Click here to switch to the map view.

The map label for this gene is adhA [H]

Identifier: 145294458

GI number: 145294458

Start: 450979

End: 452049

Strand: Reverse

Name: adhA [H]

Synonym: cgR_0413

Alternate gene names: 145294458

Gene position: 452049-450979 (Counterclockwise)

Preceding gene: 145294460

Following gene: 145294454

Centisome position: 13.64

GC content: 56.77

Gene sequence:

>1071_bases
ATGGCGCGGGTGAGTATCCCAGTAAAAGCACTTCAGAAAACCGGCCCCGACGCACCTTTCGAGGTCAAGATCATTGAACG
CCGTGACCCACGCGCAGATGATGTGGTTATTGATATCAAAGCTGCGGGCATCTGCCACAGCGATATCCACACCATCCGCA
ATGAATGGGGTGAGGCACATTTCCCACTCACAGTAGGCCACGAAATCGCAGGTGTGGTCTCTGCCGTTGGAACAGGCGTA
ACCAAGTGGAAAGTCGGCGACCGCGTTGGTGTCGGCTGCCTCGTTAACTCCTGCGGCGAATGCGAACAGTGCGTCGCAGG
ATTTGAAAACAACTGCCTTCGCGGAAACGTCGGAACCTACAACTCCGACGACGTCGACGGCACCATCACGCAAGGTGGCT
ACGCCGAAAAGGTAGTGGTCAACGAACGTTTCCTCTGCAGCATCCCAGAGGAACTCGACTTCGATGTCGCAGCACCACTG
CTGTGCGCAGGCATCACCACCTACTCCCCAATCGCTCGCTGGAACGTCAAAGAAGGCGACAAAGTAGCAGTCATGGGCCT
CGGCGGACTCGGCCACATGGGTGTCCAAATCGCCGCAGCCAAGGGCGCTGACGTTACCGTTCTGTCCCGTTCCCTGCGCA
AGGCTGAACTTGCCAAGGAACTCGGCGCAGCTCGCACGCTTGCGACTTCTGATGAGGATTTCTTCACCGAACACGCCGGT
GAATTCGACTTCATCCTCAACACCATTAGCGCATCCATCCCAGTCGACAAGTACCTGAGCCTTCTCAAGCCACACGGTGT
CATGGCTGTTGTCGGTCTGCCACCAGAGAAGCAGCCACTGAGCTTCGGTGCGCTCATCGGCGGCGGAAAAGTCCTCACCG
GATCCAACATTGGCGGCATCCCTGAAACCCAGGAAATGCTCGACTTCTGTGCAAAACACGGCCTCGGTGCGATGATCGAA
ACTGTCGGCGTCAACGATGTTGATGCAGCCTACGACCGCGTTGTTGCCGGCGACGTTCAGTTCCGCGTTGTTATTGATAC
TGCTTCGTTTGCTGAGGTAGAGGCGGTTTAG

Upstream 100 bases:

>100_bases
CAATCTCTTGAATAATCCGATTCAGTTCCAACATATGTACAACCCTAATTTCGTTGATGTTTTGCTTCTTGATCTTTTCT
GACCGTAAAAAATCGGTACC

Downstream 100 bases:

>100_bases
GCTTTGGCTTTTTGAGTTTGTCTCTGGAGTTGGGGTTTTGGCTTTAGGTTTCTGACGCTGGAAGCAGACTCTGAAGTACC
TCTAAGCGGCGCTGGGATTC

Product: hypothetical protein

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MARVSIPVKALQKTGPDAPFEVKIIERRDPRADDVVIDIKAAGICHSDIHTIRNEWGEAHFPLTVGHEIAGVVSAVGTGV
TKWKVGDRVGVGCLVNSCGECEQCVAGFENNCLRGNVGTYNSDDVDGTITQGGYAEKVVVNERFLCSIPEELDFDVAAPL
LCAGITTYSPIARWNVKEGDKVAVMGLGGLGHMGVQIAAAKGADVTVLSRSLRKAELAKELGAARTLATSDEDFFTEHAG
EFDFILNTISASIPVDKYLSLLKPHGVMAVVGLPPEKQPLSFGALIGGGKVLTGSNIGGIPETQEMLDFCAKHGLGAMIE
TVGVNDVDAAYDRVVAGDVQFRVVIDTASFAEVEAV

Sequences:

>Translated_356_residues
MARVSIPVKALQKTGPDAPFEVKIIERRDPRADDVVIDIKAAGICHSDIHTIRNEWGEAHFPLTVGHEIAGVVSAVGTGV
TKWKVGDRVGVGCLVNSCGECEQCVAGFENNCLRGNVGTYNSDDVDGTITQGGYAEKVVVNERFLCSIPEELDFDVAAPL
LCAGITTYSPIARWNVKEGDKVAVMGLGGLGHMGVQIAAAKGADVTVLSRSLRKAELAKELGAARTLATSDEDFFTEHAG
EFDFILNTISASIPVDKYLSLLKPHGVMAVVGLPPEKQPLSFGALIGGGKVLTGSNIGGIPETQEMLDFCAKHGLGAMIE
TVGVNDVDAAYDRVVAGDVQFRVVIDTASFAEVEAV
>Mature_355_residues
ARVSIPVKALQKTGPDAPFEVKIIERRDPRADDVVIDIKAAGICHSDIHTIRNEWGEAHFPLTVGHEIAGVVSAVGTGVT
KWKVGDRVGVGCLVNSCGECEQCVAGFENNCLRGNVGTYNSDDVDGTITQGGYAEKVVVNERFLCSIPEELDFDVAAPLL
CAGITTYSPIARWNVKEGDKVAVMGLGGLGHMGVQIAAAKGADVTVLSRSLRKAELAKELGAARTLATSDEDFFTEHAGE
FDFILNTISASIPVDKYLSLLKPHGVMAVVGLPPEKQPLSFGALIGGGKVLTGSNIGGIPETQEMLDFCAKHGLGAMIET
VGVNDVDAAYDRVVAGDVQFRVVIDTASFAEVEAV

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=353, Percent_Identity=30.028328611898, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI34577061, Length=351, Percent_Identity=29.3447293447293, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI4501929, Length=351, Percent_Identity=28.7749287749288, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI156523966, Length=323, Percent_Identity=29.1021671826625, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501939, Length=323, Percent_Identity=29.1021671826625, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI71743840, Length=309, Percent_Identity=27.5080906148867, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI262073058, Length=309, Percent_Identity=27.5080906148867, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI71565154, Length=251, Percent_Identity=31.0756972111554, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI71565152, Length=232, Percent_Identity=30.1724137931034, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786518, Length=352, Percent_Identity=46.3068181818182, Blast_Score=282, Evalue=2e-77,
Organism=Escherichia coli, GI87082401, Length=332, Percent_Identity=33.433734939759, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI87081918, Length=334, Percent_Identity=28.4431137724551, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788407, Length=248, Percent_Identity=29.8387096774194, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787863, Length=270, Percent_Identity=30.7407407407407, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788073, Length=281, Percent_Identity=29.1814946619217, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87082125, Length=219, Percent_Identity=31.0502283105023, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788075, Length=298, Percent_Identity=30.5369127516779, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790045, Length=321, Percent_Identity=26.1682242990654, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1786552, Length=233, Percent_Identity=32.618025751073, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=340, Percent_Identity=30, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17562584, Length=358, Percent_Identity=29.3296089385475, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562582, Length=343, Percent_Identity=27.6967930029155, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25146526, Length=366, Percent_Identity=26.775956284153, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=368, Percent_Identity=26.6304347826087, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=260, Percent_Identity=28.0769230769231, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=333, Percent_Identity=27.027027027027, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=215, Percent_Identity=29.7674418604651, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=328, Percent_Identity=37.1951219512195, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319949, Length=326, Percent_Identity=34.3558282208589, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6323729, Length=338, Percent_Identity=30.4733727810651, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323961, Length=356, Percent_Identity=30.3370786516854, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6324486, Length=338, Percent_Identity=30.4733727810651, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6319621, Length=351, Percent_Identity=29.9145299145299, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320033, Length=347, Percent_Identity=27.0893371757925, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=227, Percent_Identity=34.8017621145374, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=290, Percent_Identity=29.3103448275862, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6322619, Length=290, Percent_Identity=29.3103448275862, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=220, Percent_Identity=31.3636363636364, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=227, Percent_Identity=28.1938325991189, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737895, Length=308, Percent_Identity=28.2467532467532, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137530, Length=199, Percent_Identity=30.6532663316583, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737897, Length=199, Percent_Identity=30.6532663316583, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 37565; Mature: 37434

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVSIPVKALQKTGPDAPFEVKIIERRDPRADDVVIDIKAAGICHSDIHTIRNEWGEAH
CCEECCCHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCC
FPLTVGHEIAGVVSAVGTGVTKWKVGDRVGVGCLVNSCGECEQCVAGFENNCLRGNVGTY
CCEEECHHHHHHHHHHCCCCEEEECCCCCCHHHHHHCCCCHHHHHHCCCCCCEECCCCCC
NSDDVDGTITQGGYAEKVVVNERFLCSIPEELDFDVAAPLLCAGITTYSPIARWNVKEGD
CCCCCCCEEECCCCEEEEEECCCEEECCCCCCCCHHHHHHHHHCCCCCCCHHCCCCCCCC
KVAVMGLGGLGHMGVQIAAAKGADVTVLSRSLRKAELAKELGAARTLATSDEDFFTEHAG
EEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCC
EFDFILNTISASIPVDKYLSLLKPHGVMAVVGLPPEKQPLSFGALIGGGKVLTGSNIGGI
CHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCEEEECCCCCCC
PETQEMLDFCAKHGLGAMIETVGVNDVDAAYDRVVAGDVQFRVVIDTASFAEVEAV
CCHHHHHHHHHHCCCCCEEHCCCCCCHHHHHHHEEECCEEEEEEEECCCCCEEECC
>Mature Secondary Structure 
ARVSIPVKALQKTGPDAPFEVKIIERRDPRADDVVIDIKAAGICHSDIHTIRNEWGEAH
CEECCCHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCC
FPLTVGHEIAGVVSAVGTGVTKWKVGDRVGVGCLVNSCGECEQCVAGFENNCLRGNVGTY
CCEEECHHHHHHHHHHCCCCEEEECCCCCCHHHHHHCCCCHHHHHHCCCCCCEECCCCCC
NSDDVDGTITQGGYAEKVVVNERFLCSIPEELDFDVAAPLLCAGITTYSPIARWNVKEGD
CCCCCCCEEECCCCEEEEEECCCEEECCCCCCCCHHHHHHHHHCCCCCCCHHCCCCCCCC
KVAVMGLGGLGHMGVQIAAAKGADVTVLSRSLRKAELAKELGAARTLATSDEDFFTEHAG
EEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCC
EFDFILNTISASIPVDKYLSLLKPHGVMAVVGLPPEKQPLSFGALIGGGKVLTGSNIGGI
CHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCEEEECCCCCCC
PETQEMLDFCAKHGLGAMIETVGVNDVDAAYDRVVAGDVQFRVVIDTASFAEVEAV
CCHHHHHHHHHHCCCCCEEHCCCCCCHHHHHHHEEECCEEEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]