Click here to switch to the map view.

The map label for this gene is ilvC

Identifier: 145295412

GI number: 145295412

Start: 1483488

End: 1484504

Strand: Direct

Name: ilvC

Synonym: cgR_1349

Alternate gene names: 145295412

Gene position: 1483488-1484504 (Clockwise)

Preceding gene: 145295411

Following gene: 145295414

Centisome position: 44.76

GC content: 58.21

Gene sequence:

>1017_bases
ATGGCTATTGAACTGCTTTATGATGCTGACGCTGACCTCTCCTTGATCCAGGGCCGTAAGGTTGCCATCGTTGGCTACGG
CTCCCAGGGCCACGCACACTCCCAGAACCTCCGCGATTCTGGCGTTGAGGTTGTCATTGGTCTGCGCGAGGGCTCCAAGT
CCGCAGAGAAGGCAAAGGAAGCAGGCTTCGAAGTCAAGACCACCGCTGAGGCTGCAGCTTGGGCTGACGTCATCATGCTC
CTGGCTCCAGACACCTCCCAGGCAGAAATCTTCACCAACGACATCGAGCCAAACCTGAACGCAGGCGACGCACTGCTGTT
CGGCCACGGCCTGAACATTCACTTCGACCTGATCAAGCCAGCTGACGACATCATCGTTGGCATGGTTGCGCCAAAGGGCC
CAGGCCACTTGGTTCGCCGTCAGTTCGTTGATGGCAAGGGTGTTCCTTGCCTCATCGCAGTCGACCAGGACCCAACCGGA
ACCGCACAGGCTCTGACCCTGTCCTACGCAGCAGCAATCGGTGGCGCACGCGCAGGCGTTATCCCAACCACCTTCGAAGC
TGAGACCGTCACCGACCTCTTCGGCGAGCAGGCTGTTCTCTGCGGTGGCACCGAGGAACTGGTCAAGGTTGGCTTCGAGG
TTCTCACCGAAGCTGGCTACGAGCCAGAGATGGCATACTTCGAGGTTCTTCACGAGCTCAAGCTCATCGTTGACCTCATG
TTCGAAGGTGGCATCAGCAACATGAACTACTCTGTTTCTGACACCGCTGAGTTCGGTGGCTACCTCTCCGGCCCACGCGT
CATCGATGCAGACACCAAGTCCCGCATGAAGGACATCCTGACCGATATCCAGGACGGCACCTTCACCAAGCGCCTCATCG
CAAACGTTGAGAACGGCAACACCGAGCTTGAGGGTCTTCGTGCTTCCTACAACAACCACCCAATCGAGGAGACCGGCGCT
AAGCTCCGCGACCTCATGAGCTGGGTCAAGGTTGACGCTCGCGCAGAAACCGCTTAA

Upstream 100 bases:

>100_bases
ATAATGTAGTTGTCTGCCCAACCGAGTGACACTCCCACGATTTACAGTGGGGGCAGACATCTTTTCACCAAAATTTTTAC
GAAAGGCGAGATTTTCTCCC

Downstream 100 bases:

>100_bases
GTTTCACCCCTTTGACGGCTTAACCGCCGCATAGGAAATGCCCTCCGGACTAATTGTCTGGAGGGCATTTTTGCTACCTG
CTGTGCACTTTGTACATAAG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MAIELLYDADADLSLIQGRKVAIVGYGSQGHAHSQNLRDSGVEVVIGLREGSKSAEKAKEAGFEVKTTAEAAAWADVIML
LAPDTSQAEIFTNDIEPNLNAGDALLFGHGLNIHFDLIKPADDIIVGMVAPKGPGHLVRRQFVDGKGVPCLIAVDQDPTG
TAQALTLSYAAAIGGARAGVIPTTFEAETVTDLFGEQAVLCGGTEELVKVGFEVLTEAGYEPEMAYFEVLHELKLIVDLM
FEGGISNMNYSVSDTAEFGGYLSGPRVIDADTKSRMKDILTDIQDGTFTKRLIANVENGNTELEGLRASYNNHPIEETGA
KLRDLMSWVKVDARAETA

Sequences:

>Translated_338_residues
MAIELLYDADADLSLIQGRKVAIVGYGSQGHAHSQNLRDSGVEVVIGLREGSKSAEKAKEAGFEVKTTAEAAAWADVIML
LAPDTSQAEIFTNDIEPNLNAGDALLFGHGLNIHFDLIKPADDIIVGMVAPKGPGHLVRRQFVDGKGVPCLIAVDQDPTG
TAQALTLSYAAAIGGARAGVIPTTFEAETVTDLFGEQAVLCGGTEELVKVGFEVLTEAGYEPEMAYFEVLHELKLIVDLM
FEGGISNMNYSVSDTAEFGGYLSGPRVIDADTKSRMKDILTDIQDGTFTKRLIANVENGNTELEGLRASYNNHPIEETGA
KLRDLMSWVKVDARAETA
>Mature_337_residues
AIELLYDADADLSLIQGRKVAIVGYGSQGHAHSQNLRDSGVEVVIGLREGSKSAEKAKEAGFEVKTTAEAAAWADVIMLL
APDTSQAEIFTNDIEPNLNAGDALLFGHGLNIHFDLIKPADDIIVGMVAPKGPGHLVRRQFVDGKGVPCLIAVDQDPTGT
AQALTLSYAAAIGGARAGVIPTTFEAETVTDLFGEQAVLCGGTEELVKVGFEVLTEAGYEPEMAYFEVLHELKLIVDLMF
EGGISNMNYSVSDTAEFGGYLSGPRVIDADTKSRMKDILTDIQDGTFTKRLIANVENGNTELEGLRASYNNHPIEETGAK
LRDLMSWVKVDARAETA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=315, Percent_Identity=36.5079365079365, Blast_Score=152, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=300, Percent_Identity=32.6666666666667, Blast_Score=122, Evalue=6e-29,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_CORGB (A4QDN4)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138233.1
- ProteinModelPortal:   A4QDN4
- SMR:   A4QDN4
- STRING:   A4QDN4
- GeneID:   4992793
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1349
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36159; Mature: 36028

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: ACT_SITE 109-109

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIELLYDADADLSLIQGRKVAIVGYGSQGHAHSQNLRDSGVEVVIGLREGSKSAEKAKE
CEEEEEECCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
AGFEVKTTAEAAAWADVIMLLAPDTSQAEIFTNDIEPNLNAGDALLFGHGLNIHFDLIKP
CCCEEEEHHHHHHHHEEEEEECCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEEEECC
ADDIIVGMVAPKGPGHLVRRQFVDGKGVPCLIAVDQDPTGTAQALTLSYAAAIGGARAGV
CCCEEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
IPTTFEAETVTDLFGEQAVLCGGTEELVKVGFEVLTEAGYEPEMAYFEVLHELKLIVDLM
CCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FEGGISNMNYSVSDTAEFGGYLSGPRVIDADTKSRMKDILTDIQDGTFTKRLIANVENGN
HCCCCCCCCCCCCCHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
TELEGLRASYNNHPIEETGAKLRDLMSWVKVDARAETA
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AIELLYDADADLSLIQGRKVAIVGYGSQGHAHSQNLRDSGVEVVIGLREGSKSAEKAKE
EEEEEECCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
AGFEVKTTAEAAAWADVIMLLAPDTSQAEIFTNDIEPNLNAGDALLFGHGLNIHFDLIKP
CCCEEEEHHHHHHHHEEEEEECCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEEEECC
ADDIIVGMVAPKGPGHLVRRQFVDGKGVPCLIAVDQDPTGTAQALTLSYAAAIGGARAGV
CCCEEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
IPTTFEAETVTDLFGEQAVLCGGTEELVKVGFEVLTEAGYEPEMAYFEVLHELKLIVDLM
CCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
FEGGISNMNYSVSDTAEFGGYLSGPRVIDADTKSRMKDILTDIQDGTFTKRLIANVENGN
HCCCCCCCCCCCCCHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
TELEGLRASYNNHPIEETGAKLRDLMSWVKVDARAETA
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA