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The map label for this gene is pepA [H]

Identifier: 145296166

GI number: 145296166

Start: 2301206

End: 2302747

Strand: Direct

Name: pepA [H]

Synonym: cgR_2085

Alternate gene names: 145296166

Gene position: 2301206-2302747 (Clockwise)

Preceding gene: 145296163

Following gene: 145296168

Centisome position: 69.44

GC content: 55.64

Gene sequence:

>1542_bases
ATGGCGAAAAATGCCTACAGCACAACAGCACCAACCAAGGTGTCCAAGGATGCCACTCTTCCAGTTCGTGGAACGGTCGC
TGAACTCAAGCTCGAAAAGAAGTTGCCAAAGAAGATTGATGCCATCATCGTCGCGATTTTTGAGGGCGAAGATTCCATCG
AACTCGCCGGCGGCGAAATCCTCGATTTCATCTTCAGCACCGAGCAGCAGGCCGACATCCTCACTCAGCTCGAAGCTGTC
GGCGCAAAGGCCACCGCAAACAGCATCACCCGCGTCCCAGGCACCGACGTTGCGCCTGTCATTGCGGTTGGCTTGGGCAA
GGCTGATTTGCTTGACGACGAGACCCTCCGCCGCGCTTCCGGCACGGCGGCCCGCTCCCTCGGTGGTTTTGAAAATGTCG
CCACCACCATCGGCGATTTGGGGCTTGCAGCAGCGGTGACCGGTTTCGGTCTCGGTTCTTACTCCTACGCGGGTCTGCGC
AAGGAAACCGAAGAATCCAAGGACAAGACCACCACGGTCACTTTCATCAGCACGAGCAAGGATGACAAGGATGTCTTTGT
TGAAGCTCAGATCATCGTGGAATCTGTCCTGCTCGCTCGTGACTTGGTGAATACCCCTTCATCACATCTGTACCCAGAGT
CTTACTCAGTAATTGCATCCAATGAGGCGTCCAAGCACGGCTTGCAGACCACCATCCTGGATGAGAAGCAGCTTGCTGAT
AAAGGTTTCGGCGGTATCCTCGCAGTCGGTAACGGCTCCTCCCGCAAGCCTCGTCTGCTACGCGTCGATTGGAAGCCACG
CAAGGCTAAGAAGTCGATCGCTTTGGTTGGTAAAGGCATCACCTTCGACACCGGCGGAATTTCCATCAAGCCTGGCGCAA
GCATGGAGAACATGATCTCCGACATGGGTGGATCCGCATCCGTATTGGCCACCATTATCGCTGCAGCTCGTTTGAACCTG
TCGATCAACGTCTCCGCGTTCCTACCAATGGCTGAGAACATGCCATCCGGTGACGCTTTCCGCCCCGGCGATGTCATCAC
TCATTTCGGTGGTATCACCTCCGAAATCTTGAACACCGACGCTGAAGGCCGCCTCATTCTGGCAGATGCCATTGCTTACG
CTTCTGAAGATAAGCCTGACTACCTCATTGATGCAGCAACCCTGACTGGTGCTCAATTAGTCGCCTTAGGCCTGCGTACT
TCAGGTGTCATGGGTACCGATGAGTTCCGCGACAGCGTTGCCAAGACTGGCCGCGAGGTTGGCGAGCAAGCATGGGCAAT
GCCTCTTCCTGAGGAGCTCGATGAGCAGGTTAAGTCCCCTGTCGCTGACCTGCGCAATGTCACCAATTCCCGTTTCGCAG
GAATGTCTGCTGCGGGTCGTTACCTGCAGGAATTCGTTGGTGCCGACATCGAGTGGGCTCACGTCGATATCGCTGGCCCT
GCATACAACACTGCTGGTGAATTCGGTTACACGCCAAAGCGCGCAACCGGACAACCAGTGCGCACCTTCGTTCAGGTTCT
GAAGGATCTGTCGGAAAGCTAA

Upstream 100 bases:

>100_bases
GGTTTTGAGGAATGGCTAGGCTTGTTAAAAGTTAGTTTCAATTTGATGCCTCCCCCAACCAAAGCGGAGACACAACTTCA
ACGAGAGGACTCAGCTTTCA

Downstream 100 bases:

>100_bases
ACGCTAGTTAAAGATCAGGATTCTCGCCGCGCTCAAATTTAGCGCGGCGAGCTTTTTGTTCCTCACGCTTTCTTAAGATG
CGCTCATATTCAATGCGTTC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MAKNAYSTTAPTKVSKDATLPVRGTVAELKLEKKLPKKIDAIIVAIFEGEDSIELAGGEILDFIFSTEQQADILTQLEAV
GAKATANSITRVPGTDVAPVIAVGLGKADLLDDETLRRASGTAARSLGGFENVATTIGDLGLAAAVTGFGLGSYSYAGLR
KETEESKDKTTTVTFISTSKDDKDVFVEAQIIVESVLLARDLVNTPSSHLYPESYSVIASNEASKHGLQTTILDEKQLAD
KGFGGILAVGNGSSRKPRLLRVDWKPRKAKKSIALVGKGITFDTGGISIKPGASMENMISDMGGSASVLATIIAAARLNL
SINVSAFLPMAENMPSGDAFRPGDVITHFGGITSEILNTDAEGRLILADAIAYASEDKPDYLIDAATLTGAQLVALGLRT
SGVMGTDEFRDSVAKTGREVGEQAWAMPLPEELDEQVKSPVADLRNVTNSRFAGMSAAGRYLQEFVGADIEWAHVDIAGP
AYNTAGEFGYTPKRATGQPVRTFVQVLKDLSES

Sequences:

>Translated_513_residues
MAKNAYSTTAPTKVSKDATLPVRGTVAELKLEKKLPKKIDAIIVAIFEGEDSIELAGGEILDFIFSTEQQADILTQLEAV
GAKATANSITRVPGTDVAPVIAVGLGKADLLDDETLRRASGTAARSLGGFENVATTIGDLGLAAAVTGFGLGSYSYAGLR
KETEESKDKTTTVTFISTSKDDKDVFVEAQIIVESVLLARDLVNTPSSHLYPESYSVIASNEASKHGLQTTILDEKQLAD
KGFGGILAVGNGSSRKPRLLRVDWKPRKAKKSIALVGKGITFDTGGISIKPGASMENMISDMGGSASVLATIIAAARLNL
SINVSAFLPMAENMPSGDAFRPGDVITHFGGITSEILNTDAEGRLILADAIAYASEDKPDYLIDAATLTGAQLVALGLRT
SGVMGTDEFRDSVAKTGREVGEQAWAMPLPEELDEQVKSPVADLRNVTNSRFAGMSAAGRYLQEFVGADIEWAHVDIAGP
AYNTAGEFGYTPKRATGQPVRTFVQVLKDLSES
>Mature_512_residues
AKNAYSTTAPTKVSKDATLPVRGTVAELKLEKKLPKKIDAIIVAIFEGEDSIELAGGEILDFIFSTEQQADILTQLEAVG
AKATANSITRVPGTDVAPVIAVGLGKADLLDDETLRRASGTAARSLGGFENVATTIGDLGLAAAVTGFGLGSYSYAGLRK
ETEESKDKTTTVTFISTSKDDKDVFVEAQIIVESVLLARDLVNTPSSHLYPESYSVIASNEASKHGLQTTILDEKQLADK
GFGGILAVGNGSSRKPRLLRVDWKPRKAKKSIALVGKGITFDTGGISIKPGASMENMISDMGGSASVLATIIAAARLNLS
INVSAFLPMAENMPSGDAFRPGDVITHFGGITSEILNTDAEGRLILADAIAYASEDKPDYLIDAATLTGAQLVALGLRTS
GVMGTDEFRDSVAKTGREVGEQAWAMPLPEELDEQVKSPVADLRNVTNSRFAGMSAAGRYLQEFVGADIEWAHVDIAGPA
YNTAGEFGYTPKRATGQPVRTFVQVLKDLSES

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=433, Percent_Identity=36.2586605080831, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI47155554, Length=356, Percent_Identity=35.6741573033708, Blast_Score=179, Evalue=4e-45,
Organism=Escherichia coli, GI1790710, Length=498, Percent_Identity=32.1285140562249, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI87082123, Length=327, Percent_Identity=38.2262996941896, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=308, Percent_Identity=36.038961038961, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=357, Percent_Identity=25.4901960784314, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221379063, Length=288, Percent_Identity=37.8472222222222, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI221379062, Length=288, Percent_Identity=37.8472222222222, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI21357381, Length=288, Percent_Identity=37.8472222222222, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21355725, Length=434, Percent_Identity=29.0322580645161, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24661038, Length=432, Percent_Identity=28.0092592592593, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI161077148, Length=431, Percent_Identity=30.3944315545244, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI20130057, Length=431, Percent_Identity=30.3944315545244, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI20129969, Length=422, Percent_Identity=28.1990521327014, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24662227, Length=422, Percent_Identity=27.9620853080569, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21355645, Length=426, Percent_Identity=27.9342723004695, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24662223, Length=426, Percent_Identity=27.9342723004695, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI19922386, Length=337, Percent_Identity=29.3768545994065, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI20129963, Length=408, Percent_Identity=27.9411764705882, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646701, Length=377, Percent_Identity=28.1167108753316, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24646703, Length=377, Percent_Identity=28.1167108753316, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21358201, Length=377, Percent_Identity=28.1167108753316, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54138; Mature: 54007

