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The map label for this gene is pcaK [H]

Identifier: 145296352

GI number: 145296352

Start: 2497468

End: 2498808

Strand: Direct

Name: pcaK [H]

Synonym: cgR_2267

Alternate gene names: 145296352

Gene position: 2497468-2498808 (Clockwise)

Preceding gene: 145296351

Following gene: 145296355

Centisome position: 75.36

GC content: 56.45

Gene sequence:

>1341_bases
ATGGATATCCGCCAAACAATTAACGACACAGCAATGTCGAGATATCAGTGGTTCATTGTATTTATCGCAGTGCTGCTCAA
CGCACTGGACGGTTTTGATGTCCTCGCCATGTCTTTTACTGCGAATGCAGTGACCGAAGAATTTGGCTTGAGCGGCAGCC
AGCTTGGTGTGCTGCTGAGTTCCGCGCTGTTCGGCATGACCGCTGGATCTTTGCTGTTCGGTCCGATCGGTGACCGTTTC
GGCCGTAAGAATGCCCTGATGATCGCGCTGCTGTTCAACGTGGTGGGATTGGTATTGTCCGCCACCGCGCAGTCCGCAGG
CCAGTTGGGCGTGTGGCGTTTGATCACTGGTATCGGCATCGGCGGAATCCTCGCCTGCATCACAGTGGTGATCAGTGAGT
TCTCCAACAACAAAAACCGCGGCATGGCCATGTCCATCTACGCTGCTGGTTACGGCATCGGCGCGTCCTTGGGTGGTTTC
GGCGCAGCGCAGCTCATCCCAACATTTGGATGGCGCTCCGTGTTCGCAGCCGGTGCGATCGCAACTGGTATCGCCACCAT
CGCTACTTTCTTCTTCCTGCCAGAATCCGTTGATTGGCTGAGCACTCGCCGCCCTGCGGGCGCTCGCGACAAGATCAATT
ACATTGCGCGCCGCCTGGGCAAAGTCGGTACCTTTGAGCTTCCAGGCGAACAAAGCTTGTCGACGAAAAAAGCCGGTCTC
CAATCGTATGCAGTGCTCGTTAACAAAGAGAACCGTGGAACCAGCATCAAGCTGTGGGTTGCGTTCGGCATCGTGATGTT
CGGCTTCTACTTCGCCAACACCTGGACCCCGAAGCTGCTCGTGGAAACCGGAATGTCAGAACAGCAGGGCATCATCGGTG
GTTTGATGTTGTCCATGGGTGGAGCATTCGGTTCCCTGCTCTACGGTTTCCTCACCACCAAGTCCAGCTCCCGAAACACA
CTGATGACCTTCATGGTGCTGTCCGGCCTGACGCTGATCCTGTTCATTTCCTCCACCTCTGTTCCCTCCATCGCGTTTGC
CAGCGGCGTTGTCGTGGGCATGCTGATCAATGGTTGTGTGGCTGGTCTGTACACCCTGTCCCCACAGCTGTACTCCGCTG
AAGTACGCACCACTGGTGTGGGCGCTGCGATTGGTATGGGTCGTGTCGGTGCGATTTCCGCGCCACTGCTGGTGGGTAGC
CTGCTGGATTCTGGCTGGTCCCCAACGCAGCTGTATGTTGGTGTGGCAGTGATTGTTATTGCCGGTGCAACCGCATTGAT
TGGGATGCGCACTCAGGCGGTAGCCGTCGAAAAGCAGCCTGAAGCCCTAGCGACCAAATAG

Upstream 100 bases:

>100_bases
CCGACGCAAAGGCATGCGCCTGCGTGTCTCGAGTAGTCTCCTCCCCTTCCTCGTCCCCAACCTCGACCATTACGGTCGCC
CTCTCGTAAAGGAGCCTGGC

Downstream 100 bases:

>100_bases
GGCCGCGATTCCTAGCATGCCCAGCAGCGCTAGGAACGTGGTGAGGAAGACCGTATCGCGGGCGACGATCTCGCCCTTGC
GATACGTCGCCGCGTAGTTG

Product: hypothetical protein

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MDIRQTINDTAMSRYQWFIVFIAVLLNALDGFDVLAMSFTANAVTEEFGLSGSQLGVLLSSALFGMTAGSLLFGPIGDRF
GRKNALMIALLFNVVGLVLSATAQSAGQLGVWRLITGIGIGGILACITVVISEFSNNKNRGMAMSIYAAGYGIGASLGGF
GAAQLIPTFGWRSVFAAGAIATGIATIATFFFLPESVDWLSTRRPAGARDKINYIARRLGKVGTFELPGEQSLSTKKAGL
QSYAVLVNKENRGTSIKLWVAFGIVMFGFYFANTWTPKLLVETGMSEQQGIIGGLMLSMGGAFGSLLYGFLTTKSSSRNT
LMTFMVLSGLTLILFISSTSVPSIAFASGVVVGMLINGCVAGLYTLSPQLYSAEVRTTGVGAAIGMGRVGAISAPLLVGS
LLDSGWSPTQLYVGVAVIVIAGATALIGMRTQAVAVEKQPEALATK

Sequences:

>Translated_446_residues
MDIRQTINDTAMSRYQWFIVFIAVLLNALDGFDVLAMSFTANAVTEEFGLSGSQLGVLLSSALFGMTAGSLLFGPIGDRF
GRKNALMIALLFNVVGLVLSATAQSAGQLGVWRLITGIGIGGILACITVVISEFSNNKNRGMAMSIYAAGYGIGASLGGF
GAAQLIPTFGWRSVFAAGAIATGIATIATFFFLPESVDWLSTRRPAGARDKINYIARRLGKVGTFELPGEQSLSTKKAGL
QSYAVLVNKENRGTSIKLWVAFGIVMFGFYFANTWTPKLLVETGMSEQQGIIGGLMLSMGGAFGSLLYGFLTTKSSSRNT
LMTFMVLSGLTLILFISSTSVPSIAFASGVVVGMLINGCVAGLYTLSPQLYSAEVRTTGVGAAIGMGRVGAISAPLLVGS
LLDSGWSPTQLYVGVAVIVIAGATALIGMRTQAVAVEKQPEALATK
>Mature_446_residues
MDIRQTINDTAMSRYQWFIVFIAVLLNALDGFDVLAMSFTANAVTEEFGLSGSQLGVLLSSALFGMTAGSLLFGPIGDRF
GRKNALMIALLFNVVGLVLSATAQSAGQLGVWRLITGIGIGGILACITVVISEFSNNKNRGMAMSIYAAGYGIGASLGGF
GAAQLIPTFGWRSVFAAGAIATGIATIATFFFLPESVDWLSTRRPAGARDKINYIARRLGKVGTFELPGEQSLSTKKAGL
QSYAVLVNKENRGTSIKLWVAFGIVMFGFYFANTWTPKLLVETGMSEQQGIIGGLMLSMGGAFGSLLYGFLTTKSSSRNT
LMTFMVLSGLTLILFISSTSVPSIAFASGVVVGMLINGCVAGLYTLSPQLYSAEVRTTGVGAAIGMGRVGAISAPLLVGS
LLDSGWSPTQLYVGVAVIVIAGATALIGMRTQAVAVEKQPEALATK

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=426, Percent_Identity=23.4741784037559, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI7662270, Length=165, Percent_Identity=32.1212121212121, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI216548223, Length=165, Percent_Identity=30.9090909090909, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI213021148, Length=409, Percent_Identity=22.7383863080685, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI87081723, Length=391, Percent_Identity=30.690537084399, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788068, Length=450, Percent_Identity=24.4444444444444, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082231, Length=473, Percent_Identity=24.1014799154334, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788074, Length=362, Percent_Identity=25.9668508287293, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786229, Length=374, Percent_Identity=24.331550802139, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87082404, Length=201, Percent_Identity=26.865671641791, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082159, Length=388, Percent_Identity=23.1958762886598, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789312, Length=250, Percent_Identity=26.4, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=392, Percent_Identity=25.5102040816327, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323735, Length=175, Percent_Identity=30.2857142857143, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922874, Length=423, Percent_Identity=23.8770685579196, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922616, Length=372, Percent_Identity=24.4623655913978, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640198, Length=264, Percent_Identity=25.7575757575758, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640196, Length=264, Percent_Identity=25.7575757575758, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640200, Length=264, Percent_Identity=25.7575757575758, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24649618, Length=398, Percent_Identity=24.8743718592965, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46647; Mature: 46647

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRQTINDTAMSRYQWFIVFIAVLLNALDGFDVLAMSFTANAVTEEFGLSGSQLGVLLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SALFGMTAGSLLFGPIGDRFGRKNALMIALLFNVVGLVLSATAQSAGQLGVWRLITGIGI
HHHHHHCCCCCEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCH
GGILACITVVISEFSNNKNRGMAMSIYAAGYGIGASLGGFGAAQLIPTFGWRSVFAAGAI
HHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHHH
ATGIATIATFFFLPESVDWLSTRRPAGARDKINYIARRLGKVGTFELPGEQSLSTKKAGL
HHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHCH
QSYAVLVNKENRGTSIKLWVAFGIVMFGFYFANTWTPKLLVETGMSEQQGIIGGLMLSMG
HEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHC
GAFGSLLYGFLTTKSSSRNTLMTFMVLSGLTLILFISSTSVPSIAFASGVVVGMLINGCV
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
AGLYTLSPQLYSAEVRTTGVGAAIGMGRVGAISAPLLVGSLLDSGWSPTQLYVGVAVIVI
HHHHHCCCCCEECCCEECCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
AGATALIGMRTQAVAVEKQPEALATK
HHHHHHHHCCHHEEEECCCCHHHCCC
>Mature Secondary Structure
MDIRQTINDTAMSRYQWFIVFIAVLLNALDGFDVLAMSFTANAVTEEFGLSGSQLGVLLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SALFGMTAGSLLFGPIGDRFGRKNALMIALLFNVVGLVLSATAQSAGQLGVWRLITGIGI
HHHHHHCCCCCEECCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCH
GGILACITVVISEFSNNKNRGMAMSIYAAGYGIGASLGGFGAAQLIPTFGWRSVFAAGAI
HHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHHH
ATGIATIATFFFLPESVDWLSTRRPAGARDKINYIARRLGKVGTFELPGEQSLSTKKAGL
HHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHCH
QSYAVLVNKENRGTSIKLWVAFGIVMFGFYFANTWTPKLLVETGMSEQQGIIGGLMLSMG
HEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHC
GAFGSLLYGFLTTKSSSRNTLMTFMVLSGLTLILFISSTSVPSIAFASGVVVGMLINGCV
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
AGLYTLSPQLYSAEVRTTGVGAAIGMGRVGAISAPLLVGSLLDSGWSPTQLYVGVAVIVI
HHHHHCCCCCEECCCEECCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
AGATALIGMRTQAVAVEKQPEALATK
HHHHHHHHCCHHEEEECCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]