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The map label for this gene is cobC [C]

Identifier: 145296194

GI number: 145296194

Start: 2333846

End: 2334988

Strand: Reverse

Name: cobC [C]

Synonym: cgR_2112

Alternate gene names: 145296194

Gene position: 2334988-2333846 (Counterclockwise)

Preceding gene: 145296195

Following gene: 145296192

Centisome position: 70.45

GC content: 54.51

Gene sequence:

>1143_bases
GTGAAATTAGTCATCGAGGCTGACGGGGGCTCCCGCGGAAACCCCGGCGTGGCAGGCTCCGGCACCGTGGTGTACTCCGA
CAACAAGGCAGAAGTTCTCAAAGAAATCGCTTACGTTGTCGGAACAAAAGCCACCAACAACGTCGCCGAATACCGCGGAC
TACTCGAAGGCCTCAAAGCAGCCCGCGAACTCGGCGCTACCTCCGTGGACGTCTACATGGACTCTAAACTTGTCGTTGAA
CAAATGTCCGGCCGGTGGAAAATTAAACACCCCGACATGAAAGTTCTAGCGCTCGAAGCTAAGGAGATTGCTTCCGAAAT
CGGGTCCGTTTCTTATACGTGGATTCCACGTGAGAAAAACAAACGAGCTGATGCATTGTCCAACGTGGCGATGGATGCAG
CAGCGGCTGGTAAGCCGGTAGGTGTTGTGGGGGATTCGGCTTCTTCTGCTGCTTCAGTTGCGGACTCCGAGAAAGAAGAC
CTCAACTGCACCGAAACCAAACCCACCAATTGGAACGGCGCAACCACGGATCCCACTCGTTTTTTGTTGCTTCGCCACGG
TCAAACTGCGATGTCAGCGGCACGCCTTTACTCCGGAAGATCCAACCCAGAGCTGTCTGAACTTGGTGAAAAACAAGCAG
CGGCGGCAGCACGACGACTCGCTCAGGCCGGCGGCATTGACGCCATTGTGAGTTCTCCGCTCACCCGCACGATGCAAACC
GCAGAAGCCGCAGCTGCTGCATTGGGAATGAAAGTGCGTGTTATCGATGATCTCATCGAAACTGACTTTGGACTGTGGGA
TGGAAAGTCATTTTCAGAAGCCCACGAACAAGATCCAGAATTGCACACCAAGTGGCTCACTGACTCTTCTGTCGCACCAC
CCGGTGGCGAGTCCCTGCAGACGGTTAATCGACGTGTGAAAAAGGCTCGTGAAAGTCTCCAACGCGAATACGGTGCAGCG
AATGTTTTGGTGGTCAGCCACGTCACCCCAATCAAAGCCATCATGAGGCAAGCATTGGACGCAGGCCCATCCTTCTTTCA
GAAGGCACACCTCGACTTGGCGTCGCTGTCGATCGCAGAGTTTTACGAAGACGGCCCAACCTGCGTAAGACTGTTCAACG
ACACCTCACACCTGGAAGCGTGA

Upstream 100 bases:

>100_bases
CGGCATCTCCGACATCCGCAACACCCCCAAAGATGAGGTTCCACAGTGCCCAGAATGCGGCTCTTACCTTATCACTGACA
TCTCTTAGAAAGACCACCCA

Downstream 100 bases:

>100_bases
CGACAGTCTGACGGAAGCTCGGCGAAGCTCGCCGGAGTTTTTAAGTTTTTCCACCCTCGAGGTGTAAAGTAAAACGTTGC
GAATGAGGCAACCGGGTGAT

Product: bifunctional RNase H/acid phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKLVIEADGGSRGNPGVAGSGTVVYSDNKAEVLKEIAYVVGTKATNNVAEYRGLLEGLKAARELGATSVDVYMDSKLVVE
QMSGRWKIKHPDMKVLALEAKEIASEIGSVSYTWIPREKNKRADALSNVAMDAAAAGKPVGVVGDSASSAASVADSEKED
LNCTETKPTNWNGATTDPTRFLLLRHGQTAMSAARLYSGRSNPELSELGEKQAAAAARRLAQAGGIDAIVSSPLTRTMQT
AEAAAAALGMKVRVIDDLIETDFGLWDGKSFSEAHEQDPELHTKWLTDSSVAPPGGESLQTVNRRVKKARESLQREYGAA
NVLVVSHVTPIKAIMRQALDAGPSFFQKAHLDLASLSIAEFYEDGPTCVRLFNDTSHLEA

Sequences:

