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The map label for this gene is iscS [H]

Identifier: 145295371

GI number: 145295371

Start: 1440042

End: 1441133

Strand: Direct

Name: iscS [H]

Synonym: cgR_1309

Alternate gene names: 145295371

Gene position: 1440042-1441133 (Clockwise)

Preceding gene: 145295370

Following gene: 145295375

Centisome position: 43.45

GC content: 60.35

Gene sequence:

>1092_bases
ATGCGTGAGGTGGCCGCAGCTGCGTGGATGGAAAACGCGCAGGCATTGAATCCCGCGAGTCAGTACGGTTCGGGGCGTAA
GGCGCGCAGCGTTGCGGATTCGGCTCGTGAAGAAATTGCTTCTTTGCTGGGCTGTGAACCCATCGAGGTTGTGTTTACCG
CGTCCGGCACGGAGGCAGATAACCTCGCTGTACAGGGGTTATTCCACGCATCGCCTCTCAATCGGATTATTTCTACGCCG
ATCGAGCACCCCGGGATTCTGGAAACCGTCAAGGCTCTAGAACTTGGCGGGGCAGAGGCGGAGCTCATGCCGATCGGTCC
AGATGGACGAGTGTCTTCCTTCGAAGCGCTGGACAAGCCTGCCGCGGTTGCCACTATGATGTGGGCGAACAATGAGACCG
GCGCGATTCAGCCGGTTTCTGAGTTCATCGCCGCCGCGCAGGCGTCCGGCACGCCAACACACATCGATGCGGTTCAGGTC
GTTGGCCATCTGCCGGTTAATTTTGATGAGCTCGGCGCCACCACATTGGCTGCCTCCGCGCACAAATTCGGTGGACCACG
TGGCGTCGGCCTGCTGTTGGCGAGGCGCTCGCCAGCACCTTCAGCCGTATTGCACGGAGGCGGTCAGGAGCGCGGCATCC
GTCCAGGCACCCTCGATGTCGCCGGCGCAGCTGCCACCGCAGCCGCATTACGCGAAGCAGTGGCCGAGCTTGACGGCGAA
GCCACCCGCCTGCGCGGACTTAAAAAGATGCTTCTCGACGCCATCCTCCACACCATCCCCAACGTACTGGTCCACACCAC
CGAACCATCCCTGCCAGGACATCTGCATCTCTCCTTCCCAGGAGCAGAAGGCGATAGTTTGATCATGCTGCTCGACTCCT
TGCGGATCGAAGCCTCCACAGGTTCGGCCTGCTCCAACGGTGTAAACCGTGCCAGCCACGTCCTTTTGGCCATGGGAATT
TCCGAAACCGACGCCCGTGGCGCCATCCGATTCACCCTCGGAAGAACCACCACTGAAGAATCCATCAAGGCAGTGATCGC
CGTGATCGAAGACGTAGTGACCAGGGCTCGTACTGCGGGAATGGCTTTTTAG

Upstream 100 bases:

>100_bases
GCGACCTCTTTGACATCGCCCCTGCGCTCATCGAAGAGATCAACAAGCGCAAGTAGGAGTTTTGAACACTTTTTATCTGG
ACCATGCAGCCACCACACCA

Downstream 100 bases:

>100_bases
CGACCGTAAATCGCATAGTGCAGTTCCGTTGCCAGCGGGCAGATCACCTGCTGGTGAGACAGCGGAACATTTTGGCAGTC
GCCAACAACGGGAGATCCCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MREVAAAAWMENAQALNPASQYGSGRKARSVADSAREEIASLLGCEPIEVVFTASGTEADNLAVQGLFHASPLNRIISTP
IEHPGILETVKALELGGAEAELMPIGPDGRVSSFEALDKPAAVATMMWANNETGAIQPVSEFIAAAQASGTPTHIDAVQV
VGHLPVNFDELGATTLAASAHKFGGPRGVGLLLARRSPAPSAVLHGGGQERGIRPGTLDVAGAAATAAALREAVAELDGE
ATRLRGLKKMLLDAILHTIPNVLVHTTEPSLPGHLHLSFPGAEGDSLIMLLDSLRIEASTGSACSNGVNRASHVLLAMGI
SETDARGAIRFTLGRTTTEESIKAVIAVIEDVVTRARTAGMAF

Sequences:

>Translated_363_residues
MREVAAAAWMENAQALNPASQYGSGRKARSVADSAREEIASLLGCEPIEVVFTASGTEADNLAVQGLFHASPLNRIISTP
IEHPGILETVKALELGGAEAELMPIGPDGRVSSFEALDKPAAVATMMWANNETGAIQPVSEFIAAAQASGTPTHIDAVQV
VGHLPVNFDELGATTLAASAHKFGGPRGVGLLLARRSPAPSAVLHGGGQERGIRPGTLDVAGAAATAAALREAVAELDGE
ATRLRGLKKMLLDAILHTIPNVLVHTTEPSLPGHLHLSFPGAEGDSLIMLLDSLRIEASTGSACSNGVNRASHVLLAMGI
SETDARGAIRFTLGRTTTEESIKAVIAVIEDVVTRARTAGMAF
>Mature_363_residues
MREVAAAAWMENAQALNPASQYGSGRKARSVADSAREEIASLLGCEPIEVVFTASGTEADNLAVQGLFHASPLNRIISTP
IEHPGILETVKALELGGAEAELMPIGPDGRVSSFEALDKPAAVATMMWANNETGAIQPVSEFIAAAQASGTPTHIDAVQV
VGHLPVNFDELGATTLAASAHKFGGPRGVGLLLARRSPAPSAVLHGGGQERGIRPGTLDVAGAAATAAALREAVAELDGE
ATRLRGLKKMLLDAILHTIPNVLVHTTEPSLPGHLHLSFPGAEGDSLIMLLDSLRIEASTGSACSNGVNRASHVLLAMGI
SETDARGAIRFTLGRTTTEESIKAVIAVIEDVVTRARTAGMAF

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=350, Percent_Identity=32.8571428571429, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI156713448, Length=383, Percent_Identity=29.242819843342, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI48994898, Length=349, Percent_Identity=37.5358166189112, Blast_Score=215, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI25143064, Length=351, Percent_Identity=33.048433048433, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17533177, Length=319, Percent_Identity=32.6018808777429, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6319831, Length=349, Percent_Identity=32.0916905444126, Blast_Score=183, Evalue=4e-47,
Organism=Drosophila melanogaster, GI20129463, Length=335, Percent_Identity=34.3283582089552, Blast_Score=191, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 37539; Mature: 37539

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVAAAAWMENAQALNPASQYGSGRKARSVADSAREEIASLLGCEPIEVVFTASGTEAD
CCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
NLAVQGLFHASPLNRIISTPIEHPGILETVKALELGGAEAELMPIGPDGRVSSFEALDKP
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCC
AAVATMMWANNETGAIQPVSEFIAAAQASGTPTHIDAVQVVGHLPVNFDELGATTLAASA
HHHEEEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHCCHHHHHHH
HKFGGPRGVGLLLARRSPAPSAVLHGGGQERGIRPGTLDVAGAAATAAALREAVAELDGE
HHCCCCCCCEEEEEECCCCCCHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCH
ATRLRGLKKMLLDAILHTIPNVLVHTTEPSLPGHLHLSFPGAEGDSLIMLLDSLRIEAST
HHHHHHHHHHHHHHHHHHHCHHEEECCCCCCCCEEEEECCCCCCCEEEEEEEHHEEECCC
GSACSNGVNRASHVLLAMGISETDARGAIRFTLGRTTTEESIKAVIAVIEDVVTRARTAG
CCHHHHHHHHHHHEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHC
MAF
CCC
>Mature Secondary Structure
MREVAAAAWMENAQALNPASQYGSGRKARSVADSAREEIASLLGCEPIEVVFTASGTEAD
CCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
NLAVQGLFHASPLNRIISTPIEHPGILETVKALELGGAEAELMPIGPDGRVSSFEALDKP
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHCCC
AAVATMMWANNETGAIQPVSEFIAAAQASGTPTHIDAVQVVGHLPVNFDELGATTLAASA
HHHEEEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHCCHHHHHHH
HKFGGPRGVGLLLARRSPAPSAVLHGGGQERGIRPGTLDVAGAAATAAALREAVAELDGE
HHCCCCCCCEEEEEECCCCCCHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCH
ATRLRGLKKMLLDAILHTIPNVLVHTTEPSLPGHLHLSFPGAEGDSLIMLLDSLRIEAST
HHHHHHHHHHHHHHHHHHHCHHEEECCCCCCCCEEEEECCCCCCCEEEEEEEHHEEECCC
GSACSNGVNRASHVLLAMGISETDARGAIRFTLGRTTTEESIKAVIAVIEDVVTRARTAG
CCHHHHHHHHHHHEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHC
MAF
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA