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The map label for this gene is trxC [H]

Identifier: 145299244

GI number: 145299244

Start: 2415424

End: 2415852

Strand: Direct

Name: trxC [H]

Synonym: ASA_2287

Alternate gene names: 145299244

Gene position: 2415424-2415852 (Clockwise)

Preceding gene: 145299240

Following gene: 145299245

Centisome position: 51.37

GC content: 51.05

Gene sequence:

>429_bases
ATGTCATTTATCACTACCTATTGTAGTCATTGCTTCACCAGAAACCGCCTGCCCGCCGAAAAAATGGATTCAAACGCGAA
ATGTGGTCGTTGCAAGTCCTCGCTTTTTGGTATCACACCTGTCATCGGCCGTGAGGATCAATTCGATATTCTTATCCAAT
CCGATCTTCCGGTCGTGGTGGACTTCTGGGCCAGCTGGTGCGGACCATGCCTACAATTTTCACCAATTTTTCAACAGGTT
GCCAGCGAACTTAAGCCCCACTTCCGCTTTGTCAAAGTCGACACGGAACAACAAGCTGCCATCGCAGCCCGTTACGCCAT
CCGCAGCATTCCCACCCTGATGATATTCAAACAGGGCAAGATGGTGGCACAACGCAGCGGCTCTCTGCCCAAAAGCCTGT
TCAAGGAGTGGGTTGCCTCTGTGGCATAG

Upstream 100 bases:

>100_bases
GACCACTGGCTGTGAAAAATAACTGACTGCTATGTTACCGTTACTCTGCCCTGTCAGTGCAATAAAGATGTTGCAGGGCT
TATGCTTACAGGAATCAATT

Downstream 100 bases:

>100_bases
CTTCAATTGATAAATAATTATTTAATTTTTGTTTTTCAAGTGTTTCGCGCTGCTTTGAGTCTGTGAGTCCCGGCATGATT
TGACGACTTCCCCCTGTTTC

Product: thioredoxin 2

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MSFITTYCSHCFTRNRLPAEKMDSNAKCGRCKSSLFGITPVIGREDQFDILIQSDLPVVVDFWASWCGPCLQFSPIFQQV
ASELKPHFRFVKVDTEQQAAIAARYAIRSIPTLMIFKQGKMVAQRSGSLPKSLFKEWVASVA

Sequences:

>Translated_142_residues
MSFITTYCSHCFTRNRLPAEKMDSNAKCGRCKSSLFGITPVIGREDQFDILIQSDLPVVVDFWASWCGPCLQFSPIFQQV
ASELKPHFRFVKVDTEQQAAIAARYAIRSIPTLMIFKQGKMVAQRSGSLPKSLFKEWVASVA
>Mature_141_residues
SFITTYCSHCFTRNRLPAEKMDSNAKCGRCKSSLFGITPVIGREDQFDILIQSDLPVVVDFWASWCGPCLQFSPIFQQVA
SELKPHFRFVKVDTEQQAAIAARYAIRSIPTLMIFKQGKMVAQRSGSLPKSLFKEWVASVA

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=135, Percent_Identity=46.6666666666667, Blast_Score=148, Evalue=2e-37,
Organism=Escherichia coli, GI87082331, Length=95, Percent_Identity=38.9473684210526, Blast_Score=91, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI212646193, Length=109, Percent_Identity=31.1926605504587, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=91, Percent_Identity=35.1648351648352, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532380, Length=91, Percent_Identity=35.1648351648352, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=78, Percent_Identity=35.8974358974359, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=96, Percent_Identity=38.5416666666667, Blast_Score=75, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=90, Percent_Identity=36.6666666666667, Blast_Score=64, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319925, Length=106, Percent_Identity=32.0754716981132, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573567, Length=123, Percent_Identity=32.520325203252, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 16000; Mature: 15869

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFITTYCSHCFTRNRLPAEKMDSNAKCGRCKSSLFGITPVIGREDQFDILIQSDLPVVV
CCHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHH
DFWASWCGPCLQFSPIFQQVASELKPHFRFVKVDTEQQAAIAARYAIRSIPTLMIFKQGK
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCHHEEECCCC
MVAQRSGSLPKSLFKEWVASVA
HHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SFITTYCSHCFTRNRLPAEKMDSNAKCGRCKSSLFGITPVIGREDQFDILIQSDLPVVV
CHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHH
DFWASWCGPCLQFSPIFQQVASELKPHFRFVKVDTEQQAAIAARYAIRSIPTLMIFKQGK
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCHHEEECCCC
MVAQRSGSLPKSLFKEWVASVA
HHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]