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The map label for this gene is argD [H]

Identifier: 145295532

GI number: 145295532

Start: 1613309

End: 1614484

Strand: Direct

Name: argD [H]

Synonym: cgR_1460

Alternate gene names: 145295532

Gene position: 1613309-1614484 (Clockwise)

Preceding gene: 145295531

Following gene: 145295533

Centisome position: 48.68

GC content: 57.31

Gene sequence:

>1176_bases
ATGAGCACGCTGGAAACTTGGCCACAGGTCATTATTAATACGTACGGCACCCCTCCAGTTGAGCTGGTGTCCGGCAAGGG
CGCAACCGTCACTGATGACCAGGGCAATGTCTACATCGACTTGCTCGCGGGCATCGCAGTCAACGCGTTGGGCCATGCCC
ACCCGGCGATCATCGAGGCGGTCACCAACCAGATCGGCCAACTTGGTCACGTCTCGAACTTGTTCGCATCCAGGCCCGTC
GTCGAGGTCGCCGAGGAGCTCATCAAGCGTTTTTCGCTTGACGACGCCACCCTCGCCGCGCAAACCCGGGTTTTCTTCTG
CAACTCGGGTGCCGAAGCAAACGAGGCTGCTTTCAAGATTGCACGCTTGACTGGTCGTTCCCGGATTCTGGCTGCAGTTC
ATGGTTTCCACGGCCGCACCATGGGTTCCCTCGCGCTGACTGGCCAGCCAGACAAACGTGAAGCGTTCCTGCCAATGCCA
AGCGGTGTGGAGTTCTACCCTTACGGCGACACCGATTACTTGCGCAAAATGGTAGAAACCAACCCAACGGATGTGGCTGC
TATCTTCCTCGAGCCAATCCAGGGTGAAACGGGCGTTGTTCCAGCACCTGAAGGATTCCTCAAGGAAGTGCGCGAGCTGT
GCGATGAGTACGGCATCTTGATGATCACCGATGAAGTCCAGACTGGCGTTGGCCGTACCGGCGATTTCTTTGCACATCAG
CACGATGGCGTTGTTCCCGATGTGGTGACCATGGCCAAGGGACTTGGTGGCGGTCTTCCCATCGGTGCTTGTTTGGCCAC
TGGCCGTGCAGCTGAATTGATGACCCCAGGCAAGCACGGCACCACTTTCGGTGGCAACCCAGTTGCTTGTGCAGCTGCCA
AGGCAGTGCTGTCTGTTGTCGATGACGCTTTCTGCGCAGAAGTTGCCCGCAAGGGCGAGCTGTTCAAGGAACTTCTTGCC
AAGGTTGACGGCGTTGTAGACGTCCGTGGCAGGGGCTTGATGTTGGGCGTGGTGCTGGAGCGCGACGTCGCAAAGCAAGC
TGTTCTTGATGGTTTTAAGCACGGCGTTATTTTGAATGCACCGGCGGACAACATTATCCGTTTGACGCCGCCGCTGGTGA
TCACCGACGAAGAAATCGCAGACGCAGTCAAGGCTATTGCCGAGACAATCGCATAA

Upstream 100 bases:

>100_bases
GGGTGGAATTGGCACGATGGTGCTGCCGGATGTTTTTGATCGGGAGAATTATCCTGAAGGCACCGTTTTTAGAAAAGACG
ACAAGGATGGGGAACTGTAA

Downstream 100 bases:

>100_bases
AGGACTTAAACTTATGACTTCACAACCACAGGTTCGCCATTTCCTGGCTGATGATGATCTCACCCCTGCAGAGCAGGCTG
AGGTTTTGACCCTGGCCGCA

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSTLETWPQVIINTYGTPPVELVSGKGATVTDDQGNVYIDLLAGIAVNALGHAHPAIIEAVTNQIGQLGHVSNLFASRPV
VEVAEELIKRFSLDDATLAAQTRVFFCNSGAEANEAAFKIARLTGRSRILAAVHGFHGRTMGSLALTGQPDKREAFLPMP
SGVEFYPYGDTDYLRKMVETNPTDVAAIFLEPIQGETGVVPAPEGFLKEVRELCDEYGILMITDEVQTGVGRTGDFFAHQ
HDGVVPDVVTMAKGLGGGLPIGACLATGRAAELMTPGKHGTTFGGNPVACAAAKAVLSVVDDAFCAEVARKGELFKELLA
KVDGVVDVRGRGLMLGVVLERDVAKQAVLDGFKHGVILNAPADNIIRLTPPLVITDEEIADAVKAIAETIA

Sequences:

>Translated_391_residues
MSTLETWPQVIINTYGTPPVELVSGKGATVTDDQGNVYIDLLAGIAVNALGHAHPAIIEAVTNQIGQLGHVSNLFASRPV
VEVAEELIKRFSLDDATLAAQTRVFFCNSGAEANEAAFKIARLTGRSRILAAVHGFHGRTMGSLALTGQPDKREAFLPMP
SGVEFYPYGDTDYLRKMVETNPTDVAAIFLEPIQGETGVVPAPEGFLKEVRELCDEYGILMITDEVQTGVGRTGDFFAHQ
HDGVVPDVVTMAKGLGGGLPIGACLATGRAAELMTPGKHGTTFGGNPVACAAAKAVLSVVDDAFCAEVARKGELFKELLA
KVDGVVDVRGRGLMLGVVLERDVAKQAVLDGFKHGVILNAPADNIIRLTPPLVITDEEIADAVKAIAETIA
>Mature_390_residues
STLETWPQVIINTYGTPPVELVSGKGATVTDDQGNVYIDLLAGIAVNALGHAHPAIIEAVTNQIGQLGHVSNLFASRPVV
EVAEELIKRFSLDDATLAAQTRVFFCNSGAEANEAAFKIARLTGRSRILAAVHGFHGRTMGSLALTGQPDKREAFLPMPS
GVEFYPYGDTDYLRKMVETNPTDVAAIFLEPIQGETGVVPAPEGFLKEVRELCDEYGILMITDEVQTGVGRTGDFFAHQH
DGVVPDVVTMAKGLGGGLPIGACLATGRAAELMTPGKHGTTFGGNPVACAAAKAVLSVVDDAFCAEVARKGELFKELLAK
VDGVVDVRGRGLMLGVVLERDVAKQAVLDGFKHGVILNAPADNIIRLTPPLVITDEEIADAVKAIAETIA

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=394, Percent_Identity=35.2791878172589, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI284507298, Length=299, Percent_Identity=37.123745819398, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI13994255, Length=437, Percent_Identity=32.0366132723112, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI37574042, Length=406, Percent_Identity=28.5714285714286, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI24119277, Length=402, Percent_Identity=30.5970149253731, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI226442709, Length=371, Percent_Identity=29.3800539083558, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI226442705, Length=406, Percent_Identity=27.8325123152709, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1788044, Length=400, Percent_Identity=41.75, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1789759, Length=404, Percent_Identity=38.1188118811881, Blast_Score=274, Evalue=9e-75,
Organism=Escherichia coli, GI145693181, Length=402, Percent_Identity=37.5621890547264, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1787560, Length=401, Percent_Identity=35.1620947630923, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1789016, Length=403, Percent_Identity=33.9950372208437, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=29.3556085918854, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786349, Length=320, Percent_Identity=32.5, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=392, Percent_Identity=33.9285714285714, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=31.6397228637413, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI25144274, Length=267, Percent_Identity=35.9550561797753, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=428, Percent_Identity=30.8411214953271, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17541228, Length=421, Percent_Identity=25.8907363420428, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71981843, Length=180, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324432, Length=396, Percent_Identity=34.3434343434343, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6323470, Length=419, Percent_Identity=35.5608591885441, Blast_Score=219, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6324386, Length=418, Percent_Identity=26.3157894736842, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6321456, Length=427, Percent_Identity=26.463700234192, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21357415, Length=392, Percent_Identity=35.7142857142857, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=32.7146171693735, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI161085790, Length=431, Percent_Identity=32.0185614849188, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21356575, Length=407, Percent_Identity=29.4840294840295, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI281366494, Length=416, Percent_Identity=25.2403846153846, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667139, Length=416, Percent_Identity=25.2403846153846, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667143, Length=416, Percent_Identity=25.2403846153846, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 41265; Mature: 41134

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLETWPQVIINTYGTPPVELVSGKGATVTDDQGNVYIDLLAGIAVNALGHAHPAIIEA
CCCHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCEEEEEHHHHHHHHHCCCCHHHHHH
VTNQIGQLGHVSNLFASRPVVEVAEELIKRFSLDDATLAAQTRVFFCNSGAEANEAAFKI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHEEEEEEEECCCCCCHHHHHHH
ARLTGRSRILAAVHGFHGRTMGSLALTGQPDKREAFLPMPSGVEFYPYGDTDYLRKMVET
HHHCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCEECCCCCCCEEEECCCHHHHHHHHHC
NPTDVAAIFLEPIQGETGVVPAPEGFLKEVRELCDEYGILMITDEVQTGVGRTGDFFAHQ
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHCCCCCCCHHHCC
HDGVVPDVVTMAKGLGGGLPIGACLATGRAAELMTPGKHGTTFGGNPVACAAAKAVLSVV
CCCCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
DDAFCAEVARKGELFKELLAKVDGVVDVRGRGLMLGVVLERDVAKQAVLDGFKHGVILNA
HHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEC
PADNIIRLTPPLVITDEEIADAVKAIAETIA
CCCCEEEECCCEEEECHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STLETWPQVIINTYGTPPVELVSGKGATVTDDQGNVYIDLLAGIAVNALGHAHPAIIEA
CCHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCEEEEEHHHHHHHHHCCCCHHHHHH
VTNQIGQLGHVSNLFASRPVVEVAEELIKRFSLDDATLAAQTRVFFCNSGAEANEAAFKI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHEEEEEEEECCCCCCHHHHHHH
ARLTGRSRILAAVHGFHGRTMGSLALTGQPDKREAFLPMPSGVEFYPYGDTDYLRKMVET
HHHCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCEECCCCCCCEEEECCCHHHHHHHHHC
NPTDVAAIFLEPIQGETGVVPAPEGFLKEVRELCDEYGILMITDEVQTGVGRTGDFFAHQ
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHCCCCCCCHHHCC
HDGVVPDVVTMAKGLGGGLPIGACLATGRAAELMTPGKHGTTFGGNPVACAAAKAVLSVV
CCCCCHHHHHHHHHCCCCCCHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
DDAFCAEVARKGELFKELLAKVDGVVDVRGRGLMLGVVLERDVAKQAVLDGFKHGVILNA
HHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEC
PADNIIRLTPPLVITDEEIADAVKAIAETIA
CCCCEEEECCCEEEECHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8581175; 12948626 [H]