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The map label for this gene is tlrC [H]

Identifier: 145295554

GI number: 145295554

Start: 1641172

End: 1642704

Strand: Reverse

Name: tlrC [H]

Synonym: cgR_1481

Alternate gene names: 145295554

Gene position: 1642704-1641172 (Counterclockwise)

Preceding gene: 145295557

Following gene: 145295542

Centisome position: 49.57

GC content: 50.75

Gene sequence:

>1533_bases
ATGGCTAAAACCCATATTCGGTTACAGGACCTTTCCCTGTCATACACCTCAACCCCGTTAATTACGAAGCTCAATATCAC
TGTTTCTTCTGGACAGTGCGCAGTGATTGTTGGTGAGAATGGTCGAGGTAAAACCACACTTCTGCGAGCACTGGCTCGAG
AATTCCCGCCATCTGCAGGTGAGATTCTCACTCATGGCACGGTAGCAATTGCTCATCAACACATGCCTGCAGGTGATCTG
TCCGTCGGAGAGATCTGCGATGAGGCAATTCGTGATTCAAAAAATGCTCTCGAAGAGCTTGAGAGAGCTGGAGCTCTACT
TGAGACAAACACTGCGCACGCACTTGATGGATATCAACAAGCCCTTGATGCCGCTGAAGTGCTTGACGCATGGAACGCTG
AACATCGATTAGAAAAAGCTCTGCGCAGCTTTGGCGCGATCACCGATAGATCCCGTGCACTCAGTGAGCTATCGATCGGG
CAAAGGTATCGAGTACGGCTGGCCTGCCTCATCGGTGGCGATGCTGATATTTTGCTTCTCGATGAACCCACGAATCATCT
TGACCGGGGCGCGCTTAACTATCTCACCGAAGCCATAACCTCCCACAAAGGTGTGGTACTTGTTGTTTCTCATGATCAAG
CACTGATCAAAGATGTCGCGGATATCATCATCGATATTGATTCAACCCCAGACGGCCTACCACGGATCTATCATGAGGGT
TTTGATTCTTATCGACGCCAAAGGAGTGCGCTTCTTGAAACTTGGAGGCAGGATTATGCCGCTACACAAACTGCGCAACA
GCAATTGCAAGAGGATCTAGAGCACGCACGCCAGCGGGTGAATTCTTCGTGGAAACCTCCAAAAGGAACGGGAAAACACA
CTCGCGCATCTCGGGCTCCCGGAGTGGTGCAGGCCTTAAAGCGAGCACAGGATGCGTTGGATAGCAAAGCGTTGGACGTT
CCCTCGGCTCCGGCCCCATTGCTTCTGCCTACCTTGAAAGTGCGACCAGATAAACCCATGGTGGACTTTTCAGACCTTTT
TGTACCCCACCGCTTGCGTCTGCCAGGCTCACATTCAGTATTATCAGGTGACAAAATAGTGATCACTGGTGACAACGGCG
CTGGCAAATCAACGCTCATCGAAGTCTTGTCTGGGGCTTTGACTCCGGCAAGTGGTTCGGTTGAAAACCATGCCCGAACT
GGAGTTCTCGGCCAAGAATCACATGTCGGCGAGGTGCCATCAATAGCACGAGATCACGCAGTTAAGTGGGGACTTTTAAG
TGTTGAGGAGAGCCGATTTGCCCTACAGGAATTCTCAATTGGTCAACGCAGAAGACTAGATTTGGCCATGTCGTTAGCTG
GCAATCCTGAACTGTTGCTTCTCGATGAACCTTCGAACCATCTGTCTATGCACTTGGTTTCCGCACTTACAGAGTGGCTG
GACAAGACCACGGCTGCAGTGATCATGGTGACGCATGATCGACAGCTACTCCGCGATACGGCTCATTGGAGGCACATCGA
GTTGAAATCTTAA

Upstream 100 bases:

>100_bases
TGCAGGCCACATGCCTCCCAGTGCCGTCTCTGCACGTTGATTTTCCCCTGCCACGACTCGTCGCAGTGGGACTTTCTAGC
ACTTTTAAAGGAATTTTTTA

Downstream 100 bases:

>100_bases
GAATTCGCAAGGGCTTTCACGCACGAGGATGGGCCCCGCGCCACACTTCCCGCAAGCTATCGGCTGTGATGTGCGTGTAA
ATCTGAGTGGTCGTCACAGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MAKTHIRLQDLSLSYTSTPLITKLNITVSSGQCAVIVGENGRGKTTLLRALAREFPPSAGEILTHGTVAIAHQHMPAGDL
SVGEICDEAIRDSKNALEELERAGALLETNTAHALDGYQQALDAAEVLDAWNAEHRLEKALRSFGAITDRSRALSELSIG
QRYRVRLACLIGGDADILLLDEPTNHLDRGALNYLTEAITSHKGVVLVVSHDQALIKDVADIIIDIDSTPDGLPRIYHEG
FDSYRRQRSALLETWRQDYAATQTAQQQLQEDLEHARQRVNSSWKPPKGTGKHTRASRAPGVVQALKRAQDALDSKALDV
PSAPAPLLLPTLKVRPDKPMVDFSDLFVPHRLRLPGSHSVLSGDKIVITGDNGAGKSTLIEVLSGALTPASGSVENHART
GVLGQESHVGEVPSIARDHAVKWGLLSVEESRFALQEFSIGQRRRLDLAMSLAGNPELLLLDEPSNHLSMHLVSALTEWL
DKTTAAVIMVTHDRQLLRDTAHWRHIELKS

Sequences:

>Translated_510_residues
MAKTHIRLQDLSLSYTSTPLITKLNITVSSGQCAVIVGENGRGKTTLLRALAREFPPSAGEILTHGTVAIAHQHMPAGDL
SVGEICDEAIRDSKNALEELERAGALLETNTAHALDGYQQALDAAEVLDAWNAEHRLEKALRSFGAITDRSRALSELSIG
QRYRVRLACLIGGDADILLLDEPTNHLDRGALNYLTEAITSHKGVVLVVSHDQALIKDVADIIIDIDSTPDGLPRIYHEG
FDSYRRQRSALLETWRQDYAATQTAQQQLQEDLEHARQRVNSSWKPPKGTGKHTRASRAPGVVQALKRAQDALDSKALDV
PSAPAPLLLPTLKVRPDKPMVDFSDLFVPHRLRLPGSHSVLSGDKIVITGDNGAGKSTLIEVLSGALTPASGSVENHART
GVLGQESHVGEVPSIARDHAVKWGLLSVEESRFALQEFSIGQRRRLDLAMSLAGNPELLLLDEPSNHLSMHLVSALTEWL
DKTTAAVIMVTHDRQLLRDTAHWRHIELKS
>Mature_509_residues
AKTHIRLQDLSLSYTSTPLITKLNITVSSGQCAVIVGENGRGKTTLLRALAREFPPSAGEILTHGTVAIAHQHMPAGDLS
VGEICDEAIRDSKNALEELERAGALLETNTAHALDGYQQALDAAEVLDAWNAEHRLEKALRSFGAITDRSRALSELSIGQ
RYRVRLACLIGGDADILLLDEPTNHLDRGALNYLTEAITSHKGVVLVVSHDQALIKDVADIIIDIDSTPDGLPRIYHEGF
DSYRRQRSALLETWRQDYAATQTAQQQLQEDLEHARQRVNSSWKPPKGTGKHTRASRAPGVVQALKRAQDALDSKALDVP
SAPAPLLLPTLKVRPDKPMVDFSDLFVPHRLRLPGSHSVLSGDKIVITGDNGAGKSTLIEVLSGALTPASGSVENHARTG
VLGQESHVGEVPSIARDHAVKWGLLSVEESRFALQEFSIGQRRRLDLAMSLAGNPELLLLDEPSNHLSMHLVSALTEWLD
KTTAAVIMVTHDRQLLRDTAHWRHIELKS

Specific function: Responsible for tylosin resistance, and is proposed to be a subunit of a multicomponent export system for the energy- dependent efflux of tylosin [H]

