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The map label for this gene is tlrC [H]

Identifier: 145296102

GI number: 145296102

Start: 2226853

End: 2228505

Strand: Direct

Name: tlrC [H]

Synonym: cgR_2023

Alternate gene names: 145296102

Gene position: 2226853-2228505 (Clockwise)

Preceding gene: 145296101

Following gene: 145296104

Centisome position: 67.19

GC content: 56.2

Gene sequence:

>1653_bases
ATGCGCACTTTTGCCGCTTATATTGCCATTGATGGCCTCAGCTTTTCCTACCCCAACACCCACGTTTTAAGCGATATTTC
GCTCACCGTTGCCAATGGCGATATCGCCGGACTGATTGGTGAAAACGGCGCAGGAAAATCCACCCTGCTCAGCCTCATCG
CTGGCGTCATGGAACCCGACCAAGGCAGGATTTACCTCCCCGAACGCACCGGATTCATCGCCCAAGAAACAGACTTACCG
TTTGAACGGCCCGTGCAGTCGCTTATCGACGCCGCCGTCGCCCCAGTGCGCGCGGTCGATGCCGCGATTACAGATTTGTC
CACCAAGCTTGGCGACGCCTCCCTCAGCGCCGAAGAGCAGGCGCAAGTCGCCACAGATTTCGATGCAGCGCTAGGCGCTG
CAGAAGAACTCGGACTGTGGGAATTAGATGCACGTATTGAAACCATCGTCGCGGGTCTCGGCCTTGCCGAGGTGGATCGC
AGCACTCCCATTGGTGAGCTTTCCGGCGGTCAGCGCCGCAGGTTCGCGTTGGCAGCGCTGCTGTTGGAACCACACGATGC
TCTGATTTTCGATGAGCCCACCAACCACCTCGACGACACAGCCGTGGATTTCCTTATCTCGGAGATTTCCCGTTTCAAAG
GTCCAGTGCTGATCGCCAGCCACGATCGCTTCTTCCTCGACTCCGTCTGTACCGAATTAATCGACCTCGATCCTGCACTT
GGACCTGAGGGTGGATCCGGCGAAGAAGTAAAACAAGCCGTGTCTTTTGGTGGTGGATTTTCTGAATACATCAAAGAACG
CGAGACCCGCCGCACCCGCTGGGCTCAGTTGTACACCGCACAAGAAACCGAGCGGGAAAAACTCGAAGAAACCACCGGCA
CCACCGAATCGGATATTTTCCACAGCTCGGTTTCCAAATCGGAAGCTAAAATCACCGCGAAATTTTACGCAGACCGGGCA
GCTAAAACTCAAGGCAACCGCGTCCGCTCCGCCAAAAACCGCCTGAAGGAATTGGAACGCTATGAAATCCCAGCACCTCC
AAAGCCACTGGAATTCCAAGGCATCCCAGAGGCCTCCGGAAACGGTCACGGTGAAACACTAGAAGTGCGGGCTATTGCTG
TGGAAAATAGGCTTCAACCCTTGACTTTCCTCATCGATCCCGGCGACCACATCCTGGTCGAAGGCCCCAACGGTGTCGGT
AAATCCACCCTGCTGAGCGTTCTGGAAGGCGTGCTTGAACCAACCGAAGGTGAATTGCTAGTACCCGAAGGATTGAAAGT
TACGCGTCTAAAACAGGACGATCAGTGGACGGAAAAGCAGTTGAACACCCCCGTCGACGAATTGTTCGCTGCCCTATCGA
AAGGTCCGGTCGGACTTAACCTCGTGGAGATGGGACTGTTGAGGGAGACGTCGCAAAGCAGCCCGCTACGGGCACTATCG
CTCGGCCAACGCCGGCGCGTCTCGCTCGGGCTCATCCTGGCCAGCCCACCTGACCTGCTGCTTCTCGACGAGCCCACCAA
CCACCTTTCCCTCGCGCTGAGCGAAGAACTCGAGTCGGCGATAGAAAAATTCCCCGGTCGCGTTATTCTGGCCAGCCACG
ATAGGTGGATCAGAAAACGTTGGACGGGGAAGAAAATCAGCCTGAGCCGTTAA

Upstream 100 bases:

>100_bases
CTTCAATAGTCAAAACCAGCAAACTAATTTTTTAAGTTTTACGTAACTGGCCCCACCGCTTGTGGCAAGCCTTGCGTTTT
GACATTGAAGGACCCTTTTT

Downstream 100 bases:

>100_bases
ACCCTACTGAACAGGAACCTCTTCAACAGGGGCTTCCTCAACAACAGCACCCTCTTCAGCTGGGGCCTCTTCAATACCAG
CGGAAGAAGCATCAGTTCCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MRTFAAYIAIDGLSFSYPNTHVLSDISLTVANGDIAGLIGENGAGKSTLLSLIAGVMEPDQGRIYLPERTGFIAQETDLP
FERPVQSLIDAAVAPVRAVDAAITDLSTKLGDASLSAEEQAQVATDFDAALGAAEELGLWELDARIETIVAGLGLAEVDR
STPIGELSGGQRRRFALAALLLEPHDALIFDEPTNHLDDTAVDFLISEISRFKGPVLIASHDRFFLDSVCTELIDLDPAL
GPEGGSGEEVKQAVSFGGGFSEYIKERETRRTRWAQLYTAQETEREKLEETTGTTESDIFHSSVSKSEAKITAKFYADRA
AKTQGNRVRSAKNRLKELERYEIPAPPKPLEFQGIPEASGNGHGETLEVRAIAVENRLQPLTFLIDPGDHILVEGPNGVG
KSTLLSVLEGVLEPTEGELLVPEGLKVTRLKQDDQWTEKQLNTPVDELFAALSKGPVGLNLVEMGLLRETSQSSPLRALS
LGQRRRVSLGLILASPPDLLLLDEPTNHLSLALSEELESAIEKFPGRVILASHDRWIRKRWTGKKISLSR

Sequences:

>Translated_550_residues
MRTFAAYIAIDGLSFSYPNTHVLSDISLTVANGDIAGLIGENGAGKSTLLSLIAGVMEPDQGRIYLPERTGFIAQETDLP
FERPVQSLIDAAVAPVRAVDAAITDLSTKLGDASLSAEEQAQVATDFDAALGAAEELGLWELDARIETIVAGLGLAEVDR
STPIGELSGGQRRRFALAALLLEPHDALIFDEPTNHLDDTAVDFLISEISRFKGPVLIASHDRFFLDSVCTELIDLDPAL
GPEGGSGEEVKQAVSFGGGFSEYIKERETRRTRWAQLYTAQETEREKLEETTGTTESDIFHSSVSKSEAKITAKFYADRA
AKTQGNRVRSAKNRLKELERYEIPAPPKPLEFQGIPEASGNGHGETLEVRAIAVENRLQPLTFLIDPGDHILVEGPNGVG
KSTLLSVLEGVLEPTEGELLVPEGLKVTRLKQDDQWTEKQLNTPVDELFAALSKGPVGLNLVEMGLLRETSQSSPLRALS
LGQRRRVSLGLILASPPDLLLLDEPTNHLSLALSEELESAIEKFPGRVILASHDRWIRKRWTGKKISLSR
>Mature_550_residues
MRTFAAYIAIDGLSFSYPNTHVLSDISLTVANGDIAGLIGENGAGKSTLLSLIAGVMEPDQGRIYLPERTGFIAQETDLP
FERPVQSLIDAAVAPVRAVDAAITDLSTKLGDASLSAEEQAQVATDFDAALGAAEELGLWELDARIETIVAGLGLAEVDR
STPIGELSGGQRRRFALAALLLEPHDALIFDEPTNHLDDTAVDFLISEISRFKGPVLIASHDRFFLDSVCTELIDLDPAL
GPEGGSGEEVKQAVSFGGGFSEYIKERETRRTRWAQLYTAQETEREKLEETTGTTESDIFHSSVSKSEAKITAKFYADRA
AKTQGNRVRSAKNRLKELERYEIPAPPKPLEFQGIPEASGNGHGETLEVRAIAVENRLQPLTFLIDPGDHILVEGPNGVG
KSTLLSVLEGVLEPTEGELLVPEGLKVTRLKQDDQWTEKQLNTPVDELFAALSKGPVGLNLVEMGLLRETSQSSPLRALS
LGQRRRVSLGLILASPPDLLLLDEPTNHLSLALSEELESAIEKFPGRVILASHDRWIRKRWTGKKISLSR

Specific function: Responsible for tylosin resistance, and is proposed to be a subunit of a multicomponent export system for the energy- dependent efflux of tylosin [H]

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI27881506, Length=566, Percent_Identity=28.9752650176678, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI10947137, Length=565, Percent_Identity=28.6725663716814, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI148612853, Length=541, Percent_Identity=28.4658040665434, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI10947135, Length=238, Percent_Identity=34.453781512605, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI69354671, Length=239, Percent_Identity=32.6359832635983, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1789751, Length=533, Percent_Identity=28.5178236397749, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI2367384, Length=545, Percent_Identity=29.7247706422018, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1787041, Length=536, Percent_Identity=26.3059701492537, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1787182, Length=557, Percent_Identity=27.6481149012567, Blast_Score=156, Evalue=4e-39,
Organism=Escherichia coli, GI1789891, Length=243, Percent_Identity=27.9835390946502, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786253, Length=206, Percent_Identity=30.0970873786408, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1787758, Length=180, Percent_Identity=31.1111111111111, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17555318, Length=547, Percent_Identity=28.5191956124314, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17553372, Length=544, Percent_Identity=26.1029411764706, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17559834, Length=234, Percent_Identity=32.9059829059829, Blast_Score=102, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320874, Length=538, Percent_Identity=28.2527881040892, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6321121, Length=567, Percent_Identity=26.63139329806, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324314, Length=420, Percent_Identity=25.7142857142857, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325030, Length=266, Percent_Identity=27.0676691729323, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323278, Length=254, Percent_Identity=26.7716535433071, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24641342, Length=554, Percent_Identity=30.3249097472924, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24642252, Length=545, Percent_Identity=28.4403669724771, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI18859989, Length=545, Percent_Identity=28.4403669724771, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24666836, Length=573, Percent_Identity=26.7015706806283, Blast_Score=146, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 59809; Mature: 59809

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTFAAYIAIDGLSFSYPNTHVLSDISLTVANGDIAGLIGENGAGKSTLLSLIAGVMEPD
CCEEEEEEEEECCCCCCCCCEEEECEEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCC
QGRIYLPERTGFIAQETDLPFERPVQSLIDAAVAPVRAVDAAITDLSTKLGDASLSAEEQ
CCEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
AQVATDFDAALGAAEELGLWELDARIETIVAGLGLAEVDRSTPIGELSGGQRRRFALAAL
HHHHHHHHHHHCCHHHCCCEEHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHH
LLEPHDALIFDEPTNHLDDTAVDFLISEISRFKGPVLIASHDRFFLDSVCTELIDLDPAL
HCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCC
GPEGGSGEEVKQAVSFGGGFSEYIKERETRRTRWAQLYTAQETEREKLEETTGTTESDIF
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
HSSVSKSEAKITAKFYADRAAKTQGNRVRSAKNRLKELERYEIPAPPKPLEFQGIPEASG
HHHCCCCHHEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NGHGETLEVRAIAVENRLQPLTFLIDPGDHILVEGPNGVGKSTLLSVLEGVLEPTEGELL
CCCCCEEEEEEEEECCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEE
VPEGLKVTRLKQDDQWTEKQLNTPVDELFAALSKGPVGLNLVEMGLLRETSQSSPLRALS
CCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHH
LGQRRRVSLGLILASPPDLLLLDEPTNHLSLALSEELESAIEKFPGRVILASHDRWIRKR
CCCCCEEEEEEEEECCCCEEEECCCCCHHEEHHHHHHHHHHHHCCCEEEEECCCHHHHHH
WTGKKISLSR
CCCCEEECCC
>Mature Secondary Structure
MRTFAAYIAIDGLSFSYPNTHVLSDISLTVANGDIAGLIGENGAGKSTLLSLIAGVMEPD
CCEEEEEEEEECCCCCCCCCEEEECEEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCC
QGRIYLPERTGFIAQETDLPFERPVQSLIDAAVAPVRAVDAAITDLSTKLGDASLSAEEQ
CCEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
AQVATDFDAALGAAEELGLWELDARIETIVAGLGLAEVDRSTPIGELSGGQRRRFALAAL
HHHHHHHHHHHCCHHHCCCEEHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHH
LLEPHDALIFDEPTNHLDDTAVDFLISEISRFKGPVLIASHDRFFLDSVCTELIDLDPAL
HCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCC
GPEGGSGEEVKQAVSFGGGFSEYIKERETRRTRWAQLYTAQETEREKLEETTGTTESDIF
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
HSSVSKSEAKITAKFYADRAAKTQGNRVRSAKNRLKELERYEIPAPPKPLEFQGIPEASG
HHHCCCCHHEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NGHGETLEVRAIAVENRLQPLTFLIDPGDHILVEGPNGVGKSTLLSVLEGVLEPTEGELL
CCCCCEEEEEEEEECCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEE
VPEGLKVTRLKQDDQWTEKQLNTPVDELFAALSKGPVGLNLVEMGLLRETSQSSPLRALS
CCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHH
LGQRRRVSLGLILASPPDLLLLDEPTNHLSLALSEELESAIEKFPGRVILASHDRWIRKR
CCCCCEEEEEEEEECCCCEEEECCCCCHHEEHHHHHHHHHHHHCCCEEEEECCCHHHHHH
WTGKKISLSR
CCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1864505 [H]