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNAYSTTAPTKVSKDATLPVRGTVAELKLEKKLPKKIDAIIVAIFEGEDSIELAGGEI
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEEECCCCEEECCCHH
LDFIFSTEQQADILTQLEAVGAKATANSITRVPGTDVAPVIAVGLGKADLLDDETLRRAS
HHHHHCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCHHHHCCCCCHHCCCHHHHHHHC
GTAARSLGGFENVATTIGDLGLAAAVTGFGLGSYSYAGLRKETEESKDKTTTVTFISTSK
CHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHCCCCEEEEEEEECCC
DDKDVFVEAQIIVESVLLARDLVNTPSSHLYPESYSVIASNEASKHGLQTTILDEKQLAD
CCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHCCCEEEECCHHHHHC
KGFGGILAVGNGSSRKPRLLRVDWKPRKAKKSIALVGKGITFDTGGISIKPGASMENMIS
CCCCCEEEECCCCCCCCEEEEECCCCCHHHCCEEEEECCEEECCCCEEECCCCCHHHHHH
DMGGSASVLATIIAAARLNLSINVSAFLPMAENMPSGDAFRPGDVITHFGGITSEILNTD
HCCCCHHHHHHHHHHHHHCEEEEEHEECCHHCCCCCCCCCCCCHHHHHHCCHHHHHHCCC
AEGRLILADAIAYASEDKPDYLIDAATLTGAQLVALGLRTSGVMGTDEFRDSVAKTGREV
CCCCEEEEEHHHHCCCCCCCEEEEEHHHCCHHHEEEEHHCCCCCCCHHHHHHHHHHHHHH
GEQAWAMPLPEELDEQVKSPVADLRNVTNSRFAGMSAAGRYLQEFVGADIEWAHVDIAGP
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCC
AYNTAGEFGYTPKRATGQPVRTFVQVLKDLSES
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKNAYSTTAPTKVSKDATLPVRGTVAELKLEKKLPKKIDAIIVAIFEGEDSIELAGGEI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEEECCCCEEECCCHH
LDFIFSTEQQADILTQLEAVGAKATANSITRVPGTDVAPVIAVGLGKADLLDDETLRRAS
HHHHHCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCHHHHCCCCCHHCCCHHHHHHHC
GTAARSLGGFENVATTIGDLGLAAAVTGFGLGSYSYAGLRKETEESKDKTTTVTFISTSK
CHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHCCCCEEEEEEEECCC
DDKDVFVEAQIIVESVLLARDLVNTPSSHLYPESYSVIASNEASKHGLQTTILDEKQLAD
CCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHCCCEEEECCHHHHHC
KGFGGILAVGNGSSRKPRLLRVDWKPRKAKKSIALVGKGITFDTGGISIKPGASMENMIS
CCCCCEEEECCCCCCCCEEEEECCCCCHHHCCEEEEECCEEECCCCEEECCCCCHHHHHH
DMGGSASVLATIIAAARLNLSINVSAFLPMAENMPSGDAFRPGDVITHFGGITSEILNTD
HCCCCHHHHHHHHHHHHHCEEEEEHEECCHHCCCCCCCCCCCCHHHHHHCCHHHHHHCCC
AEGRLILADAIAYASEDKPDYLIDAATLTGAQLVALGLRTSGVMGTDEFRDSVAKTGREV
CCCCEEEEEHHHHCCCCCCCEEEEEHHHCCHHHEEEEHHCCCCCCCHHHHHHHHHHHHHH
GEQAWAMPLPEELDEQVKSPVADLRNVTNSRFAGMSAAGRYLQEFVGADIEWAHVDIAGP
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCC
AYNTAGEFGYTPKRATGQPVRTFVQVLKDLSES
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]