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The map label for this gene is hom

Identifier: 145295322

GI number: 145295322

Start: 1385272

End: 1386609

Strand: Direct

Name: hom

Synonym: cgR_1262

Alternate gene names: 145295322

Gene position: 1385272-1386609 (Clockwise)

Preceding gene: 145295320

Following gene: 145295323

Centisome position: 41.8

GC content: 55.46

Gene sequence:

>1338_bases
ATGACCTCAGCATCTGCCCCAAGCTTTAACCCCGGCAAGGGTCCCGGCTCAGCAGTCGGAATTGCCCTTTTAGGATTCGG
AACAGTCGGCACTGAGGTGATGCGCCTGATGACCGAGTACGGTGATGAACTTGCGCACCGCATTGGTGGCCCACTGGAGG
TTCGTGGCATTGCTGTTTCTGATATCTCAAAGCCACGTGAAGGCGTTGCACCTGAGCTGCTCACTGAGGACGCTTTTGCA
CTCATCGAGCGCGAGGATGTTGACATCGTCGTTGAGGTTATCGGTGGCATTGAGTACCCACGTGAGGTAGTTCTCGCAGC
TCTGAAGGCCGGCAAGTCTGTTGTTACCGCCAATAAGGCTCTTGTTGCAGCTCACTCTGCTGAGCTTGCTGATGCAGCGG
AAGCCGCAAACGTTGACCTGTACTTCGAGGCTGCTGTTGCAGGCGCAATTCCAGTGGTTGGCCCACTGCGTCGCTCCCTG
GCTGGCGATCAGATCCAGTCTGTGATGGGCATCGTTAACGGCACCACCAACTTCATCTTGGACGCCATGGATTCCACCGG
CGCTGACTATGCAGATTCTTTGGCTGAGGCAACTCGTTTGGGTTACGCCGAAGCTGATCCAACTGCAGACGTCGAAGGCC
ATGACGCCGCATCCAAGGCTGCAATTTTGGCATCCATCGCTTTCCACACCCGTGTTACCGCGGATGATGTGTACTGCGAA
GGTATCAGCAACATCAGCGCTGCCGACATTGAGGCAGCACAGCAGGCAGGCCACACCATCAAGTTGTTGGCCATCTGTGA
GAAGTTCACCAATAAGGAAGGAAAGTCGGCCATTTCTGCTCGCGTGCACCCGACTCTATTGCCTGTGTCCCACCCACTGG
CGTCGGTAAATAAGTCCTTTAACGCAATCTTTGTTGAAGCTGAAGCAGCTGGTCGCCTAATGTTCTACGGAAACGGTGCA
GGTGGCGCGCCAACCGCGTCTGCTGTGCTTGGCGACGTCGTTGGTGCCGCACGAAACAAGGTGCACGGTGGCCGTGCTCC
AGGTGAGTCCACCTACGCTAACCTGCCGATCGCTGATTTTGGTGAGACCACCACTCGTTACCACCTCGACATGGATGTGG
AAGATCGCGTGGGCGTTTTGGCAGAATTGGCTAGCCTGTTCTCTGAGCAAGGAATCTCCCTGCGTACAATCCGACAGGAA
GAGCGCGATGATGATGCACGTCTGATCGTTGTCACCCACTCTGCGCTGGAATCTGATCTTTCCCGCACCGTTGAACTGCT
GAAGGCTAAGCCTGTTGTTAAGGCAATCAACAGTGTGATCCGCCTCGAAAGGGACTAA

Upstream 100 bases:

>100_bases
CTATAGTGGCTAGGTACCCTTTTTGTTTTGGACACATGTAGGGTGGCCGAAACAAAGTAATAGGACAACAACGCTCGACC
GCGATTATTTTTGGAGAATC

Downstream 100 bases:

>100_bases
TTTTACTGACATGGCAATTGAACTGAACGTCGGTCGTAAGGTTACCGTCACGGTACCTGGATCTTCTGCAAACCTCGGAC
CTGGCTTTGACACTTTAGGT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MTSASAPSFNPGKGPGSAVGIALLGFGTVGTEVMRLMTEYGDELAHRIGGPLEVRGIAVSDISKPREGVAPELLTEDAFA
LIEREDVDIVVEVIGGIEYPREVVLAALKAGKSVVTANKALVAAHSAELADAAEAANVDLYFEAAVAGAIPVVGPLRRSL
AGDQIQSVMGIVNGTTNFILDAMDSTGADYADSLAEATRLGYAEADPTADVEGHDAASKAAILASIAFHTRVTADDVYCE
GISNISAADIEAAQQAGHTIKLLAICEKFTNKEGKSAISARVHPTLLPVSHPLASVNKSFNAIFVEAEAAGRLMFYGNGA
GGAPTASAVLGDVVGAARNKVHGGRAPGESTYANLPIADFGETTTRYHLDMDVEDRVGVLAELASLFSEQGISLRTIRQE
ERDDDARLIVVTHSALESDLSRTVELLKAKPVVKAINSVIRLERD

Sequences:

>Translated_445_residues
MTSASAPSFNPGKGPGSAVGIALLGFGTVGTEVMRLMTEYGDELAHRIGGPLEVRGIAVSDISKPREGVAPELLTEDAFA
LIEREDVDIVVEVIGGIEYPREVVLAALKAGKSVVTANKALVAAHSAELADAAEAANVDLYFEAAVAGAIPVVGPLRRSL
AGDQIQSVMGIVNGTTNFILDAMDSTGADYADSLAEATRLGYAEADPTADVEGHDAASKAAILASIAFHTRVTADDVYCE
GISNISAADIEAAQQAGHTIKLLAICEKFTNKEGKSAISARVHPTLLPVSHPLASVNKSFNAIFVEAEAAGRLMFYGNGA
GGAPTASAVLGDVVGAARNKVHGGRAPGESTYANLPIADFGETTTRYHLDMDVEDRVGVLAELASLFSEQGISLRTIRQE
ERDDDARLIVVTHSALESDLSRTVELLKAKPVVKAINSVIRLERD
>Mature_444_residues
TSASAPSFNPGKGPGSAVGIALLGFGTVGTEVMRLMTEYGDELAHRIGGPLEVRGIAVSDISKPREGVAPELLTEDAFAL
IEREDVDIVVEVIGGIEYPREVVLAALKAGKSVVTANKALVAAHSAELADAAEAANVDLYFEAAVAGAIPVVGPLRRSLA
GDQIQSVMGIVNGTTNFILDAMDSTGADYADSLAEATRLGYAEADPTADVEGHDAASKAAILASIAFHTRVTADDVYCEG
ISNISAADIEAAQQAGHTIKLLAICEKFTNKEGKSAISARVHPTLLPVSHPLASVNKSFNAIFVEAEAAGRLMFYGNGAG
GAPTASAVLGDVVGAARNKVHGGRAPGESTYANLPIADFGETTTRYHLDMDVEDRVGVLAELASLFSEQGISLRTIRQEE
RDDDARLIVVTHSALESDLSRTVELLKAKPVVKAINSVIRLERD

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain

Homologues:

Organism=Escherichia coli, GI1790376, Length=355, Percent_Identity=24.7887323943662, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=225, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHOM_CORGL (P08499)

Other databases:

- EMBL:   Y00546
- EMBL:   Y00476
- EMBL:   BA000036
- EMBL:   BX927151
- PIR:   S00865
- RefSeq:   NP_600409.1
- RefSeq:   YP_225473.1
- ProteinModelPortal:   P08499
- World-2DPAGE:   0001:P08499
- PRIDE:   P08499
- GeneID:   1019166
- GeneID:   3343957
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1337
- KEGG:   cgl:NCgl1136
- HOGENOM:   HBG527379
- OMA:   GIPIIEP
- PhylomeDB:   P08499
- ProtClustDB:   PRK06349
- BioCyc:   CGLU196627:CG1337-MONOMER
- BRENDA:   1.1.1.3
- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000098

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3

EC number: =1.1.1.3

Molecular weight: Translated: 46439; Mature: 46308

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: ACT_SITE 219-219 BINDING 119-119 BINDING 204-204

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSASAPSFNPGKGPGSAVGIALLGFGTVGTEVMRLMTEYGDELAHRIGGPLEVRGIAVS
CCCCCCCCCCCCCCCCHHHEEHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHH
DISKPREGVAPELLTEDAFALIEREDVDIVVEVIGGIEYPREVVLAALKAGKSVVTANKA
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCHH
LVAAHSAELADAAEAANVDLYFEAAVAGAIPVVGPLRRSLAGDQIQSVMGIVNGTTNFIL
HEEEHHHHHHHHHHHCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEE
DAMDSTGADYADSLAEATRLGYAEADPTADVEGHDAASKAAILASIAFHTRVTADDVYCE
ECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHC
GISNISAADIEAAQQAGHTIKLLAICEKFTNKEGKSAISARVHPTLLPVSHPLASVNKSF
CCCCCCHHHHHHHHHCCCEEHHHHHHHHHCCCCCCHHHHHCCCCEEECCCCCHHHHCCCC
NAIFVEAEAAGRLMFYGNGAGGAPTASAVLGDVVGAARNKVHGGRAPGESTYANLPIADF
CEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GETTTRYHLDMDVEDRVGVLAELASLFSEQGISLRTIRQEERDDDARLIVVTHSALESDL
CCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCEEEEEEHHHHHHHH
SRTVELLKAKPVVKAINSVIRLERD
HHHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSASAPSFNPGKGPGSAVGIALLGFGTVGTEVMRLMTEYGDELAHRIGGPLEVRGIAVS
CCCCCCCCCCCCCCCHHHEEHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHH
DISKPREGVAPELLTEDAFALIEREDVDIVVEVIGGIEYPREVVLAALKAGKSVVTANKA
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCHH
LVAAHSAELADAAEAANVDLYFEAAVAGAIPVVGPLRRSLAGDQIQSVMGIVNGTTNFIL
HEEEHHHHHHHHHHHCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEE
DAMDSTGADYADSLAEATRLGYAEADPTADVEGHDAASKAAILASIAFHTRVTADDVYCE
ECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHC
GISNISAADIEAAQQAGHTIKLLAICEKFTNKEGKSAISARVHPTLLPVSHPLASVNKSF
CCCCCCHHHHHHHHHCCCEEHHHHHHHHHCCCCCCHHHHHCCCCEEECCCCCHHHHCCCC
NAIFVEAEAAGRLMFYGNGAGGAPTASAVLGDVVGAARNKVHGGRAPGESTYANLPIADF
CEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GETTTRYHLDMDVEDRVGVLAELASLFSEQGISLRTIRQEERDDDARLIVVTHSALESDL
CCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCEEEEEEHHHHHHHH
SRTVELLKAKPVVKAINSVIRLERD
HHHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2835591; 3320973; 9362124; 12948626; 1902466