Click here to switch to the map view.

The map label for this gene is gltT [H]

Identifier: 145296542

GI number: 145296542

Start: 2692584

End: 2693972

Strand: Reverse

Name: gltT [H]

Synonym: cgR_2451

Alternate gene names: 145296542

Gene position: 2693972-2692584 (Counterclockwise)

Preceding gene: 145296543

Following gene: 145296541

Centisome position: 81.29

GC content: 54.36

Gene sequence:

>1389_bases
ATGGCTAACGCCACCGCACAGAAGGGCCGTTTCGGCCTTCCCGGCTGGATGACTGGCTTTGGTGCCCAGGTTATCGCCGG
CCTCATTCTTGGTCTTATTCTCGGCCTTGTCGCCCGAAGCATGGACAGCGGCGCTGCAGACGGTGAAGCAAGCTGGCTTA
CCGGTCTTCTTAGCGGCGTCGGTTCTGCTTATGTTTCTCTACTTAAAGTTATGGTTCCACCACTGGTGTTCGCTGCAGTG
GTTACCAGTGTGGCAAAGCTGCGCGAGGTAGCTAACGCTGCTCGTCTGGCTGTTTCCACCTTGGTGTGGTTCGCCATTAC
TGCATTCTTCTCTGTGCTCGCGGGTATCGCCGTAGCGCTGATTATGCAGCCTGGTGTTGGATCCACTGTCGACGCATCTA
ATGCTGCAGATCCTTCTCGCGTGGGCAGCTGGCTGGGCTTTATCCAGTCCGTTATTCCATCAAACATTTTGGGACTTTCC
GGTTCTTACAGTGAGAACTCTGGTGTGAACCTGTCCTTCAACGTGCTGCAGATCCTGGTGATCTCCATTGCGATTGGTGT
TGCAGCGCTAAAGGCTGGCAAGTCCGCTGAGCCTTTCTTGAAGTTCACCGAGTCCTTCCTCAAGATCATCCAGATCGTGT
TGTGGTGGATTATTCGCCTGGCTCCAATTGGTTCCGCTGCGCTGATCGGTAATGCTGTTGCTACCTACGGTTGGTCTGCA
CTTGGATCCCTGGGCAAGTTTGTTCTTGCGATCTACGTTGGTCTGGCAATCGTCATGTTCGTTATCTACCCAGTCGTGCT
GAAGCTCAATGGAATTCCTGTTCTTGGATTTTTTAAGCGCGTATGGCCTGTCACAAGCCTTGGCTTTGTTACCCGTTCCT
CCATGGGCGTTATGCCAGTTACCCAGCGCGTTACTGAGCAGTCCTTGGGTGTTCCATCTGCGTACGCTTCCTTTGCTATC
CCACTGGGTGCGACCAGCAAGATGGACGGCTGCGCTGCTGTCTACCCAGCTGTTGCCGCTATCTTCGTGGCACAGTTCTA
CGGCATTGACTTGAGCATCATGGATTACGTACTGATCATGATCGTCTCTGTCCTGGGCTCTGCTGCAACTGCAGGCACCA
CTGGCGCAACCGTCATGCTGACCCTGACCCTATCCACCTTGGGTCTGCCACTTGCTGGTGTTGGTCTGCTGCTGGCTATC
GAGCCAATCATCGACATGGGACGTACCGCAACCAACGTCACCGGTCAGGCACTGGTTCCTGCGATCGTTGCTAAGCGCGA
GGGCATTCTGGATCAGGATGTGTGGGATGCTGCTGAAAAGGGTGGCGCTGCTATTGATATGGCAACCGTCTCTGAGAAAG
AAACTGAGCCTGCAGAGGTTCGCTCCTAA

Upstream 100 bases:

>100_bases
CAGCTTCGGTTAATTTGGTCACACTAATGCAATAAATTCCTGTCTACAGCGTTACAGTTAATGAATTCAATTCAACCGCT
AAACGCAAGGAGTGCTACCC

Downstream 100 bases:

>100_bases
GTTCTCTTGAGTACCTGAGACCTTCTCAGCAAAACACAAAGTGCCTTCACCCAACCTGGGGTGGAGGCACTTTCTCATTG
CTAAGGTGTGCATCGTGAAC

Product: hypothetical protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MANATAQKGRFGLPGWMTGFGAQVIAGLILGLILGLVARSMDSGAADGEASWLTGLLSGVGSAYVSLLKVMVPPLVFAAV
VTSVAKLREVANAARLAVSTLVWFAITAFFSVLAGIAVALIMQPGVGSTVDASNAADPSRVGSWLGFIQSVIPSNILGLS
GSYSENSGVNLSFNVLQILVISIAIGVAALKAGKSAEPFLKFTESFLKIIQIVLWWIIRLAPIGSAALIGNAVATYGWSA
LGSLGKFVLAIYVGLAIVMFVIYPVVLKLNGIPVLGFFKRVWPVTSLGFVTRSSMGVMPVTQRVTEQSLGVPSAYASFAI
PLGATSKMDGCAAVYPAVAAIFVAQFYGIDLSIMDYVLIMIVSVLGSAATAGTTGATVMLTLTLSTLGLPLAGVGLLLAI
EPIIDMGRTATNVTGQALVPAIVAKREGILDQDVWDAAEKGGAAIDMATVSEKETEPAEVRS

Sequences:

>Translated_462_residues
MANATAQKGRFGLPGWMTGFGAQVIAGLILGLILGLVARSMDSGAADGEASWLTGLLSGVGSAYVSLLKVMVPPLVFAAV
VTSVAKLREVANAARLAVSTLVWFAITAFFSVLAGIAVALIMQPGVGSTVDASNAADPSRVGSWLGFIQSVIPSNILGLS
GSYSENSGVNLSFNVLQILVISIAIGVAALKAGKSAEPFLKFTESFLKIIQIVLWWIIRLAPIGSAALIGNAVATYGWSA
LGSLGKFVLAIYVGLAIVMFVIYPVVLKLNGIPVLGFFKRVWPVTSLGFVTRSSMGVMPVTQRVTEQSLGVPSAYASFAI
PLGATSKMDGCAAVYPAVAAIFVAQFYGIDLSIMDYVLIMIVSVLGSAATAGTTGATVMLTLTLSTLGLPLAGVGLLLAI
EPIIDMGRTATNVTGQALVPAIVAKREGILDQDVWDAAEKGGAAIDMATVSEKETEPAEVRS
>Mature_461_residues
ANATAQKGRFGLPGWMTGFGAQVIAGLILGLILGLVARSMDSGAADGEASWLTGLLSGVGSAYVSLLKVMVPPLVFAAVV
TSVAKLREVANAARLAVSTLVWFAITAFFSVLAGIAVALIMQPGVGSTVDASNAADPSRVGSWLGFIQSVIPSNILGLSG
SYSENSGVNLSFNVLQILVISIAIGVAALKAGKSAEPFLKFTESFLKIIQIVLWWIIRLAPIGSAALIGNAVATYGWSAL
GSLGKFVLAIYVGLAIVMFVIYPVVLKLNGIPVLGFFKRVWPVTSLGFVTRSSMGVMPVTQRVTEQSLGVPSAYASFAIP
LGATSKMDGCAAVYPAVAAIFVAQFYGIDLSIMDYVLIMIVSVLGSAATAGTTGATVMLTLTLSTLGLPLAGVGLLLAIE
PIIDMGRTATNVTGQALVPAIVAKREGILDQDVWDAAEKGGAAIDMATVSEKETEPAEVRS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI5032093, Length=341, Percent_Identity=29.0322580645161, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI21314632, Length=439, Percent_Identity=25.9681093394077, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI4827012, Length=446, Percent_Identity=26.6816143497758, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI194239697, Length=470, Percent_Identity=25.7446808510638, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI40254478, Length=449, Percent_Identity=26.9487750556793, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI66773030, Length=402, Percent_Identity=26.3681592039801, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI223468564, Length=250, Percent_Identity=30.4, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI223468566, Length=250, Percent_Identity=30.4, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI169790839, Length=490, Percent_Identity=25.3061224489796, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI301601644, Length=165, Percent_Identity=30.9090909090909, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI262359914, Length=415, Percent_Identity=24.3373493975904, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1790514, Length=436, Percent_Identity=30.5045871559633, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1788024, Length=423, Percent_Identity=31.2056737588652, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI1789947, Length=387, Percent_Identity=27.6485788113695, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17537407, Length=472, Percent_Identity=30.2966101694915, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71996953, Length=472, Percent_Identity=25.4237288135593, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193206505, Length=465, Percent_Identity=25.5913978494624, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17541374, Length=443, Percent_Identity=25.0564334085779, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71983099, Length=447, Percent_Identity=26.8456375838926, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=447, Percent_Identity=26.8456375838926, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI193206654, Length=455, Percent_Identity=24.6153846153846, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24583025, Length=434, Percent_Identity=24.1935483870968, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI17137668, Length=434, Percent_Identity=24.1935483870968, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24583023, Length=434, Percent_Identity=24.1935483870968, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI281360481, Length=487, Percent_Identity=25.8726899383984, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360483, Length=487, Percent_Identity=25.8726899383984, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137666, Length=487, Percent_Identity=25.8726899383984, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47661; Mature: 47530

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCCHHHHHHHHCCCCEEEEHHCCCCCCCCCCCCC
>Mature Secondary Structure 
ANATAQKGRFGLPGWMTGFGAQVIAGLILGLILGLVARSMDSGAADGEASWLTGLLSGV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH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HHHHHHCCCCCHHHHHHHHCCCCEEEEHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]