCATGCAACCTTTATCCGCTGGCACCCTGGCCCCCGACTTTTCCCTGTCAGATCAGGATG
GCAATCCGGTTCGTCTATCC

Product: glycine cleavage system transcriptional repressor

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MDERRFMTHYLVVTAIGTDRPGIVNEVTRHVSGCGCNIVDSRLGIFGNEFTFIMLLSGDWNSLMQLEISLPLRSQEWELI
TMMKRTERHHSLQYDISANAEILIRDQPGIVSQCTQFFSDHGWDIQAMQTMTLEQQPYNLLKASFQLNLAKQGEAAGSDT
AFAGFCRELGAESFEFIVNNKHA

Sequences:

>Translated_183_residues
MDERRFMTHYLVVTAIGTDRPGIVNEVTRHVSGCGCNIVDSRLGIFGNEFTFIMLLSGDWNSLMQLEISLPLRSQEWELI
TMMKRTERHHSLQYDISANAEILIRDQPGIVSQCTQFFSDHGWDIQAMQTMTLEQQPYNLLKASFQLNLAKQGEAAGSDT
AFAGFCRELGAESFEFIVNNKHA
>Mature_183_residues
MDERRFMTHYLVVTAIGTDRPGIVNEVTRHVSGCGCNIVDSRLGIFGNEFTFIMLLSGDWNSLMQLEISLPLRSQEWELI
TMMKRTERHHSLQYDISANAEILIRDQPGIVSQCTQFFSDHGWDIQAMQTMTLEQQPYNLLKASFQLNLAKQGEAAGSDT
AFAGFCRELGAESFEFIVNNKHA

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=173, Percent_Identity=41.0404624277457, Blast_Score=140, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 20739; Mature: 20739

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDERRFMTHYLVVTAIGTDRPGIVNEVTRHVSGCGCNIVDSRLGIFGNEFTFIMLLSGDW
CCCHHHHEEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEHHHHCCCCCCEEEEEEEECCC
NSLMQLEISLPLRSQEWELITMMKRTERHHSLQYDISANAEILIRDQPGIVSQCTQFFSD
CCEEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCHHHHHHHHHHC
HGWDIQAMQTMTLEQQPYNLLKASFQLNLAKQGEAAGSDTAFAGFCRELGAESFEFIVNN
CCCCEEEHEEEECCCCCHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECC
KHA
CCC
>Mature Secondary Structure
MDERRFMTHYLVVTAIGTDRPGIVNEVTRHVSGCGCNIVDSRLGIFGNEFTFIMLLSGDW
CCCHHHHEEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEHHHHCCCCCCEEEEEEEECCC
NSLMQLEISLPLRSQEWELITMMKRTERHHSLQYDISANAEILIRDQPGIVSQCTQFFSD
CCEEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCHHHHHHHHHHC
HGWDIQAMQTMTLEQQPYNLLKASFQLNLAKQGEAAGSDTAFAGFCRELGAESFEFIVNN
CCCCEEEHEEEECCCCCHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECC
KHA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]