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The map label for this gene is gmk

Identifier: 145295728

GI number: 145295728

Start: 1840569

End: 1841141

Strand: Reverse

Name: gmk

Synonym: cgR_1655

Alternate gene names: 145295728

Gene position: 1841141-1840569 (Counterclockwise)

Preceding gene: 145295729

Following gene: 145295727

Centisome position: 55.55

GC content: 52.18

Gene sequence:

>573_bases
GTGTCGGGCGATAACCAACTAGGACGGCTCGTAATTCTTGCGGGCCCCTCAGCGGTCGGTAAATCGACTGTGGTTGATCG
CCTCCGCAATGACGTTCCAAACCTGTATTTCAGTGTGTCGATGACCACTAGGGCACCTCGTCCTGGTGAAGTCGATGGAC
GTGACTATTTCTATGTCACTGCACAGGAATTTCAGGACAAAATCGACTGTGGAGAGATGCTTGAATGGGCAGATATCCAC
GGCGGTTTGCAGCGTTCAGGCACTCCAGCAGGTCCCGTCAATGAGGCTCGCCAAAATGGTCGGCCAGTATTGGTTGAGGT
TGATCTTGCAGGAGCCCGAAACATCGCTAGCTTAATTCCAGATGCAGAAACCATCTTCCTTGCTCCACCTTCATGGGAAG
TTTTGGTTGAACGCCTCACTGGACGTGGCACCGAAAGCGAAGACGTTATTGCTCGCAGGCTCGAGACCGCACGCGAAGAA
TTGGCTGCTCAGAGCGAATTTAAGCACGTCATTATCAATGATGATGTGGATACAGCCGTCAAGGCTATTGAGGATGTTCT
CCTCGGCGCTTAG

Upstream 100 bases:

>100_bases
GACGAGCTGGGCATTGCTCAGACCCGTCGTCTTCGTGGACTGGGTGACCGTCAGCGTCGCGCACTTCTCGAGCGTTTCGG
CTTCGAGGATTAATTCTTCA

Downstream 100 bases:

>100_bases
CCAAAACATAGAGCGGTAGGGTATGCTTTTCCGATTGAGCAACCTTTCCCGCTCTTAACACTACTGTCCATATACTTTTG
AAAAGGTGTCAGTGACCAAC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MSGDNQLGRLVILAGPSAVGKSTVVDRLRNDVPNLYFSVSMTTRAPRPGEVDGRDYFYVTAQEFQDKIDCGEMLEWADIH
GGLQRSGTPAGPVNEARQNGRPVLVEVDLAGARNIASLIPDAETIFLAPPSWEVLVERLTGRGTESEDVIARRLETAREE
LAAQSEFKHVIINDDVDTAVKAIEDVLLGA

Sequences:

>Translated_190_residues
MSGDNQLGRLVILAGPSAVGKSTVVDRLRNDVPNLYFSVSMTTRAPRPGEVDGRDYFYVTAQEFQDKIDCGEMLEWADIH
GGLQRSGTPAGPVNEARQNGRPVLVEVDLAGARNIASLIPDAETIFLAPPSWEVLVERLTGRGTESEDVIARRLETAREE
LAAQSEFKHVIINDDVDTAVKAIEDVLLGA
>Mature_189_residues
SGDNQLGRLVILAGPSAVGKSTVVDRLRNDVPNLYFSVSMTTRAPRPGEVDGRDYFYVTAQEFQDKIDCGEMLEWADIHG
GLQRSGTPAGPVNEARQNGRPVLVEVDLAGARNIASLIPDAETIFLAPPSWEVLVERLTGRGTESEDVIARRLETAREEL
AAQSEFKHVIINDDVDTAVKAIEDVLLGA

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=185, Percent_Identity=39.4594594594595, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI4504221, Length=185, Percent_Identity=39.4594594594595, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI226874831, Length=185, Percent_Identity=39.4594594594595, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI38570142, Length=180, Percent_Identity=30.5555555555556, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1790080, Length=183, Percent_Identity=39.344262295082, Blast_Score=130, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI193203132, Length=184, Percent_Identity=38.5869565217391, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17508835, Length=184, Percent_Identity=38.5869565217391, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320662, Length=188, Percent_Identity=39.3617021276596, Blast_Score=144, Evalue=8e-36,
Organism=Drosophila melanogaster, GI21356141, Length=184, Percent_Identity=34.2391304347826, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_CORGL (Q8NQ42)

Other databases:

- EMBL:   AB083048
- EMBL:   BA000036
- EMBL:   BX927152
- RefSeq:   NP_600820.2
- RefSeq:   YP_225891.1
- ProteinModelPortal:   Q8NQ42
- SMR:   Q8NQ42
- GeneID:   1019574
- GeneID:   3343588
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1810
- KEGG:   cgl:NCgl1544
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- PhylomeDB:   Q8NQ42
- ProtClustDB:   PRK00300
- BioCyc:   CGLU196627:CG1810-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 20657; Mature: 20526

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGDNQLGRLVILAGPSAVGKSTVVDRLRNDVPNLYFSVSMTTRAPRPGEVDGRDYFYVT
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCEEEEEE
AQEFQDKIDCGEMLEWADIHGGLQRSGTPAGPVNEARQNGRPVLVEVDLAGARNIASLIP
HHHHHCCCCHHHHHHHHHHHCCHHCCCCCCCCCHHHHHCCCCEEEEEECCCCHHHHHHCC
DAETIFLAPPSWEVLVERLTGRGTESEDVIARRLETAREELAAQSEFKHVIINDDVDTAV
CCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHH
KAIEDVLLGA
HHHHHHHCCC
>Mature Secondary Structure 
SGDNQLGRLVILAGPSAVGKSTVVDRLRNDVPNLYFSVSMTTRAPRPGEVDGRDYFYVT
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCEEEEEE
AQEFQDKIDCGEMLEWADIHGGLQRSGTPAGPVNEARQNGRPVLVEVDLAGARNIASLIP
HHHHHCCCCHHHHHHHHHHHCCHHCCCCCCCCCHHHHHCCCCEEEEEECCCCHHHHHHCC
DAETIFLAPPSWEVLVERLTGRGTESEDVIARRLETAREELAAQSEFKHVIINDDVDTAV
CCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHH
KAIEDVLLGA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626