Click here to switch to the map view.

The map label for this gene is groEL

Identifier: 145296714

GI number: 145296714

Start: 2892662

End: 2894308

Strand: Reverse

Name: groEL

Synonym: cgR_2619

Alternate gene names: 145296714

Gene position: 2894308-2892662 (Counterclockwise)

Preceding gene: 145296715

Following gene: 145296713

Centisome position: 87.33

GC content: 57.98

Gene sequence:

>1647_bases
ATGGCAAAGATCATCGCCTTTGATGAGGAAGCACGTCGTGGCCTAGAAAAGGGACTGAACACCCTGGCTGACGCTGTTAA
GGTTACTTTGGGACCAAAGGGCCGTAACGTCGTTTTGGAAAAGGCTTGGGGTGCCCCAACCATTACCAACGATGGTGTCA
CCATCGCACGTGAGATCGAGCTTGAGGATCCTTACGAGAAGATCGGCGCAGAGCTGGTCAAGGAAGTCGCTAAGAAGACT
GATGACGTCGCAGGTGACGGCACCACCACCGCTACCGTATTGGCACAGGCTCTGGTTCGGGAAGGCCTGCGCAACGTTGC
TGCTGGCTCTAACCCAATGGGCATCAAGCGTGGCATCGAGAAGGCTGTTGCTCAGGTAACTGAGAAGCTGCTCGAGGCTG
CGAAGGAAGTTGAGACCGAGGAGCAGATCGCTGCTACCGCTGGTATCTCCGCAGCTGACCCAGCTATCGGCGCACAGATT
GCTAAGGCAATGTACGCAGTTGGTGGCGGCAAGCTGAACAAGGATTCCGTCATCACTGTTGAAGAGTCCAACACTTTCGG
TGTTGAGCTCGAGGTTACTGAGGGTATGCGCTTTGATAAGGGCTACATCTCCGGCTACTTCGCAACCGACATGGAGCGCC
TCGAGGCTGTTCTGGAAGATCCTTACATCCTGCTGGTTTCCGGCAAGATCTCCAACATCAAGGACCTGCTCCCACTGCTG
GAGAAGGTCATGCAGTCCGGCAAGCCTTTGCTGATCATCTCTGAGGACGTCGAGGGCGAGGCTCTGTCCACCCTGGTTGT
CAACAAGATCCGTGGCACCTTCAAGTCTGTTGCTGTTAAGGCTCCGGGCTTCGGCGACCGTCGTAAGGCTCAGCTGCAGG
ACATCGCAGTTCTGACCGGTGGCCAGGTCATCTCCGAAGAGGTTGGCCTCTCCCTTGAGACCGCTGATCTGCCACTTCTA
GGCCAGGCACGCAAGGTTGTTGTCACCAAGGATGACACCACCATCGTTGATGGCGCAGGTTCTGAGGCTCAGATCGAGGG
TCGCGTTAACCAGATCCGCGTTGAGATCGAGAACTCTGATTCCGATTACGACCGTGAGAAGCTCAACGAGCGCCTGGCTA
AGCTTGCCGGCGGCGTTGCAGTGCTCAAGGTTGGCGCAGCTACTGAGGTTGAGCTCAAGGAGCGCAAGCACCGCATCGAG
GACGCTGTCCGTAACGCTAAGGCAGCTGTTGAAGAGGGCATCGTTGCAGGCGGTGGCGTTGCGCTGCTGCAGGCTGCTCA
CGTCCTGGACAACGATCTTGAGCTTTCCGGCGACGAGGCAACCGGCGTTCGCATCGTCCGCGAGGCTCTTACCTCTCCTC
TGAAGCAGATCGCTGCTAACGCTGGCCTCGAGCCAGGCGTTGTTGCTGACAAGGTTTCCCAGCTCCCACAGGGCGAGGGC
CTCAACGCTGCAACCGGCGAGTACGTCGACCTCATGGCTGCGGGCATCAACGACCCAGTAAAGGTCACCCGCTCCGCACT
CCAGAACGCTGCGTCCATTGCAGCTTTGTTCCTGACCACTGAGGCTGTCGTTGCTGACAAGCCACAGCCTGCAGGCGCAG
CTGGCATGCCAGGTGCAGACGAGATGGGCGGCATGGGCGGCTTCTAA

Upstream 100 bases:

>100_bases
TGGGTGAGGTTGGTCCACACTCACTAACCGTGCCGTCGCGGGCGCCTACCGGGCAGAAGACGTGAGTGTCGTCCTACAAA
TATTTCAGGAGCACAAACAC

Downstream 100 bases:

>100_bases
GCCCCTGATTCGCGCATTATAAATGCCCTCCCGCACGCTTTGCGGGAGGGCTTTTGCGTGCCAAAAGATATCGCTTTTCG
ACGTCTCCCCACCCCTTCGG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MAKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKAWGAPTITNDGVTIAREIELEDPYEKIGAELVKEVAKKT
DDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIEKAVAQVTEKLLEAAKEVETEEQIAATAGISAADPAIGAQI
AKAMYAVGGGKLNKDSVITVEESNTFGVELEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKDLLPLL
EKVMQSGKPLLIISEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDIAVLTGGQVISEEVGLSLETADLPLL
GQARKVVVTKDDTTIVDGAGSEAQIEGRVNQIRVEIENSDSDYDREKLNERLAKLAGGVAVLKVGAATEVELKERKHRIE
DAVRNAKAAVEEGIVAGGGVALLQAAHVLDNDLELSGDEATGVRIVREALTSPLKQIAANAGLEPGVVADKVSQLPQGEG
LNAATGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPQPAGAAGMPGADEMGGMGGF

Sequences:

>Translated_548_residues
MAKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKAWGAPTITNDGVTIAREIELEDPYEKIGAELVKEVAKKT
DDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIEKAVAQVTEKLLEAAKEVETEEQIAATAGISAADPAIGAQI
AKAMYAVGGGKLNKDSVITVEESNTFGVELEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKDLLPLL
EKVMQSGKPLLIISEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDIAVLTGGQVISEEVGLSLETADLPLL
GQARKVVVTKDDTTIVDGAGSEAQIEGRVNQIRVEIENSDSDYDREKLNERLAKLAGGVAVLKVGAATEVELKERKHRIE
DAVRNAKAAVEEGIVAGGGVALLQAAHVLDNDLELSGDEATGVRIVREALTSPLKQIAANAGLEPGVVADKVSQLPQGEG
LNAATGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPQPAGAAGMPGADEMGGMGGF
>Mature_547_residues
AKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKAWGAPTITNDGVTIAREIELEDPYEKIGAELVKEVAKKTD
DVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIEKAVAQVTEKLLEAAKEVETEEQIAATAGISAADPAIGAQIA
KAMYAVGGGKLNKDSVITVEESNTFGVELEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKDLLPLLE
KVMQSGKPLLIISEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDIAVLTGGQVISEEVGLSLETADLPLLG
QARKVVVTKDDTTIVDGAGSEAQIEGRVNQIRVEIENSDSDYDREKLNERLAKLAGGVAVLKVGAATEVELKERKHRIED
AVRNAKAAVEEGIVAGGGVALLQAAHVLDNDLELSGDEATGVRIVREALTSPLKQIAANAGLEPGVVADKVSQLPQGEGL
NAATGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPQPAGAAGMPGADEMGGMGGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=46.9811320754717, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=46.9811320754717, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI302058290, Length=532, Percent_Identity=24.812030075188, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI63162572, Length=536, Percent_Identity=22.5746268656716, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI38455427, Length=121, Percent_Identity=32.2314049586777, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=58.7901701323251, Blast_Score=576, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=47.0809792843691, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI193210679, Length=208, Percent_Identity=50.4807692307692, Blast_Score=198, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17564182, Length=555, Percent_Identity=22.7027027027027, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=530, Percent_Identity=49.811320754717, Blast_Score=472, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322524, Length=152, Percent_Identity=31.5789473684211, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320058, Length=184, Percent_Identity=28.804347826087, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24641193, Length=530, Percent_Identity=47.3584905660377, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24641191, Length=530, Percent_Identity=47.3584905660377, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45550936, Length=530, Percent_Identity=45.6603773584906, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45550132, Length=530, Percent_Identity=45.6603773584906, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45550935, Length=530, Percent_Identity=45.6603773584906, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI17864606, Length=528, Percent_Identity=40.1515151515151, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24584129, Length=537, Percent_Identity=34.8230912476723, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI19921262, Length=537, Percent_Identity=34.8230912476723, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24645179, Length=119, Percent_Identity=34.453781512605, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_CORGB (A4QHB7)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001139535.1
- ProteinModelPortal:   A4QHB7
- SMR:   A4QHB7
- STRING:   A4QHB7
- GeneID:   4991924
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_2619
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   NKPETAT
- ProtClustDB:   PRK00013
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57358; Mature: 57227

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKAWGAPTITNDGVTIAREIE
CCEEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCEEEEEEEC
LEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KAVAQVTEKLLEAAKEVETEEQIAATAGISAADPAIGAQIAKAMYAVGGGKLNKDSVITV
HHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEE
EESNTFGVELEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKDLLPLL
ECCCCEEEEEEECCCCEECCCHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHH
EKVMQSGKPLLIISEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDIAVLTG
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHEECC
GQVISEEVGLSLETADLPLLGQARKVVVTKDDTTIVDGAGSEAQIEGRVNQIRVEIENSD
CHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCEEEECCCCCCEECCCEEEEEEEEECCC
SDYDREKLNERLAKLAGGVAVLKVGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGV
CCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ALLQAAHVLDNDLELSGDEATGVRIVREALTSPLKQIAANAGLEPGVVADKVSQLPQGEG
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
LNAATGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPQPAGAAGMPGAD
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EMGGMGGF
HCCCCCCC
>Mature Secondary Structure 
AKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKAWGAPTITNDGVTIAREIE
CEEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCEEEEEEEC
LEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KAVAQVTEKLLEAAKEVETEEQIAATAGISAADPAIGAQIAKAMYAVGGGKLNKDSVITV
HHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEE
EESNTFGVELEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKDLLPLL
ECCCCEEEEEEECCCCEECCCHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHH
EKVMQSGKPLLIISEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDIAVLTG
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHEECC
GQVISEEVGLSLETADLPLLGQARKVVVTKDDTTIVDGAGSEAQIEGRVNQIRVEIENSD
CHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCEEEECCCCCCEECCCEEEEEEEEECCC
SDYDREKLNERLAKLAGGVAVLKVGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGV
CCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ALLQAAHVLDNDLELSGDEATGVRIVREALTSPLKQIAANAGLEPGVVADKVSQLPQGEG
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
LNAATGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPQPAGAAGMPGAD
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EMGGMGGF
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA