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The map label for this gene is wecC [H]

Identifier: 145294482

GI number: 145294482

Start: 488902

End: 490158

Strand: Reverse

Name: wecC [H]

Synonym: cgR_0437

Alternate gene names: 145294482

Gene position: 490158-488902 (Counterclockwise)

Preceding gene: 145294487

Following gene: 145294478

Centisome position: 14.79

GC content: 48.77

Gene sequence:

>1257_bases
ATGACAAACCAAACGGTTGCATTCGTCGGCCTAGGATACATCGGCCTTCCCACCGCAGTAGTAATGGCAAACTCTGGAGT
TGACGTAACCGGTGTTGACGTCAATGAAAAGAACGTGGAGCGCATCAATCGTGGTGAAGTCACTATTGTTGAACCAGGCT
TGGAAGAAGAGTTAAAGCAAGCCATCGAATCAGGAAACTTCCGTGCAACTACCACCCAGGTACACGCACAGACCTACATC
ATCGCCGTCCCTACTCCATTCACTGATGACTACGGCGTAGATATGAAATACATCTACTCTGCGGCAGAAGCGATCGCACC
AAAACTTGAAGGAAACGAACTTGTCATTTTGGAGTCAACTTCTCCACCTTTGACGACCAAGAAAATGGCCGACAAGATCC
TTGAGTTACGCCCAGATTTGGTAGCCGATGGTGCTGAAAACCCAGAAGGTAAACCAGTAATCTACTTCGCACATTGCCCT
GAACGTATTCTTCCAGGAAAGGCCATGGAAGAACTGCGAACCAACGACCGCATCATTGGTGGACAGACAGAAGAAGCTAC
CAAACGAGCAACCGCTGTGTACGCAACCTTCTGCGAAGCAGAACTACTTCCGACCAATGATGTAACTGCAGAAATGGCTA
AACTCACGGAAAACTCCTTCCGCGATGTGAACATTGCCTTTGCAAACGAGTTGTCTCTCATTGCTGACAACCTGGATATC
AACGTGTGGGAACTTATCGAGCTCGCAAACCACCACCCTCGCGTAAATATCCTTCAGCCAGGCCCTGGTGTTGGCGGCCA
CTGCATTGCAGTTGACCCGTGGTTTATCGTTTCCTCCGATCCTCAGAATTCTCGCCTAATTCGTACTGCACGAGAGGTAA
ATGACGGCAAGCCAAAATGGGTCATCGATAAGGTTGCTGAGGCACTCAACGGATACCAGACAGGGGCTAAGATCGCCACG
CTAGGAATGGCTTTCAAAGCAGATATTGATGACCTCCGCGAATCTCCTGCGCTCAATATCACTAAAGAGCTCGCAAATCG
TTTTGTTGATCAGACAATCCTGGCAGTTGAACCAAATGTGAGTAAGCTTCCAACTGATCTTGAGGGCATCAAAAACATCA
CTCTGACCGCTTACGACCAGGCTATCGCTGATGCTGATATCGTCGTTTTGCTCGTAGATCATCATGAATTCAAGGGCGTC
AGCGCCGCTCAACTCAAGGACAAGACAATCATCGACACCAAGGGACTTTGGGTCTAA

Upstream 100 bases:

>100_bases
ATTCATATCCAAGTAGTAAAGTCCGTAGAACACGGTAGAGATCACTACTTATTCATGAAAGTATCGCTGCCCAGATCTCA
CAAACATTGAGGATTCCAAA

Downstream 100 bases:

>100_bases
AAGATCTGGCAGCACCAAACTGCGGAATAGAATATCTAAATGTCCCGTACCTCGGAGGTTTTCCAGGTACGGGACATTTC
TGTAACTCAGCGGATGGCAG

Product: hypothetical protein

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTNQTVAFVGLGYIGLPTAVVMANSGVDVTGVDVNEKNVERINRGEVTIVEPGLEEELKQAIESGNFRATTTQVHAQTYI
IAVPTPFTDDYGVDMKYIYSAAEAIAPKLEGNELVILESTSPPLTTKKMADKILELRPDLVADGAENPEGKPVIYFAHCP
ERILPGKAMEELRTNDRIIGGQTEEATKRATAVYATFCEAELLPTNDVTAEMAKLTENSFRDVNIAFANELSLIADNLDI
NVWELIELANHHPRVNILQPGPGVGGHCIAVDPWFIVSSDPQNSRLIRTAREVNDGKPKWVIDKVAEALNGYQTGAKIAT
LGMAFKADIDDLRESPALNITKELANRFVDQTILAVEPNVSKLPTDLEGIKNITLTAYDQAIADADIVVLLVDHHEFKGV
SAAQLKDKTIIDTKGLWV

Sequences:

>Translated_418_residues
MTNQTVAFVGLGYIGLPTAVVMANSGVDVTGVDVNEKNVERINRGEVTIVEPGLEEELKQAIESGNFRATTTQVHAQTYI
IAVPTPFTDDYGVDMKYIYSAAEAIAPKLEGNELVILESTSPPLTTKKMADKILELRPDLVADGAENPEGKPVIYFAHCP
ERILPGKAMEELRTNDRIIGGQTEEATKRATAVYATFCEAELLPTNDVTAEMAKLTENSFRDVNIAFANELSLIADNLDI
NVWELIELANHHPRVNILQPGPGVGGHCIAVDPWFIVSSDPQNSRLIRTAREVNDGKPKWVIDKVAEALNGYQTGAKIAT
LGMAFKADIDDLRESPALNITKELANRFVDQTILAVEPNVSKLPTDLEGIKNITLTAYDQAIADADIVVLLVDHHEFKGV
SAAQLKDKTIIDTKGLWV
>Mature_417_residues
TNQTVAFVGLGYIGLPTAVVMANSGVDVTGVDVNEKNVERINRGEVTIVEPGLEEELKQAIESGNFRATTTQVHAQTYII
AVPTPFTDDYGVDMKYIYSAAEAIAPKLEGNELVILESTSPPLTTKKMADKILELRPDLVADGAENPEGKPVIYFAHCPE
RILPGKAMEELRTNDRIIGGQTEEATKRATAVYATFCEAELLPTNDVTAEMAKLTENSFRDVNIAFANELSLIADNLDIN
VWELIELANHHPRVNILQPGPGVGGHCIAVDPWFIVSSDPQNSRLIRTAREVNDGKPKWVIDKVAEALNGYQTGAKIATL
GMAFKADIDDLRESPALNITKELANRFVDQTILAVEPNVSKLPTDLEGIKNITLTAYDQAIADADIVVLLVDHHEFKGVS
AAQLKDKTIIDTKGLWV

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=369, Percent_Identity=28.7262872628726, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI296040438, Length=268, Percent_Identity=27.6119402985075, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI296040443, Length=200, Percent_Identity=29, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI48994968, Length=424, Percent_Identity=54.0094339622642, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1788340, Length=387, Percent_Identity=23.7726098191214, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560350, Length=445, Percent_Identity=26.5168539325843, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17136908, Length=366, Percent_Identity=27.8688524590164, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45581; Mature: 45450

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQTVAFVGLGYIGLPTAVVMANSGVDVTGVDVNEKNVERINRGEVTIVEPGLEEELKQ
CCCCEEEEEECCHHHCCEEEEEECCCCEEEEECCCHHHHHHCCCCCEEEECCCHHHHHHH
AIESGNFRATTTQVHAQTYIIAVPTPFTDDYGVDMKYIYSAAEAIAPKLEGNELVILEST
HHHCCCCEEEEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECC
SPPLTTKKMADKILELRPDLVADGAENPEGKPVIYFAHCPERILPGKAMEELRTNDRIIG
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHCCCHHHHHHHCCCEEEC
GQTEEATKRATAVYATFCEAELLPTNDVTAEMAKLTENSFRDVNIAFANELSLIADNLDI
CCCHHHHHHHHHHEEEECCCEECCCCCHHHHHHHHHCCCCCEEEEEEECCEEEEECCCCC
NVWELIELANHHPRVNILQPGPGVGGHCIAVDPWFIVSSDPQNSRLIRTAREVNDGKPKW
CHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEECCCCCCHHHHHHHHCCCCCCCH
VIDKVAEALNGYQTGAKIATLGMAFKADIDDLRESPALNITKELANRFVDQTILAVEPNV
HHHHHHHHHCCCCCCCEEEEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHCEEEEECCCH
SKLPTDLEGIKNITLTAYDQAIADADIVVLLVDHHEFKGVSAAQLKDKTIIDTKGLWV
HHCCCCHHHHCCEEEEEHHHHHCCCCEEEEEEECCCCCCCCHHHHCCCEEECCCCCCC
>Mature Secondary Structure 
TNQTVAFVGLGYIGLPTAVVMANSGVDVTGVDVNEKNVERINRGEVTIVEPGLEEELKQ
CCCEEEEEECCHHHCCEEEEEECCCCEEEEECCCHHHHHHCCCCCEEEECCCHHHHHHH
AIESGNFRATTTQVHAQTYIIAVPTPFTDDYGVDMKYIYSAAEAIAPKLEGNELVILEST
HHHCCCCEEEEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECC
SPPLTTKKMADKILELRPDLVADGAENPEGKPVIYFAHCPERILPGKAMEELRTNDRIIG
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHCCCHHHHHHHCCCEEEC
GQTEEATKRATAVYATFCEAELLPTNDVTAEMAKLTENSFRDVNIAFANELSLIADNLDI
CCCHHHHHHHHHHEEEECCCEECCCCCHHHHHHHHHCCCCCEEEEEEECCEEEEECCCCC
NVWELIELANHHPRVNILQPGPGVGGHCIAVDPWFIVSSDPQNSRLIRTAREVNDGKPKW
CHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEECCCCCCHHHHHHHHCCCCCCCH
VIDKVAEALNGYQTGAKIATLGMAFKADIDDLRESPALNITKELANRFVDQTILAVEPNV
HHHHHHHHHCCCCCCCEEEEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHCEEEEECCCH
SKLPTDLEGIKNITLTAYDQAIADADIVVLLVDHHEFKGVSAAQLKDKTIIDTKGLWV
HHCCCCHHHHCCEEEEEHHHHHCCCCEEEEEEECCCCCCCCHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]