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The map label for this gene is mutM [C]

Identifier: 145296990

GI number: 145296990

Start: 3205159

End: 3205968

Strand: Direct

Name: mutM [C]

Synonym: cgR_2889

Alternate gene names: 145296990

Gene position: 3205159-3205968 (Clockwise)

Preceding gene: 145296986

Following gene: 145296991

Centisome position: 96.71

GC content: 54.94

Gene sequence:

>810_bases
ATGCCTGAAGGACACGTGATTCATCGACTAGCTGGGGAGCTCACCAAGCATTTTGGCGAAACCGTTTTGGACGCCACTTC
ACCTCAAGGGCGCTTTGCTTCTGAAGCGGCGATCATCAACGGTCACCGCATCGCGGTTGCGGAGGCCTACGGCAAGCACC
TGTTCGTCGAGTTCGATGCAGATCACCCTGAGCACATCTTGTATATCCATTTGGGCCTGATTGGCACGTTACAGTTTGAG
CCTGCAGAAGAAACCCGTGGGCAGATTCGCCTGCACCTTTCCGATGGGGAGATCGCCGCTAATTTGCGCGGACCCCAATG
GTGCAGGTTGATCACCGATGCAGAGCGCACCCAGGCCATTGGAAAATTGGGCGCTGATCCGATTCGCGATGATGCCGATC
CGGAACCAATTCGGATTAAGGTGCAGCGCTCAGGGCGAAGCATTGGTTCGTTGTTGATGGATCAGAAGCTTTTCGCAGGT
GTGGGAAATATTTACCGTGCGGAGACACTTTTCCGCCTGGGGATTTCACCGTTCACCATTGGAAAAGACATCACCACGGC
ACAGTTCCGATCCATTTGGGCGGATCTTGTTGGGTTGATGAAAGACGGTGTTGTGGCTGGTCGGATTGATACTGTGCGCC
CGGAACACACACCGGAGGCGATGGGTAGGCCACCGCGGAAAGATGATCACGGCGGTGAGGTTTACACCTATCGGCGAACC
GGTCAAGAGTGCTTTCTGTGCGAAACTCCCATCAAGGAGCAGGTTATGGAGGGTCGCAACTTATTTTGGTGTCCCGGCTG
CCAACGCTAG

Upstream 100 bases:

>100_bases
CTTATTTATTTTAGGTTGCCCTATCCTAAAAGTACCGATTCCCGCAGGCCACGCTTAGTTTTTTATCAAATCGGCGCACC
GGCTACTAGGGTTGGTGATT

Downstream 100 bases:

>100_bases
ACAGATTCACTTTTTACTGTCATCATTGGCTCTACACGTTTAAATGAGGAAGTTAAGGAGTCGGCCGTGCGCTTTTATCA
GCAACTACACCTGCTGCAAA

Product: hypothetical protein

Products: NA

Alternate protein names: Putative DNA-(apurinic or apyrimidinic site) lyase Rv2464c/MT2539; Putative AP lyase Rv2464c/MT2539 [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MPEGHVIHRLAGELTKHFGETVLDATSPQGRFASEAAIINGHRIAVAEAYGKHLFVEFDADHPEHILYIHLGLIGTLQFE
PAEETRGQIRLHLSDGEIAANLRGPQWCRLITDAERTQAIGKLGADPIRDDADPEPIRIKVQRSGRSIGSLLMDQKLFAG
VGNIYRAETLFRLGISPFTIGKDITTAQFRSIWADLVGLMKDGVVAGRIDTVRPEHTPEAMGRPPRKDDHGGEVYTYRRT
GQECFLCETPIKEQVMEGRNLFWCPGCQR

Sequences:

>Translated_269_residues
MPEGHVIHRLAGELTKHFGETVLDATSPQGRFASEAAIINGHRIAVAEAYGKHLFVEFDADHPEHILYIHLGLIGTLQFE
PAEETRGQIRLHLSDGEIAANLRGPQWCRLITDAERTQAIGKLGADPIRDDADPEPIRIKVQRSGRSIGSLLMDQKLFAG
VGNIYRAETLFRLGISPFTIGKDITTAQFRSIWADLVGLMKDGVVAGRIDTVRPEHTPEAMGRPPRKDDHGGEVYTYRRT
GQECFLCETPIKEQVMEGRNLFWCPGCQR
>Mature_268_residues
PEGHVIHRLAGELTKHFGETVLDATSPQGRFASEAAIINGHRIAVAEAYGKHLFVEFDADHPEHILYIHLGLIGTLQFEP
AEETRGQIRLHLSDGEIAANLRGPQWCRLITDAERTQAIGKLGADPIRDDADPEPIRIKVQRSGRSIGSLLMDQKLFAGV
GNIYRAETLFRLGISPFTIGKDITTAQFRSIWADLVGLMKDGVVAGRIDTVRPEHTPEAMGRPPRKDDHGGEVYTYRRTG
QECFLCETPIKEQVMEGRNLFWCPGCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA b

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=265, Percent_Identity=27.9245283018868, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1786932, Length=283, Percent_Identity=24.0282685512367, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR012319
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 29958; Mature: 29826

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEGHVIHRLAGELTKHFGETVLDATSPQGRFASEAAIINGHRIAVAEAYGKHLFVEFDA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEEEECCCCEEEEEECC
DHPEHILYIHLGLIGTLQFEPAEETRGQIRLHLSDGEIAANLRGPQWCRLITDAERTQAI
CCCCEEEEEEEEEEEEEEECCCCCCCCEEEEEEECCCEEECCCCCHHEEEHHCHHHHHHH
GKLGADPIRDDADPEPIRIKVQRSGRSIGSLLMDQKLFAGVGNIYRAETLFRLGISPFTI
HHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEC
GKDITTAQFRSIWADLVGLMKDGVVAGRIDTVRPEHTPEAMGRPPRKDDHGGEVYTYRRT
CCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHCCCCCCCCCCCCEEEEEEEC
GQECFLCETPIKEQVMEGRNLFWCPGCQR
CCEEEEECCCHHHHHHCCCCEEECCCCCC
>Mature Secondary Structure 
PEGHVIHRLAGELTKHFGETVLDATSPQGRFASEAAIINGHRIAVAEAYGKHLFVEFDA
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEEEECCCCEEEEEECC
DHPEHILYIHLGLIGTLQFEPAEETRGQIRLHLSDGEIAANLRGPQWCRLITDAERTQAI
CCCCEEEEEEEEEEEEEEECCCCCCCCEEEEEEECCCEEECCCCCHHEEEHHCHHHHHHH
GKLGADPIRDDADPEPIRIKVQRSGRSIGSLLMDQKLFAGVGNIYRAETLFRLGISPFTI
HHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEC
GKDITTAQFRSIWADLVGLMKDGVVAGRIDTVRPEHTPEAMGRPPRKDDHGGEVYTYRRT
CCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHCCCCCCCCCCCCEEEEEEEC
GQECFLCETPIKEQVMEGRNLFWCPGCQR
CCEEEEECCCHHHHHHCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]