>Translated_380_residues
MKLVIEADGGSRGNPGVAGSGTVVYSDNKAEVLKEIAYVVGTKATNNVAEYRGLLEGLKAARELGATSVDVYMDSKLVVE
QMSGRWKIKHPDMKVLALEAKEIASEIGSVSYTWIPREKNKRADALSNVAMDAAAAGKPVGVVGDSASSAASVADSEKED
LNCTETKPTNWNGATTDPTRFLLLRHGQTAMSAARLYSGRSNPELSELGEKQAAAAARRLAQAGGIDAIVSSPLTRTMQT
AEAAAAALGMKVRVIDDLIETDFGLWDGKSFSEAHEQDPELHTKWLTDSSVAPPGGESLQTVNRRVKKARESLQREYGAA
NVLVVSHVTPIKAIMRQALDAGPSFFQKAHLDLASLSIAEFYEDGPTCVRLFNDTSHLEA
>Mature_380_residues
MKLVIEADGGSRGNPGVAGSGTVVYSDNKAEVLKEIAYVVGTKATNNVAEYRGLLEGLKAARELGATSVDVYMDSKLVVE
QMSGRWKIKHPDMKVLALEAKEIASEIGSVSYTWIPREKNKRADALSNVAMDAAAAGKPVGVVGDSASSAASVADSEKED
LNCTETKPTNWNGATTDPTRFLLLRHGQTAMSAARLYSGRSNPELSELGEKQAAAAARRLAQAGGIDAIVSSPLTRTMQT
AEAAAAALGMKVRVIDDLIETDFGLWDGKSFSEAHEQDPELHTKWLTDSSVAPPGGESLQTVNRRVKKARESLQREYGAA
NVLVVSHVTPIKAIMRQALDAGPSFFQKAHLDLASLSIAEFYEDGPTCVRLFNDTSHLEA

Specific function: Converts N1-(5-Phospho-Alpha-D-Ribosyl)-5,6- Dimethylbenzimidazole Into N1-Alpha-D-Ribosyl-5,6- Dimethylbenzimidazole; Involved In The Assembly Of The Nucleotide Loop Of Cobalamin. [C]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=149, Percent_Identity=30.8724832214765, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790856, Length=204, Percent_Identity=30.3921568627451, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR012337
- InterPro:   IPR014636
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00300 PGAM; PF00075 RnaseH [H]

EC number: 3.1.3.73 [C]

Molecular weight: Translated: 40587; Mature: 40587

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVIEADGGSRGNPGVAGSGTVVYSDNKAEVLKEIAYVVGTKATNNVAEYRGLLEGLKA
CEEEEECCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ARELGATSVDVYMDSKLVVEQMSGRWKIKHPDMKVLALEAKEIASEIGSVSYTWIPREKN
HHHHCCCEEEEEECCHHHHHHHCCCEEEECCCCEEEEEHHHHHHHHHCCCEEEECCCCCC
KRADALSNVAMDAAAAGKPVGVVGDSASSAASVADSEKEDLNCTETKPTNWNGATTDPTR
CHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCE
FLLLRHGQTAMSAARLYSGRSNPELSELGEKQAAAAARRLAQAGGIDAIVSSPLTRTMQT
EEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHH
AEAAAAALGMKVRVIDDLIETDFGLWDGKSFSEAHEQDPELHTKWLTDSSVAPPGGESLQ
HHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHCCCCCCCCCCCCHHHH
TVNRRVKKARESLQREYGAANVLVVSHVTPIKAIMRQALDAGPSFFQKAHLDLASLSIAE
HHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FYEDGPTCVRLFNDTSHLEA
HHCCCCEEEEEECCHHHCCC
>Mature Secondary Structure
MKLVIEADGGSRGNPGVAGSGTVVYSDNKAEVLKEIAYVVGTKATNNVAEYRGLLEGLKA
CEEEEECCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ARELGATSVDVYMDSKLVVEQMSGRWKIKHPDMKVLALEAKEIASEIGSVSYTWIPREKN
HHHHCCCEEEEEECCHHHHHHHCCCEEEECCCCEEEEEHHHHHHHHHCCCEEEECCCCCC
KRADALSNVAMDAAAAGKPVGVVGDSASSAASVADSEKEDLNCTETKPTNWNGATTDPTR
CHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCE
FLLLRHGQTAMSAARLYSGRSNPELSELGEKQAAAAARRLAQAGGIDAIVSSPLTRTMQT
EEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHH
AEAAAAALGMKVRVIDDLIETDFGLWDGKSFSEAHEQDPELHTKWLTDSSVAPPGGESLQ
HHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHCCCCCCCCCCCCHHHH
TVNRRVKKARESLQREYGAANVLVVSHVTPIKAIMRQALDAGPSFFQKAHLDLASLSIAE
HHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FYEDGPTCVRLFNDTSHLEA
HHCCCCEEEEEECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]