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The map label for this gene is purQ

Identifier: 145296584

GI number: 145296584

Start: 2751302

End: 2751973

Strand: Reverse

Name: purQ

Synonym: cgR_2492

Alternate gene names: 145296584

Gene position: 2751973-2751302 (Counterclockwise)

Preceding gene: 145296585

Following gene: 145296583

Centisome position: 83.04

GC content: 57.14

Gene sequence:

>672_bases
GTGAGCGCCAAAATCGGTGTCATTACCTTCCCAGGCACCCTTGACGATGTAGATGCAGCACGCGCTGCTCGCATCGCAGG
TGCAGAAGTAATCAGCCTGTGGCACGCTGACGAGGATCTCAAGGGCGTCGACGCAGTTGTCGTTCCCGGTGGATTCTCCT
ACGGCGATTACCTGCGCACCGGTGCAATCTCTGCACTGGCGCCAGTAATGCAGTCCGTGATTGAGCAGGCCGGTAAGGGT
ATGCCAGTCTTGGGCATTTGCAACGGCTTCCAGATCCTCACCGAAGCACGCCTGCTTCCAGGCGCGCTGACCCGCAACAA
GGGTCTGCACTTTCACTGTGTAGACGCACACCTCGTTGTAGAGAACAACACCACTGCATGGACCAACACTTTGGAAAAGG
GGCAGCAGATCCTTATTCCTGCAAAGCACGGTGAAGGTCGCTTCCAGGCAGACGCAGAGACCATCGCCCAGCTTGAGGGT
GAAGGCCGCGTGGTGTTCCGTTACACCGATAACTTCAACGGTTCCGTCAACGATATCGCCGGTATCACTAATGAAACTGG
TCGCATCGTCGGTCTCATGCCGCACCCGGAACATGCCGTCGAAAAGCTAACCGGCCCATCTATTGATGGCCTGGAGCTGT
TCCTGTCCGCCGTTGGCACCATCGCGGCTTAA

Upstream 100 bases:

>100_bases
ATGATTCCGTCACCGAAGCTGACCTAAAGAAAATTGCTGAAACCCTCCTCGCAAACACCGTCATCGAAGACTTCGATGTG
GTGGGAGTTGAGGTCGCGAA

Downstream 100 bases:

>100_bases
GAGGAGTCAAAATATGAGCACTTTTGTCAATGACACCGTCGAAGACGCAATCAAGACCCCTGAGCTGGATCAGCCATTTG
AGGCTCTTGGTCTGAAAGAC

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MSAKIGVITFPGTLDDVDAARAARIAGAEVISLWHADEDLKGVDAVVVPGGFSYGDYLRTGAISALAPVMQSVIEQAGKG
MPVLGICNGFQILTEARLLPGALTRNKGLHFHCVDAHLVVENNTTAWTNTLEKGQQILIPAKHGEGRFQADAETIAQLEG
EGRVVFRYTDNFNGSVNDIAGITNETGRIVGLMPHPEHAVEKLTGPSIDGLELFLSAVGTIAA

Sequences:

>Translated_223_residues
MSAKIGVITFPGTLDDVDAARAARIAGAEVISLWHADEDLKGVDAVVVPGGFSYGDYLRTGAISALAPVMQSVIEQAGKG
MPVLGICNGFQILTEARLLPGALTRNKGLHFHCVDAHLVVENNTTAWTNTLEKGQQILIPAKHGEGRFQADAETIAQLEG
EGRVVFRYTDNFNGSVNDIAGITNETGRIVGLMPHPEHAVEKLTGPSIDGLELFLSAVGTIAA
>Mature_222_residues
SAKIGVITFPGTLDDVDAARAARIAGAEVISLWHADEDLKGVDAVVVPGGFSYGDYLRTGAISALAPVMQSVIEQAGKGM
PVLGICNGFQILTEARLLPGALTRNKGLHFHCVDAHLVVENNTTAWTNTLEKGQQILIPAKHGEGRFQADAETIAQLEGE
GRVVFRYTDNFNGSVNDIAGITNETGRIVGLMPHPEHAVEKLTGPSIDGLELFLSAVGTIAA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=230, Percent_Identity=30.8695652173913, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321498, Length=196, Percent_Identity=31.6326530612245, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24582111, Length=194, Percent_Identity=31.4432989690722, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24582109, Length=194, Percent_Identity=31.4432989690722, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17137292, Length=194, Percent_Identity=31.4432989690722, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_CORGL (Q8NMI4)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927155
- RefSeq:   NP_601787.1
- RefSeq:   YP_226830.1
- ProteinModelPortal:   Q8NMI4
- SMR:   Q8NMI4
- World-2DPAGE:   0001:Q8NMI4
- PRIDE:   Q8NMI4
- GeneID:   1020535
- GeneID:   3345299
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg2863
- KEGG:   cgl:NCgl2500
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BioCyc:   CGLU196627:CG2863-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.3

Molecular weight: Translated: 23540; Mature: 23409

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 87-87 ACT_SITE 195-195 ACT_SITE 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKIGVITFPGTLDDVDAARAARIAGAEVISLWHADEDLKGVDAVVVPGGFSYGDYLRT
CCCCEEEEECCCCCCCHHHHHHHHHCCHHEEEEECCCCCCCCCCEEEECCCCCHHHHHHH
GAISALAPVMQSVIEQAGKGMPVLGICNGFQILTEARLLPGALTRNKGLHFHCVDAHLVV
HHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCHHHCCCCCEEEEEEEEEEE
ENNTTAWTNTLEKGQQILIPAKHGEGRFQADAETIAQLEGEGRVVFRYTDNFNGSVNDIA
ECCCCHHHHHHHCCCEEEEECCCCCCCEEHHHHHHHHHCCCCEEEEEEECCCCCCHHHHC
GITNETGRIVGLMPHPEHAVEKLTGPSIDGLELFLSAVGTIAA
CCCCCCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAKIGVITFPGTLDDVDAARAARIAGAEVISLWHADEDLKGVDAVVVPGGFSYGDYLRT
CCCEEEEECCCCCCCHHHHHHHHHCCHHEEEEECCCCCCCCCCEEEECCCCCHHHHHHH
GAISALAPVMQSVIEQAGKGMPVLGICNGFQILTEARLLPGALTRNKGLHFHCVDAHLVV
HHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCHHHCCCCCEEEEEEEEEEE
ENNTTAWTNTLEKGQQILIPAKHGEGRFQADAETIAQLEGEGRVVFRYTDNFNGSVNDIA
ECCCCHHHHHHHCCCEEEEECCCCCCCEEHHHHHHHHHCCCCEEEEEEECCCCCCHHHHC
GITNETGRIVGLMPHPEHAVEKLTGPSIDGLELFLSAVGTIAA
CCCCCCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626