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI148612853, Length=533, Percent_Identity=27.2045028142589, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI27881506, Length=531, Percent_Identity=25.6120527306968, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI10947137, Length=531, Percent_Identity=25.6120527306968, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI10947135, Length=537, Percent_Identity=27.9329608938547, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI69354671, Length=537, Percent_Identity=27.9329608938547, Blast_Score=122, Evalue=8e-28,
Organism=Escherichia coli, GI1789751, Length=509, Percent_Identity=30.6483300589391, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1787041, Length=518, Percent_Identity=25.2895752895753, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1787182, Length=529, Percent_Identity=26.4650283553875, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI2367384, Length=513, Percent_Identity=26.5107212475634, Blast_Score=125, Evalue=9e-30,
Organism=Escherichia coli, GI1790534, Length=231, Percent_Identity=31.6017316017316, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790525, Length=225, Percent_Identity=24, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786253, Length=244, Percent_Identity=28.6885245901639, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555318, Length=522, Percent_Identity=24.7126436781609, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17559834, Length=523, Percent_Identity=25.6214149139579, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17553372, Length=521, Percent_Identity=24.7600767754319, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320874, Length=537, Percent_Identity=26.6294227188082, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321121, Length=520, Percent_Identity=27.1153846153846, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24641342, Length=537, Percent_Identity=27.3743016759777, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24666836, Length=527, Percent_Identity=25.9962049335863, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24642252, Length=534, Percent_Identity=25.8426966292135, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI18859989, Length=534, Percent_Identity=25.8426966292135, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 55684; Mature: 55553

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTHIRLQDLSLSYTSTPLITKLNITVSSGQCAVIVGENGRGKTTLLRALAREFPPSAG
CCCCEEEEEECEEEECCCCEEEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCC
EILTHGTVAIAHQHMPAGDLSVGEICDEAIRDSKNALEELERAGALLETNTAHALDGYQQ
CCEECCEEEEEECCCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCCEEECCCHHHHHHHHH
ALDAAEVLDAWNAEHRLEKALRSFGAITDRSRALSELSIGQRYRVRLACLIGGDADILLL
HHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCCEEEE
DEPTNHLDRGALNYLTEAITSHKGVVLVVSHDQALIKDVADIIIDIDSTPDGLPRIYHEG
ECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHEEECCCCCCCHHHHHHHH
FDSYRRQRSALLETWRQDYAATQTAQQQLQEDLEHARQRVNSSWKPPKGTGKHTRASRAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GVVQALKRAQDALDSKALDVPSAPAPLLLPTLKVRPDKPMVDFSDLFVPHRLRLPGSHSV
HHHHHHHHHHHHHHHCCCCCCCCCCCCEECCEEECCCCCCCCHHHCCCCCEEECCCCCCE
LSGDKIVITGDNGAGKSTLIEVLSGALTPASGSVENHARTGVLGQESHVGEVPSIARDHA
ECCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHH
VKWGLLSVEESRFALQEFSIGQRRRLDLAMSLAGNPELLLLDEPSNHLSMHLVSALTEWL
HCCCEEEEHHHHHHHHHHCCCCHHHHHHHEEECCCCCEEEEECCCCHHHHHHHHHHHHHH
DKTTAAVIMVTHDRQLLRDTAHWRHIELKS
HCCCEEEEEEECCHHHHHHHHHCCEEEECC
>Mature Secondary Structure 
AKTHIRLQDLSLSYTSTPLITKLNITVSSGQCAVIVGENGRGKTTLLRALAREFPPSAG
CCCEEEEEECEEEECCCCEEEEEEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCC
EILTHGTVAIAHQHMPAGDLSVGEICDEAIRDSKNALEELERAGALLETNTAHALDGYQQ
CCEECCEEEEEECCCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCCEEECCCHHHHHHHHH
ALDAAEVLDAWNAEHRLEKALRSFGAITDRSRALSELSIGQRYRVRLACLIGGDADILLL
HHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCCEEEE
DEPTNHLDRGALNYLTEAITSHKGVVLVVSHDQALIKDVADIIIDIDSTPDGLPRIYHEG
ECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHEEECCCCCCCHHHHHHHH
FDSYRRQRSALLETWRQDYAATQTAQQQLQEDLEHARQRVNSSWKPPKGTGKHTRASRAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GVVQALKRAQDALDSKALDVPSAPAPLLLPTLKVRPDKPMVDFSDLFVPHRLRLPGSHSV
HHHHHHHHHHHHHHHCCCCCCCCCCCCEECCEEECCCCCCCCHHHCCCCCEEECCCCCCE
LSGDKIVITGDNGAGKSTLIEVLSGALTPASGSVENHARTGVLGQESHVGEVPSIARDHA
ECCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHH
VKWGLLSVEESRFALQEFSIGQRRRLDLAMSLAGNPELLLLDEPSNHLSMHLVSALTEWL
HCCCEEEEHHHHHHHHHHCCCCHHHHHHHEEECCCCCEEEEECCCCHHHHHHHHHHHHHH
DKTTAAVIMVTHDRQLLRDTAHWRHIELKS
HCCCEEEEEEECCHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1864505 [H]