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The map label for this gene is mazG [H]

Identifier: 145295124

GI number: 145295124

Start: 1182170

End: 1182757

Strand: Direct

Name: mazG [H]

Synonym: cgR_1067

Alternate gene names: 145295124

Gene position: 1182170-1182757 (Clockwise)

Preceding gene: 145295123

Following gene: 145295127

Centisome position: 35.67

GC content: 53.74

Gene sequence:

>588_bases
ATGCGCGTCGTAGTTGTTGATCCTAAACACCCCGTCCTTCCAGTCTCTTTCCTCGAGGCTGTTCTTGGGCGGGGTGAACC
TGTTTCTATCGATCCCGATTTTCCATTTGATATTGAAAAATGGGGGATCAAGACGTCGACAAGCGCCTCCTGGTTTATCA
CCGCAAAACCGCAAAGCACGCTGCTTATCGACGCGCCCCTCAACCCTTTGCATGAGGCCGTCGGCGTCATGCGGGCGGCC
GTGGGCCGCGGCGAGTGGGAACGCACGCAAACCCATGAGAGTTTGATTCCGTATCTGGAAGAAGAATCGCAGGAGTTTAT
TGAAGCGATTCATGGTGGCGATGATGAGCACATGAAAAGCGAACTGGGGGATGTTTTGCTGCAGGTGCTTTTTCATGCAG
AAATCGCCGCCCGTCAGGGTCGATTCGACATTTTTGACGTGGCGGCGAGTTTCGTAGCCAAGATGCAATCTCGTTCGCCG
TACCTGTTCGACGGCTCGACCGGAATTGTGGACACCGACGAGCAGCAGCGGCTGTGGGCTCAAGGAAAAGCCCAAGAGAA
ACTAAGCAGTGAAAAAGGAAGAAGATAG

Upstream 100 bases:

>100_bases
ACAAAGCGGATCAGATTAACAAGGTCCGTGACGCTGTCGATGAGCGCATTGGCAAAAACAACGGCGGCGAAGAGAATCCA
GCCAACTAGTATTAGGCGTC

Downstream 100 bases:

>100_bases
GTTAGAGGACAGAAGCTGCAGCTGGGAGAGGAAGTCCTGTGGATCTTCCTTCACGATTCCGCAGGTCAGTGCGCGGTTAG
CGATGCGCTCGGAGTACGCG

Product: hypothetical protein

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRVVVVDPKHPVLPVSFLEAVLGRGEPVSIDPDFPFDIEKWGIKTSTSASWFITAKPQSTLLIDAPLNPLHEAVGVMRAA
VGRGEWERTQTHESLIPYLEEESQEFIEAIHGGDDEHMKSELGDVLLQVLFHAEIAARQGRFDIFDVAASFVAKMQSRSP
YLFDGSTGIVDTDEQQRLWAQGKAQEKLSSEKGRR

Sequences:

>Translated_195_residues
MRVVVVDPKHPVLPVSFLEAVLGRGEPVSIDPDFPFDIEKWGIKTSTSASWFITAKPQSTLLIDAPLNPLHEAVGVMRAA
VGRGEWERTQTHESLIPYLEEESQEFIEAIHGGDDEHMKSELGDVLLQVLFHAEIAARQGRFDIFDVAASFVAKMQSRSP
YLFDGSTGIVDTDEQQRLWAQGKAQEKLSSEKGRR
>Mature_195_residues
MRVVVVDPKHPVLPVSFLEAVLGRGEPVSIDPDFPFDIEKWGIKTSTSASWFITAKPQSTLLIDAPLNPLHEAVGVMRAA
VGRGEWERTQTHESLIPYLEEESQEFIEAIHGGDDEHMKSELGDVLLQVLFHAEIAARQGRFDIFDVAASFVAKMQSRSP
YLFDGSTGIVDTDEQQRLWAQGKAQEKLSSEKGRR

Specific function: Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation-induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8- dihydro-2'-deoxyg

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=102, Percent_Identity=36.2745098039216, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 21757; Mature: 21757

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVVVDPKHPVLPVSFLEAVLGRGEPVSIDPDFPFDIEKWGIKTSTSASWFITAKPQST
CEEEEECCCCCCCCHHHHHHHHCCCCCEEECCCCCCCHHHCCCCCCCCCEEEEEECCCCE
LLIDAPLNPLHEAVGVMRAAVGRGEWERTQTHESLIPYLEEESQEFIEAIHGGDDEHMKS
EEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ELGDVLLQVLFHAEIAARQGRFDIFDVAASFVAKMQSRSPYLFDGSTGIVDTDEQQRLWA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHH
QGKAQEKLSSEKGRR
CCHHHHHHHHHCCCC
>Mature Secondary Structure
MRVVVVDPKHPVLPVSFLEAVLGRGEPVSIDPDFPFDIEKWGIKTSTSASWFITAKPQST
CEEEEECCCCCCCCHHHHHHHHCCCCCEEECCCCCCCHHHCCCCCCCCCEEEEEECCCCE
LLIDAPLNPLHEAVGVMRAAVGRGEWERTQTHESLIPYLEEESQEFIEAIHGGDDEHMKS
EEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ELGDVLLQVLFHAEIAARQGRFDIFDVAASFVAKMQSRSPYLFDGSTGIVDTDEQQRLWA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHH
QGKAQEKLSSEKGRR
CCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA