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The map label for this gene is uvrB [H]

Identifier: 145295505

GI number: 145295505

Start: 1577910

End: 1580072

Strand: Direct

Name: uvrB [H]

Synonym: cgR_1433

Alternate gene names: 145295505

Gene position: 1577910-1580072 (Clockwise)

Preceding gene: 145295499

Following gene: 145295506

Centisome position: 47.61

GC content: 53.68

Gene sequence:

>2163_bases
TTGCTTGCACGCTGTTTTGCTGCGGGCCACAACGTGTCCACCCTGTGGCGTATCCTAGAATGCATGGCTTTTGCTGCTGA
ACATCCTGTCCTGTCCCACTCTGAGCATCGCCCGGTTGGTGAAATCGAGCGTAGCGATGACAAATTTGTTGTCGTTAGTG
AATTTGAGCCTGCGGGTGACCAGCCTGCGGCTATTAAAGAGCTCGATGAGCGCTTAGATCGCGGTGAGCGGGACGTCGTT
TTGATGGGTGCTACCGGTACGGGTAAGTCCGCAACGGCGGCGTGGTTGATCGAAAAGCAGCAGCGCCCCACTTTGGTTAT
GGCTCCGAATAAGACGCTGGCTGCGCAGTTGGCTAATGAATTGCGGCAGCTGTTGCCCAATAACGCGGTGGAGTATTTCG
TGTCGTATTACGATTACTACCAGCCAGAAGCGTATATCGCGCAGACTGATACCTATATTGAAAAGGACTCCTCGATTAAT
GAGGATGTGGAGCGTCTGCGTCACTCGGCGACGTCGTCTTTGCTGAGTAGGCGAGACGTCGTGGTTGTTAGTTCGGTGTC
GTGTATTTATGGCTTGGGCACTCCACAGTCTTATCTTGACCGTTCCGTTGTGTTGAACGTGGGGGAGGAGATCGACCGCG
ATCGCTTTTTGCGCCTGCTGGTAGATATTCAATACGAACGCAATGATGTGGGCTTTACTCGTGGTGCTTTCCGCGTGAAA
GGCGATACCGTGGACATCATCCCGGCCTATGAGGAATTGGCGGTGCGCATTGAGTTTTTCGGTGATGAAATTGATGCGTT
GTACTACATCCACCCCCTGACTGGTGACACTATCCGGCAGGTGAATGAGATCCGTATTTTCCCAGCTACGCACTATGTTG
CGGGACCTGAGCGGATGGAAAAGGCAGTCACTGATATTAAGGCGGAGTTGGAAGTGCGCCTGGCTGATTTGGAGAACCGC
GGCAAGTTATTGGAAGCGCAGCGTCTTCGGATGCGTACTGAATATGACTTAGAAATGATCGAGCAGGTTGGTTTCTGTTC
GGGCATTGAGAACTATTCTCGCCACATTGATGGACGTGGGGAGGGAACCGCACCGGCCACGCTGATTGACTATTTCCCAG
AGGATTTCCTCACCATCATCGATGAGTCTCACGTGACTGTCCCGCAGATCGGCGGCATGTTTGAGGGCGATATGTCCCGA
AAGCGTAACCTCGTAGAATTCGGTTTCCGCCTGCCATCTGCAATGGATAACCGCCCATTGACCTGGGAGGAGTTTGATGA
ACGCCGTGGCCAAACGGTGTTTATGTCTGCAACTCCAGGCAAGTTTGAGATCGCCGCTGCCGATGGTGAGTTTGTGGAGC
AGGTCATTCGCCCAACAGGTCTGGTGGATCCAAAGGTCACCGTCAAGCCAACGAAGGGGCAGATCGATGATCTAATCCAT
GAGATTCGCCAACGCACCGATAAAGATGAGCGCGTTTTGGTCACCACGTTGACTAAGAAAATGGCCGAGGATCTTACTGA
CTACTTGTTGGAAAACGGCATCCGCGTGCGCTACCTGCACTCAGATATTGATACCTTGCAGCGTGTGGAATTGCTGCGTC
AGCTTCGCCTGGGCGAATACGATGTGTTGGTAGGTATTAACCTGCTGCGTGAGGGTCTTGACCTGCCAGAAGTCTCTCTG
GTTGCGATTCTCGACGCCGACAAGGAAGGCTTCCTGCGCTCCACCACCTCACTGATTCAGACCATTGGCCGCGCCGCCCG
AAATGTGTCCGGCGAGGTCATCATGTACGCCGACAAGATCACTGATTCGATGCAGTATGCCATCGAGGAAACCGATCGAC
GCCGTGAAAAGCAGGTCGCTTATAACAAGGAACACGGCATCGATCCGCAGCCGCTTCGAAAGAAAATCGCGGACATCCTC
GACCAGGTCTATGACAATTCCGCTGATGGAGCAGGACCTTCTGCCTCTGGCGATGCGGCAGTCGTGGCTAAACCTGACGT
GTCTAGCATGCCCGCCAAAGAAGTGCAAAAGCTTATCGACGACCTCAGCGCTCAGATGGCTGCGGCCGCGCGGGAGCTCA
AGTTCGAGCTGGCAGGGCGTCTGCGAGATGAGATCTTCGAGCTCAAGAAGGAACTGAGAGGTATCAAGGATGCCGGCATC
TAA

Upstream 100 bases:

>100_bases
GTTGCATCGAGTCCGAGGGTTTCGCACGCTTGATCTAAATTCTTGAGGGTTTTCCGGCCGTTGTTTGCGCTAAACGTAGG
GGGCAAGCGTCGAAAAGCGC

Downstream 100 bases:

>100_bases
GTCAGCTTGCTCACTTAAAGCTTCGAAATAAGCCCTTAAGTTCTCATTCTTTTGTTAGACTTGTTCACTAATTACAGACA
TCCAGGGGCTTAGATTTTTA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 720; Mature: 720

Protein sequence:

>720_residues
MLARCFAAGHNVSTLWRILECMAFAAEHPVLSHSEHRPVGEIERSDDKFVVVSEFEPAGDQPAAIKELDERLDRGERDVV
LMGATGTGKSATAAWLIEKQQRPTLVMAPNKTLAAQLANELRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSIN
EDVERLRHSATSSLLSRRDVVVVSSVSCIYGLGTPQSYLDRSVVLNVGEEIDRDRFLRLLVDIQYERNDVGFTRGAFRVK
GDTVDIIPAYEELAVRIEFFGDEIDALYYIHPLTGDTIRQVNEIRIFPATHYVAGPERMEKAVTDIKAELEVRLADLENR
GKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHIDGRGEGTAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSR
KRNLVEFGFRLPSAMDNRPLTWEEFDERRGQTVFMSATPGKFEIAAADGEFVEQVIRPTGLVDPKVTVKPTKGQIDDLIH
EIRQRTDKDERVLVTTLTKKMAEDLTDYLLENGIRVRYLHSDIDTLQRVELLRQLRLGEYDVLVGINLLREGLDLPEVSL
VAILDADKEGFLRSTTSLIQTIGRAARNVSGEVIMYADKITDSMQYAIEETDRRREKQVAYNKEHGIDPQPLRKKIADIL
DQVYDNSADGAGPSASGDAAVVAKPDVSSMPAKEVQKLIDDLSAQMAAAARELKFELAGRLRDEIFELKKELRGIKDAGI

Sequences:

>Translated_720_residues
MLARCFAAGHNVSTLWRILECMAFAAEHPVLSHSEHRPVGEIERSDDKFVVVSEFEPAGDQPAAIKELDERLDRGERDVV
LMGATGTGKSATAAWLIEKQQRPTLVMAPNKTLAAQLANELRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSIN
EDVERLRHSATSSLLSRRDVVVVSSVSCIYGLGTPQSYLDRSVVLNVGEEIDRDRFLRLLVDIQYERNDVGFTRGAFRVK
GDTVDIIPAYEELAVRIEFFGDEIDALYYIHPLTGDTIRQVNEIRIFPATHYVAGPERMEKAVTDIKAELEVRLADLENR
GKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHIDGRGEGTAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSR
KRNLVEFGFRLPSAMDNRPLTWEEFDERRGQTVFMSATPGKFEIAAADGEFVEQVIRPTGLVDPKVTVKPTKGQIDDLIH
EIRQRTDKDERVLVTTLTKKMAEDLTDYLLENGIRVRYLHSDIDTLQRVELLRQLRLGEYDVLVGINLLREGLDLPEVSL
VAILDADKEGFLRSTTSLIQTIGRAARNVSGEVIMYADKITDSMQYAIEETDRRREKQVAYNKEHGIDPQPLRKKIADIL
DQVYDNSADGAGPSASGDAAVVAKPDVSSMPAKEVQKLIDDLSAQMAAAARELKFELAGRLRDEIFELKKELRGIKDAGI
>Mature_720_residues
MLARCFAAGHNVSTLWRILECMAFAAEHPVLSHSEHRPVGEIERSDDKFVVVSEFEPAGDQPAAIKELDERLDRGERDVV
LMGATGTGKSATAAWLIEKQQRPTLVMAPNKTLAAQLANELRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSIN
EDVERLRHSATSSLLSRRDVVVVSSVSCIYGLGTPQSYLDRSVVLNVGEEIDRDRFLRLLVDIQYERNDVGFTRGAFRVK
GDTVDIIPAYEELAVRIEFFGDEIDALYYIHPLTGDTIRQVNEIRIFPATHYVAGPERMEKAVTDIKAELEVRLADLENR
GKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHIDGRGEGTAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSR
KRNLVEFGFRLPSAMDNRPLTWEEFDERRGQTVFMSATPGKFEIAAADGEFVEQVIRPTGLVDPKVTVKPTKGQIDDLIH
EIRQRTDKDERVLVTTLTKKMAEDLTDYLLENGIRVRYLHSDIDTLQRVELLRQLRLGEYDVLVGINLLREGLDLPEVSL
VAILDADKEGFLRSTTSLIQTIGRAARNVSGEVIMYADKITDSMQYAIEETDRRREKQVAYNKEHGIDPQPLRKKIADIL
DQVYDNSADGAGPSASGDAAVVAKPDVSSMPAKEVQKLIDDLSAQMAAAARELKFELAGRLRDEIFELKKELRGIKDAGI

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=668, Percent_Identity=56.437125748503, Blast_Score=737, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=212, Percent_Identity=23.5849056603774, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 81091; Mature: 81091

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLARCFAAGHNVSTLWRILECMAFAAEHPVLSHSEHRPVGEIERSDDKFVVVSEFEPAGD
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
QPAAIKELDERLDRGERDVVLMGATGTGKSATAAWLIEKQQRPTLVMAPNKTLAAQLANE
CCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHEEECCCCCEEEECCCHHHHHHHHHH
LRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINEDVERLRHSATSSLLSRRDV
HHHHCCCHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
VVVSSVSCIYGLGTPQSYLDRSVVLNVGEEIDRDRFLRLLVDIQYERNDVGFTRGAFRVK
EEEECCHHHEECCCCHHHHCHHHHHHCHHHCCHHHHHHHHHHEEECCCCCCCCCCEEEEC
GDTVDIIPAYEELAVRIEFFGDEIDALYYIHPLTGDTIRQVNEIRIFPATHYVAGPERME
CCEEEEEECHHHHEEEEEEECCCCCEEEEEECCCCHHHHHHHHEEEEECCCCCCCHHHHH
KAVTDIKAELEVRLADLENRGKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHIDGRG
HHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCC
EGTAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSRKRNLVEFGFRLPSAMDNRPL
CCCCCHHHHHHCCHHHHHHHCCCCCCHHCCCCCCCCCHHHHCHHHHHHHHCCCCCCCCCC
TWEEFDERRGQTVFMSATPGKFEIAAADGEFVEQVIRPTGLVDPKVTVKPTKGQIDDLIH
CHHHHHHHCCCEEEEECCCCCEEEEECCHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHH
EIRQRTDKDERVLVTTLTKKMAEDLTDYLLENGIRVRYLHSDIDTLQRVELLRQLRLGEY
HHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCC
DVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTTSLIQTIGRAARNVSGEVIMYADKI
HHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
TDSMQYAIEETDRRREKQVAYNKEHGIDPQPLRKKIADILDQVYDNSADGAGPSASGDAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
VVAKPDVSSMPAKEVQKLIDDLSAQMAAAARELKFELAGRLRDEIFELKKELRGIKDAGI
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLARCFAAGHNVSTLWRILECMAFAAEHPVLSHSEHRPVGEIERSDDKFVVVSEFEPAGD
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
QPAAIKELDERLDRGERDVVLMGATGTGKSATAAWLIEKQQRPTLVMAPNKTLAAQLANE
CCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHEEECCCCCEEEECCCHHHHHHHHHH
LRQLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINEDVERLRHSATSSLLSRRDV
HHHHCCCHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
VVVSSVSCIYGLGTPQSYLDRSVVLNVGEEIDRDRFLRLLVDIQYERNDVGFTRGAFRVK
EEEECCHHHEECCCCHHHHCHHHHHHCHHHCCHHHHHHHHHHEEECCCCCCCCCCEEEEC
GDTVDIIPAYEELAVRIEFFGDEIDALYYIHPLTGDTIRQVNEIRIFPATHYVAGPERME
CCEEEEEECHHHHEEEEEEECCCCCEEEEEECCCCHHHHHHHHEEEEECCCCCCCHHHHH
KAVTDIKAELEVRLADLENRGKLLEAQRLRMRTEYDLEMIEQVGFCSGIENYSRHIDGRG
HHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCC
EGTAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSRKRNLVEFGFRLPSAMDNRPL
CCCCCHHHHHHCCHHHHHHHCCCCCCHHCCCCCCCCCHHHHCHHHHHHHHCCCCCCCCCC
TWEEFDERRGQTVFMSATPGKFEIAAADGEFVEQVIRPTGLVDPKVTVKPTKGQIDDLIH
CHHHHHHHCCCEEEEECCCCCEEEEECCHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHH
EIRQRTDKDERVLVTTLTKKMAEDLTDYLLENGIRVRYLHSDIDTLQRVELLRQLRLGEY
HHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCC
DVLVGINLLREGLDLPEVSLVAILDADKEGFLRSTTSLIQTIGRAARNVSGEVIMYADKI
HHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
TDSMQYAIEETDRRREKQVAYNKEHGIDPQPLRKKIADILDQVYDNSADGAGPSASGDAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
VVAKPDVSSMPAKEVQKLIDDLSAQMAAAARELKFELAGRLRDEIFELKKELRGIKDAGI
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910 [H]