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The map label for this gene is metR [H]

Identifier: 145299295

GI number: 145299295

Start: 2483551

End: 2484471

Strand: Direct

Name: metR [H]

Synonym: ASA_2339

Alternate gene names: 145299295

Gene position: 2483551-2484471 (Clockwise)

Preceding gene: 145299292

Following gene: 145299299

Centisome position: 52.81

GC content: 65.69

Gene sequence:

>921_bases
ATGGCAGTGCCAAGCAATTCAGGCCTGGAAATCAAACACTTGAGAACCCTGGCCGCATTGGCCGAGCAAGGGTCGCTGGC
CGGCGCGGCGCAGAGCCTGAATCTGACCCAGTCGGCACTCTCCCATCAGCTCAAAGAGCTGGAGACCCGTCTTGGCCTGG
AGCTTTTTCTTCGCAAGAGCCGCCCTCTGGTGCTGACGGCGGCGGGCCAGCAGTTGCTGGCTCTGGCCCGCCAGGTGCTG
CCCGCCCTGGCACAGACCGAGAAACAGCTGCAGGCCCTGCACAGCGGTGACGCGGGCCGGTTGCACCTGGCGCTGGACTG
TCACAGCTGCATTCAGTGGCTGCTGCCGCTCTTGCCCGATTTTCGTCGCCAGTGGCCCGGGGTGGATCTGGAGGTGGAAT
CGGTGCCCGGCTTTGATGCAATCAATGCCCTGCTCGGCGGTCAGCTCGACTTGCTGCTCACCTCGGATGTACAGGCCCGC
GGGGATCTCCACTTCGAGCCGCTGTTCGCCTTCGATCTCACCCTGGTGATGGCGCCGGATCACCCTCTATGCCACCAGGG
CCGGATCACCCCGGAGGATCTCAAGCAGGAGGTGCTGCTGGTCTACCCGGTGGAGCGGGCCCGCATGGACGTGTTCAGCC
GCTTCCTGCAACCGGCCGGGGTCGAGCCCGCCCGCTGCAAGCTGGTGGACAATACCTCCGTCATGCTGCAGATGGCCGCC
GCCGGGCTCGGGGTCGCCGCCCTGCCACGCTGGGCCAGCGAGGAGTTCGTGCGCCAGGGACTGCTTGAGGCCAGGCCACT
CGGCAATGGTGTGCGCCGCCACATGTATGGGGCCGTGCGCGCCGCCGACAAGGATCAGCCCTGTTTGCAGAGCCTGTTCG
AGCGCATTCGCAGCAAGATGGGTGAGCAGAAGGAGGCGTAA

Upstream 100 bases:

>100_bases
ATCCGCAACTAGCGTGCAAGAGCCTCTTCAACGGACATGTAAGAGAGCGTTCAACGGATATGCAAGAAAGCCTTCAACTG
ATGCAACAAGGAGCCACGTC

Downstream 100 bases:

>100_bases
AAAAGCCGCCCCTGAGGCGGCTTGCGATGAGTCGGGGAGCCAGCACCCTCAGGGTTCGTCCTGGCAGTGGGTGGCGCCAT
GTCGCCTCGGGCAGTTGGCG

Product: HTH-type transcriptional regulator MetR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MAVPSNSGLEIKHLRTLAALAEQGSLAGAAQSLNLTQSALSHQLKELETRLGLELFLRKSRPLVLTAAGQQLLALARQVL
PALAQTEKQLQALHSGDAGRLHLALDCHSCIQWLLPLLPDFRRQWPGVDLEVESVPGFDAINALLGGQLDLLLTSDVQAR
GDLHFEPLFAFDLTLVMAPDHPLCHQGRITPEDLKQEVLLVYPVERARMDVFSRFLQPAGVEPARCKLVDNTSVMLQMAA
AGLGVAALPRWASEEFVRQGLLEARPLGNGVRRHMYGAVRAADKDQPCLQSLFERIRSKMGEQKEA

Sequences:

