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The map label for this gene is hyi [H]

Identifier: 145296470

GI number: 145296470

Start: 2617961

End: 2618713

Strand: Direct

Name: hyi [H]

Synonym: cgR_2382

Alternate gene names: 145296470

Gene position: 2617961-2618713 (Clockwise)

Preceding gene: 145296468

Following gene: 145296471

Centisome position: 78.99

GC content: 51.53

Gene sequence:

>753_bases
TTGTCTCGATTTGCTGCCAACCTGTCATTGACTTTCACTGAGCTAGATTTCTTGGATCGTTTTGATGCCGCTTCGAAGCA
TGCTTTCAGTGCCGTGGAGTTTCAGTACCCTTACGATTTCGATGTTCAAGAGATTAAACAGCGTGCTGATTCCGCAGGTC
TGCCCATTGAACTGTTCAATGCCCCACCTGGGGATACTTTTGGTCTTGCGGCACTGGCTTCCCCTGAAGACTTTCAACAA
TCCATCGAGCAGGCCATCACGTACGCCACGGTGTTGAAGTCAAAGAAGATGCATGTCATGGCTGGCATCGCGGACGTAAC
CTCAGAAACCACGGCGCGCTATGTGGAGAATATTCGCTGGGCTGCGCAGCAACTAGACAAGCTCGACGTTGTCGTTGTTA
TTGAACCAATTAATCACTATTCGGTTCCCGGTTATTTCCTGCACACTCTGGAACAGGCGTATTGGCTTATCGACAGCATT
GCCCACCCCAATGTGAAGATCTTATTCGATACTTTCCAGCTTCAGCAGATTCATGGCAATCTCACCCGCCGCCTGCGCGA
GGTTCATGGCGCAGGTCTTTTGGGACACGTGCAAGTGGCCTCAGTTCCTGATCGGCACGAACCTGGCACTGGCGAAGTCA
ATGCGGCGTATATCTTCCAACTCCTAAGCGAACTGGACTATGACGGTGTCATCGCTGGCGAATACCACCCTGCCGGTGAA
ACTACAGCCGGTTTAGGCTGGTTGGAGCTCTAG

Upstream 100 bases:

>100_bases
AAAAATTCGGTTCACAAAACGTTTATCAGTCCAGCTTAAACCCATCGCAGGGGCGGAAGAATTAGACTCAAGGCACATCA
CATTGAAGGAGCTTCTTATC

Downstream 100 bases:

>100_bases
ATCGTAAGTGGTGTCGTACCCATGACGTACCATTAACCACGAACGTTTTAAAGAAGCCACGAAGGAGCCTGACATGGCGT
TACCACTACCCAGCAAGAGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MSRFAANLSLTFTELDFLDRFDAASKHAFSAVEFQYPYDFDVQEIKQRADSAGLPIELFNAPPGDTFGLAALASPEDFQQ
SIEQAITYATVLKSKKMHVMAGIADVTSETTARYVENIRWAAQQLDKLDVVVVIEPINHYSVPGYFLHTLEQAYWLIDSI
AHPNVKILFDTFQLQQIHGNLTRRLREVHGAGLLGHVQVASVPDRHEPGTGEVNAAYIFQLLSELDYDGVIAGEYHPAGE
TTAGLGWLEL

Sequences:

>Translated_250_residues
MSRFAANLSLTFTELDFLDRFDAASKHAFSAVEFQYPYDFDVQEIKQRADSAGLPIELFNAPPGDTFGLAALASPEDFQQ
SIEQAITYATVLKSKKMHVMAGIADVTSETTARYVENIRWAAQQLDKLDVVVVIEPINHYSVPGYFLHTLEQAYWLIDSI
AHPNVKILFDTFQLQQIHGNLTRRLREVHGAGLLGHVQVASVPDRHEPGTGEVNAAYIFQLLSELDYDGVIAGEYHPAGE
TTAGLGWLEL
>Mature_249_residues
SRFAANLSLTFTELDFLDRFDAASKHAFSAVEFQYPYDFDVQEIKQRADSAGLPIELFNAPPGDTFGLAALASPEDFQQS
IEQAITYATVLKSKKMHVMAGIADVTSETTARYVENIRWAAQQLDKLDVVVVIEPINHYSVPGYFLHTLEQAYWLIDSIA
HPNVKILFDTFQLQQIHGNLTRRLREVHGAGLLGHVQVASVPDRHEPGTGEVNAAYIFQLLSELDYDGVIAGEYHPAGET
TAGLGWLEL

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=262, Percent_Identity=41.2213740458015, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI300068964, Length=245, Percent_Identity=40.4081632653061, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1786718, Length=257, Percent_Identity=41.2451361867704, Blast_Score=200, Evalue=8e-53,
Organism=Escherichia coli, GI1789095, Length=257, Percent_Identity=39.2996108949416, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17552022, Length=257, Percent_Identity=37.3540856031128, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17530883, Length=257, Percent_Identity=33.852140077821, Blast_Score=152, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 27796; Mature: 27664

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFAANLSLTFTELDFLDRFDAASKHAFSAVEFQYPYDFDVQEIKQRADSAGLPIELFN
CCCEECCCEEEEHHHHHHHHHCHHHHHHHEEEEEECCCCCCHHHHHHHHCCCCCCEEEEC
APPGDTFGLAALASPEDFQQSIEQAITYATVLKSKKMHVMAGIADVTSETTARYVENIRW
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHH
AAQQLDKLDVVVVIEPINHYSVPGYFLHTLEQAYWLIDSIAHPNVKILFDTFQLQQIHGN
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
LTRRLREVHGAGLLGHVQVASVPDRHEPGTGEVNAAYIFQLLSELDYDGVIAGEYHPAGE
HHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCC
TTAGLGWLEL
CCCCCCEECC
>Mature Secondary Structure 
SRFAANLSLTFTELDFLDRFDAASKHAFSAVEFQYPYDFDVQEIKQRADSAGLPIELFN
CCEECCCEEEEHHHHHHHHHCHHHHHHHEEEEEECCCCCCHHHHHHHHCCCCCCEEEEC
APPGDTFGLAALASPEDFQQSIEQAITYATVLKSKKMHVMAGIADVTSETTARYVENIRW
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHH
AAQQLDKLDVVVVIEPINHYSVPGYFLHTLEQAYWLIDSIAHPNVKILFDTFQLQQIHGN
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
LTRRLREVHGAGLLGHVQVASVPDRHEPGTGEVNAAYIFQLLSELDYDGVIAGEYHPAGE
HHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCC
TTAGLGWLEL
CCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]