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The map label for this gene is pccB [H]

Identifier: 145296859

GI number: 145296859

Start: 3055176

End: 3056726

Strand: Reverse

Name: pccB [H]

Synonym: cgR_2759

Alternate gene names: 145296859

Gene position: 3056726-3055176 (Counterclockwise)

Preceding gene: 145296860

Following gene: 145296858

Centisome position: 92.23

GC content: 57.0

Gene sequence:

>1551_bases
TTGAGTAACACCACTACTGCAGAGAAGCTAGCGGATCTGCGCGCACGCCTGGAGATTGCCAAAGACCCAGGTAGTGAACG
CGCACGTAAAAAGCGCGACGAGGAAGGCCGAACCACCCCTCGTCAGCGTATTGATGCTCTGCTTGATGCCGGATCCTTTG
TGGAGATCGGCGCGTTAGGCCGTACCCCGGATGAACCCGATGCGCCTTACTCTGACGGTGTGGTGACTGGTTATGGTCGC
ATTGATGGCCGCCCGGTGGCCATCTACGCCCATGACAAGACCGTTTACGGTGGTTCGGTCGGTATGACTTTCGGACGTAA
AGTCAGCGAAGTCATGGACATGGCCATTCGCATTGGTTGCCCAGTTATCGGTATTCAGGATTCCGGCGGAGCCCGCATTC
AGGATGCGGTGACCTCCTTGGCGATGTACTCAGAGATCGCGCGTCGTCAGCTTCCGCTGTCTGGCCGCAGCCCTCAGATT
TCCATCATGCTGGGTAAATCGGCAGGTGGCGCAGTGTATGCACCTGTGACCACTGACTTTGTTATCGGCGTTGATGGTGA
AACAGAAATGTATGTCACCGGCCCAGCCGTGATCAAGGAAGTCACCGGCGAGCAGATCACCTCCGCAGACCTCGGTGGCG
GTGCGCAGCAGATGCAAAACGGCAACATTTCCTATTTGGCGTCCTCTGAAGAAGAGGCCCTGAATATGGTCAAGGATTTG
CTCGACTTCCTGCCTTTGACCTGCAATGATCCAGCCCCTGTGTTTGCAGCACCAACGGATGAAGAGATCGCCTACGACGA
AGCTCTGAACTCGTTCATGCCTGATGACACTAACCAGGGCTACGACATGCATGACCTGCTGGACAAGCTTTTCGACGACG
CCAACCTGCTGGAAATCCAAGAGGAGTACGCCCCCAACCTGATCACTACCTTCGCCCGCGTTGATGGCAAGGCAGTCGGT
GTGGTGGCCAACCAACCAATGGATAAGGCAGGCTGCATCGACGCTGACGCCGCCGACAAGGGCGCCCGCTTCATCCGTAT
CTGCGACGCCTACAACATCCCGATCATCTTCGTCGTGGACACCCCTGGCTACCTGCCTGGCGTGGACCAAGAGAAGGTCG
GTTTGATTCACCGTGGCGCAAAGCTAGCCTTCGCAGTGGTGGAATCGACCGTCCCTAAGATTTCCTTGATCGTGCGCAAG
GCCTACGGCGGAGCATATGCCGTGATGGGTTCCAAGAACCTCACCGGTGACCTCAACTTCGCATGGCCAACCGCACAGAT
CGCAGTGATGGGCGCAGCCGCAGCTGTCGTGATGATCCAGGGCAAGCAGCTCGAAGCTGCCCCACCTGAGCAGCGTGAAT
ACATGAAGAAACTGTTCATGGACTTCTACGACGAGAACATGACCAGCCCATATGTGGCCGCCGAGCGTGGCTACATCGAC
GCCATGATCGAACCCGCAGAAACTCGTTTGGTGCTTCGCCGAGCAGTCCGCCAGCTGGAAACCAAGGCTGTGCGAGACCT
CGACAAGAAGCACACGATCATGCCGATGTAA

Upstream 100 bases:

>100_bases
CAGTTGTCGATGAACCAGAAATCGGCACAGTCGGAGCTCATTTGAGTCGCCGCATTGAAGAGATTTCTCGGAAGAATTAG
TAACGGAGAGCTGACGGAAG

Downstream 100 bases:

>100_bases
CGTCCAAAGAATTATCCAGATAGAAATCCTGTAACTAATTCACCAGAGGAGACCGCAATGGCAACCATCTTCGCAGTTCT
GTCGGGTATTGACTTCCTCA

Product: hypothetical protein

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSNTTTAEKLADLRARLEIAKDPGSERARKKRDEEGRTTPRQRIDALLDAGSFVEIGALGRTPDEPDAPYSDGVVTGYGR
IDGRPVAIYAHDKTVYGGSVGMTFGRKVSEVMDMAIRIGCPVIGIQDSGGARIQDAVTSLAMYSEIARRQLPLSGRSPQI
SIMLGKSAGGAVYAPVTTDFVIGVDGETEMYVTGPAVIKEVTGEQITSADLGGGAQQMQNGNISYLASSEEEALNMVKDL
LDFLPLTCNDPAPVFAAPTDEEIAYDEALNSFMPDDTNQGYDMHDLLDKLFDDANLLEIQEEYAPNLITTFARVDGKAVG
VVANQPMDKAGCIDADAADKGARFIRICDAYNIPIIFVVDTPGYLPGVDQEKVGLIHRGAKLAFAVVESTVPKISLIVRK
AYGGAYAVMGSKNLTGDLNFAWPTAQIAVMGAAAAVVMIQGKQLEAAPPEQREYMKKLFMDFYDENMTSPYVAAERGYID
AMIEPAETRLVLRRAVRQLETKAVRDLDKKHTIMPM

Sequences:

>Translated_516_residues
MSNTTTAEKLADLRARLEIAKDPGSERARKKRDEEGRTTPRQRIDALLDAGSFVEIGALGRTPDEPDAPYSDGVVTGYGR
IDGRPVAIYAHDKTVYGGSVGMTFGRKVSEVMDMAIRIGCPVIGIQDSGGARIQDAVTSLAMYSEIARRQLPLSGRSPQI
SIMLGKSAGGAVYAPVTTDFVIGVDGETEMYVTGPAVIKEVTGEQITSADLGGGAQQMQNGNISYLASSEEEALNMVKDL
LDFLPLTCNDPAPVFAAPTDEEIAYDEALNSFMPDDTNQGYDMHDLLDKLFDDANLLEIQEEYAPNLITTFARVDGKAVG
VVANQPMDKAGCIDADAADKGARFIRICDAYNIPIIFVVDTPGYLPGVDQEKVGLIHRGAKLAFAVVESTVPKISLIVRK
AYGGAYAVMGSKNLTGDLNFAWPTAQIAVMGAAAAVVMIQGKQLEAAPPEQREYMKKLFMDFYDENMTSPYVAAERGYID
AMIEPAETRLVLRRAVRQLETKAVRDLDKKHTIMPM
>Mature_515_residues
SNTTTAEKLADLRARLEIAKDPGSERARKKRDEEGRTTPRQRIDALLDAGSFVEIGALGRTPDEPDAPYSDGVVTGYGRI
DGRPVAIYAHDKTVYGGSVGMTFGRKVSEVMDMAIRIGCPVIGIQDSGGARIQDAVTSLAMYSEIARRQLPLSGRSPQIS
IMLGKSAGGAVYAPVTTDFVIGVDGETEMYVTGPAVIKEVTGEQITSADLGGGAQQMQNGNISYLASSEEEALNMVKDLL
DFLPLTCNDPAPVFAAPTDEEIAYDEALNSFMPDDTNQGYDMHDLLDKLFDDANLLEIQEEYAPNLITTFARVDGKAVGV
VANQPMDKAGCIDADAADKGARFIRICDAYNIPIIFVVDTPGYLPGVDQEKVGLIHRGAKLAFAVVESTVPKISLIVRKA
YGGAYAVMGSKNLTGDLNFAWPTAQIAVMGAAAAVVMIQGKQLEAAPPEQREYMKKLFMDFYDENMTSPYVAAERGYIDA
MIEPAETRLVLRRAVRQLETKAVRDLDKKHTIMPM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=506, Percent_Identity=42.8853754940711, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI295821216, Length=526, Percent_Identity=41.4448669201521, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI11545863, Length=498, Percent_Identity=28.1124497991968, Blast_Score=199, Evalue=5e-51,
Organism=Escherichia coli, GI1788655, Length=257, Percent_Identity=27.2373540856031, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25147359, Length=501, Percent_Identity=41.3173652694611, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI25147362, Length=501, Percent_Identity=41.3173652694611, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17552936, Length=507, Percent_Identity=29.3885601577909, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24586065, Length=517, Percent_Identity=29.0135396518375, Blast_Score=205, Evalue=7e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55814; Mature: 55683

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTTTAEKLADLRARLEIAKDPGSERARKKRDEEGRTTPRQRIDALLDAGSFVEIGALG
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEECCCC
RTPDEPDAPYSDGVVTGYGRIDGRPVAIYAHDKTVYGGSVGMTFGRKVSEVMDMAIRIGC
CCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCEEECCCCCCHHHHHHHHHHHHHHHHCC
PVIGIQDSGGARIQDAVTSLAMYSEIARRQLPLSGRSPQISIMLGKSAGGAVYAPVTTDF
CEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEECCCEEE
VIGVDGETEMYVTGPAVIKEVTGEQITSADLGGGAQQMQNGNISYLASSEEEALNMVKDL
EEEECCCCEEEEECHHHHHHHCCCCCCCCCCCCCHHHHCCCCEEEEECCHHHHHHHHHHH
LDFLPLTCNDPAPVFAAPTDEEIAYDEALNSFMPDDTNQGYDMHDLLDKLFDDANLLEIQ
HHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHH
EEYAPNLITTFARVDGKAVGVVANQPMDKAGCIDADAADKGARFIRICDAYNIPIIFVVD
HHHCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEC
TPGYLPGVDQEKVGLIHRGAKLAFAVVESTVPKISLIVRKAYGGAYAVMGSKNLTGDLNF
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEHHCCCEEEEECCCCCCCCCEE
AWPTAQIAVMGAAAAVVMIQGKQLEAAPPEQREYMKKLFMDFYDENMTSPYVAAERGYID
CCCCHHHHHHHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCEE
AMIEPAETRLVLRRAVRQLETKAVRDLDKKHTIMPM
EECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SNTTTAEKLADLRARLEIAKDPGSERARKKRDEEGRTTPRQRIDALLDAGSFVEIGALG
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEECCCC
RTPDEPDAPYSDGVVTGYGRIDGRPVAIYAHDKTVYGGSVGMTFGRKVSEVMDMAIRIGC
CCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCEEECCCCCCHHHHHHHHHHHHHHHHCC
PVIGIQDSGGARIQDAVTSLAMYSEIARRQLPLSGRSPQISIMLGKSAGGAVYAPVTTDF
CEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEECCCEEE
VIGVDGETEMYVTGPAVIKEVTGEQITSADLGGGAQQMQNGNISYLASSEEEALNMVKDL
EEEECCCCEEEEECHHHHHHHCCCCCCCCCCCCCHHHHCCCCEEEEECCHHHHHHHHHHH
LDFLPLTCNDPAPVFAAPTDEEIAYDEALNSFMPDDTNQGYDMHDLLDKLFDDANLLEIQ
HHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHH
EEYAPNLITTFARVDGKAVGVVANQPMDKAGCIDADAADKGARFIRICDAYNIPIIFVVD
HHHCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEC
TPGYLPGVDQEKVGLIHRGAKLAFAVVESTVPKISLIVRKAYGGAYAVMGSKNLTGDLNF
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEHHCCCEEEEECCCCCCCCCEE
AWPTAQIAVMGAAAAVVMIQGKQLEAAPPEQREYMKKLFMDFYDENMTSPYVAAERGYID
CCCCHHHHHHHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCEE
AMIEPAETRLVLRRAVRQLETKAVRDLDKKHTIMPM
EECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]