>Translated_306_residues
MAVPSNSGLEIKHLRTLAALAEQGSLAGAAQSLNLTQSALSHQLKELETRLGLELFLRKSRPLVLTAAGQQLLALARQVL
PALAQTEKQLQALHSGDAGRLHLALDCHSCIQWLLPLLPDFRRQWPGVDLEVESVPGFDAINALLGGQLDLLLTSDVQAR
GDLHFEPLFAFDLTLVMAPDHPLCHQGRITPEDLKQEVLLVYPVERARMDVFSRFLQPAGVEPARCKLVDNTSVMLQMAA
AGLGVAALPRWASEEFVRQGLLEARPLGNGVRRHMYGAVRAADKDQPCLQSLFERIRSKMGEQKEA
>Mature_305_residues
AVPSNSGLEIKHLRTLAALAEQGSLAGAAQSLNLTQSALSHQLKELETRLGLELFLRKSRPLVLTAAGQQLLALARQVLP
ALAQTEKQLQALHSGDAGRLHLALDCHSCIQWLLPLLPDFRRQWPGVDLEVESVPGFDAINALLGGQLDLLLTSDVQARG
DLHFEPLFAFDLTLVMAPDHPLCHQGRITPEDLKQEVLLVYPVERARMDVFSRFLQPAGVEPARCKLVDNTSVMLQMAAA
GLGVAALPRWASEEFVRQGLLEARPLGNGVRRHMYGAVRAADKDQPCLQSLFERIRSKMGEQKEA

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=290, Percent_Identity=50.6896551724138, Blast_Score=293, Evalue=7e-81,
Organism=Escherichia coli, GI1787879, Length=296, Percent_Identity=28.3783783783784, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789173, Length=236, Percent_Identity=31.7796610169492, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI2367136, Length=249, Percent_Identity=28.1124497991968, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI157672245, Length=227, Percent_Identity=26.8722466960352, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI145693105, Length=280, Percent_Identity=25.7142857142857, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787530, Length=255, Percent_Identity=26.2745098039216, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786401, Length=252, Percent_Identity=25, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788887, Length=265, Percent_Identity=25.2830188679245, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87081904, Length=296, Percent_Identity=27.3648648648649, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787601, Length=177, Percent_Identity=29.3785310734463, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082024, Length=324, Percent_Identity=27.1604938271605, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1790399, Length=294, Percent_Identity=26.8707482993197, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786508, Length=275, Percent_Identity=24.7272727272727, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786713, Length=175, Percent_Identity=30.2857142857143, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788748, Length=239, Percent_Identity=23.4309623430962, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790208, Length=247, Percent_Identity=26.7206477732794, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787949, Length=172, Percent_Identity=30.8139534883721, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787806, Length=268, Percent_Identity=23.5074626865672, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789506, Length=189, Percent_Identity=26.4550264550265, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788706, Length=179, Percent_Identity=28.4916201117318, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787589, Length=149, Percent_Identity=31.5436241610738, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788296, Length=246, Percent_Identity=26.0162601626016, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI145693193, Length=270, Percent_Identity=25.1851851851852, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33586; Mature: 33455

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVPSNSGLEIKHLRTLAALAEQGSLAGAAQSLNLTQSALSHQLKELETRLGLELFLRKS
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPLVLTAAGQQLLALARQVLPALAQTEKQLQALHSGDAGRLHLALDCHSCIQWLLPLLPD
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHH
FRRQWPGVDLEVESVPGFDAINALLGGQLDLLLTSDVQARGDLHFEPLFAFDLTLVMAPD
HHHHCCCCCEEECCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHEEEEEEECCC
HPLCHQGRITPEDLKQEVLLVYPVERARMDVFSRFLQPAGVEPARCKLVDNTSVMLQMAA
CCCCCCCCCCHHHHHCCEEEEECHHHHHHHHHHHHHCCCCCCCHHEEEECCHHHHHHHHH
AGLGVAALPRWASEEFVRQGLLEARPLGNGVRRHMYGAVRAADKDQPCLQSLFERIRSKM
HCCCHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GEQKEA
CCCCCC
>Mature Secondary Structure 
AVPSNSGLEIKHLRTLAALAEQGSLAGAAQSLNLTQSALSHQLKELETRLGLELFLRKS
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RPLVLTAAGQQLLALARQVLPALAQTEKQLQALHSGDAGRLHLALDCHSCIQWLLPLLPD
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHH
FRRQWPGVDLEVESVPGFDAINALLGGQLDLLLTSDVQARGDLHFEPLFAFDLTLVMAPD
HHHHCCCCCEEECCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHEEEEEEECCC
HPLCHQGRITPEDLKQEVLLVYPVERARMDVFSRFLQPAGVEPARCKLVDNTSVMLQMAA
CCCCCCCCCCHHHHHCCEEEEECHHHHHHHHHHHHHCCCCCCCHHEEEECCHHHHHHHHH
AGLGVAALPRWASEEFVRQGLLEARPLGNGVRRHMYGAVRAADKDQPCLQSLFERIRSKM
HCCCHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GEQKEA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]